Multiple Definitions Research Articles

On the proportion of patients who experience a prodrome prior to psychosis onset:A systematic review and meta-analysis.

Preventing or delaying the onset of psychosis requires identification of those at risk for developing psychosis. For predictive purposes, the prodrome - a constellation of symptoms which may occur before the onset of psychosis - has been increasingly recognized as having utility. However, it is unclear what proportion of patients experience a prodrome or how this varies based on the multiple definitions used. We conducted a systematic review and meta-analysis of studies of patients with psychosis with the objective of determining the proportion of patients who experienced a prodrome prior to psychosis onset. Inclusion criteria included a consistent prodrome definition and reporting the proportion of patients who experienced a prodrome. We excluded studies of only patients with a prodrome or solely substance-induced psychosis, qualitative studies without prevalence data, conference abstracts, and case reports/case series. We searched Ovid MEDLINE, Embase (Ovid), APA PsycInfo (Ovid), Web of Science Core Collection (Clarivate), Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, APA PsycBooks (Ovid), ProQuest Dissertation & Thesis, on March 3, 2021. Studies were assessed for quality using the Critical Appraisal Checklist for Prevalence Studies. Narrative synthesis and proportion meta-analysis were used to estimate prodrome prevalence. I2 and predictive interval were used to assess heterogeneity. Subgroup analyses were used to probe sources of heterogeneity. (PROSPERO ID: CRD42021239797). Seventy-one articles were included, representing 13,774 patients. Studies varied significantly in terms of methodology and prodrome definition used. The random effects proportion meta-analysis estimate for prodrome prevalence was 78.3% (95% CI = 72.8-83.2); heterogeneity was high (I2 97.98% [95% CI = 97.71-98.22]); and the prediction interval was wide (95% PI = 0.411-0.936). There were no meaningful differences in prevalence between grouped prodrome definitions, and subgroup analyses failed to reveal a consistent source of heterogeneity. This is the first meta-analysis on the prevalence of a prodrome prior to the onset of first episode psychosis. The majority of patients (78.3%) were found to have experienced a prodrome prior to psychosis onset. However, findings are highly heterogenous across study and no definitive source of heterogeneity was found despite extensive subgroup analyses. As most studies were retrospective in nature, recall bias likely affects these results. While the large majority of patients with psychosis experience a prodrome in some form, it is unclear if the remainder of patients experience no prodrome, or if ascertainment methods employed in the studies were not sensitive to their experiences. Given widespread investment in indicated prevention of psychosis through prospective identification and intervention during the prodrome, a resolution of this question as well as a consensus definition of the prodrome is much needed in order to effectively direct and organize services, and may be accomplished through novel, densely sampled and phenotyped prospective cohort studies that aim for representative sampling across multiple settings.

Unveiling the intellectual structure of informality: Insights from the socioeconomic literature.

In the socioeconomic sphere, the concept of informality has been used to address issues pertaining to economic dynamics, institutions, work, poverty, settlements, the use of space, development, and sustainability, among others. This thematic range has given way to multiple discourses, definitions and approaches that mostly focus on a single phenomenon and conform to traditional disciplinary lines, making it difficult to fully understand informality and adequately inform policymaking. In this article, we carried out a multilevel co-word analysis with the purpose of unveiling the intellectual structure of socioeconomic informality. Co-occurring document keywords were used, initially, to delimit the scope of the socioeconomic dimension of informality (macro level) and, later, to identify its main concepts, themes (meso level) and sub-themes (micro level). Our results show that there is a corpus of research on socioeconomic informality that is sufficiently differentiable from other types of informality. This corpus, at the same time, can be divided into six major themes and 31 sub-themes related, more prominently, to the informal economy, informal settlements and informal institutions. Looking forward, the analysis suggests, an increasing focus on context and on the experience of multiple 'informalities' has the potential, on the one hand, to reveal links that help unify this historically fragmented corpus and, on the other hand, to give informality a meaning and identity that go beyond the traditional formal-informal dualism.

