In order to compare the workability of AZ110 alloy with and without addition of La-rich Mish Metal (MM), hot compression tests were performed on a Gleeble-3500D thermo-mechanical simulator at the deformation temperature range of 473−623 K and strain rate range of 0.001-1 s−1. The flow stress, constitutive relation, DRX kinetic model, processing map and microstructure characterization of the alloys were investigated. The results show that the flow stress is very sensitive to deformation temperature and strain rate, and the peak stress of AZ110LC (LC = La-rich MM) alloy is higher than that of AZ110 alloy. The hot deformation behavior of the alloys can be accurately predicted by the constitutive relations. The derived constitutive equations show that the calculated activation energy Q and stress exponent n for AZ110 alloy are higher than the calculated values of AZ110LC alloy. The analysis of DRX kinetic models show that the development of DRX in AZ110LC alloy is earlier than AZ110 alloy at the same deformation condition. The processing maps show that the workability of AZ110LC alloy is significantly more excellent than AZ110 alloy and the microstructures are in good agreement with the calculated results. The AZ110LC alloys can obtain complete DRX microstructure at high strain rate due to its higher stored energy and weak basal texture.