Decoction Research Articles

Effect of the Chaihu-Longgu-Muli decoction on electroencephalogram and expression of brain derived neurotrophie factor in serum of patients with temporal lobe epilepsy

Objective To observe influences of Chaihu-Longgu-Muli decoction (CLMD) on electroencephalogram (EEG), serum nerve growth factor (NGF) and brain derived neurotrophie factor (BDNF) level of patients with temporal lobe epilepsy. Methods Single blind randomized controlled trial design was used. 138 patients with temporal lobe epilepsy were divided into oxcarbazepine group (including 67 patients), oxcarbazepine+ CLMD group (including 71 patients). After 28 d of treatment, EEG changes, NGF and BDNF changes in serum, and relevant serological indicator inspection of drug reactions in both groups were observed. Results The effective rate of EEG in oxcarbazepine+ CLMD group was 81.8%, which was obviously higher than the oxcarbazepine group (50.7%), with significant difference (P 0.05). Conclusions The curative effects of oxcarbazepine+ CLMD is superior to the individual oxcarbazepine and it can obviously enhance serum NGF and BDNF of patients with temporal lobe epilepsy and reduce the status epilepticus of patients with temporal lobe epilepsy and it has the high safety. Key words: Epilepsy, temporal lobe; CHAIHU LONGGU MULI DECOCTION; Electroencephalography; Nerve growth factor; Brain-derived neurotrophic factor

The clinical observation on the treatment of semen non-liquefaction with zinc gluconate granule

Objective To investigate the clinical effect of liquid decoction combined with zinc gluconate granule in the treatment of semen non-liquefaction. Methods From May 2016 to February 2017, 68 cases of semen non-liquefier were admitted with an average age of 24 to 43 years, and an average of 25.2 years. Results All patients were followed up and the treatment time was 30-150 days, with an average of 90 days.There were 64 effective cases and 4 invalid cases, the effective rate was 94.1%.And sperm concentration, semen volume, sperm motility significantly increased, dead sperm decreased, abnormal sperm percentage decreased significantly(P<0.05). Conclusions Liquid decoction combined with zinc gluconate granule which is effective to improve the condition of semen in patients with semen non-liquefaction. Key words: SEMEN UNLIQUEFACTION; DRUG THERAPY (TCD); Zinc Compounds

The effects of Kangai-Guben-Xiaozheng decoction combined with TP scheme in the treatment of advanced ovarian carcinoma in elderly patients

