Deep Relationship Research Articles

How did life become cellular?

How did life become cellular?

Efektivitas Advokat sebagai Mediator

Mediation is an initial step in the court process. This step is taken before entering into the trial process. In the mediation process it is hoped that both parties can reconcile with each other in their case. so that the mediation process is increasingly encouraged so that it can accelerate the process of resolving a dispute. In the mediation process, of course, the role of the mediator is the key to the success of mediation. Experienced mediators can of course bring together the two parties who are in dispute and reconcile it. Mediators themselves are not only limited to the court environment. However, mediators from outside the scope of the court also have a strategic role in the mediation process. An advocate is considered to have good skills in carrying out this mediation process, because an advocate has a deeper relationship with his clients. It is hoped that the inclusion of an advocate as a mediator can actually resolve the problem without any party feeling disadvantaged and the results of the mediation can be better understood by the litigants.
 Keywords: Advocate, law and Legal Profession

Research by practice in the alpine environment: discovering the activity of MonViso Institute in Ostana. Dialogue with Tobias Luthe

New ideas often come from external influences, different paths that are essential for developing an economic model that’s not based on repeating the past but on three pillars: cultural traditions, natural environment, and new ways of thinking. This happens at MonViso Institute, in the Western Italian Alps, where a group of researchers, designers and entrepreneurs has been involved in place-based research into transitions towards sustainability, regenerative design and architecture, and building a deep relationship with the social, cultural and natural environment. The Institute’s activities involve education in new technologies, climate change, permaculture, the circularity of materials, design with bio-composites, regional economics, which is embedded in outdoor projects in cooperation with European universities and other environment-oriented institutes. Together with the cultural and social realities that have been locally developing during the last decades, MonViso Institute takes part in the regeneration process of the alpine village of Ostana (CN), by representing a significant, concrete programme that can be out-scaled to describe re-inhabitation strategies that may interest several mountain territories.

Are Colonial Systems in Canada and Australia Similar? A Study on Kenneth T. Willams’ In Care and Dallas Winmar’s Aliwa!

So different, yet so alike, Canada and Australia, the land of wilderness and the land of bushes respectively, are two nations that go back thousands of years with their culture, practices, traditions, and the natives’ deep and sacred relationship with the land. The arrival of the Europeans disrupted the peace and the pattern of their lives, resulting in loss of indigenous lands, languages, cultures, and misplaced identity. Kenneth T. Williams, in his play In Care, draws attention to the flaws and loopholes in the system that trap natives like spider-webs. The second play taken up for study is Aliwa! by Dallas Winmar, an Australian play that recounts the journey of a mother, who strives hard to escape the clutches of the system trying to break her and her children up. While much research has been done on the sufferings and trauma of the native people, what really transpires on the other side is mostly kept in the dark. This paper examines how the colonial systems in Canada and Australia mirror each other in multiple aspects. It also draws attention to the systems established in colonial Canada and Australia, which aimed at obliterating any and all vestiges of Aboriginality, under the pretext of ‘civilizing’ the uncivilized. The paper utilises a play from each nation to validate the central objective of the paper, with a particular emphasis on the act of taking Aboriginal children away from their parents, a strategy used by the colonizers in both nations.

The Power of Relationships During the Pandemic: A Community Health Center's Response to COVID-19.

This report describes one community health center's response to COVID-19 by integrating Pacific Island (PI) values-which prioritize dignity, agency, and ancestral philosophies-within the context of deep relationship building. We share impacts and insights with the hope this work will resonate with other PI and Indigenous communities.

Victimization and Distress in Indigenous Maya Women: A Qualitative Investigation of Gender-Based Violence and Mental Health Outcomes in Rural Guatemala.

