What has been the contribution of African intellectuals to postcolonial and decolonial scholarship? This question arises because there is emphasis on privileging works of Diasporic scholars from the Middle East and South Asia for postcolonialism and Diasporic scholars from South America for decoloniality/decolonisation. This article contributes to the complex politics of knowledge in Africa through centring often-ignored contributions of African intellectuals to the decolonisation of knowledge and politics. Conceptually and theoretically, what is introduced are issues of how epistemology framed ontology, how the cognitive empire invaded the mental universe of Africans, and how the quest for epistemic freedom informs resurgent and insurgent decolonisation of the twenty-first century. Thus, the article performs four key tasks: (1) it explains how epistemology frames ontology as its entry into the topical politics of knowledge; (2) it introduces and defines the concepts of the cognitive empire and epistemic freedom as they enable a deeper understanding of the complex politics of knowledge; (3) it historicises African struggles for decolonisation as reflected in African decolonial scholarship and the quests for epistemic freedom; and (4) it makes sense of resurgent and insurgent decolonisation of the twenty-first century as embodied by the Rhodes Must Fall movements in South Africa.