Deep Caries Research Articles

Comparison of the effectiveness of Trioxident and Сanal Mineral Trioxide agregate for capping perforations in the pulp cavity

BACKGROUND: The modern trend of dentistry is the principle of minimal invasiveness. Preservation of the vitality of the tooth is an actual principle of operation. In the treatment of deep caries or pulpitis by a biological method, the pulp chamber is often opened. Even with bleeding, there is a chance to leave the tooth vital. After hemostasis, antibacterial treatment of the carious cavity and padding were performed. Domestic manufacturers offer two analogues for these purposes "Trioxident" and "Kanal MTA.
 AIM: The purpose of the study is to compare the effectiveness of domestic materials "Trioxident" and "Kanal MTA" when used as a therapeutic and insulating coating of pulp.
 MATERIALS AND METHODS: 27 clinical cases were analyzed in patients aged 2335 with a diagnosis of "deep dentine caries" K02.2 (according to ICD-10) of molars and premolars of the upper and lower jaws. All clinical cases combined patients' complaints of intermittent aching pains, the depth of carious cavities and the opened tooth cavity at one point. The patients were divided into two groups, in each of which the following stages of diagnosis and treatment were carried out. Diagnostics was carried out before the start of work and during examination after 7 days, 6, 12, 18 months. The stages of caries treatment were the same, only the materials for closing the perforations differed: in group 1 "Trioxidant", in group 2 "Kanal MTA".
 RESULTS: It is noted that the use of materials "Trioxident" and "Kanal MTA" is an effective choice for closing perforations of the pulp chamber in the treatment of deep caries and chronic pulpitis. Pain was absent in 30.8% and 42.1% of patients in groups 1 and 2, respectively. After 6, 12, 18 months, patients did not complain about the treated teeth, the cold test was positive for a short time in 26 cases, the average current at electroodontodiagnostic (minimum value 4, maximum value 8) was 5.6 A, 25 restorations had an Alpha rating according to Ryge criteria, in one case in group 1, the tooth crown darkened pointwise from the vestibular surface.
 CONCLUSION: The materials "Trioxident" and "Kanal MTA" are recommended for use in the biological method of pulpitis treatment. They have therapeutic potential to cover the pulp and are competitive in relation to the foreign equivalent of "MTA Prorut", which gives them an economic advantage in providing dental care within the framework of compulsory medical insurance.

Radiological Appraisal of Biodentine and Pulpotec Individually or in Combination with Photo-activated Disinfection as Pulp-capping Cements in Mature Teeth

The aim of the study was to evaluate and compare radiographically, Pulpotec cement and Biodentine as direct pulp-capping agents in mature teeth, individually and in combination with photo-activated disinfection (PAD). In the present study, 80 mature teeth with deep occlusal caries were selected for direct pulp-capping procedure and randomly assigned to one of the four groups [Pulpotec (I), Biodentine (II), Pulpotec + PAD (III), and Biodentine + PAD (IV)] allocating 20 teeth to each group. Direct pulp capping and cavity disinfection were performed based on the group allotted followed by permanent restoration with composite. The teeth were evaluated radiographically (densitometric analysis) at intervals of 3, 6, and 12 months. The radiographic gray values obtained at follow-up periods for each group were subjected to two-way analysis of variance (ANOVA) with repeated measures. There was a significant improvement (p <0.0001) in the scores of all the groups at follow-ups as compared to the baseline. There was a significant difference between group I/group II with groups III and IV (p = 0.000) with group IV scoring highest at all follow-ups. However, the difference between groups I/II and groups III/IV was nonsignificant. Both, Biodentine and Pulpotec can be used for direct pulp capping of mature teeth. Furthermore, PAD prior to material application significantly improved the radiographical success of Biodentine and Pulpotec, with Biodentine showing better results than Pulpotec. Biodentine and Pulpotec demonstrated comparable success as a pulp-capping agent and PAD application exhibited a synergistic effect when used in conjunction with these materials.