There is currently scant research exploring Indigenous Guatemalan women's experiences of gender-based violence and mental health outcomes, but existing research suggests further exploration in this area is necessary. The current study aimed to address this gap by analyzing the experiences with violence and subsequent well-being of Indigenous Maya women in rural Guatemala. Data were collected in an ethnographic project on mental health in Panajachel, Guatemala, consisting of a cross-sectional survey on violence exposure and mental health history, followed by semi-structured interviews to elaborate on the experiences. Interviews with seven Kaqchikel Maya women who had been exposed to violence provided the qualitative basis for this study, supplemented by the survey results. Descriptive statistics of survey results and thematic analysis of interviews are presented. The survey results pointed to a deep relationship between violence victimization and mental health issues. Recurring themes in the interviews included symptoms of post-violence emotional distress including fear, sadness, physical ailments, and suicidal ideation; the role of the women as mothers; lack of legal and mental health support; and the importance of spirituality and religion. These results highlight the importance of examining emotional distress as separate from diagnostic psychiatric disorders in addressing women's mental health post-violence. This exploratory study provides examples of violence exposure, mental health, and resource availability among Guatemalan Maya women and suggests possibilities for future investigation.

Women’s experiences of continuity of care from student midwives – A qualitative study from Norway

ObjectiveThe study aimed to gain a deeper understanding of women's experience of continuity of care by student midwives during the childbearing process. MethodA qualitative approach was the design used in this study. In-depth interviews were conducted with nine women who had received continuity of care during their childbearing process by student midwives. The interviews were analysed with the help of systematic text condensation. The study was approved by the Norwegian Centre for Research Data (ref. 905085) and the Regional Research Ethics Committee (ref. 2019/608). FindingsContinuity of care enabled a deep relationship between the woman and the student midwife and made the care provided more individualised, giving the woman emotional support and preparing her for birth. The presence of a student midwife during labour and birth who knew the woman’s story made the woman able to focus on the birth process. Even when unexpected events occurred, the woman had a positive birth experience due to the relationship between her and the student midwife. Continuity of care made the women feel safe and taken care of and was the preferred model of care. ConclusionContinuity of care contributes to individualised and personalised care, enabling all aspects of the woman's needs to be considered throughout the childbearing process. Due to the positive impact on the women in the present study, it is appropriate to implement a continuity of care model in midwifery education programmes. Further research should be conducted to examine how doing so would influence both student midwives and women.

Structural boundary and deep contact relationship between the Yangtze and Cathaysia Blocks from crustal thickness gradients

The deep boundary and contact relationship between the Yangtze and Cathaysia Blocks (the major tectonic units of the Southern China Block), as well as the tectonic attributes of the Jiangnan Orogenic Belt, have remained unknown or controversial. Using data recorded by 128 portable broadband stations and 96 permanent stations, we obtained high-resolution images of crustal thickness and Poisson’s ratio in the study area. The influences of crustal anisotropy and inclined interface were eliminated by using the newly proposed receiver function H–κ–c stacking method. We then used a gradient analysis method to obtain crustal thickness gradients at the boundary of the Yangtze and Cathaysia Blocks for the first time. Our results reveal that the crustal thickness varies from >38 km in the Qinling–Dabie Orogenic Belt to <30 km east of the Tanlu Fault and Cathaysia Block. Areas with high Poisson’s ratios (>0.27) are concentrated on the flanks of the deep fault zone and the continental margin of the study area; those with low Poisson’s ratios (<0.23) are concentrated in the Jiangnan Orogenic Belt. Large crustal thickness gradients are found beneath the eastern part of the Jiujiang–Shitai buried fault (>5 km/°). Combined with the velocity structure and discontinuity characteristics at different depths, these findings suggest that the Jiujiang–Shitai fault may constitute a deep tectonic boundary dividing the Yangtze and Cathaysia Blocks on the lithospheric scale. Moreover, our results support that the Cathaysia Block subducted northwest-ward toward the southeastern margin of the Yangtze Block in the Neoproterozoic, and that the Jiujiang–Shitai buried fault and Jiangshan–Shaoxing fault are the deep and shallow crustal contact boundaries of the two Blocks, respectively; that is, the Yangtze Block overlaps the Cathaysia Block.

