Decrease In Mean Platelet Volume Research Articles

Antioxidant Effects of Vitamin C on Some Hematological Parameters of Male Wistar Rats Exposed to Lead Acetate

The study investigated the effects of vitamin C on platelet parameters, white blood cell count and white blood cells differentials in Wistar rats exposed to lead acetate. A total of twenty-four male Wistar rats weighing between 160g and 200g were utilized. The experimental animals were divided into four groups of six rats each (n=6). Group 1 served as the control group (received normal feed and water), group II received 10mg/kg body weight of lead acetate, group III received 100mg/kg body weight of Vitamin C, and group IV received 10mg/kg body weight of lead acetate followed by 100mg/kg body weight of Vitamin C. Lead and Vitamin C, along with normal feed, were administered for four weeks. Blood samples were collected via jugular puncture and stored in EDTA bottles for analysis to determine the blood profile of the rats. The results showed significant increase in Platelet Count (PLT) in group III and a significant decrease in Mean Platelet Volume (MPV) in group IV (Pb + vitamin C). The Mean Platelet Width (MPW) showed decrease in groups 2, 3, and 4 compared to the control group, although this decrease was not statistically significant. The study also noted an elevated level of white blood cells (WBC) in response to the antioxidant treatment, indicating a potential positive impact on immune function. In conclusion, this study demonstrates the therapeutic effect of Vitamin C against the toxic effects of lead on platelet parameters and white blood cell count and differentials.

Obstrüktif Uyku Apnede (OUA) Ortalama Trombosit Hacmi (OTH) ve OUA'da Sürekli Pozitif Hava Yolu Basıncı (CPAP) Tedavisinin OTH Üzerine Etkisi

Aims: In this study, our objective was to evaluate mean platelet volume (MPV), an indirect marker of platelet activation, in patients with obstructive sleep apnea (OSA), and assess the effect of OSA treatment with continuous positive airway pressure (CPAP) on MPV
 Methods: In this study, records of consecutive patients who underwent polysomnographic evaluation for OSA symptoms in the Sleep Disorders Laboratory during a one-year period were reviewed retrospectively. Patients who had both complete blood count and MPV measurements were included in the study.
 Results: A total of 158 patients, including 51 females (32.3%) and 107 males (67.7%), were included in the study. The mean age of the patients was 51±13 (min-18, max-82) years. OSA was detected in 74.1% (117/158) of the patients. It was determined that as the severity of OSA increased, hemoglobin and hematocrit values increased significantly. There was no significant difference in platelet count according to the presence and severity of OSA. The MPV was significantly lower in severe OSA cases compared to those without OSA and mild OSA cases. A negative correlation was observed between MPV and the apnea-hypopnea index, desaturation index, and the amount of oxygen saturation below 90% during sleep. There was no significant difference in median erythrocyte and thrombocyte counts, hematocrit percentage and hemoglobin values before and after treatment in OSA patients who used CPAP therapy. However, a significant decrease in MPV was observed after OSA treatment compared to pre-treatment. (p=0.021).
 Conclusions: The results of the study do not support an increase in MPV and hence platelet activation in severe OSA patients compared with those without OSA. However, the results suggest that one month of CPAP treatment reduces MPV and thus platelet activation in severe OSA patients. Further controlled, prospective studies including treatment outcomes are needed on this subject.

The effect of vitamin D deficiency on platelet parameters in patients with COVID-19.

