Event Abstract Back to Event Mapping the functional architecture of working memory in Macaque pre-frontal cortex using movable electrode arrays David A. Markowitz1* and Bijan Pesaran1 1 New York University, Center for Neural Science, United States Prefrontal cortex (PFC) is the hub of a distributed system that coordinates the selection, planning and execution of motor behaviors. Working memory links these operations in PFC by providing temporal continuity between prior experience and present action. Although patterns of intra- and inter-layer synaptic connectivity have been identified in PFC, the laminar organization of sensory, motor and memory-related activity within this network remains unknown. To address this problem, we used a chronically implanted microdrive with independently movable electrodes to map the depth dependence of spatially tuned local field potentials (LFP) in PFC of Rhesus macaques (Macaca mulatta) as they performed memory-guided eye movements. We show that the persistent representation of a remembered target location is limited to superficial layers of PFC. By contrast, the representation of target position during cue and saccade epochs is distributed across superficial and deep cortical layers. This indicates that superficial PFC may be specialized for the maintenance of spatial working memory. Keywords: laminar, local field potential, multielectrode array, pre-frontal cortex, working memory Conference: BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011, Freiburg, Germany, 4 Oct - 6 Oct, 2011. Presentation Type: Poster Topic: neural encoding and decoding (please use "neural coding and decoding" as keyword) Citation: Markowitz DA and Pesaran B (2011). Mapping the functional architecture of working memory in Macaque pre-frontal cortex using movable electrode arrays. Front. Comput. Neurosci. Conference Abstract: BC11 : Computational Neuroscience & Neurotechnology Bernstein Conference & Neurex Annual Meeting 2011. doi: 10.3389/conf.fncom.2011.53.00082 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Aug 2011; Published Online: 04 Oct 2011. * Correspondence: Dr. David A Markowitz, New York University, Center for Neural Science, New York, New York, 10003, United States, david.markowitz@nyu.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers David A Markowitz Bijan Pesaran Google David A Markowitz Bijan Pesaran Google Scholar David A Markowitz Bijan Pesaran PubMed David A Markowitz Bijan Pesaran Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.