Decrease In Body Mass Index Research Articles

Integrating High-Intensity Interval Training into a School Setting Improve Body Composition, Cardiorespiratory Fitness and Physical Activity in Children with Obesity: A Randomized Controlled Trial.

The aim of this study was to examine the effects of school-based high-intensity interval training (HIIT) on cardiorespiratory fitness and visceral adipose tissue (VAT) in children with obesity. A total of 40 students (11.0 ± 0.6 years; 20 boys) were randomized into an intervention group (IG) and control group (CG). The IG group performed a 12-week HIIT intervention with three sessions per week. Each session included 18 min of training (three sets of eight bouts of 15 s run at 100% maximal aerobic speed (MAS) separated by eight bouts of 15 s recovery run at 50% MAS) in PE class; the CG group were instructed to continue their normal behaviors. All subjects had indices of body mass index (BMI), fat mass (FM), body fat percentage (%BF), fat free mass (FFM), VAT, and maximal oxygen uptake (VO2max) measured at baseline and post-intervention. The cooperation of students was high, and all 40 students were included in the final analysis. A significant group–time interaction was determined in body composition (p < 0.05), with a significant decrease in BM (−3.4 ± 1.4 kg, p = 0.001; η2 = 0.63), BMI (−1.7 ± 0.5, p = 0.001; η2 = 0.58), %BF (−3.3 ± 1.4, p = 0.001; η2 = 0.54), and FM (−3.2 ± 1.4 kg, p = 0.001; η2 = 0.69), and VAT (−22.4 ± 9.8 cm2; p = 0.001; η2 = 0.61) in the IG. Furthermore, VO2max exhibited a significant increase in the IG (4.5 ± 1.6 mL/kg/min, p = 0.001; η2 = 0.84) and CG groups (1.7 ± 1.1 mL/kg/min, p = 0.001; η2 = 0.44). Integrating regular school-based HIIT sessions is a suitable method to improve body composition, cardiorespiratory fitness, and physical activity in students with obesity. Trial Registration: ChiCTR2100048737.

Hip aspiration: A comparison of ultrasound and fluoroscopic guidance

IntroductionHip aspirations are commonly performed for diagnostic purposes using either fluoroscopic or ultrasound guidance. The superiority of one type of image guidance over another for aspiration of a native or replaced hip remains a matter of debate. The questions to be evaluated in this study include 1) to determine if hip aspiration using fluoroscopy or ultrasound guidance more often obtains fluid from native and post-arthroplasty hip joints, and 2) to identify patient-related factors associated with the ability to obtain fluid. Material and methodsA retrospective analysis of all hip aspirations (433) performed at a single institution was undertaken, with the primary outcome variable being successful attainment of joint fluid. Age, body mass index (BMI), sex, presence of a trainee, presence of an arthroplasty at the time of aspiration on the affected side, amount of fluid collected, and type of image guidance were used as independent variables in regression models. Results1) The likelihood of obtaining fluid was approximately 2.1 times greater with ultrasound guidance than fluoroscopy guidance (95% CI = 1.382, 3.117; p < 0.001). 2) Ultrasound guidance and lower BMI were independently associated with a significantly higher likelihood of obtaining fluid. Additionally, one unit decrease in BMI was associated with about a 3% increase in the odds of obtaining fluid (95% CI = 0.950, 0.998; p = 0.033). ConclusionThis study demonstrates that the use of ultrasound guidance for hip joint aspiration, when compared to fluoroscopic guidance, is more likely to result in a successful aspiration and the acquisition of a greater volume of fluid. Therefore, ultrasound guidance is the preferred method for hip aspiration in both native and replaced hips.

Gastric Bypass Versus Sleeve Gastrectomy: Comparison of Patient Outcomes, Satisfaction, and Quality of Life in a Single-Center Experience.