Since there is very little information about the relationship between platelet parameters and vitamin D concentration in patients with COVID-19, the aim of this study is to investigate the relationship between serum vitamin D level and platelet parameters in patients with COVID-19 and to compare these parameters in patients with COVID-19 without vitamin D deficiency and, subsequently, the prognostic value of these parameters in cases of vitamin D deficiency. Seven hundred and forty-three patients diagnosed with COVID-19 were enrolled in this study. Patients were divided into two groups: those with and without vitamin D deficiency. The associations between platelet indices and vitamin D levels were analyzed by Pearson's correlation analysis and a one-way ANOVA test. Platelet count and mean platelet volume (MPV) were significantly higher in the patients with vitamin D deficiency than in the patients without vitamin D deficiency. There was a significant negative correlation between platelet count and MPV with vitamin D levels in patients with vitamin D deficiency (r = -0.835, P = 0.001 & r = -0.324, P = 0.042, respectively). Vitamin D levels in COVID-19 patients can determine the platelet count and MPV of the patients. The aforementioned results imply that maintaining an elevated concentration of vitamin D in COVID-19 patients is important because it is associated with a decrease in MPV, which in turn reduces susceptibility to diseases such as coronary artery disease.

Mean platelet volume and D-dimer as predictors for complicated community-acquired pneumonia in hospitalized children

BackgroundCommunity-acquired pneumonia (CAP) is one of the primary causes of child mortality and morbidity. The primary objective of our research was to assess the value of mean platelet volume (MPV) and D-dimer levels in predicting complicated community-acquired pneumonia in hospitalized children.MethodsThis observational retrospective study gathered medical data from the electronic medical records of children diagnosed with CAP who were admitted to the Pediatric Pulmonology Unit between December 2021 and December 2022.ResultsThis study included 154 pediatric patients. Their age at presentation was 4.15 ± 3.60 years. A comparison of patients with complicated CAP and non-complicated CAP revealed a statistically significant decrease of MPV in the complicated CAP group than in the non-complicated group (p = 0.016). The D-dimer level was significantly higher in the complicated CAP 3.42 ± 3.02 µg/ml compared than in the non-complicated 1.63 ± 2.04 µg/ml, p = 0.002). Low MPV and increased D-dimer were powerful indicators of complicated CAP (OR 0.577, p = 0.021, OR 1.419, p = 0.003).ConclusionThe current study highlights that low MPV and high D-dimer levels can be useful predictors of pulmonary complications of CAP in children. However, prospective observational studies are needed to evaluate the changes in these predictors during the disease and assess the time needed for normalization.

The mean platelet volume (MPV) in patients with systemic lupus erythematosus (SLE) and its correlation with disease activity: a cross-sectional/case–control study

Introduction: Systemic lupus erythematosus (SLE) is a systemic disease, with unknown etiology. The authors aimed in this study to determine the connection between mean platelet volume (MPV) and disease activity of SLE. Although it has been studied in other rheumatological conditions like rheumatoid arthritis, its role in adult patients with SLE needs to be defined, especially in Syria. Materials and methods: The authors have included in a cross-sectional study, 80 patients with SLE and 80 controls. The SLE group was divided into two groups based on their disease activity index: the active disease group and the non-active disease group. In all groups, MPV and erythrocyte sedimentation rate (ESR) were analyzed. Clinical findings and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) were evaluated in all patients. Results: MPV was significantly lower in SLE patients compared to the control group (8.49±1.2 fl and 10.0±0.5 fl, respectively) (P=0.001). A decrease in MPV below the cut-off value (7.2 fl) increased the risk of active disease by an odds ratio of 9.79 (95% CI: 3.4–27.9) (P<0.001). Conclusion: MPV may be a disease activity indicator in patients with SLE. MPV is reduced in patients with active SLE and presents an inverse correlation with SLEDAI.

Effects of Methanol Extract of Albizia lebbeck Leaves on the Body Weight, Hematological Parameters and Histological Structures of Digestive Organs in Rats (Rattus norvegicus)