Objective To investigate the clinical effects of Kangai-Guben-Xiaozheng decoction based on pathogenesis theory of cancerous toxin combined with TP scheme in the treatment of advanced ovarian carcinoma in elderly patients. Methods A total of 218 elderly patients with advanced ovarian carcinoma in our hospital were randomly divided into the observation and control group, 109 in each group. The control group was treated by TP scheme, while the observation group was treated by Kangai-Guben-Xiaozheng decoction based on pathogenesis theory of cancerous toxin combined with TP scheme. Both groups received 1 chemotherapy cycle at 3 weeks, and a total of 4 cycles of chemotherapy were followed up for 2 years. Quality of life was assessed by Functional Assessment of Cancer Therapy- ovarian Cancer v4.0 (FACT-OV4). Enzyme-linked immunosorbent assay (ELISA) was used to detect tumor markers, including Integrin-Linked Kinase (ILK), Hypoxic Inducible Factor-α (HIF-α), Human Epididymal Protein (HE4) and Epithelial-type calcium mucin (E-cadherin). The toxic and side effects of two groups were observed and the clinical efficacy was evaluated. The survival rate, total survival time and disease-free survival time were observed and recorded during follow-up. Results The control rate and effective rate of the observation group were 90.8% (99/109) and 41.3% (45/109), respectively, and those of the control group were 64.2% (70/109) and 28.4% (31/109), respectively. The comparison of control rate and effective rate between the two groups were statistically significant (Z value were 4.002, 3.401, respectively, all Ps<0.05). After treatment, the ILK (12.31 ± 1.15 ng/L vs. 23.57 ± 2.32 ng/L, t=3.245), HIF-α (2.41 ± 0.22 mg/L vs. 6.67 ± 0.67 mg/L, t=3.596), HE4 (0.34 ± 0.03 pg/L vs. 1.24 ± 0.12 pg/L, t=3.621) levels in the observation group are significantly lower than those in the control group (P<0.05), while the E-cadherin (5.25 ± 0.56 ng/L vs. 2.52 ± 0.26 ng/L, t=3.434) was significantly higher than that in the control group (P<0.05). After treatment, the scores of functional status and social/family status in the observation group were significantly higher than those in the control group (t values were 3.282, 3.214, all Ps<0.05), and the scores of additional attention, emotional status and physiological status were significantly lower than those in the control group (t values were 3.121, 3.512, 3.526, all Ps<0.05). During the treatment period, the incidence of cardiac toxicity, liver toxicity, renal toxicity, bone marrow suppression, nausea and vomiting, abdominal pain and diarrhea in the observation group were significantly lower than those in the control group (χ2 value were 4.947, 4.893, 4.525, 4.692, 4.637, 4.905, respectively, all Ps<0.05). During the follow-up, the 1, 2 year survival rate in the observation group was higher than those in the control group (χ2 value were 3.782, 3.893, respectively, all Ps<0.05). Conclusions The Kangai-Guben-Xiaozheng decoction based on the theory of cancer pathogenesis, combined with TP regimen show effectiveness for the Ⅳ stage of ovarian cancer of the elderly patients. Key words: Ovarian neoplasms; Aged; Antineoplastic combined chemotherapy protocols; Kangai-Guben-Xiaozheng decoction; Disease-free survival; Survivorship

Clinical study on Duhuo-Xuduan decoction combined with massage in the treatment of lumbar intervertebral disc herniation with yin deficiency of liver and kidney type

Objective To explore the Duhuo-Xuduan decoction combined with massage in the treatment of lumbar intervertebral disc herniation with yin deficiency of liver and kidney type. Methods According to the random number table method, 67 patients were divided into the control group (n=33) and the study group (n=34). The patients in the control group were treated with traditional massage, while the patients in the study group were treated with Duhuo-Xuduan decoction on the basis of the control group. The groups were treated continuously for 4 weeks. After treatment, the total clinical effective rate of the two groups was counted. The Visual analogue scale (VAS) and Oswestry dysfunction index were measured before and after treatment. At the same time, the level of serum Aggrecan, bone morphogenetic protein 7 (BMP-7), P substance (SP), 5-hydroxytryptamine (5-HT), dopamine (DA) were detected respectively before and after treatment. In addition, the adverse reaction of the two groups were observed. Results The total clinical effective rate of the study group was 97.06% (33/34), significantly higher than 81.82% (27/33) of the control group, and the difference was statistically significant (χ2=4.157, P=0.041). After treatment, the VAS score, Oswestry dysfunction index and serum SP, 5-HT, DA of study group was significantly lower than those of the control group (t=13.175, 12.524, 14.481, 15.729, 14.391, all Ps<0.01), while the level of serum Aggrecan, and BMP-7 of study group was significantly higher than that of the control group (t=18.697, 16.222, all Ps<0.01). There were no serious adverse reactions during treatment in both groups. Conclusions The Duhuo-Xuduan decoction combined with massage can alleviate pain, improve dysfunction of the patients with lumbar intervertebral disc herniation with yin deficiency of liver and kidney type. It is speculated that its mechanism may be related to analgesia and promoting cartilage regeneration of injured lumbar intervertebral disc. Key words: Intervertebral disc displacement; Syndrome of yin deficiency of liver and kidney; Tui Na therapy; Duhuo-Xuduan decoction; Integrated Chinese traditional and western medicine therapy

Clinical effect of Guben-Huoxue decoction on chronic obstructive pulmonary disease

