Deep Learning-based Techniques Research Articles

Deep Learning-Based Techniques in Glioma Brain Tumor Segmentation Using Multi-Parametric MRI: A Review on Clinical Applications and Future Outlooks.

This comprehensive review explores the role of deep learning (DL) in glioma segmentation using multiparametric magnetic resonance imaging (MRI) data. The study surveys advanced techniques such as multiparametric MRI for capturing the complex nature of gliomas. It delves into the integration of DL with MRI, focusing on convolutional neural networks (CNNs) and their remarkable capabilities in tumor segmentation. Clinical applications of DL-based segmentation are highlighted, including treatment planning, monitoring treatment response, and distinguishing between tumor progression and pseudo-progression. Furthermore, the review examines the evolution of DL-based segmentation studies, from early CNN models to recent advancements such as attention mechanisms and transformer models. Challenges in data quality, gradient vanishing, and model interpretability are discussed. The review concludes with insights into future research directions, emphasizing the importance of addressing tumor heterogeneity, integrating genomic data, and ensuring responsible deployment of DL-driven healthcare technologies. EVIDENCE LEVEL: N/A TECHNICAL EFFICACY: Stage 2.

A hybrid model for the detection of retinal disorders using artificial intelligence techniques

The prevalence of vision impairment is increasing at an alarming rate. The goal of the study was to create an automated method that uses optical coherence tomography (OCT) to classify retinal disorders into four categories: choroidal neovascularization, diabetic macular edema, drusen, and normal cases. This study proposed a new framework that combines machine learning and deep learning-based techniques. The utilized classifiers were support vector machine (SVM), K-nearest neighbor (K-NN), decision tree (DT), and ensemble model (EM). A feature extractor, the InceptionV3 convolutional neural network, was also employed. The performance of the models was evaluated against nine criteria using a dataset of 18000 OCT images. For the SVM, K-NN, DT, and EM classifiers, the analysis exhibited state-of-the-art performance, with classification accuracies of 99.43%, 99.54%, 97.98%, and 99.31%, respectively. A promising methodology has been introduced for the automatic identification and classification of retinal disorders, leading to reduced human error and saved time.

A ‘deep’ review of video super-resolution

Video super-resolution (VSR) is an ill-posed inverse problem where the goal is to obtain high-resolution video content from a low-resolution counterpart. In this survey, we trace the history of video super-resolution techniques beginning with traditional methods, showing the evolution towards techniques that use shallow networks and finally, the recent trends where deep learning algorithms result in state-of-the-art performance. Specifically, we consider 60 neural network-based VSR techniques in addition to 8 traditional VSR techniques. We extensively cover the deep learning-based techniques including the latest models and introduce a novel taxonomy depending on their architecture. We discuss the pros and cons of each category of techniques. We consider the various components of the problem including the choice of loss functions, evaluation criteria and the benchmark datasets used for evaluation. We present a comparison of the existing techniques using common datasets, providing insights into the relative rankings of these methods. We compare the network architectures based on their computation speed and the network complexity. We also discuss the limitations of existing loss functions and the evaluation criteria that are currently used and propose alternate suggestions. Finally, we identify some of the current challenges and provide future research directions towards video super-resolution, thus providing a comprehensive understanding of the problem.

MCV-UNet: a modified convolution & transformer hybrid encoder-decoder network with multi-scale information fusion for ultrasound image semantic segmentation.

In recent years, the growing importance of accurate semantic segmentation in ultrasound images has led to numerous advances in deep learning-based techniques. In this article, we introduce a novel hybrid network that synergistically combines convolutional neural networks (CNN) and Vision Transformers (ViT) for ultrasound image semantic segmentation. Our primary contribution is the incorporation of multi-scale CNN in both the encoder and decoder stages, enhancing feature learning capabilities across multiple scales. Further, the bottleneck of the network leverages the ViT to capture long-range high-dimension spatial dependencies, a critical factor often overlooked in conventional CNN-based approaches. We conducted extensive experiments using a public benchmark ultrasound nerve segmentation dataset. Our proposed method was benchmarked against 17 existing baseline methods, and the results underscored its superiority, as it outperformed all competing methods including a 4.6% improvement of Dice compared against TransUNet, 13.0% improvement of Dice against Attention UNet, 10.5% improvement of precision compared against UNet. This research offers significant potential for real-world applications in medical imaging, demonstrating the power of blending CNN and ViT in a unified framework.