The Effect of Discounts and Free Shipping on Impulsive Purchases Moderated by Seller Service

This research was conducted to determine the relationship between discounts, free shipping and impulse purchases moderated by the seller's service. The population in this study were all Generation-Z users of the Shopee marketplace in Yogyakarta using the Smart PLS 3 application. The research sample uses a non-probability sampling technique with purposive sampling method. This study shows a relationship between discounts and free shipping on impulse purchases. In addition, the seller's service is pure moderation between discounts, free shipping against impulse purchases. The reseacrh has limitations that it is to be on a discount, free shipping, seller service, impulse purchases and focus on a Generation-Z that’s avaliable in Yogyakarta. This study will give insight to readers especialy in the field of marketing about the impulsive buying behavior of Generation-Z in the Shopee marketplace with discounts and free shipping as the independent variables, as well as the involvement of seller services as a moderating variable. The difference in this research is to use the seller's service as a moderating variable to find out a deeper relationship between the independent and dependent variables. Using Generation-Z in Yogyakarta which has never been done by previous researchers.

The frequency of somatic mutations in cancer predicts the phenotypic relevance of germline mutations.

Genomic sequence mutations can be pathogenic in both germline and somatic cells. Several authors have observed that often the same genes are involved in cancer when mutated in somatic cells and in genetic diseases when mutated in the germline. Recent advances in high-throughput sequencing techniques have provided us with large databases of both types of mutations, allowing us to investigate this issue in a systematic way. Hence, we applied a machine learning based framework to this problem, comparing multiple models. The models achieved significant predictive power as shown by both cross-validation and their application to recently discovered gene/phenotype associations not used for training. We found that genes characterized by high frequency of somatic mutations in the most common cancers and ancient evolutionary age are most likely to be involved in abnormal phenotypes and diseases. These results suggest that the combination of tolerance for mutations at the cell viability level (measured by the frequency of somatic mutations in cancer) and functional relevance (demonstrated by evolutionary conservation) are the main predictors of disease genes. Our results thus confirm the deep relationship between pathogenic mutations in somatic and germline cells, provide new insight into the common origin of cancer and genetic diseases, and can be used to improve the identification of new disease genes.

Indigenous knowledge, climate change and transformations of Gwadar fishing community

PurposeThis paper explores the indigenous climate knowledge (ICK) of the Gwadar fishing community in Pakistan. The main purpose of this paper is to explore the accuracy of ICK and how climatic change brings changes to it and the social lives of local fishers.Design/methodology/approachQualitative research methods, including participant observation, in-depth interviews and oral histories, were used to collect the data.FindingsFinding from this long fieldwork shows that this fishing community has a harmonious relationship with nature and local ecology. Their knowledge of local ecology enables them to have equal access to natural resources, sustainable resource management, disaster risk reduction and strong social organization on the coast of Gwadar. Recently their deep relationship with local ecology and sociocultural organization has been disturbed due to huge climate changes caused by human manipulation of the environment. Their ability to foresee climatic events has been reduced. They are finding it impossible to estimate fish availability due to massive climate changes. Local communities are losing their traditional livelihoods and socioeconomic autonomy as a result of growing climate change. Climatic change adds to the existing poverty situation and increases political instability in the region.Practical implicationsThe study suggests using the fishermen’s valuable indigenous knowledge of local ecology, climate and its ties to local traditions, culture and resource management for a scientific understanding of climate change and marine resource management in Gwadar, Pakistan.Originality/valueThis is an ethnographic study based on a long term field work. Fishing community is passing through catastrophic climatic changes in the region. This community has been ignored by both government and researchers to record their problems and bring them to academia and media. Therefore, this study will help them raise their voices.

CULTURAL CODE AS THE SEMANTIC CONTENT OF SOCIO-CULTURAL ACTIVITIES: INTERCONNECTION AND MUTUAL INFLUENCE

The article is devoted to the definition of the functional role of the cultural code in the theory and practice of social and cultural activities. The cultural code is a semantic matrix, the correlation of information with certain symbols, allowing us to understand their meaning. Modern socio-cultural activity is used as a powerful resource for the formation of the cultural component of Russian civic identity. The heuristic significance of the culturological approach to the study of the determinants of socio-cultural activity is revealed. There is a co-evolution of the cultural code and the content of socio-cultural activities. It is argued that, while undergoing historical changes, the cultural code retains the status of a semantic core and system-forming factor; there is an ontological unity of the cultural code and socio-cultural practices. The cultural code of Russia is aimed at strengthening the Russian statehood; it is the key to a shared vision of the world. There is a deep relationship and mutual influence of the potential of socio-cultural activities and the cultural code in the system of pedagogical activity. Scientists of the Siberian Federal University analyze the educational process as a space that helps solve a set of problems in the formation of a cultural code among young people in forms that are convincing to them and contribute to the process of their socialization in society.