Temperature Changes in Composite Materials during Photopolymerization

During polymerization, composite materials cause a temperature rise which may lead to irreversible changes in the dental pulp. The mechanical properties of composite materials depend on a number of factors, such as the composition of the material, the type of polymerization unit, the polymerization mode, and the duration of polymerization. The objective of this study was to assess the temperature rise values and flexural strength of composite materials, as obtained using different modes and times of polymerization. A total of six composite materials were used in the study. Samples of each of the materials were cured using seven polymerization protocols. A CMP-401 digital meter (Sonel, Świdnica, Poland), complete with a type K thermocouple (NiCr-Ni), was used to record the temperature increases during the light curing of the resin composites. Temperature rises were recorded beneath the composite disc in an acrylic matrix. The specimens were tested for flexural strength using a Cometech QC-508M2 testing machine. The lowest results for the increased mean temperature were obtained for Fast-Cure 3 s (39.0 °C), while the highest results were obtained for Fast-Cure 20 s (45.8 °C). The highest average temperature values for all tested protocols were recorded for the Z550 Filtek material. Mean flexural strengths as measured in each test group were higher than the minimum value for composite materials as per the ISO:4049 standard. In the case of deep caries with a thin layer of dentin separating the filling from pulp, a base layer or a short polymerization duration mode is recommended to protect pulp from thermal injury.

Recent Advances in Indirect Pulp Treatment Materials for Primary Teeth: A Literature Review.

AimTo provide an overview of the techniques of indirect pulp treatment (IPT) and the new materials used.BackgroundIndirect Pulp Treatment (IPT) is a conservative treatment approach that can be used in primary molars. Pulpotomy has been adopted as the treatment of choice for deep caries in primary molars. IPT showed higher success rates in recent researches.Materials and methodsElectronic search of English scientific papers was accomplished using PubMed, ScienceDirect, and Scopus. Papers published from 1995 to 2019 were included. Search terms used were recent advances, indirect pulp treatment, mineral trioxide aggregate (MTA), biodentine, TheraCal–LC, chlorhexidine gluconate (CHX), resin-modified glass ionomer (RMGI), and calcium hydroxide.Review resultsSeventy two papers were obtained from the electronic search and references of selected studies. Thirty five papers explained recent advances in IPT materials for primary molars. MTA produces more dentinal bridging with superior quality than calcium hydroxide. Similarly, Biodentine can form reparative dentin in a very short period. TheraCal–LC has increased stability and durability with strong physical properties and low solubility. Furthermore, CHX is a chemical disinfectant which can aid in increasing the success rate of IPT when conjugated with other materials. It produced highly successful IPT when combined with RMGI or calcium hydroxide.ConclusionIPT is the preferred treatment approach for preservation of primary dentition. CHX is an emerging material that can provide promising results in IPT when combined with other materials.Clinical significanceUp to date, no material had replaced the popular use of calcium hydroxide in IPT. The use of CHX with RMGI can increase the success rate while preserving the advantages of the latter as it is considered the liner of choice for primary teeth, making IPT a suitable substitute for pulpotomy in primary molars.How to cite this articleSaber AM, El Meligy OA, Alaki SM. Recent Advances in Indirect Pulp Treatment Materials for Primary Teeth: A Literature Review. Int J Clin Pediatr Dent 2021;14(6):795–801.

