The WHO has recommended self-isolation and social distancing measures for containing the coronavirus 19 (COVID-19) pandemic, and the Centers of Disease Control and Prevention (CDC) and the vast majority of countries have adopted it, with strategies varying in terms of degrees of containment (Wilder-Smith and Freedman, 2020). Despite the worldwide efforts in understanding and combating the disease, many uncertainties remain, including the precise rates of transmission and mortality, not to mention the proper treatment, leading to concerns and confusion regarding the necessary duration of the isolation measures. The possible need to adopt intermittent strategies of social distancing has also been raised, alternating periods of stricter and looser isolation (Kissler et al., 2020) until the discovery of a vaccine or efficient treatment is made. Social isolation by itself leads to stress and negative mood (Brooks et al., 2020). The uncertainties mentioned above potentiate these effects, particularly in patients with a history of mental health disorders. Social isolation and loneliness are also associated with increased overall mortality (Steptoe et al., 2013), worse cardiovascular, and mental health outcomes (Leigh-Hunt et al., 2017) and cognitive decline (Evans et al., 2019). Furthermore, the recent Covid-19 outbreak has been associated with post-traumatic stress disorder (PTSD) symptoms, which were identified both in medical staff and the general population (Wang et al., 2020). Numerous studies have demonstrated how non-invasive neuromodulatory techniques such as rTMS and tDCS can help prevent and ameliorate stress, with effects not only on emotion, cognition, and behavior but also on the cardiovascular (Makovac et al., 2017) and autonomic nervous systems (Schestatsky et al., 2013). Although non-invasive, repetitive TMS is expensive and not portable (the only portable option applies a very short train of pulses). Therefore, it is not appropriate during the context of social isolation since patients would have to leave their homes to receive the treatment. On the other hand, tDCS is potentially portable, and its feasibility in home-based settings has been previously studied with promising results regarding its safety and effectiveness (Martens et al., 2018; Brietzke et al., 2020). Our objective in this short communication is to provide a comment on the potential tDCS application on preventing and treating stress-related symptoms during social isolation, while addressing the feasibility and efficacy of home-based tDCS.