The application of deep learning-based technique detection model in table tennis teaching and learning

With the development of computer technology, the teaching methods of table tennis have ushered in a new technological revolution. To solve the problem of traditional teaching methods overly focusing on athlete limbs and athlete force movements, this study uses an improved deep learning algorithm technology detection model to analyze the trajectory of table tennis and provide targeted tactical training for athletes. The results showed that the success rate and accuracy score of the model were 95 % and 96 %, respectively, with a calculation time of only 21.75 ms, indicating high analytical accuracy and computational efficiency. Meanwhile, the winning rate of the training strategy under this method can reach over 65 %, effectively improving the winning rate of athletes. This proves that the proposed technology detection model has good algorithm performance and data analysis ability, and can provide data support for table tennis training and teaching work.

Moving Vehicle Number Plate Detection

Abstract: The ability to detect and recognize vehicle license plates is a crucial task in various applications such as traffic management, law enforcement, and parking systems. In this project, we propose a system for moving vehicle license plate detection using image and video processing techniques. The system employs a combination of computer vision algorithms and machine learning models to accurately locate and recognize license plates from moving vehicles in real-time. The input images or video frames are preprocesses to enhance the regions containing license plates and reduce noise. This preprocessing step may include operations such as resizing, grayscale conversion, noise reduction, and contrast enhancement. Next, object detection algorithms such as Haar cascades or deep learning-based techniques like YOLO (You Only Look Once) are utilized to detect candidate regions in the image/frame that potentially contain license plates. After candidate regions are identified, a series of image processing techniques such as morphological operations, contour detection, and character segmentation are employed to isolate and extract the license plate characters. Machine learning models like Support Vector Machines (SVM), Convolutional Neural Networks (CNNs) are then applied to recognize the characters on the license plate.

Deepfake Detection System

Abstract: Because deep fake technology allows for the creation of incredibly realistically modified material that has the potential to mislead viewers and possibly cause instability across a range of businesses, it poses a severe threat to modern society. These days, detecting such modified content is crucial to maintaining the trustworthiness and integrity of digital media. In response, this research proposes a robust deep learning-based technique for detecting deep fakes in videos. Our method uses the Deep fake Detection Challenge dataset, which contains both real and deep fake films, to train and assess our deep learning model. We want to provide a dependable solution that can differentiate between artificially generated information and actual content using stateof-the-art neural networks. Artificial intelligence-generated phony videos are more likely to spread thanks to deep learning algorithms, which raises serious concerns about official blackmail, terrorist propaganda, revenge pornography, and political manipulation. To alleviate these concerns, our approach is designed to automatically identify several forms of deep forgery, including replacement and re-enactment techniques. By means of extensive testing and analysis, we demonstrate the effectiveness of our deep fake detection system in precisely distinguishing bogus films from authentic ones. Our system, which combines cutting-edge deep learning methods with a large dataset, offers a promising way to lessen the hazards related to the spread of deep fake technologies

Deep Learning Empowered Decision Support Systems for Thyroid Cancer Detection and Management