Evaluation of two conservative different treatment protocols for symptomatic proximal deep caries management in molar teeth; an 18-month clinical report

Aim: The primary aim of this clinical trial was to observe the clinical success in conservative management of symptomatic deep proximal caries in permanent molar teeth with two treatment pulpotomy with Biodentine and indirect pulp capping with calcium hydroxide. Materials and Methods: A total of 71 patients who reported to department for the management of symptomatic proximal deep carious lesions in molar teeth participated in the trial. Posttreatment clinical success at 18 months was defined as asymptomatic teeth positively responding to cold pulp sensibility test (only in indirect pulp capping) and absence of periapical infection. Chi-squared test and Kaplan–Meier survival analysis were done. Results: Chi-squared test revealed no significant association between pulp status and posttreatment follow-up in both the treatment groups. Kaplan–Meier survival analysis showed mean survival of pulpotomy procedure for moderate and ambiguous pulp as 66.16 and 67.77 weeks, respectively, with no significant difference for two different pulp statuses. In indirect pulp capping procedure, there was significant difference (P = 0.038) (Log-rank Mantel-Cox) between the two pulp status category with moderate pulpitis having mean survival period of 69.27 weeks and ambiguous pulp with 42.83 weeks. Conclusion: Pulpotomy with Biodentine yielded better results than compared to indirect pulp capping.

Preserving pulp vitality: part one - strategies for managing deep caries in permanent teeth.

This is the first article in a series reviewing the current literature surrounding the management of deep caries in permanent teeth. Approaches to caries management are continuing to evolve, with more conservative management increasingly favoured. This philosophy has never been more important than in managing the deep carious lesion. Evidence is emerging that the use of selective caries removal to reduce the risk of pulp exposure, in conjunction with calcium silicate cements, can be successful in maintaining pulp vitality, delaying the restorative cycle and prolonging the lifespan of the tooth.

Presença do canal mésio-vestibular 2 em primeiros molares superiores – série de casos

The aim of this study was to report a series of clinical cases that show how the presence of the mesiovestibular 2 canal l(MV2) in the first maxillary molar is truly found. Patients complained of spontaneous pain with a history of element 26 or 16, some with deep caries and extensive restorations. Vertical and horizontal percussion tests, thermal tests. and radiographic analysis were performed. The canal was disinfected with abundant irrigation of 2.5% sodium hypochlorite. After, the root canals were located with files # 8 and #10, then the foraminal patency was performed with the EASY system file #25.01, root canal preparations were performed with EASY files from the Logic series #25.05, #40.05 and files #25.04, #30.03, #35.03. After using each file, irrigation with sodium hypochlorite was performed. After the canals were prepared, the cone test was carried out. After drying the canals, the final filling was performed with calibrated Tanari cones and AH plus cement. It was concluded that the occurrence of MV2 canal is high in the first maxillary molars and their location for disinfection is of paramount importance.

Treating Deep Caries in 277 Adult Teeth With Silver Fluoride

Background: Silver diamine fluoride has been widely studied as an agent for managing dental decay. This case report explores its potential for managing peripulpal decay in older adults and for preserving vital pulps.Case description: This is a case report on the use SDF with incomplete caries removal in adult asymptomatic deep caries in 277 teeth. All were indirect pulp caps that were immediately filled with resin or amalgam-bonded fillings in a one-step approach. Over 95% did not require root canal treatment after follow-up (average 16 months, up to six years) and there was no significant postoperative sensitivity.Practical implications: SDF has the potential to offer a fast, cost-effective approach for older patients with deep decay and offers guidance for treatment planning for cases of xerostomia and rampant decay.

Comparative evaluation of biodentine and endosequence root repair material as direct pulp capping material: A clinical study.

Aim:The study was designed to clinically evaluate biodentine and endosequence root repair material (ERRM) as direct pulp capping agent at 3 months, 6 months, and 12 months intervals.Materials and Methods:Sixty permanent posterior teeth with deep caries, without any signs of irreversible pulpitis were allotted into two experimental groups: Group I -Biodentine, Group II-ERRM. Follow-up evaluations were done. Every 24 h for 7 days, the pain was assessed using visual analog scale.Statistical Analysis:Paired t-test along with Pearson's Chi-square test was performed.Results:The success rate of clinical assessment at 12 months for biodentine group is 78.60% and ERRM Group is 64.70%.Conclusion:Biodentine group performed superior than ERRM group clinically at all-time interval and hence it can be successfully used to restore exposed vital tooth.

