Degree Of Closure Research Articles

Finds of skulls of juvenile <I>Kurdalagonus maicopicus</I> (Сetacea, Cetotheriidae) in the upper Miocene of the Republic of Adygea

Fragments of two skulls of young cetotherium baleen whales have been described from the Fortep’yanka 2 locality (Russia, Republic of Adygea, Maikop district, Fortep’yanka river valley, Upper Miocene, Upper Sarmatian, Blinovskaya Formation). Based on the morphology of the posterior (mastoid) process of the petrous bone, the structure of the posterior edge of the temporal fenestra, and the S-shaped shape of the superoccipital ridges, the finds were attributed to Kurdalagonus maicopicus (Spasskii, 1951). The proportions of the skull and the degree of closure of the sutures of the skull made it possible to determine the individual age of these whales within a year. New findings significantly complement the data on the structure of the sutures of the lateral wall of the skull and age-related variability of cranial morphology in representatives of the genus Kurdalagonus.

Time-Dependent Morphological Changes in Traumatic Immature Teeth With Necrotic Pulps Following Regenerative Endodontic Treatment: A Retrospective Study.

Regenerative endodontic treatment is a promising approach for healing periapical lesions and continuous root maturation. Although previous studies have reported its outcomes, the dynamics of morphological changes over time remain unclear. Therefore, this study aimed to evaluate changes in the periapical status and root dimensions over a 60-month follow-up period. The follow-up duration, periapical status changes, calcific barrier formation, degree of apical closure and radiographic root area changes were compared with those of the last follow-up in this retrospective study. Radiographic root area changes were calculated as the difference between the total root and total canal areas. Fifty-eight patients (81 teeth) underwent regenerative endodontic treatment during the study period, of whom 32 patients (36 teeth, 62%) were included. The survival and success rates of the treated teeth were 100% and 94.4%, respectively. All teeth developed a calcific bridge in the cervical third of the root canal, indicating the presence of vital tissue. Apical narrowing (partial or total) was observed in 75% of the cases. The root maturation stage affected the percentage increase in the radiographic root area. Teeth in Cvek stages II-III showed a higher radiographic root area increase than more mature teeth. All tooth radiographic root areas increased significantly in the initial 20 months of the treatment and moderately thereafter. Regenerative endodontic treatment is a safe approach for traumatised immature teeth. The presence of a radiographic calcified bridge may be an early indication of treatment success. The main complete tooth morphological changes occur after approximately 20 months posttreatment. These findings may help clinicians better understand the time-dependent changes in the root morphology after treatment, improve the follow-up schedule and predict the progress of healing during follow-up visits.

Factors determining economic growth in Syria in 2014 – 2023 : macroeconomic analysis

The economy of Syria has been experiencing very strong and diverse pressure from Western countries on the national economy for a long period. Despite this, the country was able to survive and continues its development, although very unstable. In this regard, the issue of thefactors of the growth of the Syrian economy in the last decade, the problems and prospects for the development of the national economy and the foreign trade sector of the country, as well as the prospects for its cooperation with foreign partners, including at the regional level, remains relevant. The article shows that in the last decade, the Syrian economy has faced serious problems, including two new (external) factors – the global COVID-19 pandemic and the escalation of military tensions in the Middle East region, affecting both the territory (and the economy) of Syria. At the domestic socio-economic level, market volatility affects the dynamics of macroeconomic indicators (high instability of development, including in the field of per capita income, a significant degree of closure of the national economy – low indicators of the foreign trade quota with continued import dependence, a significant share of agriculture and low urbanization relative to other countries in the region), while high final consumption costs do not allow the country to ensure the necessary level of fixed capital accumulation for the development and diversification of the national economy. At the same time, Syria's economy remains one of the most diversified in the region, and the country does not face a high degree of food dependence like its regional neighbors. From this, the authors conclude that it is necessary and possible at this stage to intensify and escalate intraregional inter-Arab economic cooperation and trade as one of the tools to reduce existing risks.

Stomatal closure as a driver of minimum leaf conductance declines at high temperature and vapor pressure deficit in Quercus.

