Wall Deformation Research Articles

Simulating cardiac fluid dynamics in the human heart.

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin valve leaflets. There has been longstanding scientific, engineering, and medical interest in creating mathematical models of the heart that capture, explain, and predict these fluid-structure interactions (FSIs). However, existing computational models that account for interactions among the blood, the actively contracting myocardium, and the valves are limited in their abilities to predict valve performance, capture fine-scale flow features, or use realistic descriptions of tissue biomechanics. Here we introduce and benchmark a comprehensive mathematical model of cardiac FSI in the human heart. A unique feature of our model is that it incorporates biomechanically detailed descriptions of all major cardiac structures that are calibrated using tensile tests of human tissue specimens to reflect the heart's microstructure. Further, it is the first FSI model of the heart that provides anatomically and physiologically detailed representations of all four cardiac valves. We demonstrate that this integrative model generates physiologic dynamics, including realistic pressure-volume loops that automatically capture isovolumetric contraction and relaxation, and that its responses to changes in loading conditions are consistent with the Frank-Starling mechanism. These complex relationships emerge intrinsically from interactions within our comprehensive description of cardiac physiology. Such models can serve as tools for predicting the impacts of medical interventions. They also can provide platforms for mechanistic studies of cardiac pathophysiology and dysfunction, including congenital defects, cardiomyopathies, and heart failure, that are difficult or impossible to perform in patients.

Unraveling cereal physical barriers composed of cell walls and protein matrix: Insights from structural changes and starch digestion

Physical barriers composed of cell walls and protein matrix in cereals, as well as their cooking changes, play important roles in starch digestion. In this study, the physical barriers of native and cooked highland barley (HB), brown rice (BR), and oats (OA) kernels and their contribution to starch digestion were investigated. The resistant starch content was similar in cereal flours, but varied among cooked kernels (HB > BR > OA: 45.05 %, 10.30 %, and 24.71 %). The water adsorption, gelatinization enthalpy, and decrease in hardness of HB kernels were lower than those of OA and BR kernels. Microstructural observations of native kernels showed that HB had the thickest cell walls. After cooking, the lowest cell wall deformation and a dense continuous network developed from the protein matrix were observed in HB kernels. During digestion, undigested starch granules encapsulated by the stable cell walls and strong protein network were observed in HB kernels, but not in BR or OA kernels. Furthermore, the heavily milled HB kernels still had more resistant starch than the intact OA and BR kernels. Therefore, the physical barriers of HB kernels exhibited stronger inhibition of starch gelatinization and digestion. Differences in cereal physical barriers led to various inhibitory effects.

Comprehensive evaluation of right ventricular function in patients with acute pulmonary embolism

Objective. To study indices of right ventricular (RV) longitudinal deformation at transthoracic echocardiography (TTE) in patients with acute pulmonary embolism (APE), to determine their threshold values; to study indices of right ventricular-arterial coupling (RVAC) in patients with APE, to determine their threshold values.Methods. We examined 34 patients with acute massive and submassive pulmonary embolism. The diagnosis was made on the basis of computed-tomography pulmonary angiogram. The mean age was 61 ±13 years. Of these, 16 were women (47,1%) and 18 were men (52,9%). As a control group, 30 healthy individuals were examined: 14 males and 16 females. The mean age of the healthy individuals was 39±9,8 years. Echocardiography was performed on Vivid E95 (GE HealthCare, USA) with data postprocessing on EchoPak workstation. The indices of right ventricular (RV) systolic and diastolic function, the magnitude of global longitudinal deformation of the right ventricle (GLS RV) and longitudinal deformation of the right ventricular free wall (RVFWLS) were studied using two-dimensional speckle-tracking echocardiography. We studied indices of right ventricular-arterial coupling (RVAC). We determined the relationship of longitudinal deformation of RV and RVAC with other indices of its systolic function. Results. Mean values of traditional parameters of RV contractile function were within normal limits, whereas mean values of longitudinal strain in APE were significantly lower than normal. There was also a significant decrease ( P < 0,0001) of all measured parameters of right ventricular-arterial coupling in patients with APE in comparison with the control group.Conclusions. When longitudinal deformation parameters are included in the criteria of RV dysfunction in APE, its detectability increases from 26,47% to 61,77%. The revealed decrease of right ventricular-arterial coupling parameters in APE indicates a more frequent disturbance of the connection between RV and the small circle of blood circulation