Deep learning convolutional neural network algorithms for the early detection and diagnosis of dental caries on periapical radiographs: A systematic review.

PurposeThe aim of this study was to analyse and review deep learning convolutional neural networks for detecting and diagnosing early-stage dental caries on periapical radiographs.Materials and MethodsIn order to conduct this review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Studies published from 2015 to 2021 under the keywords (deep convolutional neural network) AND (caries), (deep learning caries) AND (convolutional neural network) AND (caries) were systematically reviewed.ResultsWhen dental caries is improperly diagnosed, the lesion may eventually invade the enamel, dentin, and pulp tissue, leading to loss of tooth function. Rapid and precise detection and diagnosis are vital for implementing appropriate prevention and treatment of dental caries. Radiography and intraoral images are considered to play a vital role in detecting dental caries; nevertheless, studies have shown that 20% of suspicious areas are mistakenly diagnosed as dental caries using this technique; hence, diagnosis via radiography alone without an objective assessment is inaccurate. Identifying caries with a deep convolutional neural network-based detector enables the operator to distinguish changes in the location and morphological features of dental caries lesions. Deep learning algorithms have broader and more profound layers and are continually being developed, remarkably enhancing their precision in detecting and segmenting objects.ConclusionClinical applications of deep learning convolutional neural networks in the dental field have shown significant accuracy in detecting and diagnosing dental caries, and these models hold promise in supporting dental practitioners to improve patient outcomes.

Management of deep caries lesions with or without pulp involvement in primary teeth: a systematic review and network meta-analysis

There is a lack of evidence about the best approach for cavitated caries lesions with the possibility of pulpal involvement in primary teeth. Thus, the present authors aimed to verify the best treatment for deep caries lesions with or without pulp involvement in primary teeth. The search was conducted in MEDLINE/Pubmed and Web of Science databases until May 2020. Studies that compared techniques to manage deep caries lesions with at least 12 months of follow-up were included. The risk of bias was evaluated using the RoB tool. Network meta-analysis and pairwise meta-analyses were conducted considering the treatment clinical success as an outcome, according to the pulp health condition. From 491 potentially eligible studies, 9 were included. For deep caries lesions with pulp vitality, the Hall Technique presented the highest probability of success (78%). In the event of accidental pulp exposure, pulpectomy presented a 76% chance of providing the best clinical results. For pulp necrosis, no difference was observed between a pulpectomy and non-instrumented endodontic treatment (RR = 0.69; 95%CI: 0.21-2.33) Thus, it was concluded that the Hall Technique may be a better option for deep caries lesions with pulp vitality. In cases of accidental pulp exposure of vital teeth during caries removal, a pulpectomy may be considered the best option. However, there are insufficient studies to build up evidence about the best treatment option when irreversible pulpitis or pulp necrosis is present.

Management of dental caries lesions in Latin American and Caribbean countries.

Caries management at the lesion level is dependent on the lesion activity, the presence of a cavitation (either cleanable or non-cleanable), and lesion depth as evaluated via radiographic examination. A variety of non-invasive, micro-invasive, and minimally invasive treatment (with or without restoration) options are available for primary and permanent teeth. Non-invasive strategies include oral hygiene instructions, dietary counseling, and personal as well as professional use of fluoridated products that reduce demineralization and increase re-mineralization. Micro-invasive procedures include the use of occlusal resin sealants and resin infiltrants, while minimally invasive strategies comprise those related to selective removal of caries tissues and placement of restorations. Deep caries management includes indirect pulp capping, while exposed pulp may be treated using direct pulp capping and partial or complete pulpotomy. The aim of the present study was to review available evidence on recommended preventive and restorative strategies for caries lesions in Latin American/Caribbean countries, and subsequently develop evidence-based recommendations for treatment options that take into consideration material availability, emphasize ways to adapt available treatments to the local context, and suggest ways in which dentists and health systems can adopt these treatments.

