Introduction: Oral malignancy is usually preceded by lesions which are non-malignant to begin with and which are therefore been termed as premalignant. Many premalignant lesions and conditions like leukoplakia, erythroplakia, oral lichen planus, oral submucous brosis have malignant potentials. Aims: To evaluate the serum lipid prole in premalignant lesions and conditions like Oral Leukoplakia, Oral Submucous brosis and in Oral squamous cell carcinoma and its comparison with the lipid prole among control groups. Material and method: A total number of 225 patients were selected for the study from the OPD in Chandra Dental College and Hospital, Barabanki, U.P. the patients were selected under the criteria mentioned below. Patients with clinically evident and histopathologically conrmed with oral submucous brosis, oral lichen planus, oral leukoplakia, erythoplakia, and oral malignancy, for leukoplakia patients with histopathological conrmation sample collection was done, for patients with Oral Submucous Fibrosis after histopathological conrmation, sample collection was done and for Oral Malignancy sample collection was done after histopathological conrmation were included in this study. Result: In Control Group (1 Vs 3), the mean HDL (mean± s.d.) of patients was 72.9885± 8.6803. In Malignant Group (1 Vs 3), the mean HDL (mean± s.d.) of patients was 38.2000± 3.5106. Distribution of mean HDL with Group (1 Vs 3) was statistically signicant (p<0.0001). In Control Group (1vs3), the mean VLDL (mean± s.d.) of patients was 36.8640± 3.0412. In Malignant Group (1vs3), the mean VLDL (mean± s.d.) of patients was 26.1600± 1.5905. Distribution of mean VLDL with Group 1vs3 was statistically signicant (p<0.0001). In Control Group1 vs3, the mean LDL (mean± s.d.) of patients was 96.4448± 12.7468. In Malignant Group1 vs3, the mean LDL (mean± s.d.) of patients was 94.8000± 5.9233. Distribution of mean LDL with Group 1 Vs3 was not statistically signicant (p=0.3125). Conclusion: There was statistically signicant decrease in plasma total cholesterol, TG, LDL, VLDL and HDL observed in malignant patients as compared to the premalignant control group. The low lipid levels associated with Oral malignancy indicates that there is inverse relationship between oral cancer and serum lipid prole. Decrease in the lipid levels may be considered as a useful biochemical marker in the early diagnosis of oral malignancy.