Objective To explore the clinical effect of Guben-Huoxue decoction on chronic obstructive pulmonary disease (COPD) and its influence on patients'respiratory rehabilitation and quality of life. Methods A total 108 patients with COPD admitted to our hospital from May 2013 to January 2018 were selected as the research subjects. The patients were divided into control group and observation group by random number table grouping method, 54 in each group. All patients were given basic treatment such as oxygen inhalation, anti-infection, bronchiectasis, and correction of acidosis. The control group was treated with budesonide formoterol powder inhalation, while the observation group was treated with Guben-Huoxue decoction on the basis of the control group. The maximum ventilation volume per minute (MVV), forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), forced expiratory volume in the second (FEV1%) were measured by pulmonary function meter. Adverse reactions were recorded. Results The difference of FVC, MVV, FEV1%, symptoms, activity ability, disease influence and comprehensive scores in the observation group were significantly greater than those in the control group (t values were 6.480, 13.679, 5.853, 3.743, 5.786, 5.309, 5.058, respectively, all Ps<0.05). The total effective rate (94.4%) in the observation group were significantly higher than those in the control group (79.6%); the total incidence of adverse reactions (9.3%) was significantly lower than that of the control group (25.9%), and the difference was statistically significant (P<0.05). Conclusions The Guben-Huoxue decoction can improve the clinical symptoms and pulmonary function of COPD patients, promote respiratory rehabilitation and improve the quality of life. Key words: Pulmonary disease, chronic obstructive; Guben-Huoxue decoction; Maximal voluntary ventilation; Forced expiratory volume; Forced expiratory flow rates; Quality of life; Integrated Chinese traditional and western medicine therapy

Clinical effect of Shiquan Dabu Decoction combined with nitroglycerin on acute heart failure after myocardial infarction

Objective To summarize and discuss the clinical effect of Shiquan Dabu Decoction combined with nitroglycerin in the treatment of heart failure after acute myocardial infarction. Methods From January 2016 to June 2017, 110 patients with heart failure after acute myocardial infarction admitted to the Department of Cardiology of Lishui Hospital of Traditional Chinese Medicine were selected as study objects.The patients were randomly divided into observation group and control group according to the digital table, with 55 cases in each group.The control group was treated with routine nitroglycerin therapy, while the observation group was treated with routine nitroglycerin therapy combined with Shiquan Dabu Decoction.The therapeutic effect of the two groups after one week of treatment was observed. Results The total effective rate in the observation group was 92.73%, which was significantly higher than that of the control group(78.18%), and the difference between the two groups was statistically significant(χ2=4.681, P 0.05). Conclusion For patients with heart failure after acute myocardial infarction, the combination of traditional Chinese medicine Shiquan Dabu Decoction in clinical routine treatment has better effect and is worthy of popularizing. Key words: Myocardial infarction; Heart failure; Shiquan Dabu Tang; Nitroglycerin; Clinical effect

Effect of Huangqi-Baoxin decoction combined with routine western medicine therapy on cardiac function in patients with diabetic cardiomyopathy