Exploiting the capability of deep learning-based techniques, this research addresses an important and relevant problem on how to cost effectively detect thyroid cancer. In recent decades, there has been a significant increase in the incidence of thyroid cancer, prompting the need to understand its epidemiology. Existing studies have primarily employed qualitative techniques to investigate a single risk factor correlated with the disease development at a time. However, such an approach is inefficient and tends to ignore the interwoven connections among factors, resulting in a considerable disagreement with the identified risk factors among scholars. Additionally, the use of deep learning techniques in conjunction with medical imaging for computer-aided diagnostic (CAD) systems design has shown promises in detecting the disease, while there are research gaps regarding the detection of subtype and their co-existence. More importantly, existing CAD systems have shortcomings in adapting to different sample groups. To address these challenges, this research aims to shed light on the pathogenesis of thyroid cancer, enhance diagnostic performance, and improve generalisation of deep learning-based decision support systems. By harnessing the power of machine learning, specifically data mining and deep learning techniques, we seek to improve our understanding of the underlying mechanisms of the disease and develop innovative, robust, accurate, and efficient diagnostic tools. Extensive experiments indicate superior performance of the proposed methods than existing works. The systems proposed in this study have great impact to the wider society and contribute to the advancement of thyroid cancer research while enhancing clinical practice in related detection and subsequent management.

Automatic construction of direction-aware sentiment lexicon using direction-dependent words

AbstractExplainability, which is the degree to which an interested stakeholder can understand the key factors that led to a data-driven model’s decision, has been considered an essential consideration in the financial domain. Accordingly, lexicons that can achieve reasonable performance and provide clear explanations to users have been among the most popular resources in sentiment-based financial forecasting. Since deep learning-based techniques have limitations in that the basis for interpreting the results is unclear, lexicons have consistently attracted the community’s attention as a crucial tool in studies that demand explanations for the sentiment estimation process. One of the challenges in the construction of a financial sentiment lexicon is the domain-specific feature that the sentiment orientation of a word can change depending on the application of directional expressions. For instance, the word “cost” typically conveys a negative sentiment; however, when the word is juxtaposed with “decrease” to form the phrase “cost decrease,” the associated sentiment is positive. Several studies have manually built lexicons containing directional expressions. However, they have been hindered because manual inspection inevitably requires intensive human labor and time. In this study, we propose to automatically construct the “sentiment lexicon composed of direction-dependent words,” which expresses each term as a pair consisting of a directional word and a direction-dependent word. Experimental results show that the proposed sentiment lexicon yields enhanced classification performance, proving the effectiveness of our method for the automated construction of a direction-aware sentiment lexicon.

Advancements in Telehealth: Enhancing Breast Cancer Detection and Health Automation through Smart Integration of IoT and CNN Deep Learning in Residential and Healthcare Settings

The rapid evolution of telehealth, or telemedicine, has spurred crucial technological advancements aimed at addressing the early stages of complex cancer conditions, where conventional diagnostic methods face challenges. This research introduces a cancer detection system that utilizes Internet of Things (IoT)-based patient records and machine learning. The primary objective is to automate real-time breast cancer monitoring and detection in residential institutions and smart hospitals, thus enhancing the delivery of quality cancer healthcare. Background: Traditional diagnostic methods, particularly physical inspection, exhibit inherent limitations in identifying breast cancer at early stages. This research responds to this challenge by leveraging innovative technologies, such as IoT and deep learning-based techniques, to overcome the constraints of conventional approaches. Objective: The primary goal of this study is to develop and implement a cancer detection system that integrates IoT-based patient records and machine learning for real-time breast cancer monitoring in residential and healthcare settings. Method: The research employs a synergistic combination of IoT technology for collecting images of residential users and Convolutional Neural Network (CNN), a deep learning technique, for early cancer prediction. The focus lies on contributing to the overall well-being of individuals who may unknowingly be living with cancer. Result: Simulated outcomes after 25 epochs are presented, emphasizing the training accuracy of the model and its validation accuracy using the proposed VGG16 classifier. Graphical representations of the results indicate consistent performance metrics, with both validation and training accuracy exceeding 99%. Specifically, the training accuracy measures at an impressive 99.64%, while the validation accuracy stands at 99.12%. Main Findings: The study demonstrates the effectiveness of the integrated IoT and deep learning techniques in achieving high accuracy rates for early breast cancer prediction. The findings affirm the potential of this approach to assist dermatologists in identifying breast malignancies at treatable stages. Conclusion: This research establishes a foundational framework for the integration of IoT and deep learning techniques, presenting a promising avenue for advancing early cancer detection in smart healthcare systems. The proposed cancer detection system holds significant potential for improving healthcare outcomes and contributing to the overall well-being of individuals at risk of breast cancer.