Cognitive flexibility in women who recovered from anorexia nervosa – a model-based approach

Research findings on cognitive flexibility (CF) functioning in women who recovered from anorexia nervosa (RAN) were found to be inconsistent. This was attributed to the multiple definitions of CF and the diverse measuring tools used to assess it. Applying a deductive approach to explore CF function may address these inconsistencies; thus, we used a model that divides CF into three subtypes, namely, stimulus-response mapping, switching sets and task switching. Additionally, we explored the association between CF subtypes and the disorder’s clinical measures to assess the relation of CF to recovery. Forty-three RAN and 54 healthy controls performed tasks designed to assess CF subtypes based on the model’s division, and the RAN group completed the Eating Disorder Examination Questionnaire. The results showed that the RAN group performed significantly worse than controls only in the stimulus-response mapping subtype. Additionally, there were no correlations between CF subtypes and clinical symptoms or the disorder measures – current and nadir body mass index, age of onset, time since recovery, and disorder duration. In conclusion, the study revealed CF impairment after recovery from AN, specifically in stimulus-response mapping. The variability in performance of the CF subtypes supports the application of a theory-driven perspective viewing CF as a modular ability in RAN. Additionally, CF is unrelated to clinical measures post-recovery and thus may not be used as a criterion for evaluating recovery.

Tortuosity of pore channels in tight rocks as a key parameter in fluid flow ability

Tortuosity is a significant parameter in porous materials analysis. Not only, when it comes to rocks or soils but also cellular materials, alloys or cells, the multiple definitions exist for tortuosity and several purposes. Geometrical tortuosity describes the pore network paths; on the other hand thermal, diffusional, electrical and hydraulic tortuosity refers to the transport processes in the pore network. Computed X-ray tomography (CT) is the best solution in tortuosity estimation, thanks to the 3D images. In particular, computed X-ray tomography, together with mercury porosimetry (MICP), pulse- and pressure-decay permeability methods (PDP), as well as electrical parameter measurements (EPM), links and expands the information about the tortuosity into the greater meaning. The geological material was composed of tight, low-porosity and low-permeability gas-saturated rocks cored from the present depth of deposition below 3000 m, containing different lithologies, as sandstones, mudstones, limestones, and dolomites. The research presents the novel approach in the identification and analysis of the main pore channels based on 3D CT images. Algorithm of the central axis identifies and analyzes the whole main flow path and calculates tortuosity. High correlation was observed between the tortuosity and Swanson parameter from mercury porosimetry data. Moreover, the high correlation was detected between the tortuosity and saturation exponent from electrical parameter measurement in analyzed tight low-porosity and low-permeability deposits. Multilinear regression (MLR) allows estimating absolute permeability taking CT, MICP and EPM parameters into consideration. Combination of these parameters in one equation with high determination coefficient gives credence in estimating preliminary absolute permeability (PDP) based on the data which is executed as standard core analysis (MICP and EPM) and data from the non-invasive method (CT).

Development of a standardized consensus lexicon for terms related to micronutrient programs.