Objective To explore the effect of Huangqi-Baoxin decoction combined with conventional western medicine on the cardiac function of the patients with diabetic cardiomyopathy (DCM). Methods A total of 103 DCM patients who met the inclusion criteria were divided into the control group (51 cases) and the research group (52 cases) by random number table method. The control group was treated with conventional therapy, while the study group was treated with Huangqi-Baoxin decoction on the basis of the control group. Both groups were treated for 3 months. TCM syndromes were scored before and after treatment. The serum GSH-Px, SOD and CRP levels were measured by ELISA. Left ventricular ejection fraction (LVEF) and E/A ratio of early diastolic peak velocity to late diastolic peak velocity (E/A) were measured by echocardiography and then evaluate the clinical efficacy. Results The total effective rate was 92.3% (48/52) in the study group and 76.5% (39/51) in the control group. There was significant difference between the two groups (χ2=4.922, P=0.027). After treatment, the scores of palpitation, shortness of breath, chest tightness and chest pain, fatigue, hypochondriac mass, spontaneous sweating, edema and total scores in the study group were significantly lower than those in the control group (t values were 10.603, 9.997, 10.546, 10.074, 5.211, 3.981, 6.438, 13.502, P<0.01). After treatment, LVEF (46.03% ± 1.70% vs. 42.33% ± 1.63%, t=11.271) and E/A (1.02 ± 0.17 vs. 0.90 ± 0.16, t=3.796) in the study group were significantly higher than those in the control group (P<0.01). After treatment, the serum GSH-Px and SOD levels in the study group were significantly higher than those in the control group (t values were 7.585, 6.816, P<0.01), and CRP level was significantly lower than the control group (t=10.854, P<0.01). Conclusions The Huangqi-Baoxin decoction combined with routine western medicine therapy can improve the clinical symptoms and cardiac function of DCM patients, reduce oxidative stress injury and inhibit inflammation. Key words: Diabetic cardiomyopathy; Huangqi-Baoxin decoction; Cardiac insufficiency; Clinical application

Clinical study of Qixie-Huoxue-Tongluo decoction combined with ozagrel sodium injection in treatment of cerebral thrombosis

Objective To study the clinical efficacy of Qixie-Huoxue-Tongluo decoction combined with ozagrel sodium injection in treatment of cerebral thrombosis. Methods According to the random number table method, 91 cerebral thrombosis patients who met the inclusion criteria were divided into the control group (45 cases) and the study group (46 cases). The control group was treated with ozagrel sodium injection on the basis of routine treatment, while the study group was treated with Qixie-Huoxue-Tongluo decoction on the basis of the control group. The two groups were treated for 7 days. The National Institute of Health Stroke Scale (NIHSS)was used to assess the degree of neurological impairment, the Activity of Daily Living (ADL) was used to assess the quality of life; and the levels of MDA, SOD, NO, neuron-specific enolase (NSE) and neuronal protein (S-100β)were detected by ELISA.The clinical efficacy was evaluated. Results The total effective rate was 93.5% (43/46) in the study group and 71.1% (32/45) in the control group, there was significant difference between the two groups (χ2=7.853, P=0.005). After treatment, the NIHSS score in the study group was significantly lower than that in the control group (16.1 ± 5.0 vs. 20.3 ± 5.3; t=3.889, P<0.01), and the ADL score in the study group (51.9 ± 9.3 vs. 45.3 ± 8.6, t=3.461) was significantly higher than that in the control group (P<0.01); the serum level of MDA (3.10 ± 0.48 mmol/L vs. 4.25 ± 0.76 mmol/L, t=11.427) and NO (41.14 ± 6.74 U/L vs. 62.20 ± 8.43 U/L, t=10.028) in the study group were significantly lower than those in the control group (P<0.01), the SOD (204.36 ± 21.29 vs. 163.39 ± 17.45, t=13.177) level in the study group was significantly higher than that of the control group (P<0.01); the serum NSE (4.85 ± 1.03 μg/L vs. 7.93 ± 1.14 μg/L, t=13.529) and S-100β protein (0.18 ± 0.03 μg/L vs. 1.02 ± 0.15 μg/L, t=37.232) levels in the study group were significantly lower than those in the control group (P<0.01). Conclusions Qixie-Huoxue-Tongluo decoction combined with ozagrel sodium injection can improve the degree of neurological impairment in patients with cerebral thrombosis, improve the quality of life clinical efficacy. And the mechanism may be related to inhibition of lipid peroxidation, anti-free radicals and so on. Key words: Intracranial thrombosis; Qixie-Huoxue-Tongluo decoction; Brain ischemia; Quality of life; Clinical studies

Mechanism of Shengxian decoction in treatment of heart failure based on serum metabolomics