Background: Laparoscopic sleeve gastrectomy (LSG) is the most common primary bariatric operation performed in the United States. Its relative technical ease, combined with a decreased risk for anatomic and malabsorptive complications make LSG an attractive option compared to laparoscopic gastric bypass (LGB) for many patients and surgeons. However, emerging evidence for progressive gastroesophageal reflux disease (GERD) after LSG, and the inferior weight loss in many studies, suggests that the enthusiasm for LSG requires reassessment. We hypothesized that patient satisfaction and quality of life (QoL) may be lower after LSG compared to LGB because of these differences. Methods: We distributed a survey querying weight-loss outcomes, complications, foregut symptoms, QoL, and overall satisfaction to patients who underwent bariatric operations at our institution between 2000 and 2020 and who had electronic mail contact information available. Mean follow-up was 2.75 ± 2.41 years for LGB patients and 3.37 ± 2.18 (P = .021) years for LSG patients. We compared these groups for weight-loss outcomes, changes in foregut symptoms, gastrointestinal QoL, postbariatric QoL, and overall satisfaction using appropriate statistical tests. Results: Among 323 respondents, 126 underwent LGB and 197 underwent LSG. LGB patients had larger body mass index (BMI) reduction than LSG patients (-17.16 ± 9.07 kg/m2 versus -14.87 ± 7.4 kg/m2, P = .023). LGB patients reported less reflux (P = .003), with decreased heartburn (P < .0001) and regurgitation (P = .0027). However, a greater proportion of LGB patients reported at least one complication (P = .025). Despite this, more LGB patients reported satisfaction (92.86%) than LSG patients (73.6%). Conclusion: LGB patients are significantly more likely to be satisfied than LSG patients. Factors contributing to the higher level of satisfaction include less GERD and better BMI decrease.

Lifestyle Intervention for Patients with Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial Based on the Theory of Planned Behavior.

Introduction Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, accounting for about 25% and 33% of the world's adult population and Iranians, respectively. There is currently no effective therapeutic agent available for the treatment of NAFLD. However, lifestyle modifications aimed at weight loss have been introduced as a cornerstone of NAFLD management. The aim of the present study was to evaluate the effect of educational intervention on lifestyle and anthropometric indices in patients with NAFLD. Methods The randomized controlled clinical trial was performed on 87 overweight or obese patients with NAFLD, including intervention (n = 42) and control (n = 45) groups. The intervention received 8 training sessions based on theory of planned behavior (TPB), while the control groups received nutritional and physical activity recommendations from their internal specialist and nutritionist. Analyses were carried out based on data collected from TPB constructs and anthropometric indices (weight, body mass index (BMI), waist size, and waist-hip ratio (WHR)) at three stages (before intervention and two and 12 weeks after the intervention), as well as data obtained from liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), and ultrasound-based grading of NAFLD at two stages (before and 12 weeks after the intervention). Results After the intervention, a significant difference was found between the intervention and control groups, resulting in the increased mean scores of TPB constructs, decreased liver enzymes, and decreased degree of NAFLD ultrasound. In addition, the intervention group experienced more activity and healthy diet as compared with the control group. Anthropometric indices showed only a significant decrease in BMI in the intervention group (p < 0.05). Conclusions TPB-based training, as compared with traditional training, is a more effective and cost-effective strategy for altering nutritional behavior and physical activity of patients with NAFLD.

The Effect of High-Intensity Interval Training and Sleep Regulation on Some Inflammatory Markers, Anaerobic Capacity, and Body Composition in Teenage Girls with Sleep Disorders

Introduction: The present study aimed to compare the effect of high-intensity interval training (HIIT), sleep regulation, and the combined method on interleukin-6 (IL-6), high-sensitivity reactive protein (hs-CRP), anaerobic capacity, and body mass index (BMI) of adolescent girls with sleep disorders. Method: Eighty teenage girls with sleep disorders were randomly assigned to HIIT, sleep regulation, a combination of the two (HIIT+ sleep regulation), and control groups. All girls participated in pre-test and post-test sessions for the measurements two days before and after the research process. The participants in the HIIT and combined groups underwent a HIIT training program for four weeks, three sessions per week, and the subjects in the sleep regulation and combined groups performed the sleep regulation program by extending the sleep time duration by five minutes every night. Results: The findings showed a significant difference between groups for the serum levels of IL-6 and hs-CRP, BMI, and anaerobic power (P&lt;0.001). Bonferroni's post hoc test showed a significant decrease in BMI and serum levels of IL-6 and hs-CRP and a significant increase in the minimum power in the combined group compared to the other three groups (P&lt;0.001). In addition, a significant increase in anaerobic power (peak and average power) was respectively observed in the combined and HIIT groups, compared to the sleep regulation and control groups (P&lt;0.001). Conclusion: The HIIT+ sleep regulation combined intervention can be a valuable interventional treatment to improve the care of sleep disorders in adolescent girls and, consequently, reduce the problems and costs of treatment for these individuals and their families

Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis.

BackgroundDietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a novel direction, and the existing clinical studies have little effective evidence for its therapeutic effect, and some studies have inconsistent results. The effectiveness of dietary polyphenols in the treatment of NAFLD is still controversial. The aim of this study was to evaluate the therapeutic efficacy of oral dietary polyphenols in patients with NAFLD.MethodsThe literature (both Chinese and English) published before 30 April 2022 in PubMed, Cochrane, Medline, CNKI, and other databases on the treatment of NAFLD with dietary polyphenols was searched. Manual screening, quality assessment, and data extraction of search results were conducted strictly according to the inclusion and exclusion criteria. RevMan 5.3 software was used to perform the meta-analysis.ResultsThe RCTs included in this study involved dietary supplementation with eight polyphenols (curcumin, resveratrol, naringenin, anthocyanin, hesperidin, catechin, silymarin, and genistein) and 2,173 participants. This systematic review and meta-analysis found that 1) curcumin may decrease body mass index (BMI), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Triglycerides (TG) total cholesterol (TC), and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) compared to placebo; and curcumin does not increase the occurrence of adverse events. 2) Although the meta-analysis results of all randomized controlled trials (RCTs) did not reveal significant positive changes, individual RCTs showed meaningful results. 3) Naringenin significantly decreased the percentage of NAFLD grade, TG, TC, and low-density lipoprotein cholesterol (LDL-C) and increased high-density lipoprotein cholesterol (HDL-C) but had no significant effect on AST and ALT, and it is a safe supplementation. 4) Only one team presents a protocol about anthocyanin (from Cornus mas L. fruit extract) in the treatment of NAFLD. 5) Hesperidin may decrease BMI, AST, ALT, TG, TC, HOMA-IR, and so on. 6) Catechin may decrease BMI, HOMA-IR, and TG level, and it was well tolerated by the patients. 7) Silymarin was effective in improving ALT and AST and reducing hepatic fat accumulation and liver stiffness in NAFLD patients.ConclusionBased on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes. For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.

The height of the sinuses of Valsalva depending on anthropometric data among Ukrainian population

Sinuses of Valsalva height is an important parameter in planning cardiac surgery, percutaneous coronary intervention and transcatheter aortic valve implantation (TAVI). The aim of the study is to analyze the height of the sinuses of Valsalva depending on height, weight, body mass index, body surface area, and sex using computed tomography angiography images in Ukrainian population. 59 chest computed tomography angiography examination for non-cardiac reasons were retrospectively evaluated. Data were collected from Ukrainian citizen. The height of the Sinuses of Valsalva was measured as the distance between aortic annulus and sinotubular junction. All three sinuses of Valsalva height were higher in men than in women (p&lt;0.001). In men, three Sinuses of Valsalva had a correlation with height and body surface area (BSA) (р&lt;0.05). In women, a correlation has been confirmed only between anthropometric measurements and the height of left and right coronary sinuses (р&lt;0,05). The left coronary sinus height had a correlation with height, weight, body mass index (BMI) and BSA (р&lt;0,05). The right coronary sinus height had a correlation with weight, BMI, and BSA (р&lt;0.05). The parameters of the non-coronary sinus in women do not have confirmed direct correlations with any anthropometric measurements observed. The sinuses of Valsalva height is higher in males. The most significant confirmed correlations were between height and left and right coronary sinuses in men and women. Increased size of sinuses in men correlated with an increase of height, weight and decrease of BMI and BSA values.

Gastrointestinal Hormones, Morphological Characteristics, and Physical Performance in Elite Soccer Players.

To determine the relationship between gastrointestinal hormones (leptin, glucagon-like peptide-1), ghrelin, cholecystokinin, peptide YY, morphological characteristics, and physical performances in elite soccer players. Q2 Twenty-two elite male soccer players (age = 23.1 [2.7]y, height = 177.0 [0.1]cm, weight = 70.2 [2.9]kg, body mass index = 22.1 [1.8]kg/m2) completed 3-day food records each week during the 5-week training period. Blood samples were drawn after an overnight fast before and after preseason training to assess gastrointestinal hormones (leptin, glucagon-like peptide-1, ghrelin, cholecystokinin, and peptide YY). Continuous analysis of the training load was used during the training period. Preintervention and postintervention tests assessed jumping (countermovement jump), sprinting (10, 20, and 30 m), and endurance fitness (the Yo-Yo Intermittent Recovery Test Level 1 [YYIRT1]) levels. Preseason training decreased body mass index (P = .001; effect size [ES] = 0.183) and body fat percentage (P = .001; ES = 0.516). There were increases in countermovement jump (P = .032; ES = 0.215), 20- (P = .016; ES = 0.195) and 30-m sprints (P = .001; ES = 0.188), and YYIRT1 performance (P = .001; ES = 0.9). Levels of cholecystokinin, peptide YY, and ghrelin did not change during preseason training, although changes in leptin (P = .001; ES = 0.41) and glucagon-like peptide-1 levels (P = .039; ES = 0.606) were recorded. Leptinemia correlated with anthropometric parameters (body mass index, r = .77, P = .001; percentage of body fat,r = .67, P = .006) and the total distance covered during the YYIRT1 (r = -.54; P = .03). Changes in morphological parameters and physical performance in elite-level male soccer players are related to variations in selected gastrointestinal hormones.