Inconsistent use of terminology among diverse stakeholders hinders effective communication in micronutrient programs, especially large-scale food fortification (LSFF) which involves stakeholders from different sectors. To align the terminology use, the Micronutrient Data Innovation Alliance (DInA) of the Micronutrient Forum (MNF) created a lexicon of terms related to LSFF and other micronutrient programs. The purpose of this lexicon is to establish a central repository of consensus definitions of key terms to facilitate communication among diverse stakeholders involved in micronutrient programs including public and private sectors, donor agencies, food industries, academic institutions, etc. This paper describes the methodology of lexicon development. Important terms related to micronutrient programs were compiled from multiple sources, including United Nations agencies, program implementation and technical support agencies, relevant websites, and scientific literature. The selection of terms was guided by key micronutrient interventions (fortification, supplementation, dietary diversification) and the program cycle (assessment, planning, implementation, monitoring and evaluation). Definitions of terms were identified from these references and checked for consistency across different sources. For terms with multiple definitions, a modified Delphi method was applied to harmonize the definitions. The first draft lexicon (n = 113 terms) was reviewed by six experts from the University of California, Davis (UCD) and MNF, and second draft (n = 115 terms) was shared with 24 global micronutrient experts for feedback. Fifty-four terms were found to have multiple definitions. Of which, minor modification was made for 12-terms with nominal difference and remaining 42-terms were shared with over 140 micronutrient-experts disseminated via an online survey through newsletters and emails to solicit experts' opinions on the most appropriate definition or a modified one. Nineteen legal terms and 83 micronutrient terms (n = 102 terms) were subsequently added. Overall, 39 experts from diverse areas of expertise (LSFF, micronutrient program planning and implementation, surveys and research, policy development, food industry regulations, food safety, and public health nutrition) participated in the online survey. The terms with >75% agreement among experts were considered as final, while the remaining were reviewed again by experts from UCD and MNF until consensus was reached on harmonized definitions. The current lexicon is available online at the DInA-website. and contains 217 terms and will be maintained as a "living document". The lexicon will facilitate the ability of key stakeholders of micronutrient programs to evaluate and compare program performance in order to make informed decisions on how to ensure future progress in reducing micronutrient deficiencies.

Requirements management for lean digital twins

Abstract The “digital twin” is now a recognized core component of the Industry 4.0 journey, helping organizations to understand their complex processes, resources and data to provide insight, and help optimize their operations. Despite this, there are still multiple definitions and understandings of what a digital twin is; all of which has led to a “mysticism” around the concept. Following the “hype curve” model, it can be seen that digital twins have moved past their initial hype phase with only minimal implementation in industry, this is often due to the perceived high cost of initial development and sensor outfit. However, a second hype peak is predicted through the development of “lean digital twins.” Lean digital twins represent conceptual or physical systems in much lower detail (and hence at much lower cost to build and manage the models), focusing in on the key parameters and operators that most affect the desired optimal outcomes of the physical system. These lean digital twins are requirements managed with the system to ensure added value and tapping into existing architectures such as onboard platform management systems to minimize costs. This article was developed in partnership between BMT and Siemens to demystify the different definitions and components of a lean digital twin and discuss the process of implementing a lean digital twin solution that is tied to the core benefits in question and outlining the tools available to make implementation a reality.

In Search of Institutional Servingness: Institutional Characteristics and Outcomes of Minority-Serving Institutions

Minority-serving institutions (MSIs) are considered models of excellence to support underrepresented racial and ethnic students; however, multiple definitions of MSIs complicate the consumption and production of research on these critical institutions. The U.S. Department of Education (ED) uses set criteria to define MSIs, based primarily on enrollment. However, scholars and practitioners have argued for considering factors beyond enrollment, such as equitable student outcomes and institutional markers of a serving culture. This study used descriptive analyses of IPEDS data to explore the extent to which MSIs served their target population. We use national weighted averages to report results on each MSI category compared to all other institutions. We found that MSIs enrolled higher percentages of MSI-aligned students and employed more-significant percentages of MSI-aligned instructional staff. Most MSIs generally retained higher percentages of MSI-aligned students. Most MSIs showed higher completion proportions, though nearly all MSI categories had lower graduation rates among MSI-aligned students. Some MSIs provided institutional aid to higher proportions of students; others provided lower proportions. Findings confirm that enrollment alone cannot be a proxy for servingness. We encourage researchers, practitioners, and government agencies to use more-holistic definitions. We make recommendations for government agencies to remove burdens to researching MSIs.