Ukraine Health System during the 2022 War Crisis: The Battling Concern of the Hour

While Ukraine and Russia have similar historical beginnings, the country's west has far deeper relations with its European neighbors, notably Poland, and nationalist fervor is greatest there. In the metropolis and the industrialized east, a considerable minority of the population speaks Russian as their native tongue. Among postcommunist European states, Ukraine's system is without a doubt one of the worst. Throughout the postcommunist transition era, it was characterized by organizational and budgetary inefficiencies, inadequacy to the population's health demands, and a lack of broader reform attempts. Ukraine's citizens have been subjected to a series of cruel regimes. Stalin's deliberate campaign of starvation murdered three and a half million Ukrainians during the Holodomor, or Great Famine, of 1932–33. Hitler invaded Ukraine in June 1941, and during the German occupation, three and a half million Ukrainians were slaughtered. There can be no true prospect for human health or thriving without peace. For today's Ukrainians, the invasion is more than a tragedy. It will also have a significant impact on future generations' well-being.

Briefly Discussing Measures to Promote the Clean Energy Accommodation

Following the national strategies of energy conservation and environmental protection and sustainable development, it is necessary to clarify the requirements for clean energy development to alleviate energy shortage and control environmental pollution, which can provide support for clean energy development projects. Many companies in China have been involved in clean energy development activities under the guidance of preferential national policies and have made a lot of useful attempts, which have so far yielded certain results. Clean energy accommodation involves a wide range of elements, covering economic, technical and policy aspects. In addition, the extremely deep interest relationship exists between new energy generation companies, conventional energy generation companies and users . Due to the complexity of the situation, it is difficult to realize the idea of clean energy consumption in the short term. Based on the “14th Five-Year Plan” development policy system, this paper proposes measures to promote clean energy accommodation around the new energy and hydrogen energy industries. And on this basis, combined with the operation of the electricity market, this paper gives suggestions to promote the level of clean energy consumption in order to have a positive role in promoting energy consumption in China.

Common words for Solon Evenki and Buryatia Mongolian

The Solon Ewenki and the Buryat Mongols both belong to cross-border peoples, living in China, Mongolia and Russia. The Solon Ewenki and Buryat Mongols in China live in the China-Mongolia-Russia border areas of Hulunbuir, Inner Mongolia. There are many commonalities or similarities in history, culture, society, religion and language, especially, the common relationship shown in linguistics is more obvious. According to the first-hand language information we have, there is a certain number of shared words in Solon Ewenki and Buryat Mongolian, These common words mainly involve nouns, verbs, pronouns, adjectives and so on. Through the analysis and study of these common words, we can further scientifically explore the complex and changeable deep historical relationship between the Ewenki people and the Buryat Mongols.

Greening the GDP——Exploration of the Relationship between Economy and Environment

GDP has always been regarded as a significant indicator to measure the overall economic volume of a country. However, blindly pursuing high economic growth may cause waste of natural resources and damage to the ecological environment, which is not conducive to the long-term and sustainable economic development of the country. This paper aims to explore the deep relationship between economy and resources and environment through the study of Green GDP. Using CoalProducts, Fossil fuels (% equivalent primary energy), PM2.5 air pollution, mean annual exposure (micrograms per cubic meter) and other effective indicators, we developed a TOPSIS model based on The System of Environmental Economic Accounting (SEEA) to assess impacts on climate mitigation. It collects data from reliable sources, including around 42 countries and 18 statistical indicators. In addition, through the forecast of future resource consumption, population and GDP changes, it is further concluded that it is worthwhile to choose Green GDP as an indicator to measure the economy. This study takes China as an example, and the empirical results show that using Green GDP instead of GDP to calculate the national economy can effectively mitigate the negaitve impact of climate, which has certain reference value for the sustainable development and green economy construction of countries around the world.