ASSOCIATION BETWEEN ENTERAL NUTRITION AVAILABILITY WITH NUTRITIONAL FULFILLMENT AND NUTRITIONAL STATUS IN HEAD AND NECK CANCER PATIENTS

Background: The availability of enteral nutrition is one of nutritional intervention that can be given to prevent a decrease in nutritional intake and nutritional status in HNC patient.&#x0D; Research objective: This study aims to see the correlation between the availability of enteral nutrition with nutritional fulfillment and nutritional status.&#x0D; Methodology: A cross sectional study was conducted on adult subjects with HNC after radiation therapy at the RSCM radiotherapy outpatient clinic. Nutritional fulfillment was assessed by semi-quantitative FFQ while nutritional status was measured by calculating body mass index (BMI).&#x0D; Research results: Forty-one subjects mean age of 51 years participated in the study. The mean BMI of subjects with enteral nutrition was lower than those on oral nutrition, 18,2±2,6 kg/m2 compared to 21,2±3,5 kg/m2 respectively. The mean total energy intake of subjects with enteral nutrition route was higher, which was 1498,1±430,6 Kcal/day compared to 1291,4±393,3 Kcal/day. There was a moderate negative correlation between the availability of enteral nutrition and nutritional status (r=-0,346, p=0,027), meanwhile there was a weak positive correlation with nutritional fulfillment (r=0,216, p=0,174). However, in this study we found that the proportion of subjects with enteral nutrition who experienced a decrease in BMI was less than the proportion of subjects on the oral route, which was 22,2% compared to 43,8% respectively.&#x0D; Conclusion: There is a moderate negative correlation between the availability of enteral nutrition with nutritional status and a weak positive correlation with nutritional fulfillment which is still influenced by confounding factors.

Impact of the Health-Smart Holistic Health Program: A CBPR Approach to Improve Health and Prevent Adverse Outcomes for Black Older Adults

Black older adults experience poorer health and health-related outcomes than their non-Hispanic White counterparts. Novel, tailored strategies to promote health and prevent adverse health-related outcomes that are aligned with the preferences and values of Black older adults are needed given the limited effectiveness of “one-size-fits-all” approaches. The present study evaluated the impact of a 9-week, community-based participatory research-informed program called the Health-Smart Holistic Health Program for Seniors that aimed to improve health and prevent adverse outcomes among Black older adults by targeting body mass index (BMI), loneliness, food insecurity, and physical and psychological health-related quality of life. Participants ( N = 139) were community dwelling, economically disadvantaged Black older adults living in an underserved area. Results indicated that from pre-intervention to post-intervention there were (a) significant decreases in BMI, loneliness, and food insecurity and (b) significant increases in the participating seniors’ psychological and physical health-related quality of life. Most of these changes were maintained at a 3-month post-intervention follow-up. These results have implications for similar efforts attempting to prevent adverse health outcomes among Black older adults, a high-risk and understudied group. Such efforts should be tailored and should address factors at multiple levels.

Associations of body mass index (BMI) and BMI change with progression of chronic kidney disease in children.