Interfacial Micro Gaps between Dentin Bases and Hard Setting Calcium Hydroxide Liner

Abstract Objective: This study is aimed to investigate interfacial micro gaps between bases and hard setting calcium hydroxide liner. Materials and Methods: Twelve sound extracted human maxillary premolars were selected and immersed in 0.1% thymol solution. Samples were subjected to Class I cavity preparations with the width of 2.5 mm buccolingually, 3 mm mesiodistally, and 2 mm depth from the dentinoenamel junction (DEJ). The cavities were lined with hard setting calcium hydroxide lining (Dycal®), (Dentsply, USA) and then divided randomly into two groups. The cavities were restored with smart dentin replacement (SDR®), (Dentsply, Germany) and glass ionomer cement Ketac™ N100 (3M ESPE, USA) for Group 1 and 2, respectively, (n = 6 for each group) up to DEJ level. All samples were then packed with composite resin. Samples were cut longitudinally using a hard tissue cutter (Exact, Japan) and sanded with increasing grit sandpaper (#320, #500, #800, and #1200) for 30 s each and subjected for interfacial micro gaps analysis using scanning electron microscopy. Results: There was a significant difference of micro gap formation between two groups of base materials and hard setting calcium hydroxide (Dycal®) (P &lt; 0.05). Conclusions: Lesser micro gap between Dycal® and SDR® compared to Dycal® and Ketac™ N100 suggested SDR® as a better base material to be used with Dycal® for deep caries management.

Post-operative pain after 38% silver diamine fluoride application in primary molars with deep caries versus interim restorative therapy: A randomized pilot study

Aim: To compare the post-operative pain after application of Silver Diamine Fluoride (SDF) 38% in cavitated primary molars, in relation to Interim Restorative Therapy (IRT).Design: The study was performed on 20 carious primary molars in children aged 4-6 years attending the clinic in Pediatric Dentistry and Dental Public Health Department- Faculty of Dentistry -Cairo University. Partial excavation of caries on the walls of the cavity was performed then in group (A) SDF was applied in two visits with one-week interval, and finally Resin Modified Glass Ionomer Restoration (RMGI) was applied to the cavity. While, in group (B) Resin Modified Glass Ionomer restoration was applied immediately after partial caries excavation. Clinical and radiographic examinations were performed at three and six month’s follow-up periods for both groups.Results: In both groups, 100% of patients had no complications at three and six months follow up periods; except for 10% of patients experienced failure of restoration at three months in group B. The results showed insignificant differences between groups regarding clinical and radiographic outcomes at both three and six months. Conclusions: Silver Diamine Fluoride and Interim Restorative Therapy were clinically and radiographically successful when used in primary molars with cavitated dentin carious lesions.

Profuse diversity and acidogenicity of the candida-biome of deep carious lesions of Severe Early Childhood Caries (S-ECC)

ABSTRACT Introduction: The retentive niches of deep caries lesions have a distinct biome. Methods: We evaluated the site-specific (occlusal and proximal) Candida-biome of Severe-Early Childhood Caries (S-ECC) in 66- children (132 lesions). Asymptomatic primary molars fitting the definition of the International Caries Detection and Assessment-(ICDAS)-caries-code 5/6 were analyzed. Deep-dentinal sampling and simultaneous assessment of pH were performed. Clinical isolates were speciated using multiplex-PCR and evaluated for their acidogenic and aciduric potential.Results: Surprisingly, a high prevalence of Candida species (72.7%), either singly or in combination, was noted from both the proximal and occlusal cavities. C. tropicalis was the most prevalent species (47%; 34/72), followed by C. krusei (43.1%; 31/72) and C. albicans (40.3%; 29/72), with C. glabrata being the least (9.7%; 7/72). Over 45% low-pH niches (pH <7) of both sites yielded either dual or triple species of Candida. Genotyping revealed three distinct C. albicans genotypes (A, B, and C) with (14/29; 48.3%) of strains belonging to Genotype A. All four evaluated Candida species exhibited acidogenic and aciduric potential, C. tropicalis being the most potent.Conclusion: This, the first report of the high-density, multispecies, yeast colonization of deep-dentinal lesions in S-ECC, suggests that the Candida-biome plays a significant etiologic role in the condition, possibly due to their profound acidogenicity in milieus rich in dietary carbohydrates.