Chromosome doubling increases PECTIN METHYLESTERASE 2 expression, biomass, and osmotic stress tolerance in kiwifruit

Abstract Chromosome doubling-induced polyploidization is a popular tool for crop breeding. Polyploidy crops commonly have multiple advantages, including increased biomass and stress tolerance. However, little is known about the genes responsible for these advantages. We found kiwifruit (Actinidia chinensis cv. Hongyang) PECTIN METHYLESTERASE 2 (AcPME2)is substantially upregulated in artificially created tetraploid plants that show increased biomass and enhanced tolerance to osmotic stress. Overexpression (OE) of AcPME2 led to increased biomass and enhanced stress tolerance in Arabidopsis (Arabidopsis thaliana), tomato (Solanum lycopersicum), and kiwifruit. Upon short-term osmotic stress treatment, AcPME2-OE plants showed higher levels of demethylesterified pectins and more Ca2+ accumulation in the cell wall than Col-0 plants, which led to increased cell wall stiffness. The stress-induced plasmolysis assays indicated that AcPME2 dynamically mediated the cell wall stiffness in response to osmotic stress, which is dependent on Ca2+ accumulation. Transcriptomic analysis discovered that dozens of stress-responsive genes were significantly upregulated in the AcPME2-OE plants under osmotic stress. Besides, AcPME2-mediated cell wall reinforcement prevented cell wall collapse and deformation under osmotic stress. Our results revealed a single gene contributes to two advantages of polyploidization (increased biomass and osmotic stress tolerance) and that AcPME2 dynamically regulates cell wall stiffness in response to osmotic stress.

Safety evaluation of deformed coke drum with nested stress at cold spot

In this article, the strain limit criterion and classical strength theories are used to evaluate the strength at the cold spot with nested effect of the deformed coke drum. First, the geometric model of the cold spot with nested effect before and after the deformation of the drum wall is established in the selected area, and the nested stress at the cold spot is calculated. Then, according to the calculated stress–strain results, the stress analysis of the drum wall at the cold spot is carried out. The results show that the coke drum yields during the cooling stage according to the strain limit criterion. According to classical strength theories, coke drum yields during the coke production and cooling stages. Finally, the paths are selected to calculate the equivalent stress–strain, and the stress–strain curves along the paths are plotted. By comparing the results of stress and strain evaluation, three evaluation methods are compared and studied.

A spatiotemporal data mining method for advanced prediction and assessment of large combined excavation-induced wall deformations and risks

A holistic and precise assessment of retaining wall deformations is critical for on-site risk management of large combined deep excavation projects, where the risk-related points are highly dispersed, evolving, and interacting. Despite extensive exploration of this topic in previous studies, the omission of intricate spatiotemporal characteristics of wall deformations has resulted in diminished prediction accuracy and stability. To mitigate this deficiency, a spatiotemporal characteristics matrix for all data points and time series was first generated for a deep excavation scenario and used as input for a new hybrid model that combines convolutional neural network (CNN) and long short-term memory (LSTM) with incorporated attention mechanism (CNN-LSTM-Att), which enables the cross-learning mechanism and improves interpretability. In addition, by leveraging the attention weight, a new risk assessment index for retaining wall deformations across various scenarios was formulated. Then the proposed method was applied in a large combined deep excavation in Shanghai, China. The results show that: (1) The incorporation of fed-in characteristic data and the attention mechanism enables the proposed method to produce satisfactory prediction results for the holistic spatiotemporal distribution of a large combined excavation; (2) Compared with other published models, the proposed model shows much better prediction accuracy, interpretability, and stability, especially in medium- and long-term predictions; and (3) The new risk assessment index serves as a reliable decision-making tool for assessing the risk evolution of retaining wall deformations and provides valuable guidance for effective risk management in multi-scenario excavation projects.