Rising global temperatures and vapor pressure deficits (VPD) are increasing plant water demand and becoming major drivers of large-scale plant mortality. Controlling transient leaf water loss after stomatal closure (gmin) is recognized as a key trait determining how long plants survive during soil drought. Yet, substantial uncertainty remains regarding how gmin responds to elevated temperatures and VPD and the underlying mechanisms. We measured gmin in 24 Quercus species from temperate and Mediterranean climates to determine if gmin was sensitive to a coupled temperature and VPD increase. We also explored mechanistic links to phenology, climate, evolutionary history, and leaf anatomy. We found that gmin in all species exhibited a non-linear negative temperature and VPD dependence. At 25°C (VPD = 2.2 kPa), gmin varied from 1.19 to 8.09 mmol m-2 s-1 across species but converged to 0.57 ± 0.06 mmol m-2 s-1 at 45°C (VPD = 6.6 kPa). In a subset of species, the effect of temperature and VPD on gmin was reversible and linked to the degree of stomatal closure, which was greater at 45°C than at 25°C. Our results show that gmin is dependent on temperature and VPD, is highly conserved in Quercus species, and is linked to leaf anatomy and stomatal behavior.

Analysis of failure properties of red sandstone with structural plane subjected to true triaxial stress paths

In order to study the mechanical behavior and failure characteristics of rock mass with the structural plane in complex deep stress environment, the QKX-YB200 true triaxial rockburst test system, acoustic emission, and digital video recorder were adopted to conduct true triaxial loading and unloading indoor tests on the red sandstone cube specimens. The results show that: (1) Under true triaxial loading conditions, all specimens propagate in the form of anti-wing crack, and the dip angle of the structural plane is linearly related to the average value of the anti-wing crack propagation angle; under true triaxial unloading conditions, the specimens with structural plane dip angles of 30°, 45°, and 60° propagate in the form of wing crack, while those with a 90° angle propagate anti-wing cracks, and the closure of structural plane is related to the the crack type at the tips of structural plane. (2) The unstable failure stages in the stress–strain curve under true triaxial unloading are longer and exhibit more pronounced fluctuations; the peak strength of the specimens under the conditions of true triaxial loading and unloading decrease first and then increase with the increase of the dip angle, reaching the lowest at 45°. (3) During the true triaxial unloading tests, the rockburst degree of the intact rock specimens is more violent than that of the specimens with a structural plane. Additionally, the dip angle of the structural plane influences the severity of rockbursts under the same stress path. (4) The crack propagation mechanism and the closure degree of structural planes under different true triaxial stress paths and dip angles are discussed. It is observed that the crack initiation mode around the structural plane tips and the crack mode near free surface are closely related to the stress environment in different areas of the specimens. (5) Based on the indoor test results and previous experimental data, the differences in peak strength characteristics between open structural planes and closed structural planes are preliminarily analyzed and compared.

Mackey convergence and separation in $(L, M)$-fuzzy bornological vector spaces

This paper aims to introduce the concepts of Mackey convergence degree for sequences and separation degree for spaces in $(L, M)$-fuzzy bornological vector spaces. Additionally, the paper presents the concept of bornological closure degree for fuzzy sets. Moreover, the paper discusses various characteristics of these concepts. Furthermore, the paper examines the degree relationships among a Mackey convergence sequence, a separated space, and a bornologically closed fuzzy set. Finally, the paper analyzes the properties of functors $\omega$ and $\iota$ between $M$-fuzzifying bornological vector spaces and $(L, M)$-fuzzy bornological vector spaces in terms of Mackey convergence degree and separation degree.

Molecular Dynamics Simulation Combined with Neural Relationship Inference and Markov Model to Reveal the Relationship between Conformational Regulation and Bioluminescence Properties of Gaussia Luciferase.

Gaussia luciferase (Gluc) is currently known as the smallest naturally secreted luciferase. Due to its small molecular size, high sensitivity, short half-life, and high secretion efficiency, it has become an ideal reporter gene and is widely used in monitoring promoter activity, studying protein-protein interactions, protein localization, high-throughput drug screening, and real-time monitoring of tumor occurrence and development. Although studies have shown that different Gluc mutations exhibit different bioluminescent properties, their mechanisms have not been further investigated. The purpose of this study is to reveal the relationship between the conformational changes of Gluc mutants and their bioluminescent properties through molecular dynamics simulation combined with neural relationship inference (NRI) and Markov models. Our results indicate that, after binding to the luciferin coelenterazine (CTZ), the α-helices of the 109-119 residues of the Gluc Mutant2 (GlucM2, the flash-type mutant) are partially unraveled, while the α-helices of the same part of the Gluc Mutant1 (GlucM1, the glow-type mutant) are clearly formed. The results of Markov flux analysis indicate that the conformational differences between glow-type and flash-type mutants when combined with luciferin substrate CTZ mainly involve the helicity change of α7. The most representative conformation and active pocket distance analysis indicate that compared to the flash-type mutant GlucM2, the glow-type mutant GlucM1 has a higher degree of active site closure and tighter binding. In summary, we provide a theoretical basis for exploring the relationship between the conformational changes of Gluc mutants and their bioluminescent properties, which can serve as a reference for the modification and evolution of luciferases.