Due to its use in traditional medication and its leaves and pods being considered as potential fodder for livestock the toxicity of Albizia lebbeck needs to be thoroughly explored. The study evaluated the effects of 70% methanol extract of Albizia lebbeck leaves on body weight, hematological parameters and histopathology of digestive organs in Wistar rats. Twenty-one healthy adult female rats were experimented with and divided into two groups of six and fifteen animals. Six rats were randomly subdivided into two groups of three rats each for plant extract LD50 determination at 2000 mg/kg and 5000 mg/kg dosages, respectively. Fifteen rats were randomly sub-allotted into three groups of five animals. Group I the control received distilled water by gavaging. Groups II and III received 100mg/kg and 400mg/kg of the extract, respectively—treatment covered 30 days. On day 31, the body weight of each rat was recorded before being sacrificed under chloroform. Blood was collected for hematological analysis. The liver and stomach were trimmed and processed for histopathology. The results revealed the LD50 of the extract to begreater than 5000 mg/kg. Extract treatment had no significant effects on the rat’s body weight. A significant (P<0.05) increase in WBC, Eosinophils, RBC, and Hematocrit was revealed at 100 mg/kg of extract treatment. A dosage of 400 mg/kg of the extract caused a significant increase in Eosinophils and Lymphocytes. However, the plant extract caused a significant (P<0.05) decrease in Mean Platelet Volume and Platelet Distribution Width at both doses, Monocytes and Neutrophils at 400 mg/kg and Mean Corpuscular Volume and Mean Corpuscular Hemoglobin at 100 mg/kg compared with the control. Both doses of the extract treatments caused lesions in the liver characterized by, necrosis, sinusoidal dilatation and inflammatory cell infiltration with no significant lesions in the stomach. In conclusion, the extract of Albizia lebbeck leaves caused a significant decrease in some hematological parameters and some lesions in the liver at 100 mg/kg and 400 mg/kg.

EVALUATION OF MEAN PLATELET VOLUME LEVEL AS A BIOMARKER IN ACUTE APPENDICITIS IN CHILDREN AND ADOLESCENT: A RETROSPECTIVE STUDY

Objective: This study aims to investigate the diagnostic value of mean platelet volume (MPV) in early diagnosis of acute appendicitis cases in children and adolescents. Methods: 50 patients with the age of ≤20 years were chosen retrospectively from the case files of the patients admitted to the hospital between May 2021 and May 2022 in whom the definite diagnosis of acute appendicitis was confirmed with postoperative pathological examination. This group was labeled as case group. The control group consists of 50 patients with the age of ≤20 years who came for the regular health checkups at our institute. All blood samples were analyzed for complete blood count that includes MPV also in a fully automated 6-part hematology cell counter. These data of both the groups were analyzed statically to calculate p value using the online Student’s t-test calculator. The value p<0.05 is considered to be statistically significant. Results: Majority of acute Appendicitis cases (n=30, 60%) belong to 16–20 years, followed by 24% in 11–15-year-age group. The mean age was 14.96±2.75 years. According to gender, 66% (n=33) were male. The mean platelet count in the case of group was 3.10±0.5 Lakhs/ml whereas in the case of Group was 2.86±0.7 lakhs/mL. There was no statistically significant difference among the group with respect to platelet count (p=0.188 >0.05) The MPV in the case of case Group was 7.92±0.3 fL whereas in the case of the control group was 8.62±0.4 fL. There was a statistically significant difference among the in terms of MPV (p=0.04 <0.05). Conclusion: The diagnosis of acute appendicitis in children and adolescents is aided by a decrease in MPV. The rate of negative appendectomy in children and adolescents with suspected acute appendicitis may decrease if the clinician pays attention to the MPV (which is determined routinely as a part of automated count) alongside other parameters and clinical evaluations.

Associations Between Mean Platelet Volume and Various Factors in Type 2 Diabetes Patients: A Single-Center Study from Poland.