The impact of pier height on the construction costs of integral road bridges: An application of artificial intelligence

There are multiple definitions for integral road bridges. One of them explains that these are single-span bridges without expansion joints or bearings at the discontinuity locations. In terms of durability and maintenance, discontinuity locations are considered to be construction parts most exposed to damage in this type of structure. Engineers' efforts to lower maintenance costs and extend the durability of structures have led to the emergence of integral bridges. Early assessment of construction costs is crucial in determining the justification for constructing such structures, as it allows both the investor and the contractor to gauge their involvement in the project's implementation. The construction costs can be determined based on the structure characteristics. One of the major characteristics of integral bridges is the height of their piers. This paper examines how the pier height affects the construction costs of integral road bridges. The prognostic model in the Python 3.7.6 software package applies neural networks to determine the impact of pier height. According to the research, the pier height accounts for up to 20% of the total construction costs of integral road bridges.

Knowledge about research and facilitation of co-creation with children. Protocol for the article "scoping review of research about co-creation with children".

Children and young people's participation, as stipulated in the Convention on the Rights of the Child, applies to both matters that directly and indirectly affect children. Participation is in some countries recognized as a fundamental right and children's engagement seen as a valuable resource. Assisted by conceptual understanding of co-creation, children may be enabled to engage and participate in a variety of contexts. Knowledge about research on, and facilitation of, co-creation involving children is the theme of the scoping review presented by this protocol. The protocol outlines a scoping review which is to use a systematic approach to synthesize knowledge of research about co-creation with children. By systematically scoping the existing research about co-creation with children, the review will survey the available literature (evidence), identify key concepts, and uncover gaps in knowledge. The overall objective of this scoping review is to gain knowledge of research conducted about all types of co-creation with children, and to identify the gaps that future research should address. This scoping review acknowledges the existence of multiple definitions of co-creation, which vary depending on different contexts. The review will also recognize several other associated concepts, such as co-production, co-design, co-research, and co- innovation, since they are used interchangeably with or align with the understanding of co-creation being reviewed. The methodological framework outlined by the Joanna Briggs Institute (JBI) for scoping review will be used as a guide for this review. The PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation will be used during the process. The databases, ERIC (Education Resources Information Centre), Teacher Reference Center, Idunn, Oria, Libris, Kungliga biblioteket, ScienceDirect, ProQuest, Scopus, Academic search elite, Web of Science, Google scholar, will be searched for information on academic books and articles, in May 2024. Also grey literature will be searched for relevant academic references. There are no limitations in date of publication. Language will be limited to English, Norwegian, Swedish, and Danish. Following the selection of studies, data will be extracted and analysed. Ethical approval is not required, because only secondary data is collected. Dissemination will include peer-reviewed publications and presentations at conferences regarding public innovation, education, and children`s participations contexts.

What is the Goal of Defining Family? Best Practices for Teaching Family Communication

Family Communication is an inherently value-laden class. When students walk into the classroom, some of them come with a very negative view of family, whereas others walk in with an extremely narrow view of family. By prioritizing and facilitating the importance of multiple definitions of families, instructors can move through more complex topics over the course of the semester knowing that students have an understanding of why defining family is important—even if they are hesitant to change their definition. In this article I present eight best practices for teaching family communication. This set of practices provides a foundation for educators to broach a value-laden topic while building classroom rapport.

Interobserver Agreement When Diagnosing Hypoventilation in Children With Neuromuscular Disorders

Neuromuscular disorders can lead to nocturnal hypoventilation. Accurate diagnosis of hypoventilation is imperative to guide treatment decisions. This study determined interobserver agreement for a number of definitions of nocturnal hypoventilation in children and adolescents with neuromuscular disorders. Overall mean interobserver agreement was 89% (range 66–100%); however, reliability of agreement was moderate at best (Fleiss κ = 0.574, p < 0.001). When hypoventilation was present, the objective definition used most frequently was an average increase in partial pressure of carbon dioxide (pCO<sub>2</sub>) ≥ 3 mm Hg from NREM to REM. The appearance of the transcutaneous CO<sub>2</sub> (TCO<sub>2</sub>) trend graph and an increase in pCO<sub>2</sub> ≥ 10 mm Hg from awake to asleep were most often associated with a false positive diagnosis. The variation and at best moderate agreement between pediatric sleep physicians observed in this study when diagnosing hypoventilation in children with neuromuscular disorders may be partially explained by the existence of multiple definitions and failure to remove artifact and “drift” from the TCO<sub>2</sub> data.