The assessment method of lip closure ability based on sEMG nonlinear onset detection algorithms.

To overcome the limitations of traditional diagnosis of orbicularis oris muscle function in mouth-breathing patients, this study aims to propose a surface electromyographic (sEMG) based method for reliable and accurate quantitative assessment of lip closure ability. A total of 21 volunteers (16 patients and 5 healthy subjects, aged 8-16) were included in the study. Three nonlinear onset detection algorithms- Teager-Kaiser Energy (TKE) operator, Sample Entropy (SampEn), and Fuzzy Entropy (FuzzyEn)- were compared for their ability to identify lip closure in sEMG signals. Lip Closure EMG Activity Index (LCEAI) was proposed based on the action segments detected by the best performing algorithm for the quantitative assessment of lip closure. The results indicated that FuzzyEn had the highest lip closure identification rate at 93.78 %, the lowest average onset delay of 47.50 ms, the lowest average endpoint delay of 73.10 ms, and the minimal time error of 111.61 ms, exhibiting superior performance. The calculation results of the LCEAI closely corresponded with the actual degree of lip closure in patients. The lip closure ability assessment method proposed in this study can provide a quantitative basis for the diagnosis of mouth breathing.

Detecting Intrathoracic Airway Closure during Prehospital Cardiopulmonary Resuscitation Using Quasi-Static Pressure-Volume Curves: A Pilot Study.

Background: Intrathoracic airway closure frequently occurs during cardiac arrest, possibly impairing ventilation. Previously, capnogram analysis was used to detect this pathophysiological process. In other populations, quasi-static pressure-volume curves obtained during constant low-flow inflations are routinely used to detect intrathoracic airway closure. This study reports the first use of quasi-static pressure-volume curves to detect intrathoracic airway closure during prehospital cardiopulmonary resuscitation. Methods: Connecting a pressure and flow sensor to the endotracheal tube enabled the performance of low-flow inflations during cardiopulmonary resuscitation using a manual resuscitator. Users connected the device following intubation and performed a low-flow inflation during the next rhythm analysis when chest compressions were interrupted. Determining the lower inflection point on the resulting pressure-volume curves allowed for the detection and quantification of intrathoracic airway closure. Results: The research device was used during the prehospital treatment of ten cardiac arrest patients. A lower inflection point indicating intrathoracic airway closure was detected in all patients. During cardiac arrest, the median pressure at which the lower inflection point occurred was 5.56 cmH20 (IQR 4.80, 8.23 cmH20). This value varied considerably between cases and was lower in patients who achieved return of spontaneous circulation. Conclusions: In this pilot study, quasi-static pressure-volume curves were obtained during prehospital cardiopulmonary resuscitation. Intrathoracic airway closure was detected in all patients. Further research is needed to determine whether the use of ventilation strategies to counter intrathoracic airway closure could lead to improved outcomes and if the degree of airway closure could serve as a prognostic factor.

Transnational grieving: The lived experience of Overseas Filipino Workers who lost their loved ones due to COVID-19

This study aimed to gain an insight into the lived experience of Overseas Filipino Workers (OFWs) who lost their family members due to COVID-19 during the lockdown in 2020. Five OFWs volunteered to participate in this study and underwent online semi-structured interviews. An interpretative phenomenological approach guided the data analysis, through which four major themes were derived: (1) experiencing the emotional strains of unexpected death while physically distant; (2) enduring the absence of traditional mourning rituals; (3) managing grief from a distance; and (4) finding closure through physical and symbolic presence. These findings shed light on how OFWs experienced loss and grief during the lockdown, as well as how they coped amidst the distance and eventually finding a degree of closure.

Finds of Skulls of Juvenile Kurdalagonus maicopicus (Cetacea, Cetotheriidae) in the Upper Miocene of the Republic of Adygea.