BACKGROUND Thromboembolic episodes, which are largely mediated by blood platelets, are prevalent chronic complications of diabetes. The mean platelet volume (MPV) serves as a marker for in vivo platelet activation. This study aimed to assess the factors influencing MPV in 106 patients with type 2 diabetes, compared with 59 non-diabetic individuals at a single center in Poland. MATERIAL AND METHODS We performed linear regression analysis, with MPV as the dependent variable and factors such as age, sex, thrombopoiesis-influencing cytokines, blood pressure, body mass index, glycosylated hemoglobin percentage, platelet count, large platelet count, lipid profile parameters, creatinine concentration, estimated glomerular filtration rate, treatment modalities, and comorbidities as independent variables. MPV was measured using the ADVIA 2120 hematology analyzer, with a reference range of 7-12 fL. RESULTS The analysis revealed that in patients with type 2 diabetes, an increase in platelet count by 10×10³/μL resulted in a decrease in MPV by 0.05 (P<0.001), while an increase in large platelet count by 1×10³/μL led to an increase in MPV by 0.18 (P<0.001). Additionally, patients taking ß-blockers or insulin had lower MPVs by 0.77 (P=0.008) and 5.63 (P<0.001), respectively, compared with those not on these medications. CONCLUSIONS This study delineates the relationship between MPV, platelet parameters, and treatment modalities in type 2 diabetes, paving the way for further research to elucidate underlying mechanisms and potential clinical applications.

Can Propranolol Affect Platelet Indices in Infantile Hemangioma?

Propranolol, a nonselective beta-blocker used in the medical treatment of infantile Hemangioma (IH), has been shown to decrease the levels of vascular endothelial growth factor and reduce angiogenesis with its antiproliferative and antiangiogenetic effects. It has been reported that the storage, transport, and secretion of vascular endothelial growth factor (VEGF) are associated with platelet volume indices (PVI). We aimed to investigate the effect of propranolol on PVI in IH patients. Propranolol treatment was started on 22 IH patients. Platelets, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit values in the follow-ups at months 0, 1, and 2 were compared between 22 patients who received treatment and 25 patients who did not. While a statistically significant difference between months 0, 1, and 2 in PDW and MPV values was detected in the treated group, it was not detected in the untreated group. Taking into consideration that VEGF levels were higher at the beginning of the treatment in the pathophysiology of the disease, it was thought that the decrease in VEGF levels by propranolol may have led to a decrease in MPV and PDW levels in the treatment group. Consequently, in IH cases, propranolol response follow-up can be evaluated with PVIs, especially MPV and PDW, and it may facilitate clinicians' monitoring of the disease after propranolol administration.

Mean platelet volume and glycaemic control in patients with new-onset Type 2 diabetes mellitus.

Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with vascular complications that are attributable to dysregulated platelet reactivity as measured by mean platelet volume (MPV). This study aimed at determining a relationship between MPV and glycaemic control in new-onset T2DM. This was a prospective study conducted on 236 new-onset T2DM patients divided in two groups as group A, glycosylated haemoglobin A1c (HbA1c < 7.9%; n = 70) and group B, HbA1c ⩾ 8% (n = 107) who were followed up for 6 months for change in platelet and glycaemic parameters. At 6-month follow-up, there was a significant decrease in HbA1c and MPV (group A (HbA1c: 7.40 ± 0.40 vs 7.03 ± 0.23%, p < 0.03; MPV: 9.65 fl ± 0.74 vs 9.46 fl ± 0.71, p < 0.001) and group B (HbA1c: 10.59 ± 1.89% vs 9.29 ± 1.50%, p < 0.001; MPV: 10.89 fL ± 1.29 vs. 10.23 fL ± 1.40, p< 0.001)). The percentage decline in HbA1c was more in group B (11.81 ± 5.87 vs 4.76 ± 4.58, p < 0.01). There was a positive correlation between ΔMPV and ΔHbA1c in group B; however, we did not observe significant correlation for group A. We interpret that in people with diabetes with baseline HbA1c ⩾ 8%, with improvement in glycaemic control, there is a significant decrease in MPV. We propose that a routine MPV testing can be used as a potential marker for glycaemic control in T2DM.

Low Mean Platelet Volume is Associated with Deep Vein Thrombosis in Older Patients with Hip Fracture.