Different perspectives on engagement, where to from here? A systematic literature review

AbstractEngagement has emerged as a significant focus in contemporary management research, widely acknowledged for its positive impact on wellbeing and performance. However, over 30 years since its introduction, the concept of engagement remains fractured with multiple definitions, ongoing theoretical debates, and inconsistent empirical evidence of practical value. This review addresses the evolving nature of work‐related engagement, recognizing the need for fresh perspectives to better understand this complex phenomenon. To facilitate progressing the research agenda beyond current debates, we used a meta‐narrative review as a systematic approach for synthesizing our findings and problematizing techniques to generate innovative ideas. Our review identified six distinct groups, each arguing for different conceptualizations of engagement. We illuminated opportunities for further research directions by mapping and challenging dominating narratives. Specifically, our review highlights the need to conduct research outside the predominant positivist/postpositivist perspective. It also identifies a need for additional research to understand how task‐level engagement happens through the interplay of individuals and the environment. Our study makes significant conceptual contributions by offering clear boundaries of existing knowledge, an alternative conceptualization of engagement, and a platform for new directions. Contribution to literature review methodology using integrative and generative approaches is also discussed.

Drought characterization: A systematic literature review

<p>This study examined the worsening severity of global droughts caused by climate change. However, the multiple definitions and varied range of drought indices pose challenges in effectively monitoring and assessing the prevalence and severity of droughts. This study aims to give a comprehensive overview of the various drought definitions found in the literature and how they have evolved based on their applications. Specifically, the focus was to shed light on the dynamic nature of drought characterization and offer insights into the factors that shaped its conceptualization over time. Within this context, this study explored three primary categories of drought indices: climatic, remote sensing, and composite. Each category was discussed in relation to its utility in specific fields, such as meteorological, agricultural, and hydrological drought assessments, along with an analysis of their strengths and limitations. Furthermore, this study presents modified meteorological drought indices that have been adapted to better monitor agricultural droughts. Additionally, the authors used geographic information systems to create a map showing the distribution of drought-related publications globally over the past decade. The findings showed that countries with arid and semi-arid climates are more actively involved in drought research, highlighting their particular interest and concern regarding the subject matter. The implications of this study emphasize the urgent need for immediate and coordinated efforts to address the escalating issue of droughts caused by climate change. By improving monitoring and assessment methods and focusing on tailored strategies in vulnerable regions, it is possible to mitigate the far-reaching consequences of drought and to build more resilient communities and ecosystems.</p>

Territory as a Public Law Category: Concept and Logical Relationship with the State

The article is devoted to several conceptual issues of legal understanding of the state territory. The author analyzes the construction of the notion of state territory and substantiates that its multiple definitions are theoretically acceptable. However, modern legal practice implies the inevitability of recognizing a specific approach to understanding state territory as a sphere where state sovereignty manifests itself. The author considers the discrepancies in the legally fixed descriptions of the RF territory composition. It is stated that the discussion about this composition has no scientific solution and can only be arbitrarily terminated, namely by means of enumerating the components of the territory in the legislation or recognizing the correctness of a certain approach by the academic community. The article addresses some issues of using the relevant terminology in legal doctrine and legal regulation. The author shows that legal and linguistic traditions of the describing of territorial issues in various countries do not agree, and that under certain conditions jurisprudence can technically manage without the term “territory” and similar words. Nevertheless, although the term “territory” is flawed, it has practically no alternative in modern Russian-language jurisprudence. The article reveals that in order to assess if a state requires territory, one should consider the interpretation of the notions of territory and state, as well the used scientific methodology. Besides, it demonstrates that it is methodologically precarious to interpret territory as a feature, element, condition or prerequisite of the state. The author shows that the spatial nature of the state bodies jurisdiction and of the national law operation, as well as the spatial structuring of such jurisdiction and of the legal order stay relevant for the modern period of the statehood development. However, the intensive digitalization implementation taking place in the sphere of public functions and public services can lead to a noticeable reduction of the practical need for territorial structuring of the state.