Effect of middle stud on ultimate strength and behavior factor of brick masonry shear wall in cold formed steel frame

AbstractLightweight steel framing is one of the modern construction technology systems. This system is mostly used for low to mid-rise buildings. The lightweight steel framing system has many advantages, including lightness, ease of installation, high execution speed, and being more cost-efficient. Since the manufacturers of cold formed steel frames use bricks in an unprincipled way to cover these structures and because of less laboratory research in this regard, in the present research to principled use of this structure, the effect of the middle stud was evaluated on seismic behavior of brick shear wall in cold formed steel frame with brick face. For this purpose, four cold formed steel frames were made in two different configurations (without middle stud and with middle stud) using cement sand mortar, wire mesh, and brick shear walls. Based on the results, the middle stud would cause weakness in the permissible deformation of the brick walls, and in shear walls without middle stud, deformations occur along with the acquisition of resistance to larger deformations. Accordingly, the presence of the middle stud increases the average shear strength by 30%, and this increase in resistance causes a decrease in the behavior factor and ductility of the walls, which practically indicates the seismic behavior of the frames with the middle stud.

Study on cell wall deformation in ultrasonic cutting aluminum honeycomb by straight-blade knife

Aluminum honeycomb sandwich structure has been widely used in the aeronautic and astronautic fields. As the core part, aluminum honeycomb needs to be machined but defects are easily generated. Ultrasonic cutting is an advanced machining technology for honeycomb materials due to improved machining quality. However, ultrasonic cutting aluminum honeycomb by straight-blade knife is usually accompanied by cell wall deformation, which results in poor machining quality. To facilitate the industrial use of ultrasonic cutting aluminum honeycomb with a straight-blade knife, a finite element (FE) model was developed, and experimental studies had been performed. The effects of the blade-inclined angle and lead angle of the straight-blade knife were studied by analyzing the cutting force, the stress and deformation in the cutting zone. Results showed that the cell wall deformation was significantly suppressed when cutting with a corresponding blade-inclined angle and a lead angle. Meanwhile, effects of ultrasonic cutting parameters on the cell wall deformation were also studied, indicating that a well-machined cell wall could be obtained when cutting with large ultrasonic amplitude.

The individualized treatment for minimally invasive repair of pectus carinatum in adolescent: a single center’ s retrospective study

BackgroundPectus carinatum (PC) mainly present at the growth spurt time of the early teenage years or the puberty. Poor outer appearance is a major reason for seeking help for surgeons to increase self-confidence and self-esteem. At present, minimally invasive repair (MIR) is one of effective ways to correct the chest wall deformity. Therefore, there is great practical significance to conduct clinical research on MIR about the adolescent PC.MethodsWe applied Abramson procedure in PC group or we applied Abramson procedure and Nuss procedure in PC/PE group. We retrospectively reviewed the results of 41 cases who underwent the surgical correction at our department from January 2020 to April 2023.ResultsAll the procedures were successfully done without severe complications. The median operation Time was 80 min in PC group while was 130 min in PC/PE group. The median LOS were 4 days in PC group while 5 days in PC/PE group. The median compression depth was 32 mm in PC group while 12 mm in PC/PE group. Postoperatively, there are some complications. All Pneumothorax patients being treated conservatively were found in 9 patients in two groups. One patient suffered overcorrection after operation. There were 3 patients suffered steel wires breakage in two groups. One patient reoperation postoperatively for the dislocation of the bar secondary to steel wires breakage.ConclusionsThe Abramson procedure or Abramson procedure and Nuss procedure have good short-term results in repair PC and PC/PE. Select one or two procedures should be done individually based on whether the lower plane over depressed after Abramson procedure.