Obesity is prevalent among children with chronic kidney disease (CKD) and is associated with cardiovascular disease and reduced quality of life. Its relationship with pediatric CKD progression has not been described. We evaluated relationships between both body mass index (BMI) category (normal, overweight, obese) and BMI z-score (BMIz) change on CKD progression among participants of the Chronic Kidney Disease in Children study. Kaplan-Meier survival curves and multivariable parametric failure time models depict the association of baseline BMI category on time to kidney replacement therapy (KRT). Additionally, the annualized percentage change in estimated glomerular filtration rate (eGFR) was modeled against concurrent change in BMIz using multivariable linear regression with generalized estimating equations which allowed for quantification of the effect of BMIz change on annualized eGFR change. Participants had median age of 10.9years [IQR: 6.5, 14.6], median eGFR of 50ml/1.73 m2 [IQR: 37, 64] and 63% were male. 160 (27%) of 600 children with non-glomerular and 77 (31%) of 247 children with glomerular CKD progressed to KRT over a median of 5years [IQR: 2, 8]. Times to KRT were not significantly associated with baseline BMI category. Children with non-glomerular CKD who were obese experienced significant improvement in eGFR (+ 0.62%; 95% CI: + 0.17%, + 1.08%) for every 0.1 standard deviation concurrent decrease in BMI. In participants with glomerular CKD who were obese, BMIz change was not significantly associated with annualized eGFR change. Obesity may represent a target of intervention to improve kidney function in children with non-glomerular CKD. A higher resolution version of the Graphical abstract is available as Supplementary information.

Evaluation of the Relationship Between Depression, Emotional Appetite, and Mindful Eating in University Students

Aim: The aim of this study was to evaluate the relationship between depression, emotional appetite, and mindful eating in university students. Subjects and Method: The study sample consists of 940 university students (348 males, 592 females). The “Beck Depression Inventory (BDI)” was used to determine the level of depression, the “Emotional Appetite Questionnaire (EMAQ)” to evaluate the relationship between eating behavior and mood, and the “Mindful Eating Questionnaire (MEQ)” to assess mindful eating. Some anthropometric measurements (body weight, height, waist, and hip circumferences) of the individuals were taken. Results: The mean BDI score of males was higher than females. Out of total, 25% of the students have mild, 17% moderate, and 4% severe depression. There was a significant negative correlation between depression and body mass index (BMI) (r: -0.124). As the BDI score increases, the EMAQ scores increase. A significant positive correlation was found between a negative score of EMAQ and BMI (r: 0.120). It was determined that the MEQ score decreased as the level of depression increased. The MEQ score was negatively correlated with both the EMAQ negative and positive scores to a significant degree (respectively, -0.258, -0.195). As the MEQ score increases, the BMI decreases. Conclusion: University students are at risk for depression. Negative mood can cause obesity by affecting the amount of food consumed, diet quality, and food choices because of emotional appetite. Mindful eating can prevent obesity by having a positive effect on both depression and emotional appetite. Nutritional knowledge and habits of depressed individuals should be evaluated by dietitians.

Effects and dose-response relationships of exercise intervention on weight loss in overweight and obese children: a meta-regression and system review.

The aim of this study was to determine the effectof different exercise doses on weight loss in obese/overweight children. PubMed, Embase, SPORTDiscus, and the Cochrane library were searched from inception to November 2020 for randomized controlled trials. Fourty sixtrials involving 2,599 obese/overweight children were finally included. Different exercise dose interventions had different impacts. Exercise intervention reduce body weight (BW) by 1.46kg (95% CI,-2.35 to-0.56, p=0.001), body fat percentage (BF%) by 2.24 (95% CI,-2.63 to-1.84, p<0.001) and body mass index (BMI) by 1.09kg/m2 (95% CI,-1.45 to-0.73, p<0.001). Each MET-h/week was association with 0.147kg (95% CI,-0.287 to-0.007, p=0.039) decrease in BW, 0.060 (95% CI,-0.118 to-0.002, p=0.042) decrease in BF%, and 0.069kg/m2 (95% CI,-0.125 to-0.014, p=0.015) decrease in BMI. The findings suggest that there is a positive liner between exercise dose and weight loss, each MET-h/week associated with 0.147kg, 0.060 and 0.069kg/m2 decrease in body weight, BF%, BMI, respectively.

HBV Reactivation After Bariatric Surgery for HBV-Infected Obese Patients.

