Polyisobutylene (PIB), commonly used as the primary sealant of double, triple, and multi glazed insulating glass units (IGUs), provides the key moisture barrier function and determines the expected lifespan of the IGUs and even the entire glass curtain wall systems (GCWSs). Slipping and debonding of the PIB, caused by temperature changes, have resulted in numerous instances of premature failure of building envelopes. However, available research is inadequate in accurately evaluating the service environment of IGUs and thermal-deformation behaviors of this energy-saving building material. This paper presented a simplified method for analyzing the thermal environment of IGUs, considering outdoor air temperature, solar radiation, wind speed, and angle to the horizontal. A numerical modeling method was proposed and validated with the heat transfer tests. Three finite element (FE) models were built and utilized for the precise analysis of temperature-induced deformations of double, tripled, and quadruple glazed IGUs. Simplified calculation formulas for the maximum thermal deformation of PIB in the X and Y directions under different temperature conditions were obtained, taking a new concept “cavity-to-pane ratio” into consideration. Finally, the relationship between the PIB’s temperature-induced deformation and its probability was proposed. The results show that the IGUs in Beijing suffer more than 22 % of their time in harsh service conditions where the difference between indoor and outdoor temperatures exceeds 20 °C. For DIGUs, the maximum temperature-induced deformations of the PIB in X (along the short side of the panel) and Y (along the long side of the panel) directions are 0.142 and 0.214 mm, respectively, corresponding to shear strains of 28.4 % and 42.8 % for the PIB with a thickness of only 0.5 mm. For TIGUs, the maximum deformations increase to 0.159 and 0.239 mm, corresponding to shear strains of 31.8 % and 47.8 %. For QIGUs and the other multi-glazed IGUs, these values can increase to 36.8 % and 55.4 % or more. The methodology proposed in this paper aims to lay the groundwork for further addressing premature failure issues and optimizing edge bond constructions of multi-glazed IGUs.