Objective To explore the mechanism of Shengxian decoction in the treatment of heart failure by using metabolomic technology. Methods Rats were randomly divided into the control group, model group and administration group according to body weight, with 10 rats in each group. Rats in model group and administration group were induced by intraperitoneal injection of adriamycin to duplicate rat heart failure model. The rats in the treatment group were given Shengxian decoction 3.83 g/kg, while those in the control group and model group were given distilled water of equal volume once a day for 4 weeks. The levels of CK, AST, LDH and MDA in serum of rats were detected by ultraviolet spectrophotometer, and the metabolite profiles were collected by high resolution tandem mass spectrometry. The data were analyzed by principal component analysis and partial least squares discriminant analysis. Metabolic pathways were obtained by pathway enrichment analysis, focusing on key metabolic enzymes and metabolic pathways. Results Compared with the model group, the serum CK (1 015.44 ± 201.49 U/L vs. 1 301.89 ± 311.54 U/L), AST (210.59 ± 80.34 U/L vs. 421.56 ± 120.32 U/L), LDH (1 211.64 ± 416.61 U/L vs. 601.58 ± 311.74 U/L) in the administration group significantly decreased (P<0.05), and MDA (209.21 ± 151.15 nmol/ml vs. 1 251.15 ± 110.64 nmol/ml) levels significantly increased (P<0.05). The metabolic distribution of rats in the control group was significantly separated from that in the model group, and the administration group was between the two groups. After dimension reduction, blood biomarkers were obtained by partial least squares discriminant analysis, including citric acid, succinic acid, malic acid, arachidonic acid, canine uric acid, serine, sphingosine, Cer (d18:0/14:0), SM (d18:1/22:0), SM [d18:0/18:1 (11Z)], SM (d18:0/16:1). Metabo Analyst 4.0 analysis showed abnormal metabolism in heart failure rats, which mainly involved arachidonic acid metabolism, glycine, serine and threonine metabolism, sphingolipid metabolism, citric acid metabolism and aminoacyl-tRNA biosynthesis. Conclusions The Shengxian decoction has a good therapeutic effect on heart failure rats. Regulation of arachidonic acid metabolism, glycine, serine and threonine metabolism, sphingolipid metabolism, citric acid metabolism and aminoacyl-tRNA biosynthesis may be the key mechanisms for its treatment of heart failure. Key words: Sheng Xian Tang; Heart failure; Metabolomics; Biomarkers; Metabolic networks and pathways

Clinical study of Yiqi-Jiedu decoction combined with mesalazine sustained release granules for the patients with ulcerative colitis

Objective To evaluate the effect of Yiqi-Jiedu decoction combined with mesalazine sustained release granules for the patients with ulcerative colitis (UC). Methods A total of 93 UC patients who met the inclusion criteria were divided into control group (46 cases) and study group (47 cases) according to the random number table method. The control group was treated with mesalazine sustained release granules orally. The treatment group added Yiqi-Jiedu decoction on the basis of the control group. Both groups were treated for 2 months. The level of plasma thromboxane B2 (TXB2), 6-keto-prostaglandin F1α (6-Keto-PGF1α) and serum CRP, IL-1 and TNF-α were measured by ELISA, and the clinical effect was evaluated. Results The total effective rate was 95.7% (45/47) in the treatment group and 78.3% (36/46) in the control group. There was significant difference between the two groups (χ2=6.323, P=0.012). After treatment, the plasma TXB2 level in the treatment group was significantly lower than that in the control group (601.14 ± 13.31 pg/ml vs. 780.33 ± 16.54 pg/ml; t=57.619, P<0.01), and the plasma 6-Keto-PGF1α level was significantly higher than that in the control group (84.04 ± 11.39 pg/ml vs. 69.48 ± 10.21 pg/ml; t=6.487, P<0.01). After treatment, the level of CRP, IL-1 and TNF-α in the treatment group was significantly lower than those in the control group (t=15.457, 7.006 and 17.434, respectively, all Ps<0.01). Conclusions The Yiqi-Jiedu decoction combined with mesalazine sustained release granules can reduce the level of serum inflammatory cytokines in UC patients, reduce the level of plasma TXB2, and increase the level of plasma 6-Keto-PGF1α, so as to improve the clinical effectiveness. Key words: Colitis, ulcerative; Yiqi-Jiedu decoction; Inflammation; Therapies, investigational