This study aimed to explore the association between mean platelet volume (MPV) and preoperative deep vein thrombosis (DVT) in older patients with hip fracture. A total of 352 consecutive older patients with hip fracture were included from January 2014 to December 2020. MPV values were measured on admission, and color Doppler ultrasonography was performed for DVT screening before the planned surgery. The receiver operating characteristic (ROC) curve was used to establish the optimal cut-off value for the prediction of DVT. Univariate and multivariate logistic regression analysis were used to examine the association between factors and DVT. The overall prevalence of preoperative DVT was 15.1%, and patients with DVT had a lower value of MPV than non-DVT patients (11.6 ± 1.2 fL vs 12.3 ± 1.4 fL, P < .01). The cut-off point according to the ROC curve for MPV was 13.3 fL, and multivariate logistic regression analysis showed that MPV level < 13.3 fL was significantly associated with an increased risk of DVT (OR = 4.857, 95% CI: 1.091-21.617, P = .038), and with every 1.0 fL decrease in MPV, the risk increased by 27.7% (OR = 1.277, 95% CI: 1.001-1.629, P = .047). Our findings indicate that a low MPV level is associated with DVT in older patients with hip fracture. As MPV is a simple indicator that can be calculated from the blood routine test, it may be a potential biomarker of DVT with the combination of other tests, further studies are needed to confirm these results.

Diagnostic Value of Mean Platelet Volume in Prediction of Acute Myocardial Infarction

Background: Acute myocardial infarction (AMI) is one of the main etiologies of death globally. In AMI, platelets were demonstrated to play a main role in thrombotic processes that limit the patency of the recanalized, infarct-related coronary artery and contribute to reperfusion injury. Platelet volume is an important indicator for platelet function and activation. Objective: The aim of the present study was to evaluate mean platelet volume (MPV) as an early and independent predictor for AMI in patients with acute chest pain. Patients and methods: This retrospective observational analytical study included a total of 107 patients presenting with acute chest pain presenting to Mansoura Emergency Hospital within the period from January 2019 to January 2020. Of them, 36 cases were diagnosed as stable coronary artery disease and 71 cases were diagnosed as AMI. Results: There were statistically significant differences among both groups regarding age, female sex and BMI being increased in AMI group. Hypertension, DM and dyslipidemia were significantly increased among AMI cases compared to stable coronary artery disease ones. Stable coronary artery disease cases demonstrated significant increase in platelet count and significant decrease in MPV compared to AMI ones. Hypertension, DM, dyslipidemia, family history of CAD, prior MI, prior PCI and MPV could be used as significant predictors for AMI. Conclusion: The current study concluded that larger platelet volumes may be used as predictor for AMI as well as ischemic complications.

Exercise-Based Cardiac Rehabilitation Has a Strong Relationship with Mean Platelet Volume Reduction.

ResumoFundamentoO volume plaquetário médio (VPM), uma medida simples de ativação plaquetária, tornou-se recentemente um tópico interessante no campo da pesquisa cardiovascular. A reabilitação cardíaca (RC) baseada em exercícios é uma intervenção abrangente que diminui a morbidade-mortalidade em pacientes com doença arterial coronariana (DAC). Estudos sobre os efeitos do exercício físico na ativação plaquetária têm produzido resultados conflitantes.ObjetivoO objetivo deste estudo foi determinar o efeito de um programa de RC baseado em exercícios sobre o VPM em pacientes com DAC estável.MétodosA amostra foi composta por 300 pacientes consecutivos com DAC estável. Os pacientes foram divididos em dois grupos: grupo RC (n = 97) e grupo não RC (n = 203). Foi feito um hemograma. As medidas de correlação ponto-bisserial foram tiradas para mostrar a correlação entre a alteração do VPM e a RC. Valor de p<0,05 foi considerado estatisticamente significativo.ResultadosA diminuição do VPM foi maior no grupo CR do que no grupo não CR [(-1,10 (-1,40-(-0,90)) vs. (-0,10 (-2,00-0,00)); p<0,001]. ΔVPM teve correlação positiva com Δ neutrófilos (r = 0,326, p<0,001), ΔTG (r = 0,439, p<0,001), ΔLDL-c (r = 0,478, p<0,001), ΔGB (r = 0,412, p<0,001) e ΔPCR (r = 0,572, p <0,001). Foi encontrada uma correlação significativa entre ΔVPM% e CR (r = 0,750, p <0,001).ConclusõesPudemos mostrar que a RC baseada em exercícios tem forte relação com a redução do VPM em pacientes com DAC. Consideramos que a diminuição da ativação plaquetária com RC baseada em exercícios pode desempenhar um papel importante na redução do risco trombótico em pacientes com DAC estável. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)