The association between non-alcoholic fatty liver disease and hepatitis B virus (HBV) infection is inconclusive. The aim of this study was to investigate the viral dynamic of HBV and its association with change of body mass index (BMI), aspartate transaminase (AST), and alanine transaminase (ALT) levels after bariatric surgery. Patients who underwent bariatric surgery between June 2011 and May 2014 were selected in this retrospective study. BMI, AST, ALT, and HBV DNA levels were calculated pre-operatively and at 1st, 3rd, and 6th postoperative months. Two hundred and seventy-nine patients including 34 (12.2%) HBsAg-positive and 245 (87.8%) HBsAg-negative patients were enrolled. Eighteen HBsAg-positive and HBeAg-negative patients were matched with 36 HBsAg-negative patients. A significant decrease in BMI was found since 1st postoperative month in both groups. AST and ALT increased at 1st postoperative month, but decreased at 3rd and 6th postoperative months in both groups. However, a significant increase in HBV DNA level was observed in HBeAg-negative patients since 1st postoperative month with the highest peak at 3rd postoperative month. HBV reactivation occurred in 4 out of 17 (23.5%) patients, 8 out of 16 (50.0%) patients, and 4 out of 12 (33.3%) patients at 1st, 3rd, and 6th postoperative months, respectively. The change of HBV DNA was not associated with change of BMI, AST, or ALT after bariatric surgery. Bariatric surgery can achieve significant weight loss and improvement of liver function tests. However, there existed significant risk of HBV reactivation after bariatric surgery for patients with obesity.

Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study.

Unhealthy diet is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). Previous studies showed the benefits of a Mediterranean diet (MedDiet) on Metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases, which usually have a pathophysiological relationship with NAFLD. To assess the effect of adherence to a MedDiet on NAFLD in MetS patients after lifestyle intervention, this multicentre (Mallorca and Navarra, Spain) prospective randomized trial, with personalized nutritional intervention based on a customized MedDiet, coupled with physical activity promotion was performed to prevent, and reverse NAFLD among patients with MetS. The current analysis included 138 patients aged 40 to 60 years old, Body Mass Index (BMI) 27–40 kg/m2, diagnosed with NAFLD using MRI, and MetS according to the International Diabetes Federation (IDF). A validated food frequency questionnaire was used to assess dietary intake. Adherence to Mediterranean diet by means of a 17-item validated questionnaire, anthropometrics, physical activity, blood pressure, blood biochemical parameters, and intrahepatic fat contents (IFC) were measured. The independent variable used was changes in MedDiet adherence, categorized in tertiles after 6 months follow-up. Subjects with high adherence to the MedDiet showed higher decreases in BMI, body weight, WC, SBP, DBP, and IFC. An association between improvement in adherence to the MedDiet and amelioration of IFC after 6-month follow-up was observed. High adherence to the MedDiet is associated with better status of MetS features, and better values of IFC.

Determination of the Impact of Nutrition Specialist-Led Treatments on Paediatric Weight Management Objectives Such as BMI, BMI Z Score, and Waist Circumference

Aim: The information that comes from nutrition experts to multicomponent pediatric weight maintenance intervention groups hasn't been assessed despite the fact that they are regarded as essential team members. This methodical study's objective was to determine the relative efficacy of interventions on pediatric weight maintenance results, such as body mass index, BMI z score, in addition waist circumference, for procedure teams that contain a nutrition specialist in comparison to procedure workgroups that do not contain the nutrition specialist. Methods: The outcomes of an extensive literature seek as well as a structured and more directed keep updating of that search were incorporated into the concept. These searches should include a search of controlled studies that had been accepted for publication among October 2020 and September 2022, which was carried out as part of the 2020 Nephrology Weight Management Notification Scheme of Institute of Education of Nutrition in addition Dietetics Possible to figure Library, as well as a notification of randomized trials that had been authored among October 2020 and September 2022 with only a concentrate based on a more selected demographic. In studies, participants ranged in age from 7 to 19 and were either overweight or obese. They were undergoing outpatient therapy for weight control. The extraction of data from each of the studies that were found was carried out utilizing a standardized tool. The information that was uncovered as a consequence of search and methodical update was combined. In all, 99 publications and 219 diverse research arms were taken into consideration for this research. An exploratory concept was undertaken utilizing alternate meta-analytic approaches that were developed for complex and heterogeneous treatments. The goal of this meta-analysis has been to assess the relative benefits made by each intervention source type at specified time points. In order to determine whether or not each provider category had substantial deviations from the reference group, the meta-regression analysis was carried out. Results: All across the course of the study, the categorization that consisted of neither nutrition specialists nor behavioralists led to smaller decreases in BMI z score when particularly in comparison to the nutrient consultant situation, the combined nutrition consultant and treat specific classification, and the categorization that consisted of neither nutrition specialists nor behavioralists. According to the results of a research study, the variation in BMI z score here among nutrition specialist-only classification and benchmark classification has been statically important at four different time points: between four and seven months, among eight and 1.5 years, and between one and two years (P140.02, P140.06, and P140.02, including both). This result is significant at the 4 to 7 months and 1-year to 2-years’ time periods (P140.002 and P140.06, correspondingly) for the nutrition specialist-only service set, where there were lower rises in BMI over time compared with the original categories. At no moment did we find any statistically significant variations in the body composition across the different provider groups. Conclusion: Indirect data suggested that the involvement of a nutrition expert in the provision of treatment led to improved results in pediatric weight managing in terms of BMI z score and BMI at chosen time periods. Keywords: Body Mass Index (BMI), Nutrition Specialist, multicomponent pediatric weight maintenance intervention groups.

