This entry explores the emergence of ONE Paleopathology as a holistic, interdisciplinary approach to understanding health through deep time. The entry discusses key areas where paleopathological research provides crucial insights: animals as sentinels of environmental health, the evolution and transmission of infectious diseases, the impacts of urbanization and pollution on human health, and the effects of climate change on disease patterns. Special attention is given to case studies involving malaria, tuberculosis, and environmental toxicity, demonstrating how past human–environment interactions inform current health strategies. The entry also emphasizes the importance of indigenous and local knowledge (ILK) systems in understanding and managing health challenges, highlighting how traditional ecological knowledge complements scientific approaches. By bridging past and present, ONE Paleopathology offers valuable perspectives for addressing modern health challenges in the context of accelerating environmental change, while promoting more equitable and sustainable approaches to global health.
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