55 senior-aged sedentary women (66±5 yrs, 79±11 kg; 44±4% body fat) participated in the Curves circuit resistance-training program 3-d per wk for 14 wk. Subjects were assigned to an exercise only group (E) or a high carbohydrate (HC) or high protein (HP) diet group. Diets consisted of 1,200 kcal/d for 1-wk, 1,600 kcal/d for 9 wks, followed by a 2,100 kcals/d maintenance diet for 4 wks. The HC and maintenance diets contained 55% CHO, 15% PRO, and 30% Fat while the HP diet contained 7–15% CHO, 55–63% PRO, and 30% Fat. Data were analyzed by repeated measures ANOVA and are presented as means ± SD changes from baseline for the E, HC, and HP groups, respectively. Significant time effects were observed in total cholesterol (10 wks 8.5±17, 9.7±36, 2.1±16; 14 wks −3.4±12, 8.7±40, −3.7±11 %), LDL-c (10 wks 15.4±24, 2.6±27, 2.4±18; 14 wks −0.3±17, 0.9±27, −0.8±13 %), triglycerides (10 wks 22.8±29, 13.8±31, 4.0±51; 14 wks −0.2±18, 15.7±32, 4.7±42 %), and the ratio of CHL/HDL (10 wks 6.1±19, 9.7±40, 4.8±17; 14 wks −6.0±11, 4.4±39, −2.0±12 %). No differences were seen in fasting glucose (10 wks 8.5±17, 9.7±36, 2.1±16; 14 wks −3.4±12, 8.7±40, −3.7±11 %). Subjects experienced significant decreases in waist (−1.5±2; −1.9±3; −3.4±2 %) and hip (−1.0±2; −1.7±3; −3.9±4 %) measurements with subjects on the HP diet experiencing greater effects. Results indicate that participation in the Curves program improves some general markers of health status.