Objective: The present study aims at comparing the temperament-character dimensions, coping styles, and defense mechanisms in substance abusers under methadone maintenance treatment (MMT) and untreated abusers. Theoretical Framework: Staying in treatment is one of the most important issues that patients with substance abuse are facing. Determining the role of personality dimensions and coping mechanisms in substance abuse, were the gap of previous research leading us to conduct present research Method: In a retrospective study, 60 individuals (30 persons under treatment and 30 persons without any treatment) were selected by convenient sampling methods. Coping Inventory for Stressful Situ-ations (CISS), Temperament and Character Inventory (TCI), and Defense Style Questionnaire (DSQ) were used for collecting data. Results and Discussion: The results illustrated that there is a significant difference among the four dimensions of character-personality: novelty seeking (p<0.001), harm avoidance (p<0.001), self-directedness (p<0.001) and cooperation (p<0.001). In addition, there was a significant difference between two groups in the problem-oriented coping style (p<0.001) and the avoidance coping style (p<0.001). In the defensive styles, there were significant differences between two groups in the developed (p<0.001) and the non-developed (p<0.01) defensive styles. According to the results, it can be concluded that the novelty seeking, harm avoidance, self-directedness and cooperation personality dimensions also, problem-oriented and avoidance coping styles and non-developed defensive style are determinant factors of maintenance in treatment. Research Implications: The results have important implications in the clinical field, since knowing the characteristics of the personality profile of abusers leads us to identify risky personality traits (novelty seeking and harm avoidance) and protective personality traits (self-direction and cooperativeness). Originality/Value: This study contributes to the literature by analyzing the main predictive factors to the abuse phenomenon; coping styles oriented towards the problem and avoidance, as well as mature and immature defense mechanisms represent important dimensions that are little analyzed in the literature in order to prevent the phenomenon.
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