The properties, formation, and dissipation of the North Pacific Eastern Subtropical Mode Water (ESTMW), their interannual variability, and impact on spiciness anomalies in the upper permanent pycnocline were investigated using Argo profiling float data in 2005–2015. The core temperature and salinity of ESTMWs were horizontally compensated to a constant density, and core potential density concentrates in a range of 24.5–25.2 kg m−3 with two distinct peaks. ESTMWs showed different spatial distribution and persistence for its core potential density. Denser ESTMWs with a potential density of 24.9–25.2 kg m−3 were formed in winter mixed layer depth maximum centered at 30°N, 140°W and lighter ESTMWs of 24.5–24.9 kg m−3 were formed south and east of it. After formation through shoaling of the winter mixed layer, the former persisted until the following autumn and a small part of it subducted in winter, while the latter dissipated in summer. The formation region of ESTMW corresponded to the summer sea surface density maximum resulting from its poleward sea surface salinity front. Sea surface density maximum maintains weak stratification during summer, preconditioning the deepening of the winter mixed layer and hence the formation of ESTMWs. A relationship between the ESTMW formation region and the summer sea surface density maximum was also found in the North Atlantic and the South Pacific, implying the importance of sea surface salinity fronts and the associated summer sea surface density maximum to ESTMW formation. Interannual variations of ESTMW reflected that of the winter mixed layer in its formation region, and the thickness of ESTMW was related to the Pacific decadal oscillation. ESTMW contributed to the occurrence of spice injection and affected spiciness anomalies in the upper permanent pycnocline through its formation and dissipation.