Fragments of two skulls of young cetotheriid baleen whales were described from the Fortep'yanka 2 locality (Russia, Republic of Adygea, Maikop district, Fortep'yanka River valley, Upper Miocene, Upper Sarmatian, Blinovskaya Formation). The finds were attributed to Kurdalagonus maicopicus (Spasskii, 1951) based on the morphology of the posterior (mastoid) process of the petrosal bone, the structure of the posterior edge of the temporal fossa, and the S-like shape of the supraoccipital ridges. The skull proportions and the degree of suture closure made it possible to determine the individual age of the whales within a year. New finds significantly complement the data on the structure of the sutures of the lateral wall of the skull and age-related variability of cranial morphology in representatives of the genus Kurdalagonus.

Cyclic cumulative strain of coarse-grained soil under large cyclic stress amplitude

The deformation behavior of coarse-grained soil under large cyclic stresses, such as those induced by strong earthquakes, has received limited attention. This study aims to investigate the cyclic accumulation behaviors and hysteresis loops of coarse-grained soil during drained cyclic triaxial tests, spanning a range from small to large cyclic stresses. The cyclic triaxial tests were primarily conducted under anisotropic consolidation conditions, with an axial-to-radial stress ratio of 2.0, confining pressures ranging from 100 to 500 kPa, and cyclic stresses varying from 0.01 to 1.85 times the confining pressure. Additionally, cyclic triaxial tests under isotropic consolidation conditions and constant mean stress conditions were performed for comparison and validation. The test results reveal that the properties of the hysteresis loops exhibit significant nonlinear behavior as cyclic stress increases, particularly concerning their shape, symmetry, degree of closure, and initial tangent modulus of elasticity. The cumulative axial strain displays three stages: strain increases slightly and gently at small cyclic stress, increases rapidly and substantially at medium cyclic stress, and decreases at large cyclic stress. The delineation of these phases is largely governed by the behaviors observed during the first cycle. Moreover, the cumulative volumetric strain increases monotonically with the increase of cyclic stress, with a more rapid increase at large cyclic stress. This study provides valuable insights into the cyclic deformation and constitutive modeling of coarse-grained soil under significant cyclic stress.

Early periodontal wound healing after chlorhexidine rinsing: a randomized clinical trial

ObjectivesThis single-center randomized, parallel design, clinical trial with a 2-week follow-up involved patients affected by periodontitis undergoing periodontal surgery. The aim was to evaluate periodontal surgical wound healing with the use of chlorhexidine-based mouth rinses versus an untreated control group.Materials and methodsPeriodontal surgery was performed following a standardized protocol. Patients were randomly prescribed i) chlorhexidine (CHX) + anti-discoloration system (ADS) + hyaluronic acid (HA), ii) CHX + ADS or iii) no treatment (control group). Plaque score, gingival inflammation, and Early Healing Index (EHI), assessing the degree of wound closure and the presence of fibrin and necrosis, were evaluated at 3, 7 and 14 days after surgery.ResultsIn total, 33 patients were enrolled. Patients were comparable at baseline for all measured clinical parameters. At 3-days wound healing was significantly improved in all patients treated with CHX + ADS-based mouth rinses with a lower EHI score at the interdental papillae compared with control group (p < 0.01). CHX + ADS + HA group presented improved healing across all time points in terms of EHI, plaque containment, and gingival inflammation when compared to control group (p < 0.01).ConclusionsThe usage of CHX-ADS following periodontal surgery improved early wound healing, reduced plaque accumulation and gingival inflammation. During the early post-operative period the adjunct of HA further improved soft tissue closure.Clinical relevanceThis study aims at evaluating the response of gingival tissues to mouth rinsing with chlorhexidine and anti-discoloration system (CHX + ADS) or CHX + ADS + hyaluronic acid (CHX + ADS + HA) versus no rinse in terms of healing of the periodontal surgical wound. CHX + ADS mouth rinses enhanced early soft tissue closure after periodontal surgery and contributed to the reduction in plaque accumulation and gingival inflammation. The adjunct of HA may be beneficial especially in the early post-operative period. CHX + ADS administration following periodontal surgery may improve soft tissue healing in the first two post-operative weeks.