PSO-PSP-Net + InceptionV3: An optimized hyper-parameter tuned Computer-Aided Diagnostic model for liver tumor detection using CT scan slices

An automated diagnostic system leads to a supreme requirement in medical image analysis, greatly impacting the death rate due to the high spreading rate of liver tumors. However, the traditional histopathological diagnostic processes cause more disruption in the medical detection framework because of the procedure of manual estimation of CT scans and medical labor-intensive, which lead to the time consumption process. It is a highly challenging task for the segmentation of liver tumor because of the irregular appearance, distinct densities, patchy edges, and tumor sizes. To overcome this issue, an automated computer-aided diagnosis framework has been utilized to diagnose the liver cancer quickly and accurately with the less workload of expert radiologists.Presently, Deep learning-based techniques have been applied to identify the tumor regions and assist radiologists in the initial diagnosis and scrutinizing the severity level. The proposed work presents a modified pyramid scene parsing network (PSP-Net) model based on InceptionV3 deep network architecture with a particle swarm optimization algorithm, which increases the efficiency and effectiveness of the liver diagnostic model. Three publicly accessible benchmark datasets have been engaged with the pre-processing task accomplished by image normalization and data augmentation techniques. Moreover, a hyper-parameter tuned improved PSO-PSP-Net algorithm has analyzed the optimal set of gathered features. In the experimental evaluation, the proposed model outperformed than grey wolf optimization (GWO-PSP-Net), PSO-U-Net, GWO-U-Net, opposition based spotted hyena optimization (O-SHO-CRNN), and grey wolf-class topper optimization (GW-CTO) + U-Net by 8.42 %, 4.9 %, 9.54 %, 5.12 %, and 1.75 %, respectively in terms of accuracy for LiTS dataset. The developed PSO-PSP-Net model attained better accuracy than GWO-PSP-Net, PSO-U-Net, GWO-U-Net, and Residual Atrous U-Net (RA-U-Net) for the segmentation of Type-I and Type-II liver tumors by 6.88 %, 8.44 %, 13.75 %, 5.99 % and 6.12 %, 9.74 %, 17.3 %, and 5.11 %, respectively for 3DIRCAD-b1 dataset. The obtained accuracy of the developed model is 14.09 %, 7.54 %, 16.36 %, 2.64 %, and 14.9 %, 8.86 %, 17.76 %, and 4.87 % maximized than GWO-PSP-Net, PSO-U-Net, GWO-U-Net, and RA-U-Net, respectively, for the segmentation of the infected arteries and bones in the 3DIRCAD-b1 dataset. For the CHAOS dataset, the improved PSO-PSP-Net model outperformed GWO-PSP-Net, PSO-U-Net, and GWO-U-Net, respectively, in terms of overall accuracy by 7.44 %, 8.85 %, and 17.2 %, respectively. The investigational analysis validates the proposed PSO-PSP-Net model's effectiveness and performance in obtaining high segmentation accuracy in comparison with other state-of-the-art approaches.

HERITAGE CATEGORIZATION OF MONUMENTS USING DEEP LEARNING

One of the most important tasks in the digital documentation of cultural heritage is the classification of the photos that are taken when measuring an architectural asset. Since many images are typically handled classifying them is a laborious process that takes a lot of time and is prone to error. Additionally properly categorizing the existing images enables more effective management and searches using particular keywords supporting the tasks of researching and analyzing the relevant historical asset. This articles primary goal is to classify photos of architectural heritage using deep learning-based techniques. By creating different pictures of the specific landmarks along with their geo-locations (latitudes longitudes and landmark coordinates) we can use this project to create a variety of landmarks that are present in a given monument. Keywords: geolocations, prone to errors

Brain Tumor Detection and Segmentation using Improved Bat Algorithm with Improved Invasive Weed Optimization

