To further understand the thermal stability of a parchment manufactured from deer skin, DSC measurements carried out on this biomaterial at several heating rates were used for kinetic analysis of the endothermic processes of denaturation in water excess and of the phase transition in dry state. The last process could be attributed to melting of crystalline (rigid) zone of parchment or the denaturation consisting in the evaporation of residual strongly bond water and continued conformational changes of super-helix of collagen that is the main component of parchment. The kinetic analyses of non-isothermal DSC data were performed by isoconversional and “multivariate non-linear regression” (Multivar-NLR) methods. The application of differential isoconversional method suggested by Friedman put in evidence that for both investigated processes, the apparent activation energy depends on the conversion degree. This suggests that the investigated processes exhibit complex mechanisms. The computation of non-isothermal data by Multivar-NLR method shows that these processes are described from kinetic point of view by Lumry–Eyring mechanism (a reversible process followed by an irreversible one). According to the results obtained by kinetic analysis, the process occurring in dry state seems to be rather a denaturation than a melting of crystalline (rigid) zone of parchment.