Comparative evaluation of the application of calcium hydroxide and material on the basis of mineral trioxide of the bio-dent unit in the treatment of deep caries with temporary teeth with low invasive methods

The aim of the work was to evaluate the comparative clinical efficacy of the use of a material based on calcium hydroxide, which has successfully proven itself in pediatric dental practice, and the innovative material "Bio-Dent" (Dentals Pfarma), the experience of which is limited in the treatment of deep caries of deciduous teeth using minimally invasive methods. Clinical studies were carried out on the basis of the Department of Hospital and Clinical Dentistry at the Children's Regional Dental Clinic in Andijan. The basis for the clinical analysis was the data obtained during the examination and treatment of 52 somatically healthy children 4–5 years of age with a compensated form of caries. Summarizing the results of the studies, it was concluded that the use of the "Bio-Dent" material in the teeth of temporary occlusion is the most effective and promising in the treatment of deep caries while maintaining the vitality of the pulp.

Evaluation of the Success Rate of Indirect Pulp Capping Treatment using Different Materials: A Clinical Study

Abstract The aim of this clinical study was to evaluate the success rate of indirect pulp capping (IPC) treatment with three pulp capping materials; Dycal, Biner LC, and TheraCal LC in permanent premolars and molars teeth. A total of 200 permanent posterior teeth with deep carious lesions indicated for IPC treatment were included in the study. The number of patients was 130 of both genders, age 18-55 years old. Teeth were divided into three groups according to the material used for pulp capping. IPC treatment was performed using Dycal, Biner LC, and TheraCal LC in 67, 68, and 65 teeth respectively. Teeth were then restored with nanohybrid resin composite. Patients were clinically evaluated at 8 weeks, 6 months, and one year follow up period for the success of IPC treatment. Data were statistically analyzed using SPSS software. A high success rate of IPC treatment was observed with the three pulp capping materials and that there was no statistically significant difference between the three investigated groups (P˃0.05). At one year evaluation period, the success rate of Dycal, Biner LC, and TheraCal LC was 97%, 97.1, and 98.5% respectively. The three materials were exhibited a high success rate and found to be very successful as IPC agents; however, TheraCal LC showed the best results up to one year follow- up period. I PC treatment maintained the pulp vitality and function of the restored permanent teeth, and that the success of IPC treatment is independent of the pulp capping material. Keywords: Deep caries, Indirect pulp capping, Dycal, Calcium hydroxide, Biner LC, TheraCal LC.

Direct Pulp Capping With ProRoot MTA Alone and in Combination With Er:YAG Laser Irradiation: A Clinical Trial.

Background: Due to the complications of root canal treatment, conservative modalities to preserve pulp vitality are favorable. Direct pulp capping (DPC) refers to the coverage of the pulp tissue exposed by a biocompatible agent that can improve the prognosis of the tooth by 44% to 95%. Some recent studies have reported more predictable results (a success rate of about 90%) for DPC with laser and regenerative materials such as mineral trioxide aggregate (MTA). This study aimed to clinically compare DPC with ProRoot MTA alone and in combination with Er:YAG (erbium-doped yttrium aluminium garnet) laser irradiation (2940 nm). Methods: This clinical trial was conducted on 26 patients with a mean age of 29 years (in the range of 17 to 46 years) who required DPC following pulp exposure during deep caries removal. The teeth were divided into two groups. In the control group, the teeth underwent DPC with ProRoot MTA while in the test group, the teeth were first irradiated with a 2940 nm Er:YAG laser and then underwent DPC with ProRoot MTA. The patients were recalled at one, 3 and 6 months for the follow-up (clinical and radiographic examinations). The data were analyzed using Fisher exact test. Results: The success rate was 75% in the laser group and 93% in the control group. The groups were not significantly different (P>0.05). Conclusion: No significant difference was found in terms of the success rate of DPC with ProRoot MTA alone and in combination with Er:YAG laser irradiation.