Seismic Performance of Cylindrical Liquid Storage Tanks in the 2023 Kahramanmaras Earthquakes: A Case Study of a Self-Supported Oil Storage Tank

ABSTRACT This paper covers the seismic performance of liquid tanks due to 2023 Türkiye earthquakes and a case study of a moderately damaged self-supported tank is studied. Typical types of damage were sloshing induced upper tank wall deformations, sliding and uplift of the base, and rupture at tank-pipe connections. Besides, slip-prone tanks were less vulnerable to tank damage. The coupling between sliding and uplift responses of a self-supported tank is investigated considering different coefficients of friction. The results revealed that tank wall stresses can be significantly reduced due to sliding effect.

Nucleation-assisted microthermometry: A novel application to fluid inclusions in halite

Halite deposits have long been utilized for interrogating past climate conditions. Microthermometry on halite fluid inclusions has been used to determine ancient water temperatures. One notable obstacle in performing microthermometric measurements, however, is the lack of a vapor bubble in the single-phase liquid inclusions at room temperature. (Pseudo-) isochoric cooling of the inclusions to high negative pressures, far below the homogenization temperature, has commonly been needed to provoke spontaneous vapor bubble nucleation in the liquid. High internal tensile stress in soft host minerals like halite, however, may induce plastic deformation of the inclusion walls, resulting in a wide scatter of measured homogenization temperatures. Nucleation-assisted (NA) microthermometry, in contrast, employs single ultra-short laser pulses provided by a femtosecond laser to stimulate vapor bubble nucleation in metastable liquid inclusions slightly below the expected homogenization temperature. This technique allows for repeated vapor bubble nucleation in selected fluid inclusions without affecting the volumetric properties of the inclusions, and yields highly precise and accurate homogenization temperatures.In this study, we apply, for the first time, NA microthermometry to fluid inclusions in halite and we evaluate the precision and accuracy of this thermometer utilizing (i) synthetic halite crystals precipitated under controlled laboratory conditions, (ii) modern natural halite that precipitated in the 1980s in the Dead Sea, and (iii) Late Pleistocene halite samples from a sediment core from Death Valley, CA. Our results demonstrate an unprecedented accuracy and precision of the method that provides a new opportunity to reconstruct reliable quantitative temperature records from evaporite archives.

U shaped costal cartilage resection to reduce donor site morbidity

ObjectiveThe aim of our study is to reduce the complications of pain and chest wall deformity by modifying conventional costal cartilage graft harvesting. MethodIn this method while the superior part of the costal cartilage is removed completely, medial, lateral, and inferior parts are excised incompletely and used as a graft. Hence, continuity of the costal cartilage is maintained inferiorly. ResultsNineteen primary and 28 revision rhinoplasty patients were included in the study. There were no donor site complications in the early postoperative period or during one-year follow-up. ConclusionThe modified costal cartilage graft harvesting technique we described is a safe conservative surgical method.

Contribution of transient receptor potential vanilloid 1 (TRPV1) channel to cholinergic contraction of rat bladder smooth muscle.

Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel that is gated by the pungent constituent of red chili pepper, capsaicin, and by related chemicals from the group of vanilloids, in addition to noxious heat. It is expressed mostly in sensory neurons to act as a detector of painful stimuli produced by pungent chemicals and high temperatures. Although TRPV1 is also found outside the sensory nervous system, its expression and function in the bladder detrusor smooth muscle (DSM) remain controversial. Here, by using Ca2+ imaging and patch clamp on isolated rat DSM cells, in addition to tensiometry on multicellular DSM strips, we show that TRPV1 is expressed functionally in only a fraction of DSM cells, in which it acts as an endoplasmic reticulum Ca2+-release channel responsible for the capsaicin-activated [Ca2+]i rise. Carbachol-stimulated contractions of multicellular DSM strips contain a TRPV1-dependent component, which is negligible in the circular DSM but reaches ≤50% in the longitudinal DSM. Activation of TRPV1 in rat DSM during muscarinic cholinergic stimulation is ensured by phospholipase A2-catalysed derivation of arachidonic acid and its conversion by lipoxygenases to eicosanoids, which act as endogenous TRPV1 agonists. Immunofluorescence detection of TRPV1 protein in bladder sections and isolated DSM cells confirmed both its preferential expression in the longitudinal DSM sublayer and its targeting to the endoplasmic reticulum. We conclude that TRPV1 is an essential contributor to the cholinergic contraction of bladder longitudinal DSM, which might be important for producing spatial and/or temporal anisotropy of bladder wall deformation in different regions during parasympathetic stimulation. KEY POINTS: The transient receptor potential vanilloid 1 (TRPV1) heat/capsaicin receptor/channel is localized in the endoplasmic reticulum membrane of detrusor smooth muscle (DSM) cells of the rat bladder, operating as a calcium-release channel. Isolated DSM cells are separated into two nearly equal groups, within which the cells either show or do not show TRPV1-dependent [Ca2+]i rise. Carbachol-stimulated, muscarinic ACh receptor-mediated contractions of multicellular DSM strips contain a TRPV1-dependent component. This component is negligible in the circular DSM but reaches ≤50% in longitudinal DSM. Activation of TRPV1 in rat DSM during cholinergic stimulation involves phospholipase A2-catalysed derivation of arachidonic acid and its conversion by lipoxygenases to eicosanoids, which act as endogenous TRPV1 agonists.

Clinical characteristics and early results of the modified abramson technique to treat pectus carinatum at Viet Đuc Hospital from 2020-2023

Pectus carinatum is the second most common congenital anterior chest wall deformity. This study describe the clinical, paraclinical characteristics and evaluate the early results of the modified Abramson technique to treat pectus carinatum at Viet Duc Hospital. This is a retrospective descriptive study, in all cases diagnosed with pectus carinatum and underwent surgery according to the modified Abramson technique at Viet Duc Hospital from 1/2020 to 12/2023. In 134 patients, 131 were male, the mean age 13.6 ± 1.98 years. All patients presented with cosmetic complaints, and 85.2% patients have BMI <18.5. 94/134 cases (70.2%) had symmetrical deformities, 37/134 cases (27.6%) had asymmetrical deformities, and 3 cases (2.2%) had mixed pectus deformities. The average Haller index is 2.1 ± 0.3. All patients were operated using a bar, fixed at both ends with steel thread. Operative time was 33.6 ± 7.76 minutes, and hospital stay was 5.3 ± 0.76 days (4–7 days). There was no significant early postoperative complications. Conclusion: clinical examination and computed tomography play an important role in diagnosing pectus carinatum. The modified Abramson technique is a minimally invasive surgical method for pectus carinatum patients with short operative time, hospital stay, and the first step gives good treatment results. TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back

Bi-valve braces for treatment of pectus carinatum in teenagers: impact on patients quality of life

BackgroundPectus carinatum may be a major issue for adolescent patients, as chest-wall malformations can have a negative impact on body image and induce self-esteem disorders. Bracing has become the first line treatment for adolescent patients whose anterior chest wall is still flexible. The main obstacle is the tolerability of the bracing device along with the patient’s compliance to the device. The aim of this study was to examine the quality of life of adolescent patients treated with bracing to correct pectus carinatum in our institution. From November 2021 to July 2023, 28 patients with pectus carinatum were treated with bracing therapy in our chest wall deformities unit. We used a bivalve brace, manufactured with computer-aided design. All patients were asked to answer a multiple-choice questionnaire designed to assess how bracing therapy impacts their daily life, treatment compliance, and overall satisfaction. Patients who wore the brace for at least 3 months, and at least 5 days per week and 10 h per day, are defined as compliant with the bracing protocol.ResultsThe mean age of the patients was 14 ± 1.36 years. Patients wore the brace for an average of 10.1 ± 6.9 months in the compliance group (n = 18), and 2.2 ± 2.5 months in the non-compliance group (n = 10). Our results show that compliant patients are fairly satisfied of the comfort of the brace, with a limited impact of the device on their daily activities and social life. However, non-compliant patients report the following dissatisfactions regarding the brace: higher pain scores, difficulty in breathing, and issues sleeping with the brace. The compliant patients noted a significant improvement in the appearance of their chest, and were satisfied with the appearance of their chest. The non-compliant patients did not notice any changes.ConclusionsCompliant patients treated with a bi-valve brace for pectus carinatum seem to have a good quality of life with a limited impact on their daily life and social activities. The bi-valve brace also seems to be an effective therapy in compliant patients.