Clinical study of modified Xuefu-Zhuyu decoction combined with conventional western medicine in the treatment of nonarteritic anterior ischemic optic neuropathy

Objective To evaluate the efficacy of modified Xuefu-Zhuyu decoction in the treatment of nonarteritic anterior ischemic optic neuropathy (NAION). Methods A total of 87 patients with NAION who met the inclusion criteria were divided into control group (43 cases) and study group (44 cases) by the random number table method. The control group was given the routine treatment combined with compound anisodine injection, while the study group was treated with routine treatment combined with modified Xuefu-Zhuyu decoction. Both groups were treated for 28 days. The standard logarithmic visual acuity chart was used to detect and record the best corrected visual acuity. The Visual field photosensitivity and visual field defect was recorded by visual field program(Oc-topus-101). The systolic peak blood flow velocity (PSV), end diastolic velocity (EDV), resistance index (RI) of the posterior ciliary short artery were measured by color Doppler ultrasound. The clinical effect was evaluated. Results The total effective rate was 97.7% (43/44) in the study group and 76.7% (33/43) in the control group. There were significant differences between the two groups (χ2=8.669, P=0.003). After treatment, the best corrected visual acuity (0.85 ± 0.21 vs. 0.72 ± 0.32 , t=2.245), visual field photosensitivity (18.71 ± 4.79 φ/db vs. 16.32 ± 5.22 φ/db, t=2.226) in the study group was significantly higher than those in the control group (P<0.05); the visual field defect (6.06 ± 1.52 φ/db vs. 8.13 ± 2.43 φ/db, t=4.775) in the study group was significantly lower than that of the control group (P<0.05); the PSV (10.03 ± 1.79 cm/s vs. 8.85 ± 1.88 cm/s, t=2.999), EDV (3.06 ± 0.37 cm/s vs. 2.67 ± 0.31 cm/s, t=5.323) in the study group was significantly higher than those of the control group (P<0.05), RI (0.61 ± 0.08 vs. 0.69 ± 0.09, t=4.385) in the study group was significantly lower than that of control group (P<0.05). Conclusions The modified Xuefu-Zhuyu decoction combined with conventional medicine can effectively improve the hemodynamics and visual function of posterior ciliary short artery in NAION patients and improve the clinical efficacy. Key words: Optic neuropathy, ischemic; Vision disorders; Xue Fu Zhu Yu Tang; Visual fields; Hemorheology; Integrated Chinese traditional and western medicine therapy

Analysis of Wu Weiping’s medication rules on treating the onset of bronchial asthma based on data mining

Objective To analyze Professor Wu Weiping’s medication rules on treating the onset of bronchial asthma based on data mining. Methods The patients’records and prescriptions of Professor Wu Weiping on treating the onset of bronchial asthma were collected and collated, and the frequency and regularity of drug combinations were researched by using the association rules of TCM inheritance support system to analyze the medication experience of Professor Wu Weiping. Results By analyzing the 249 prescriptions of 61 patients, drug properties of the prescription: cold (45.6%), warm (42.6%), bitter(37.9%), pungent (27.5%). Channel tropism: lung, spleen, liver, stomach. The top 10 herbal medicine are Qingbanxia, Chaihu, Fangfeng, Huangqin, Mahuang, Wuweizi, Wumei, Qianhu, Chishao, Kuxingren. The top 3 treatment principle is reducing phlegm, expelling wind evil and regulating qi. Xiaochaihu decoction and Guomin decoction were showed in the article. Conclusions Data dining could help to discover the rules of Professor Wu Weiping’s treatment of the onset of bronchial asthma. The cold and warm drugs, acrid and bitter drugs were used together frequently, while the drugs belonging to the lung, spleen, liver and stomach meridians were used commonly. The evil of phlegm, qi and wind were paid attention to eliminate pathogen. Key words: Asthma; The onset of bronchial asthma; Wu Weiping; Data mining; Medication rule

Inhibitory effects of herbal decoction Ojeoksan on proliferation and migration in vascular smooth muscle cells.