Seasonal exposure to phthalates and inflammatory parameters: A pilot study with repeated measures

Exposure to phthalates poses potential to damage multiple organs and system in the body. However, limited data are available regarding effects of seasonal exposure levels of phthalates and indicators reflecting inflammatory response. We designed a pilot study with repeated measures. We recruited 106 eligible habitants from Wuhan city, China. They completed questionnaires, physical examinations and provided urine specimens in winter and summer seasons. We found that urinary levels of low-molecular-weight phthalate metabolites were higher in summer than in winter (all P < 0.01). In winter, an interquartile range increase (1.264 μg/L) in 3-day moving average of high-molecular-weight phthalate metabolites corresponded to a 13.634% (95% CI: −22.331, −3.941) decrease in mean platelet volume, 25.879% (95% CI: −37.424, −12.204) for lymphocyte count or 10.862% (95% CI: −18.716, −2.125) for platelet count (P < 0.05 or P < 0.01). However, in summer, an interquartile range increase (1.215 μg/L) in urinary levels of high-molecular-weight phthalate metabolites corresponded to an 8.743% (95% CI: 4.217, 13.467) increase in platelet distribution width value or a 4.597% (95% CI: 2.335, 6.780) for mean platelet volume value at 3-day lag (both P < 0.01). In conclusion, phthalate exposure exhibited the potential for the activation of platelet function, particularly in winter. Seasonal variations of phthalate exposure should be considered when assessing health risk.

Mean platelet volume levels in children with sleep-disordered breathing: a meta-analysis

BackgroundPediatric sleep-disordered breathing (SDB) correlated with respiratory conditions of snoring and hypopnea. Mean platelet volume (MPV) was an inflammatory marker, related to increased inflammatory condition of pediatric patients. Increase of MPV level may cause failure to thrive or increased upper airway infection rate. The aim of this study was to perform systematic review and meta-analysis to investigate the difference on MPV values for pediatric SDB, and compare the change on MPV after surgery in patients with pediatric SDB.MethodsA systemic review of the studies from PubMed, EMBASE, and Cochrane Library databases was conducted in March 2020, supported by reviewing of published articles for studies comparing MPV in pediatric SDB. Meta-analysis was used to compare the change of MPV in pediatric SDB, and sub-group analysis was also used to compare the MPV decrease after surgeries of adenoidectomy or adenotonsillectomy.ResultsThere were seven studies included in the review. Six of them including 963 subjects showed that a significant increase of MPV was noted in pediatric SDB compared to those in pediatric non-SDB (P < 0.05). Total standardized mean difference (SMD) in MPV between pediatric SDB and non-SDB was 0.51 (95% CI =0.30–0.72, P < 0.05). A significant decrease of MPV was found in pediatric SDB patients who underwent surgery (total SMD = − 0.36; 95% CI = − 0.70– -0.02, P < 0.05). Decreases of MPV after adenoidectomy and adenotonsillectomy were observed, but only the effect of adenotonsillectomy had a statistical significance (total SMD = − 0.72; 95% CI = − 1.18 – -0.26, P < 0.05).ConclusionThe MPV was significantly higher in patients with pediatric SDB, indicating the presence of increased platelet activity in pediatric SDB patients. The level of MPV could be reduced by the two surgeries, especially adenotonsillectomy.