Dissecting the heterogeneity of “in the wild” stress from multimodal sensor data

Stress is associated with numerous chronic health conditions, both mental and physical. However, the heterogeneity of these associations at the individual level is poorly understood. While data generated from individuals in their day-to-day lives “in the wild” may best represent the heterogeneity of stress, gathering these data and separating signals from noise is challenging. In this work, we report findings from a major data collection effort using Digital Health Technologies (DHTs) and frontline healthcare workers. We provide insights into stress “in the wild”, by using robust methods for its identification from multimodal data and quantifying its heterogeneity. Here we analyze data from the Stress and Recovery in Frontline COVID-19 Workers study following 365 frontline healthcare workers for 4–6 months using wearable devices and smartphone app-based measures. Causal discovery is used to learn how the causal structure governing an individual’s self-reported symptoms and physiological features from DHTs differs between non-stress and potential stress states. Our methods uncover robust representations of potential stress states across a population of frontline healthcare workers. These representations reveal high levels of inter- and intra-individual heterogeneity in stress. We leverage multiple stress definitions that span different modalities (from subjective to physiological) to obtain a comprehensive view of stress, as these differing definitions rarely align in time. We show that these different stress definitions can be robustly represented as changes in the underlying causal structure on and off stress for individuals. This study is an important step toward better understanding potential underlying processes generating stress in individuals.

Navigating the Emotional Classroom: How experience shapes educators' anxiety and self-worth

Most of the teaching staff agrees that traits such as "personality" or "mental integrity", along with behavioral manifestations, show substantial significance in the context of the classroom; some of them might even argue that these character attributes have a higher relevance than competence in the specialized field or teaching skills themselves. When an educator experiences failures, they are often attributed to inadequacies of a personal nature, including but not limited to suboptimal empathy, excessive or insufficient enthusiasm, or, as appropriate, excessive authoritarianism, inflexibility, or, conversely, excessive permissiveness. The sphere of stress, tension and anxiety, respectively, within the teaching body is configured as a compartment of the personality and mental health of teachers, which has been almost neglected from a cause-effect relationship perspective. Many postgraduate protagonists went to great lengths to emphasize that dealing with and managing anxiety turned out to be experiences of exceptional significance in the context of their subsequent professional work. A substantial segment of this population showed a strong inclination towards careful consideration of anxiety as a central theme in the educational sphere. As a comprehensive entity, frequently accompanied by an implicit nuance or predispositional character (ie, acting as an internal cause of manifested behavior), anxiety lends itself to multiple operational definitions. The prevalence of various forms of emotional maladjustment, especially anxiety, among the teaching staff has been a subject of sustained research since the first decades of this century. Self-esteem is a trait dedicated to the individual characteristic affective evaluation of one's own person. It is assumed that the level of self-efficacy of the teaching staff is influenced by the degree of self-esteem they show. Thus, the hypothesis is drawn that self-esteem plays an essential role in the academic itinerary of the teachers. A positive self-evaluation intrinsically facilitates the individual's professional development, translated into visible and consistent performance over the relevant time period.