An Evaluation on Deep Caries Removal Method and Management Performed by Undergraduate Dental Students: A Malaysia Experience.

Objectives The aim of this study was to investigate the current knowledge and attitude of deep caries removal method among dental students in Malaysia. Materials and Methods A total of 303 students ( n = 303) responded to the online questionnaire. The first part of questionnaire was to evaluate the demographic data of the respondents and focused on the technique and management approach used for deep caries lesion. The second part investigated the preferred treatment used for deep caries based on the designated clinical case, while the third part assessed the factors that affected the decision on deep caries management. Statistical Analysis Independent t -test was used to compare difference between the two groups. Results Seventy four percent of the students have the knowledge of the different methods of caries removal, while 25.8% were only familiar with complete caries removal. The preferred method for deep caries removal in permanent teeth was partial caries removal (53%). For primary dentition, 45.6% of the students prefer to perform pulpotomy as compared with other techniques. There was no significant difference in caries removal method for permanent teeth between undergraduate year of study ( p > 0.05), which was partial caries removal at 52.7 and 53.5%, respectively. For primary dentition, the preferred caries removal method was pulpotomy for year 4 (39.8%) and year 5 (52%) students. The popular material to restore deep caries was resin composite (42%) followed by glass ionomer cement (23.3%). Conclusions This study showed that partial caries removal was the preferred method despite partial understanding on the identification of the clinical indicators of the technique.

Notoginsenoside R1 functionalized gelatin hydrogels to promote reparative dentinogenesis

Pulp-capping materials are commonly adopted in the clinic to form reparative dentin and thus protect dental pulp tissues from cases of deep caries, accidentally exposed pulps or partial pulpotomy. Some traditional pulp capping materials used in the clinic include calcium hydroxide and mineral trioxide aggregates. However, there are limitations to thin restorative dentin, and a long period of time is needed to cause degenerative changes in dental pulp. In this paper, injectable colloidal gels were developed to induce the formation of reparative dentin through a simple UV method from methacrylic acid functionalized gelatin loaded with notoginsenoside R1 (Gel-MA/NGR1). The results of the physicochemical property examinations showed that the prepared Gel-MA/NGR1 hydrogel possessed an appropriate interconnected porous microarchitecture with a pore size of 10.5 micrometres and suitable mechanical properties with a modulus of 50-60 kPa, enabling cell adhesion and proliferation. The hydrogel remained hydrophilic with sustained drug release performance. In addition, Gel-MA/NGR1 significantly enhanced the odontogenetic differentiation of mouse dental papilla cells by elevating the expression levels of the dentinogenic markers ALP and OCN and extracellular matrix mineralization. In vivo stimulation was carried out by injecting the precursors into the predrilled alveolar cavity of Sprague-Dawley rats followed by immediate in situ UV crosslinking. The results showed that Gel-MA/NGR1 has a strong capacity to promote reparative dentin formation. Haematoxylin& eosin, Masson, and immunohistochemical staining (DMP-1, DSPP, OCN and RUNX2) and micro-CT were employed to illustrate the effectiveness of dentinogenesis, and the relative volumes of calcification were found to have increased ~175-fold. All of the results showed that the Gel-MA/NGR1 hydrogel promoted reparative dentin formation, which suggests that this hydrogel provides great potential as a pulp-capping material to induce dentin formation.