Numerical investigations of GRS wall performance with tiered configurations

Geosynthetic Reinforced Soil (GRS) walls have become increasingly popular as a result of their numerous advantages. In some cases these structures are constructed in a multi-tiered configuration, which makes their behavior more complicated. Nevertheless, the response of the multi-tiered walls is insufficiently explained by the existing design manuals and literature studies. This paper investigated the performance of GRS walls with multi-tiered configurations using two-dimensional (2D) finite element numerical models. This study compares the performance of two-tiered GRS walls with simple GRS walls (single-tiered). It also examines the impact of offset distance, backfill strength properties, and reinforcement parameters (vertical spacing and reinforcement length) on horizontal deformations and reinforcement tensile loads in two-tiered GRS walls. Adopting a multi-tiered configuration for GRS walls can significantly reduce both the horizontal wall deformation and the maximum reinforcement tensile loads. Additionally, the critical offset distance found in this study is significantly smaller than that recommended by the Federal Highway Administration (FHWA) guidelines. The finite element results also demonstrate that using high-quality backfill soil can minimize interaction between lower and upper tiers. Using a uniform reinforcement length of 0.6H for both tiers significantly reduces horizontal deformation compared to the FHWA recommendation of 0.6H and 0.35H for the lower and the upper tier respectively.

Numerical investigation on ground and structure response of ancient site in complex strata caused by groundwater fluctuation and rainfall

As more and more ancient sites are discovered around the world, protecting them in situ has become a challenge due to issues such as ground settlement and masonry wall leaks caused by groundwater fluctuation or rainfall. In this study, laboratory tests, borehole tests and field high‐density resistivity detections are conducted to obtain information for numerical modelling, including design parameters. A complex three‐dimensional hydrological–mechanical coupling model is then established to investigate ground settlement and wall deformation caused by groundwater fluctuation and rainfall. The seepage simulation results for the initial state are accurately verified by high‐density resistivity imaging. Both measured data and numerical results indicate that changes in a single water head point mainly result in wall settlement. The pattern of wall deformation changes from settlement to lateral deformation with an increase in the drawdown rate of groundwater level. Furthermore, delayed rainfall and high‐intensity rainfall can increase foundation settlement and wall deformation. Settlement deformation determines the upper limit of the global deformation when wall nodes are mainly affected. In contrast, if lateral spreading dominates wall deformation, it determines the lower limit of the global deformation. This study provides reference for in situ protection and foundation reinforcement of ancient sites.

