Background: Intradiverticular papillae, periampullary tumor infiltration, and obstructing downstream pancreatic strictures and stones may lead to therapeutic ERCP failure. When conventional ERCP methods have failed, EUSCP may be an adjunct for difficult pancreaticobiliary access. Limited data exists on a single-operator technique. Methods: Transenteric bile duct (BD) or pancreatic duct (PD) puncture was attempted using a 19G or 22G FNA needle followed by contrast injection and antegrade placement of a 0.035” or 0.018” wire ideally across the papilla for rendezvous ERCP. Results: 9 patients (5F, 4M, mean age 64) underwent attempted EUSCP after failed attempts at ERCP for BD (N = 6) or PD (N = 3) access. Anatomical reasons for failed ERCP included: intradiverticular papillae (N = 4), periampullary tumor infiltration with duodenal compression (N = 2), and downstream PD obstruction from chronic pancreatitis (N = 3). Interventions at time of EUS-guided cholangiogram: sphincterotomy and stone extraction (N = 1), transpapillary stent for malignant obstruction (N = 2), transduodenal stent (N = 1), sphincterotomy for papillary stenosis (N = 1), and failed attempt to puncture the BD due to angulation (N = 1). Antegrade transpapillary wire placement was not possible in the papillary stenosis case but ERCP was facilitated by EUS-cholangiography enhancing visualization of the papilla on the rim of a diverticulum. EUS-cholangiography also served as a fluoroscopic landmark for retrograde cannulation in the case of periampullary tumor infiltration. The patient with transduodenal stent placement had an intradiverticular papilla with obstructing downstream biliary stones that prohibited transpapillary wire placement. She required PTC and rendezvous ERCP for sphincterotomy and stone extraction. Interventions at time of EUS-guided pancreatography: transgastric pancreatic duct stent for decompression (N = 1), rendezvous ERCP via the minor papilla with sphincterotomy, pancreatoscopy with electrohydraulic lithotripsy, and stone extraction (N = 1), retrograde stricture dilation and stent placement for chronic pancreatitis (N = 1). Overall, 6/9 (67%) had successful retrograde ductal access at the same procedure as EUSCP. Conclusions: 1. In this preliminary series, single-operator EUS-guided cholangiopancreatography is successful in gaining retrograde access for difficult ERCP in the majority of patients with obstructed ducts. 2. Obstruction from papillary stenosis or stones may limit successful antegrade placement of the wire across the papilla but EUSCP may enhance endoscopic visualization of the papilla and/or serve as a fluoroscopic landmark to facilitate retrograde cannulation.