The MIND is a novel eating plan preserve cognitive function. Propolis is a resinous substance that has several biological and medicinal properties. This study examines the effect of the MIND diet and propolis supplementation on MetS indices among metabolic syndrome subjects. This RCT study, was conducted on adults with metabolic syndrome who were referred to the Hazrat Ali Health Center in Isfahan. 84 eligible subjects were divided into 3 groups. including MIND diet + Propolis supplement, MIND diet + placebo, and control group. The data obtained from the subjects was analyzed in two descriptive and analytic levels. The Shapiro-Wilk test and examination of skewness were conducted to assess the normality of the distribution of quantitative variables. Quantitative variables were reported using either the mean (SD). SPSS Statistics software version 26 was used for statistical analysis of data. In this study the MIND + Propolis supplement group compared to the control group showed a significant decrease (p-value < 0.05) in weight, BMI, WC, SBP, and TG (p-value < 0.001) after adjusting variables by 0.97 times (3%), 0.97 times (3%), 0.98 times (2%), 0.93 times (7%), and 0.78 times (22%), respectively; this significant change was also observed in DBP (p-value < 0.05) and FBS (p-value < 0.001) by 0.94 times (6%) and 0.82 times (18%), respectively; and HDL-C has shown a significant increase (p-value < 0.05) after adjusting variables by 1.16 times (16%). MIND group compared to the control group showed significant decrease (p-value < 0.05) in weight, BMI, WC, SBP, and TG (p-value < 0.001) by 0.98 times (2%), 0.97 times (3%), 0.98 times (2%), 0.95 times (5%), and 0.73 times (27%), respectively; this significant change (p-value < 0.001) was also observed in DBP and FBS by 0.92 times (8%) and 0.80 times (20%), respectively; and HDL-C has shown a significant increase (p-value < 0.001) by 1.20 times (20%). This study indicated that the MIND diet + Propolis supplement and MIND diet compared to the control group can significantly decrease weight, BMI, WC, SBP, DBP, FBS, TG, and also increase HDL-C.The present study's protocol was approved by the Iranian Registry of Clinical Trials (www.irct.ir) on 3/28/2023 and a registration reference is IRCT20230105057054N1.