Brain tumours are serious diseases that grow in the brain and are made up of a collection of abnormal and unwanted cells. Therefore, the use of magnetic resonance imaging (MRI) for segmentation and early detection of such tumors is more important to save lives. When it comes to finding people with brain tumors, MRI is very effective and has a slightly higher detection rate than other imaging tests. Detection of brain tumors is an important complex issue in medical imaging systems due to their size, appearance, and irregular shape. Detection of brain tumors is a difficult task with medical imaging systems. In order to address the above-said issue and to develop an effective brain tumor detection technique, an improved Bat algorithm with improved Invasive Weed Optimization algorithm has been proposed in this paper. The improved Invasive Weed Optimization (IIWO) approach has been utilized in the proposed IBIIW algorithm along with the improved Bat algorithm (IBA). In the proposed work weight factor which is used for classification has been improved. Extensive experiments has been performed and it suggests that, the use of MR imaging to segment tumors has a significant influence on early detection of brain cancers. In addition to this, with MR images, the deep learning-based technique produced better detection results. The proposed method has outperformed against the baseline methods in terms of accuracy, sensitivity, and specificity with remarkable results giving values of 0.9394, 0.9281, and 0.9165 respectively.

Assessing the quality of experience in wireless networks for multimedia applications: A comprehensive analysis utilizing deep learning-based techniques

In the context of the burgeoning progression of wireless network technology and the corresponding escalation in the demand for mobile Internet-based multimedia transmission services, the task of preserving and augmenting user satisfaction has emerged as an imperative concern. This necessitates a sophisticated and accurate evaluation of multimedia service quality within the sphere of wireless networks. To systematically address the nuanced issue of user experience quality, the present study introduces a novel method for evaluating multimedia Quality of Experience (QoE) in wireless networks, employing an advanced deep learning model as the underlying analytical framework. Initially, the research undertakes the task of modeling the video session process, giving due consideration to the status of each temporal interval within the session's architecture. Subsequently, the challenge of QoE prediction is dissected and investigated through the lens of recurrent neural networks (RNNs), culminating in the proposition of an all-encompassing QoE prediction model that harmoniously integrates video information, Quality of Service (QoS) data, user behavior analytics, and facial expression analysis. The empirical segment of this research serves to validate the efficacy of the suggested video QoE evaluation method, engaging both quantitative and qualitative comparison metrics with contemporaneous state-of-the-art QoE models, employing the RTVCQoE dataset as the empirical foundation. The experimental findings illuminate that the QoE model elucidated in this study transcends competing models in performance metrics such as PLCC, SRCC, and KRCC. Consequently, this investigation stands as a seminal contribution to academic literature, furnishing an exacting and dependable QoE evaluation methodology. Such a contribution augments the user experience landscape in multimedia services within wireless networks, and instigates further scholarly exploration and technological innovation in the mobile Internet domain.

BConvLSTM: a deep learning-based technique for severity prediction of a traffic crash

Predicting the severity of crashes has become a significant issue in research on road accidents. Traffic accident severity prediction is essential for protecting vulnerable road users and preventing traffic accidents. For practitioners to identify significant risk variables and set appropriate countermeasures in place, explainability of the forecast is also essential. Most previous research ignores the severity of property loss caused by traffic accidents and cannot differentiate between different levels of fatalities and property loss severity. Additionally, while an understandable structure of deep neural networks (DNN) is significantly lacking in existing works, understanding traditional systems is quite simple. An inability to use structural data when describing forecasting and the many attempts to incorporate neural networks afflict the absence of hidden layers. We propose a Deep Learning (DL) framework for forecasting traffic crash severity to overcome the accident severity prediction. It has three steps to process. Initially, collected input data are cleaned. Data cleaning is performed in a preprocessing step. We conduct experiments on two datasets, A Countrywide (US) Traffic Accident Dataset and UK Road Accident Dataset. The outcomes of the experiments demonstrate that the proposed technique outperformed other approaches and produced the best accuracy.