Pharmaceutical targeting Th2-mediated immunity enhances immunotherapy response in breast cancer

BackgroundBreast cancer is a complex disease with a highly immunosuppressive tumor microenvironment, and has limited clinical response to immune checkpoint blockade (ICB) therapy. T-helper 2 (Th2) cells, an important component of the tumor microenvironment (TME), play an essential role in regulation of tumor immunity. However, the deep relationship between Th2-mediated immunity and immune evasion in breast cancer remains enigmatic.MethodsHere, we first used bioinformatics analysis to explore the correlation between Th2 infiltration and immune landscape in breast cancer. Suplatast tosilate (IPD-1151 T, IPD), an inhibitor of Th2 function, was then employed to investigate the biological effects of Th2 blockade on tumor growth and immune microenvironment in immunocompetent murine breast cancer models. The tumor microenvironment was analyzed by flow cytometry, mass cytometry, and immunofluorescence staining. Furthermore, we examined the efficacy of IPD combination with ICB treatment by evaluating TME, tumor growth and mice survival.ResultsOur bioinformatics analysis suggested that higher infiltration of Th2 cells indicates a tumor immunosuppressive microenvironment in breast cancer. In three murine breast cancer models (EO771, 4T1 and EMT6), IPD significantly inhibited the IL-4 secretion by Th2 cells, promoted Th2 to Th1 switching, remodeled the immune landscape and inhibited tumor growth. Remarkably, CD8+ T cell infiltration and the cytotoxic activity of cytotoxic T lymphocyte (CTL) in tumor tissues were evidently enhanced after IPD treatment. Furthermore, increased effector CD4+ T cells and decreased myeloid-derived suppressor cells and M2-like macrophages were also demonstrated in IPD-treated tumors. Importantly, we found IPD reinforced the therapeutic response of ICB without increasing potential adverse effects.ConclusionsOur findings demonstrate that pharmaceutical inhibition of Th2 cell function improves ICB response via remodeling immune landscape of TME, which illustrates a promising combinatorial immunotherapy.

On ‘Safety’ and EU Externalization of Borders:

Abstract This article questions whether Tunisia – a country of departure, transit and destination of migrants and refugees, and a key interlocutor in EU externalization and readmission policies – can be considered a “safe country of origin” for Tunisian nationals and a “safe third country” for foreigners in search of protection. In discussing the rapidly evolving domestic legal and political system and the treatment of minorities, vulnerable groups, and refugees in Tunisia, this article adopts a socio-legal perspective also relying on interviews with key stakeholders. Finally, it proposes a reflection on the main (conceptual and empirical) elements of continuity between the “safe country of origin” notion and the “safe third country” one, by highlighting their deep relationship, how they may mutually influence each other, and the need to reconnect various perspectives on safety, avoiding reproducing Eurocentric analytic approaches, interpretations, and narratives.

Objects matter: Learning object relation graph for robust absolute pose regression

Visual relocalization aims to estimate the pose of a camera from one or more images. In recent years deep learning-based absolute pose regression (APR) methods have attracted many attentions. They feature predicting the absolute poses without relying on any prior built maps or stored images, making the relocalization very efficient. However, robust relocalization under environments with complex appearance changes and real dynamics remains very challenging. In this paper, we propose to enhance the distinctiveness of the image features by extracting the deep relationship among objects. In particular, we extract objects in the image and construct a deep object relation graph (ORG) to incorporate the semantic connections and relative spatial clues of the objects. We integrate our ORG module into several popular APR models. Extensive experiments on various public indoor and outdoor datasets demonstrate that our ORG module greatly enhances the robustness of image representation to environmental changes and improves the pose regression performance. The code is available athttps://github.com/qcyay/ORGMapNet.

Group Theory and Ring Theory

Group theory is an important theory in abstract algebra. A ring is a kind of algebraic system with two operations (addition and multiplication). It has a deep relationship with groups, especially with the Abelian group. In this essay, the ring and the residual class ring will be talked about. Firstly, this passage is aim to talk about some basic knowledge about the ring which will let readers have a basic understanding of a ring. Then this passage will discuss the residual class ring and subring of the residual class ring of modulo. Some concepts about the ring are also mentioned, such as the centre of the ring, the identity of the ring, the classification of a ring, the residual class ring, the field and the zero divisors. The definitions of mathematical terms mentioned before are stated, as well as some examples of the part of those terms are given. In this passage, there are also some lemmas which are the properties of ring and subring. Future studies of rings and subrings can focus on the application of physics.