Pectus excavatum: the effect of tricuspid valve compression on cardiac function

BackgroundPectus excavatum (PE) is a common congenital chest wall deformity with various associated health concerns, including psychosocial impacts, academic challenges, and potential cardiopulmonary effects.ObjectiveThis study aimed to investigate the cardiac consequences of right atrioventricular groove compression in PE using cardiac magnetic resonance imaging.Materials and methodsA retrospective analysis was conducted on 661 patients with PE referred for evaluation. Patients were categorized into three groups based on the degree of right atrioventricular groove compression (no compression (NC), partial compression (PC), and complete compression(CC)). Chest wall indices were measured: pectus index (PI), depression index (DI), correction index (CI), and sternal torsion.ResultsThe study revealed significant differences in chest wall indices between the groups: PE, NC=4.15 ± 0.94, PC=4.93 ± 1.24, and CC=7.2 ± 4.01 (P<0.0001). Left ventricle ejection fraction (LVEF) showed no significant differences: LVEF, NC=58.72% ± 3.94, PC=58.49% ± 4.02, and CC=57.95% ± 3.92 (P=0.0984). Right ventricular ejection fraction (RVEF) demonstrated significant differences: RVEF, NC=55.2% ± 5.3, PC=53.8% ± 4.4, and CC=53.1% ± 4.8 (P≥0.0001). Notably, the tricuspid valve (TV) measurement on the four-chamber view decreased in patients with greater compression: NC=29.52 ± 4.6; PC=28.26 ± 4.8; and CC=24.74 ± 5.73 (P<0.0001).ConclusionThis study provides valuable insights into the cardiac consequences of right atrioventricular groove compression in PE and lends further evidence of mild cardiac changes due to PE.Graphical abstract

Constitutive behavior of asymmetric multi-material honeycombs with bi-level variably-thickened composite architecture

Bi-level tailoring of cellular metamaterials involving a dual design space of unit cell and elementary beam level architectures has recently gained traction for the ability to achieve extreme elastic constitutive properties along with modulating multi-functional mechanical behavior in an unprecedented way. This article proposes an efficient analytical approach for the accurate evaluation of all constitutive elastic constants of asymmetric multi-material variably-thickened hexagonal lattices by considering the combined effect of bending, stretching, and shearing deformations of cell walls along with their rigid rotation. A tri-member unit cell is conceptualized, wherein all nine constitutive constants are obtained through the mechanics under one cell wall direction and subsequent repetitive coordinate transformations. We enhance the design space of lattice metamaterials substantially here by introducing multiple exploitable dimensions such as asymmetric geometry, multi-material unit cells and variably-thickened cell walls, wherein the conventional monomaterial auxetic and non-auxetic hexagonal configurations can be analyzed as special cases along with other symmetric and asymmetric lattices such as a range of rectangular and rhombic geometries. The generic analytical approach along with extensive numerical results presented in this paper opens up new avenues for efficient optimized design of the next-generation multi-functional lattices and cellular metamaterials with highly tailored effective elastic properties.

Spinal posture, mobility, and position sense in adolescents with chest wall deformities: a comparison of pectus excavatum, pectus carinatum and healthy peers

PurposeThe study aimed to compare spinal posture, mobility, and position sense in adolescents with pectus excavatum (PE), pectus carinatum (PC), and healthy control (HC).Methods22 with PE, 22 with PC, and 21 HC were included in the study. The spinal posture (thoracic kyphosis, lumbar lordosis, pelvic tilt, thoracic, lumbar, pelvic lateral tilt angles) and mobility (thoracic, lumbar, hip/sacral, and overall, in the sagittal and frontal plane) with the spinal mouse, and spinal position sense (repositing errors) with the inclinometer were assessed.ResultsThe thoracic kyphosis angle of PE and PC was higher than in HC (p < 0.001; p = 0.001). Hip/sacral mobility in the sagittal plane was lower in the PE and PC than control, respectively (p < 0.001; p < 0.001). Overall sagittal spinal mobility (p:0.007) and hip/sacral mobility in the frontal plane (p:0.002) were lower in the PC than in HC. Overall frontal spinal mobility was lower in the PE and PC than in HC (p:0.002; p:0.014). The PE and PC repositing errors were higher (p < 0.001; p:0.014).ConclusionThe study found that adolescents with PE and PC had decreased spinal mobility, spinal alignment disorders, and a decline in spinal position sense. It is important not to overlook the spine during physical examinations of adolescents with chest wall deformities. In clinical practice, we suggest that adolescents with chest deformities should undergo a spine evaluation and be referred for physical therapy to manage spinal disorders.