Error estimates for POD-DL-ROMs: a deep learning framework for reduced order modeling of nonlinear parametrized PDEs enhanced by proper orthogonal decomposition

POD-DL-ROMs have been recently proposed as an extremely versatile strategy to build accurate and reliable reduced order models (ROMs) for nonlinear parametrized partial differential equations, combining (i) a preliminary dimensionality reduction obtained through proper orthogonal decomposition (POD) for the sake of efficiency, (ii) an autoencoder architecture that further reduces the dimensionality of the POD space to a handful of latent coordinates, and (iii) a dense neural network to learn the map that describes the dynamics of the latent coordinates as a function of the input parameters and the time variable. Within this work, we aim at justifying the outstanding approximation capabilities of POD-DL-ROMs by means of a thorough error analysis, showing how the sampling required to generate training data, the dimension of the POD space, and the complexity of the underlying neural networks, impact on the solutions us to formulate practical criteria to control the relative error in the approximation of the solution field of interest, and derive general error estimates. Furthermore, we show that, from a theoretical point of view, POD-DL-ROMs outperform several deep learning-based techniques in terms of model complexity. Finally, we validate our findings by means of suitable numerical experiments, ranging from parameter-dependent operators analytically defined to several parametrized PDEs.

Wind Profile Reconstruction Based on Convolutional Neural Network for Incoherent Doppler Wind LiDAR

The rapid development of artificial intelligence (AI) and deep learning has revolutionized the field of data analysis in recent years, including signal data acquired by remote sensors. Light Detection and Ranging (LiDAR) technology is widely used in atmospheric research for measuring various atmospheric parameters. Wind measurement using LiDAR data has traditionally relied on the spectral centroid (SC) algorithm. However, this approach has limitations in handling LiDAR data, particularly in low signal-to-noise ratio (SNR) regions. To overcome these limitations, this study leverages the capabilities of customized deep-learning techniques to achieve accurate wind profile reconstruction. The study uses datasets obtained from the European Centre for Medium Weather Forecasting (ECMWF) Reanalysis v5 (ERA5) and the mobile Incoherent Doppler LiDAR (ICDL) system constructed by the University of Science and Technology of China. We present a simulation-based approach for generating wind profiles from the statistical data and the associated theoretical calculations. Whereafter, our team constructed a convolutional neural network (CNN) model based on the U-Net architecture to replace the SC algorithm for LiDAR data post-processing. The CNN-generated results are evaluated and compared with the SC results and the ERA5 data. This study highlights the potential of deep learning-based techniques in atmospheric research and their ability to provide more accurate and reliable results.

Social4Fashion: An intelligent expert system for forecasting fashion trends from social media contents

The fashion field is continually expanding and evolving, and social media play a significant role in shaping current fashion trends through the influence of online personalities, such as influencers. As a result, fashion designers often turn to social media to gain insights into the latest trends and draw inspiration, while in the past they used to physically visit fashion districts. To automate and speed up this process, an expert system is much needed; thus, Social4Fashion has been created, an end-to-end framework that leverages deep learning-based techniques in order to support creatives in their research and decision-making process, with the final goal of analyzing and predicting trends. This system employs several steps, starting with the automatic data collection from Instagram, using hashtags provided by domain experts. Next, retrieved images are filtered to remove non-fashion related pictures, leaving only those pertaining to the fashion area for further processing. Then, to obtain more specific information about the images, the handbags present (if any) are detected and classified, based on their type; finally, dominant colors of the handbags are retrieved through clustering on the images. All the data collected with this system are then stored and analyzed via user-friendly dashboards, created with the objective of highlighting relevant information, in order to perform analysis on current and future fashion trends. Results show the effectiveness of the proposed system, with an accuracy of 97% (95% confidence interval 0.95–1) for the fashion image classification and a mAP of 0.77 (95% confidence interval 0.73–0.82) for the handbag detection, which makes it suitable for fashion domain analysis. Also, as a result of this work, a novel fashion-related dataset has been made available to the research community. This system can greatly improve the way fashion trends are analyzed, and allow for more efficient and effective design processes in the future.