True triaxial unloading test on the mechanical behaviors of sandstone: Effects of the intermediate principal stress and structural plane

A series of true triaxial unloading tests are conducted on sandstone specimens with a single structural plane to investigate their mechanical behaviors and failure characteristics under different in situ stress states. The experimental results indicate that the dip angle of structural plane (θ) and the intermediate principal stress (σ2) have an important influence on the peak strength, cracking mode, and rockburst severity. The peak strength exhibits a first increase and then decrease as a function of σ2 for a constant θ. However, when σ2 is constant, the maximum peak strength is obtained at θ of 90°, and the minimum peak strength is obtained at θ of 30° or 45°. For the case of an inclined structural plane, the crack type at the tips of structural plane transforms from a mix of wing and anti-wing cracks to wing cracks with an increase in σ2, while the crack type around the tips of structural plane is always anti-wing cracks for the vertical structural plane, accompanied by a series of tensile cracks besides. The specimens with structural plane do not undergo slabbing failure regardless of θ, and always exhibit composite tensile-shear failure whatever the σ2 value is. With an increase in σ2 and θ, the intensity of the rockburst is consistent with the tendency of the peak strength. By analyzing the relationship between the cohesion (c), internal friction angle (φ), and θ in sandstone specimens, we incorporate θ into the true triaxial unloading strength criterion, and propose a modified linear Mogi-Coulomb criterion. Moreover, the crack propagation mechanism at the tips of structural plane, and closure degree of the structural plane under true triaxial unloading conditions are also discussed and summarized. This study provides theoretical guidance for stability assessment of surrounding rocks containing geological structures in deep complex stress environments.

ZmASR1 negatively regulates drought stress tolerance in maize

Abscisic acid-, stress-, and ripening-induced (ASR) proteins in plants play a significant role in plant response to diverse abiotic stresses. However, the functions of ASR genes in maize remain unclear. In the present study, we identified a novel drought-induced ASR gene in maize (ZmASR1) and functionally characterized its role in mediating drought tolerance. The transcription of ZmASR1 was upregulated under drought stress and abscisic acid (ABA) treatment, and the ZmASR1 protein was observed to exhibit nuclear and cytoplasmic localization. Moreover, ZmASR1 knockout lines generated with the CRISPR–Cas9 system showed lower ROS accumulation, higher ABA content, and a higher degree of stomatal closure than wild-type plants, leading to higher drought tolerance. Transcriptome sequencing data indicated that the significantly differentially expressed genes in the drought treatment group were mainly enriched in ABA signal transduction, antioxidant defense, and photosynthetic pathway. Taken together, the findings suggest that ZmASR1 negatively regulates drought tolerance and represents a candidate gene for genetic manipulation of drought resistance in maize.

Economic returns to reproducing parents' field of study.

Research on the influence of family background on college graduates' earnings has not considered the importance of the match between parents' and children's field of study. Using a novel design based on within-family comparisons, I examine long-term earnings returns to reproducing parents' field of study in Denmark. I find that individuals whose field of study matches that of a parent have earnings that are 2 percent higher than those of their siblings with college degrees in different fields, on average. Earnings returns to field inheritance are highest in the fields of law (9 percent), medicine (6 percent), and engineering (4 percent) and are driven mainly by income from self-employment. I find no direct evidence of nepotism as the earnings advantage does not arise from inheritance of parents' firms or employment in parents' occupational network. My findings indicate that, although a college degree generally equalizes family background differences in economic outcomes, there are additional payoffs to field inheritance, particularly in traditional fields characterized by a high degree of social closure and self-employment.

Elastin expression in the conjoint fascial sheath and levator palpebrae superioris muscle of children with unilateral severe congenital ptosis with different muscle strengths.