Haptoglobin polymorphism modulates cardiometabolic impacts of four consecutive weeks, dawn to sunset Ramadan intermittent fasting among subjects with overweight/obesity

AimsHaptoglobin (Hp) is a multifaceted marker of inflammation, and mediates the interplay between obesity, inflammation, and cardiometabolic dysfunction. However, the role of the Hp phenotype in modulating intermittent fasting (IF)-induced cardiometabolic changes remains to be elucidated. MethodsHp phenotype was determined for the study subjects. Cardiometabolic markers were assessed before and at the end of four consecutive weeks, dawn to sunset IF. ResultsA total of 114 subjects (75 males and 39 females, 38.7 ± 11.7 years, body mass index (BMI) of 30.41 ± 5.09 kg/m2) were recruited. Hp2-2 (n = 55, 48.2 %) and Hp2-1 (n = 53, 46.5 %) were the predominant phenotypes. Significant reductions were observed in serum Hp, IL-6, TNF-α, triglycerides (TG), total cholesterol (TC), LDL, BMI, and fat mass (FM), while a significant elevation was observed in serum CD163, HDL, and IL-10 at the end of the IF month for the whole population. Based on the Hp polymorphism, significant decreases in Hp, BMI, FM, TG, LDL, and TNF-α, with significant increases in HDL and CD163 levels were observed among subjects with Hp2-2 and Hp2-1 phenotypes. A more pronounced reduction in FM was reported in subjects with Hp2-2 in comparison with Hp2-1. ConclusionHp gene polymorphism modulates IF-induced changes in cardiometabolic markers.Clinical Trial Registration number: ISRCTN18205186; https://trialsearch.who.int/?TrialID=ISRCTN18205186.

Prognostic Impact of a Body Mass Index Decrease during First Chemotherapy in Patients with Advanced Follicular Lymphoma.

Objective Follicular lymphoma (FL) is an indolent B-cell malignancy, usually treated by immunochemotherapy in advanced-stage and high-tumor-burden cases. Although some reports have shown no significant relationship between the pre-treatment body mass index (BMI) and the overall survival (OS) in FL, little is known regarding BMI changes during chemotherapy. We analyzed the impact of a BMI decrease during chemotherapy on the OS in FL patients. Methods We retrospectively analyzed 56 patients with untreated advanced FL who underwent chemotherapy at our institute between July 2009 and December 2020. The BMI change was defined based on the BMI before and at three months after the first chemotherapy session. The cut-off for a BMI decrease was set at 1.42 kg/m2 according to the receiver operating characteristics curve for the OS. We compared the survival outcome between two BMI groups based on this cut-off. Results A BMI decrease was significantly associated with a worse OS (5-year OS: 86.7% vs. 60.5%, p=0.019), although the pre-treatment BMI showed no significant relationship with the survival. The adverse impact of a BMI decrease remained in a multivariate analysis for the OS (hazard ratio, 3.972; p=0.045). The decreased-BMI group tended to show a higher cumulative incidence of early-onset histological transformation (HT) than the non-decreased-BMI group (20% vs. 0.0%). A BMI decrease during chemotherapy in previously untreated FL patients might reflect the hyperactivation of tumor-induced metabolism related to HT. Conclusion A BMI decrease during chemotherapy might be an independent adverse prognostic factor in FL patients. BMI changes in addition to the condition of FL patients should be monitored during chemotherapy.