Smart grading of diabetic retinopathy: an intelligent recommendation-based fine-tuned EfficientNetB0 framework.

Diabetic retinopathy is a condition that affects the retina and causes vision loss due to blood vessel destruction. The retina is the layer of the eye responsible for visual processing and nerve signaling. Diabetic retinopathy causes vision loss, floaters, and sometimes blindness; however, it often shows no warning signals in the early stages. Deep learning-based techniques have emerged as viable options for automated illness classification as large-scale medical imaging datasets have become more widely available. To adapt to medical image analysis tasks, transfer learning makes use of pre-trained models to extract high-level characteristics from natural images. In this research, an intelligent recommendation-based fine-tuned EfficientNetB0 model has been proposed for quick and precise assessment for the diagnosis of diabetic retinopathy from fundus images, which will help ophthalmologists in early diagnosis and detection. The proposed EfficientNetB0 model is compared with three transfer learning-based models, namely, ResNet152, VGG16, and DenseNet169. The experimental work is carried out using publicly available datasets from Kaggle consisting of 3,200 fundus images. Out of all the transfer learning models, the EfficientNetB0 model has outperformed with an accuracy of 0.91, followed by DenseNet169 with an accuracy of 0.90. In comparison to other approaches, the proposed intelligent recommendation-based fine-tuned EfficientNetB0 approach delivers state-of-the-art performance on the accuracy, recall, precision, and F1-score criteria. The system aims to assist ophthalmologists in early detection, potentially alleviating the burden on healthcare units.

Reduction of ADC bias in diffusion MRI with deep learning-based acceleration: A phantom validation study at 3.0 T

PurposeFurther acceleration of DWI in diagnostic radiology is desired but challenging mainly due to low SNR in high b-value images and associated bias in quantitative ADC values. Deep learning-based reconstruction and denoising may provide a solution to address this challenge. MethodsThe effects of SNR reduction on ADC bias and variability were investigated using a commercial diffusion phantom and numerical simulations. In the phantom, performance of different reconstruction methods, including conventional parallel (SENSE) imaging, compressed sensing (C-SENSE), and compressed SENSE acceleration with an artificial intelligence deep learning-based technique (C-SENSE AI), was compared at different acceleration factors and flip angles using ROI-based analysis. ADC bias was assessed by Lin's Concordance correlation coefficient (CCC) followed by bootstrapping to calculate confidence intervals (CI). ADC random measurement error (RME) was assessed by the mean coefficient of variation (CV¯) and non-parametric statistical tests. ResultsThe simulations predicted increasingly negative bias and loss of precision towards lower SNR. These effects were confirmed in phantom measurements of increasing acceleration, for which CCC decreased from 0.947 to 0.279 and CV¯ increased from 0.043 to 0.439, and of decreasing flip angle, for which CCC decreased from 0.990 to 0.063 and CV¯ increased from 0.037 to 0.508. At high acceleration and low flip angle, C-SENSE AI reconstruction yielded best denoised ADC maps. For the lowest investigated flip angle, CCC = {0.630, 0.771 and 0.987} and CV¯={0.508, 0.426 and 0.254} were obtained for {SENSE, C-SENSE, C-SENSE AI}, the improvement by C-SENSE AI being significant as compared to the other methods (CV: p = 0.033 for C-SENSE AI vs. C-SENSE and p < 0.001 for C-SENSE AI vs. SENSE; CCC: non-overlapping CI between reconstruction methods). For the highest investigated acceleration factor, CCC = {0.479,0.926,0.960} and CV¯={0.519,0.119,0.118} were found, confirming the reduction of bias and RME by C-SENSE AI as compared to C-SENSE (by trend) and to SENSE (CV: p < 0.001; CCC: non-overlapping CI). ConclusionADC bias and random measurement error in DWI at low SNR, typically associated with scan acceleration, can be effectively reduced by deep-learning based C-SENSE AI reconstruction.