Elastin expression in the conjoint facial sheath (CFS) of patients of different ages with severe ptosis has been extensively studied, but its expression in the CFS of pediatric patients with severe ptosis with different muscle strengths remains poorly understood. The aim of the present study was to investigate the expression of elastin in the CFS and levator palpebrae superioris muscle (LM) of children with severe congenital ptosis with different LM strengths. In total, 20 pediatric patients with unilateral severe congenital ptosis (20 eyes) were included, who underwent CFS + LM complex suspension surgery from June 2020 to February 2022. Among these patients, the LM strength was 0-1 mm in 10 patients and 2-3 mm in the other 10 patients. Excess CFS and LM tissue samples were obtained from the patients during surgery, before the protein expression levels of elastin in the specimens were measured by western blotting. During the 6-month postoperative follow-up period, the good correction rate, the degree of incomplete eyelid closure and the incidence of complications were observed. Western blotting results showed that, compared with that in the 0-1 mm group, elastin expression was not significantly different in the CFS, whereas it was significantly increased (P=0.021) in the LM of the 2-3 mm group. In addition, elastin expression in the CFS was markedly higher compared with that in the LM in both groups (in the 0-1 mm group, P=0.005; in the 2-3 mm group, P=0.009). Additionally, the curative effect evaluation revealed that the good correction rates in the 0-1 and 2-3 mm groups were 90 and 100%, respectively. In total, 3 patients experienced conjunctival prolapse during the follow-up period, including 2 patients in the 0-1 mm group and 1 patient in the 2-3 mm group, but there were no other complications. To conclude, elastin expression in the CFS was found to be higher compared with that in the LM of children with severe congenital ptosis. Although elastin expression in the LM was positively associated with LM strength, its expression in the CFS displayed no clear association with LM function. Therefore, these observations suggested that CFS + LM complex suspension surgery is viable to correct severe congenital ptosis in pediatric patients.

Entheseal variation and locomotor behavior during growth.

Entheses are acknowledged as skeletal markers capable of revealing several biological and behavioral aspects of past individuals and populations. However, entheseal changes (ECs) of juvenile individuals have not yet been studied with a systematic approach. This contribution aims at investigating the morphological changes occurring at the femoral insertion of the gluteus maximus and tibial origin of the soleus muscles to highlight a potential link between the morphological features of those entheses and skeletal maturity in relation to sex, age, and locomotor developmental patterns. The sample consisted of 119 skeletons (age-at-death: 0-30 years) belonging to the Documented Human Skeletal Collection of the Certosa Cemetery (Bologna, Italy). The entheseal variation during the last stages of skeletal maturation in young adults was assessed using existing recording standards. A recording protocol for each enthesis was developed for immature individuals to subdivide the morphological variability into discrete categories. Univariate, bivariate, and multivariate statistical analyses were performed to investigate the variation of entheseal morphologies and measurements in relation to bone metrics, degree of epiphyseal closure, sex, age, and locomotor developmental patterns. A statistically significant relationship was observed between ECs morphological patterns and age for both entheses, while sexual differences were negligible. A relationship between ECs morphological pattern and locomotor milestones emerged only for the gluteus maximus. Even though further testing is needed on other documented skeletal collections, our protocol could be usefully applied in forensic and archaeological fields and serving as important reference for evolutionary investigations.

Dynamics of microorganism population in the soil of pine plantations under technogenic load

The degree of crown closure is an important parameter of tree plantations that determines the environmental conditions for all organisms in the ecosystem. Studies assess the effect of the degree of crown closure on the microorganism dynamics in the rock dump soil with and without a potentially fertile layer. It was found that the amount of soil microorganisms varies significantly during the period, which is associated with variations in the hydrothermal conditions of the soil. The activity of microorganisms decomposing mineral nitrogen and microscopic fungi varies depending on the degree of crown closure.

Groundwater Basin Openness and Sustainability

AbstractGroundwater pumping from wells, together with water uses such as agricultural irrigation have been converting formerly open groundwater basins into closed systems that accumulate total dissolved solids (TDS). This process of anthropogenic basin closure and salinization (ABCSal) would appear to pose a threat to groundwater sustainability that is at least as formidable as groundwater overdraft and contamination from the surface, yet has been little explored. Models of groundwater flow and solute transport herein show that groundwater basin openness itself should be considered a primary determinant of sustainability. Results show that groundwater basin closure is a threshold condition that sets the aquifer system on a path of increasing salinity that can only be halted by opening the basin. Further, the magnitude of groundwater pumping and degree of basin closure significantly influence the spatial distribution of salinity. In open basins, salinity approaches dynamic equilibrium over long‐term conditions. Stratification of higher‐TDS groundwater overlying lower‐TDS groundwater occurs below farmlands whose irrigation‐supplying wells are impacted by irrigation return flow from upstream farmlands, and act to redistribute relatively saline groundwater to the land surface. More intensive pumping leads to groundwater basin closure and more vertically‐oriented groundwater flow toward pumping wells. TDS retainment in the basin and repeated well capture, re‐distribution as irrigation water, and evapoconcentration lead to progressive salinization. Regardless of basin closure status, fresh recharge protects nearby downstream portions of the basin from salinization, indicating that managing or limiting the spread of contaminated groundwater may be achieved via managed aquifer recharge of good quality water.