Is There a Role for Levo-Thyroxine for the Treatment of Arterial Erectile Dysfunction? The Clinical Relevance of the Mean Platelet Volume

Background: Arterial erectile dysfunction (ED) is an early sign of vascular damage. Rare evidence has been published so far as to whether subclinical hypothyroidism (SCH) affects arterial erectile function. Therefore, the objective of this study was to fill this gap. Methods: Patients with arterial ED and SCH were consecutive enrolled and randomly divided into Group A (n = 20) and Group B (n = 20). Group A was treated with levo-thyroxine (LT4) at the dose of 1 µg/kg/day for six months, whereas patients of the group B did not receive any treatment. Thyroid stimulating hormone (TSH), free-thyroxine (FT4), peak systolic velocity (PSV), International Index of Erectile Function 5-item version (IIEF-5) score, mean platelet volume (MPV), and total cholesterol were evaluated at enrollment (T0) and after six months (T1). Patients without hypertension, diabetes mellitus, dyslipidemia, not on drugs, and with normal total testosterone (TT) values were included in this study. Results: Group A and B did not differ for age (61.2 ± 4.8 vs. 60.3 ± 5.6 years), body-mass index (28.7 ± 2.5 vs. 28.3 ± 2.6 Kg/m2), and serum TT levels (481.2 ± 54.0 vs. 492.1 ± 59.7 ng/dL). At T0, serum TSH levels (6.5 ± 1.2 vs. 6.0 ± 1.0 µIU/mL), FT4 (8.8 ± 0.6 vs. 8.8 ± 0.6 pmol/L), PSV (26.5 ± 1.4 vs. 25.8 ± 2.1 cm/s), IIEF-5 score (8.2 ± 1.7 vs. 9.0 ± 1.7), and total cholesterol (167.8 ± 21.7 vs. 171.6 ± 21.3 mg/dL) did not significantly differ in patients of Group A vs. those of Group B. MPV was significantly higher in Group A than in Group B (12.3 ± 0.3 vs. 11.8 ± 0.7 fL). At T1, Group A showed significantly lower TSH (2.26 ± 0.5 µIU/mL), MPV (9.5 ± 0.3 fL), and total cholesterol (137.8 ± 29.2 mg/dL) and significantly higher FT4 (9.3 ± 0.4 pmol/L), PSV (40.0 ± 2.6 cm/s), and IIEF-5 score (20.2 ± 3.6) compared to pre-treatment values. None of these endpoints showed significant change at T1 compared to T0 in patients of group B. Conclusions: Lt4 therapy is associated with an improvement of the erectile function at the vascular level, a decrease in MPV and total cholesterol. LT4 therapy should be considered in patients with arterial ED and SCH.

Effects of Thioxanthene Containing Anti-Psychotic and Anti-Platelet Drug Combination on Mean Platelet Volume and Platelet Distribution Width in Rats

Aim: To evaluate the combined and individual effects of thioxanthene containing antipsychotic and anti-platlet drug on Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) in rats.&#x0D; Methods: This investigational study comprised of 100 albino rats of both sexual orientation, they were of 300 g to 350 g. We got ten groups, in which each group consisted of 10 rats (n=10).Ozagrel was used as anti-platelet and Zuclopenthixol was used as thioxanthene containing antipsychotic. Rats were treated with defined doses of Ozagrel and thioxanthene containing anti-psychotic (Zuclopenthixol) alone and in joined for three weeks (21 days). Blood test at 0, seventh, fourteenth and last day of study were taken. Mean Platelet Volume and Platelet Distribution Width were estimated from blood tests by using standard research center procedure. Results were accumulated and abridged by applying statistics. Correlation was framed between all days incentive to zero day values.&#x0D; Results: Anti-psychotic drug and antiplatelet drug both showed decrease in MPV with both doses highly significantly (p &lt; 0.001) decrease associated with maximum doses alone and with combination group. In case of PDW all individual and minimum combination group showed increase in PDW values but significantly (p &lt; 0.001) increase in maximum combination groups.&#x0D; Conclusion: Combination of both drugs can cause more decrease in MPV as compare to the individual and in case of PDW combination with maximum doses may cause decrease in values by opposing the results individual therapy. It indicated any Drug-Drug interaction between these two drugs regarding Mean platelet volume and Platelet distribution width.

