This study aims to investigate the techno-functional and thermodynamic properties of Cucumis melo peels. Besides, the protein composition of these raw materials was determined showing interesting profile and thus melon peels could be considered as a natural source of essential amino acids for foods formulation. The foam capacity of peel powder was 38.66%. The sorption isotherms were examined at three temperatures 30, 40, and 60°C using the standard static-gravimetric method. Results illustrated that the water sorption was temperature dependent as typical of food systems. We pursued the research to elucidate sorption isotherms process, which is useful to assess suitable drying and storage conditions of peels. Peleg model was found the best to fit experimental curves for both desorption/adsorption process. The net isosteric heat of sorption and sorption entropy increased with decrease in equilibrium moisture content. Microscopic features throughout peel tissue presented different samples which undergo desorption or adsorption processes. Practical applications In recent years, a growing interest on the valorization of food processing by-products has appeared. However, these materials are often prone to microbial spoilage and chemical deterioration, which are directly related to storage conditions as temperature and moisture content of the product. Sorption isotherms are recognized as valuable tools for technologists to predict shelf-life stability of the products. The principal purpose of the present work was to investigate the techno-functional properties and thermodynamic features of melon peels.