Compressed air foam has been gradually applied in super high-rise buildings due to its high extinguishing efficiency and great transportation ability. However, the transport characteristics of compressed air foam are unclear because the foam is a complex gas-liquid two-phase fluid. In this study, multi-scale experiments were conducted to investigate the foam properties of compressed air foam and pressure drop in the long-distance vertical pipe. The results show that the foam is compressed as a whole when pressure increases, resulting in a significantly increased foam density. At higher pressures, the bubble coarsening degree decreases, accompanied by a narrower particle size distribution and an increased foam size homogenization. Moreover, a critical pressure phenomenon is observed in foams with different foam expansion ratios. The average foam diameter stabilizes gradually with pressure changes after exceeding the critical pressure. A theoretical model for foam density is developed, considering various pressures, temperatures and foam expansion ratios. When the compressed air foam is transported in the vertical long-distance pipe, the pressure decreases in a slightly downward curve, which is due to the decrease in foam density. Finally, a prediction model for the pressure drop of compressed air foam in the long-distance vertical pipe is proposed, which considers changes in foam density. The accuracy of the prediction model is verified by the multi-scale experimental results. The results deepen the understanding of foam flow in the long-distance vertical pipe and provide useful guidance for applications of compressed air foam in super high-rise buildings.