Mean Platelet Volume as an Inflammatory Marker in Patients with Chronic Periodontitis – A Pilot Study

Background: Periodontitis is a widespread infectious disease of the periodontium that leads to gingival inflammation and bleeding. It has become the leading cause of tooth loss in adults. Mean platelet volume (MPV), an important index of platelet activity, reflects platelet production rate and stimulation. MPV has been considered an inflammatory marker in many chronic diseases and might reflect disease activity of periodontitis. It was also known that elevated MPV is associated with cardiovascular diseases (CVD). The aim of the present study was to investigate the relationship between MPV and chronic periodontitis and short term effects of active periodontal treatment on MPV level. Methods: 13 subjects with chronic generalized periodontitis were selected from OPD, Department of Periodontics, Kamineni institute of dental sciences. All subjects received periodontal and hematological examinations at baseline and 1week. Active periodontal treatment (APT) was administered in all the subjects Results: Decrease of MPV was related to the severe periodontal inflammation, and the value inversed shift after active APT. Key message: MPV can be used as a diagnostic marker in diagnosing patients with periodontitis and also can be used as a non pharmacological intervention in improving the platelet activity.

In Vivo Evaluation of &lt;i&gt;Jatropha curcas&lt;/i&gt; L (Euphorbiaceae) Leaves Acute and Subacute Toxicity in Mice

Jatropha curcas is a medicinal plant whose dead leaves are particularly used in arterial hypertension and diabetes treatment. The purpose of this study is to conduct an acute and subacute toxicity study of Jatropha curcas leaves aqueous extract (JCLAE) using OECD method. For acute toxicity, dose limits of 2000 and 5000 mg/kg were used. In subacute toxicity study 4 batches were constituted including a control batch that received distilled water for 28 days and the other 3 batches, JCLAE doses of respectively 200, 400, 800 mg/kg for the same duration. The LD50 was determined and the hematological, biochemical and histological parameters were analyzed in mice. The LD50 is greater than 5000 mg/kg. HDL-C is the only biochemical parameter that has experienced significant rise variation. Hematological analysis showed a decrease in mean platelet volume and Platelets number. The histological study revealed cases of hepatic cellular apoptosis and kidneys tubular necrosis among animals treated with highest dose. JCLAE is less toxic than Jatropha curcas leaves aqueous extract and high-dose JCLAE also has a moderate toxic effect on thrombocyte line and a protective effect on cardiovascular system.

Role of red cell and platelet indices as a predictive tool for transfusions in dengue

Review of literature and prevalent practices show the importance of red cell indices, especially hematocrit(HCT )in the diagnosis and prognosis of dengue. Platelet indices also may act as a tool to assess the prognosis and decide on the need for red cell and platelet transfusions in dengue. Platelet indices such as platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) are simple indices which can be done by any 3-part differential cell counter. However, immature platelet fraction (IPF) can be done only at advanced centres using more advanced cell counters. In dengue fever, red cell indices give indirect information on whether the patient is bleeding or going into impending shock. An increased HCT suggests haemoconcentration and warrants treatment with bolus IV fluids while a decreased HCT in an unstable patient may indicate bleeding and act as a predictor for red cell transfusions, whereas it suggests recovery from disease in a stable patient. Platelet counts have no role in determining need for transfusion in dengue. Platelet indices give information on whether the platelet destruction is ongoing (necessitating an impending platelet transfusion) or whether the bone marrow is responsive and platelet transfusions can be put on hold. An increase MPV with falling platelets implies destruction of platelet and signals need for platelet transfusion while a decrease in MPV with low platelets