Urbanization is a significant indicator of city progress, and as urbanization advances, carbon emissions exhibit an increasing trend that must not be disregarded. Therefore, it is imperative to thoroughly examine the spatial and temporal variations as well as the factors influencing carbon emissions during the urbanization process. In this paper, based on the 2009–2019 PRD region, carbon emissions are measured from energy consumption, industrial production process, solid waste, and wastewater according to the IPCC coefficients, and spatial and spatial differences in carbon emissions are combined with spatial analysis and the drivers analyzed using the gray correlation scale. The results show that: (1) The total carbon emissions in the PRD region have been increasing over the study period, and the distribution of total carbon emissions shows a pattern of “strong in the east and weak in the west”, with energy consumption accounting for the highest proportion of carbon emissions. (2) The global Moran Index of carbon emissions in the PRD has been decreasing, with low and low clustering concentrated in Shaoguan and Zhaoqing, high and high clustering concentrated in Dongguan and Shenzhen, and low and high clustering concentrated in Shenzhen and Guangzhou, with cold spots mainly concentrated in Zhaoqing and hot spots mainly distributed in Guangzhou, Shenzhen, and Dongguan. (3) The degree of economic growth has a substantial influence on carbon emissions in the PRD cities, and the influence of technical advancement has intensified. Guangzhou City is propelled by low-carbon regulations that have a more equitable influence on all elements. Zhuhai City has a more significant influence on energy intensity, while Foshan City has a more noticeable decrease in the effect of foreign investment. To address the issue of carbon emissions, the government should establish appropriate rules to regulate carbon emissions in areas with high emissions, foster collaborative efforts across cities, and encourage the growth of environmentally friendly enterprises.