Protective effect of Spirulina against bone fragility induced by Garcinia cambogia in high-fat diet induced obese rats

The present work evaluated the protective effects of Spirulina against the bone fragility caused by Garcinia cambogia in high-fat diet induced obese rats. High-fat diet and high-fat emulsion (HFD+HFE) were administered via oral gavage to 30 six-week-old female Sprague Dawley rats for six weeks to induce obesity, except for a normal group (n = 6). Following four weeks of treatment, the diet-induced obese groups were orally administered, daily, with (1) G. cambogia (GC); (2) Spirulina (S); and (3) G. cambogia + Spirulina (GC+S). The normal and obese control groups were treated with equal volumes of 0.9% saline water. It was found that GC significantly decreased body mass index (BMI) below the obese range (0.68 g/cm2). Additionally, GC altered bone mineral density (BMD), increased phosphate and calcium levels, and decreased maximum force and mineral apposition rates (MAR) as compared to the obese control group (p &lt; 0.05). Bone fragility caused by GC was confirmed by the decrease in bone formation marker osteocalcin (OCN), as well as an increase in bone resorption receptor activator of nuclear factor kappa-B ligand (RANKL) and tartrate-resistant acid phosphatase type 5b (TRAP5b) as compared to the obese control group. Spirulina also decreased the BMI of the obese rats. Spirulina also increased blood bone markers, BMD, maximum force, and Young’s modulus. Rats supplemented with GC+S demonstrated higher double-labelled surface (dLS/BS) and MAR as compared to those in the GC group (p &lt; 0.05). Meanwhile, the S group demonstrated improvement in all dynamic histomorphometric indices. S and GC+S groups demonstrated bone formation upregulation and bone resorption downregulation, thus indicating a bone protective effect of Spirulina. Overall, GC treatment led to bone fragility. GC+S treatment significantly augmented bone formation and mineralisation in obese rats as compared to the GC treatment alone. Rats in the S group demonstrated effective weight reduction while showing no destructive effects on the bone.

O-157 Female body mass index (BMI) influences pregnancy outcomes: An evaluation of 4349 IVF/ICSI cycles

Abstract Study question Does female body mass index (BMI) impair pregnancy outcomes after IVF/ICSI cycles? Summary answer High BMI (overweight and obesity) and low BMI (underweight) are associated with decreased clinical pregnancy and live birth rates and an increased miscarriage rate. What is known already Obese women undergoing treatment for infertility may face problems, such as the need for higher doses of drugs to stimulate ovulation, oocyte morphological changes, reduction in fertilization and implantation rates, and embryo quality. Compared to women of normal BMI, obese women submitted to IVF may present reduced rates of clinical pregnancy and live births and an increased miscarriage rate. Regarding the effects of low BMI, unfavourable pregnancy outcomes and infertility problems have been described, but evidence is still scarce and conflicting. Study design, size, duration A prospective analysis was performed of 4349 couples who underwent IVF/ICSI treatment and fresh embryo transfer. Only one cycle per couple was considered. Exclusion criteria included abnormal karyotype, uterine defects, evidence of hydrosalpinx, infections, endocrine problems, coagulation defects or thrombophilia and autoimmune defects. Couples were stratified into four groups by female BMI: &amp;lt;18.5kg/m2 (underweight); 18.5-24.9kg/m2 (normal weight); 25-29.9kg/m2 (overweight); and ≥30kg/m2 (obesity). Clinical pregnancy, miscarriage and live birth rates were the outcomes analysed. Participants/materials, setting, methods Variables such as age, duration/type of infertility, previous embryo transfers, aetiologies, endometrial thickness, type of ovarian stimulation, and number/quality/development stage of embryo transferred were included as potential confounding factors. For group comparisons, the t test or chi-square test was used. Multivariate logistic regression analyses were performed to evaluate the associations between BMI and the probabilities of clinical pregnancy (CP), miscarriage and live birth (LB). Normal-weight patients were considered as the reference group. Main results and the role of chance Regarding confounding factors, no significant differences between BMI groups were observed. -BMI-group comparisons showed that CP, miscarriage and LB rates significantly worsened with the increase in BMI (overweight and obesity groups). Miscarriage and LB rates also worsened with the decrease in BMI (underweight group) (Table 1). -Compared with the normal-weight group, the overweight and obesity groups had significantly reduced rates of CP (19%/29%, respectively) and LB (27%/40%, respectively) and an increased rate of miscarriage (1.7x and 2.3x, respectively). Underweight was associated with a 49%-reduced rate of LB and a 3.0x increase in the rate of miscarriage (Table 2). Limitations, reasons for caution Differences in sample size between BMI groups may have influenced the results. In clinical outcomes, only fresh transfers were considered (not cumulative data). Population characteristics should be considered when interpreting the results. Wider implications of the findings The study suggests that higher BMI (overweight and obesity) and lower BMI (underweight) in women have a detrimental effect on ART outcomes, especially regarding the evolution of pregnancies. Problems associated with abnormal BMI should be discussed when advising couples interested in fertility treatment. Trial registration number Not applicable.