Why Rapport Seems Challenging to Define and What to Do About the Challenge

This article explores why rapport seems challenging to define in the investigative interviewing literature. To demonstrate this issue is contemporary, I examined the most recent publications on rapport (August 2021 - January 2023; N = 19). Approximately 50% of the articles did not define rapport or posited multiple definitions, making a definitional preference impossible to detect. The 50% that specified a focal or single definition came with some form of suggestion that they were real definitions—the objective definitions of rapport. But all those definitions were different, highlighting the ambiguity of rapport in the literature. I discuss how a pragmatic approach via nominal definition can assist in flagging a single sense to use the word rapport, thereby eliminating ambiguity and limitations in assessing construct validity.

On conserved scalars that preserve stoichiometric mixture fraction

With the increasing use of carbon-free fuels in hydrocarbon blends, multiple definitions are appearing for conserved scalars that are employed in the formulation of mixture fraction. One essential requirement for such scalars is the preservation of stoichiometric mixture fraction under conditions where the elemental ratios change locally due to preferential diffusion. This short communication clarifies that the scalar introduced by Bilger in 1989, namely β=2YCWC+YH2WH−YOWO does satisfy these conditions regardless of the gaseous fuel blend, as long as the products of complete combustion are assumed to be CO2 and H2O. An explanation of the underlying foundation of this conserved scalar is provided along with an example for the generalised cases where dilution and partial premixing may be present.

Unified flash calculations with isenthalpic and isochoric constraints

In the unified flash procedure, a persistent set of unknowns and equations are solved in equilibrium calculations, allowing for simultaneous phase stability and split calculations. For fluids in a subcritical thermodynamic state characterized by pressure and temperature, modeling both liquid and gas phases with inequality conditions for phase fractions has been shown to incorporate the tangent-plane criterion and results in a consistent formulation of compositions for both present and absent phases. However, applications such as high-enthalpy systems in subsurface flow require a state definition using other state variables than pressure and temperature, as well as the capability to represent supercritical phases. Furthermore, the robustness of the flash across a wide range of state values is required if equilibrium dynamics are to be included in a flow and transport problem.This work introduces constraints in terms of enthalpy and volume to allow pressure and temperature to vary in the unified setting. The constraints are shown to arise from equilibrium conditions for the relevant state functions to be minimized. To increase the range of applicability, a modified extension procedure for the compressibility factor was devised, as well as procedures for the flash initialization.The unified formulation is extendable to allow isenthalpic and isochoric flash calculations. The initialization was devised using methodologies from the negative flash and Rachford–Rice equations. Extensive numerical tests with multiple equilibrium definitions in terms of state variables were performed. Gas–liquid, binary and a multicomponent mixture using Peng–Robinson EoS showed consistency of results which are verified using third-party code.

Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper

ImpactBronchopulmonary dysplasia has multiple definitions that are currently based on phenotypic characteristics. Using an unsupervised machine learning approach, we created BPD subclasses (e.g., endotypes) by clustering whole microarray data. T helper 17 cell differentiation was the most significant pathway differentiating the BPD endotypes.IntroductionBronchopulmonary dysplasia (BPD) is the most common complication of extreme prematurity. Discovery of BPD endotypes in an unbiased format, derived from the peripheral blood transcriptome, may uncover patterns underpinning this complex lung disease.MethodsAn unsupervised agglomerative hierarchical clustering approach applied to genome-wide expression of profiling from 62 children at day of life five was used to identify BPD endotypes. To identify which genes were differentially expressed across the BPD endotypes, we formulated a linear model based on least-squares minimization with empirical Bayes statistics.ResultsFour BPD endotypes (A, B,C,D) were identified using 7,319 differentially expressed genes. Across BPD endotypes, 5,850 genes had a p value < 0.05 after multiple comparison testing. Endotype A consisted of neonates with a higher gestational age and birthweight. Endotypes B-D included neonates between 25 and 26 weeks and a birthweight range of 640 to 940 g. Endotype D appeared to have a protective role against BPD compared to Endotypes B and C (36% vs. 62% vs. 60%, respectively). The most significant pathway focused on T helper 17 cell differentiation.ConclusionBioinformatic analyses can help identify BPD endotypes that associate with clinical definitions of BPD.