The proliferation of vascular smooth muscle cells plays a crucial role in pathogenesis of cardiovascular disease. The principal objective of this study was to determine the effects of Ojeoksan (OJS) on human aortic smooth muscle cell (HASMC) proliferation induced by tumor necrosis factor α (TNF-aα). Thymidine incorporation after TNF-α treatment was increased and this effect was inhibited significantly by OJS treatment. HASMC proliferation and migration by kinetic live cell imaging were also reduced by treatment with OJS. TNF-α induced the expression of cyclins/cyclin-dependent kinases (CDKs) and reduced the expression of p21waf1/cip1/p27kip1. However, OJS also attenuated the expression of TNF-α-induced cell-cycle regulatory proteins. The results of Western blot analysis demonstrated that the TNF-α treated HASMC secreted gelatinases, probably including MMP-2/-9, which may be involved in the invasion and migration of HASMC. Additionally, OJS suppressed the mRNA expression levels of matrix metalloproteinase-2/-9 (MMP-2/-9) in a dose-dependent manner. OJS inhibited the production of TNF-α-induced hydrogen peroxide (H2O2) and the formation of DCF-sensitive intracellular reactive oxygen species (ROS). Further, OJS suppressed the nuclear translocation and phosphorylation of inhibitor of kappa B-α (IκB-α) of nuclear factor κB (NF-κB) under TNF-α conditions. Our results demonstrate that OJS exerts inhibitory effects on TNF-α-induced HASMC proliferation and migration, suggesting the involvement of the inhibition of both MMP-2 and MMP-9 expressions, and the downregulation of ROS/NF-κB signaling. Thus, herbal decoction OJS may be a possible therapeutic approach to the inhibition of cardiovascular disease including atherosclerosis.

Clinical study of Xuefu-Zhuyu decoction combined with interactive acupuncture and ibuprofen sustained-release capsule in the treatment of acute lumbar sprain

Objective To evaluate the effect of Xuefu-Zhuyu decoction combined with interactive acupuncture and ibuprofen sustained-release capsule in the treatment of acute lumbar sprain. Methods A total of 102 patients with acute lumbar sprain were randomly divided into two groups, 51 in each group.The control group received ibuprofen sustained-release capsules orally. The study group was treated with Xuefu-Zhuyu decoction combined with interactive acupuncture on the basis of the control group. Both groups were treated for 2 weeks. The degree of low back pain was assessed by VAS and the improvement of lumbar function was assessed by modified Japanese Orthopaedic Association Scores (M-JOA). The Oswestry dysfunction index (ODI) was used to evaluate the degree of lumbar dysfunction. The serum hs-CRP, IL-6, IL-10 and prostaglandin E2 (PGE2) level was detected by ELISA. The clinical efficacy was evaluated. Results The total effective rate was 80.4% (41/51) in the study group and 62.8% (32/51) in the control group. There was significant difference between the two groups (χ2=3.903, P=0.048). After treatment, the VAS (1.85 ± 0.40 vs. 4.06 ± 0.67, t=20.226), M-JOA (4.41 ± 1.35 vs. 11.18 ± 2.25, t=18.426), and ODI (9.66 ± 3.34 vs. 16.37 ± 3.64, t=9.700) in the study group were significantly lower than those in the control group (P<0.01). The serum level of hs-CRP, IL-6, IL-10 and PGE2 in the study group were significantly lower than those in the control group after treatment (t were 6.694, 8.416, 22.110 and 12.137, respectively, all Ps<0.01). Conclusions The Xuefu-Zhuyu decoction combined with interactive acupuncture and ibuprofen sustained-release capsule can improve the degree of lumbago and lumbar dysfunction in patients with acute lumbar sprain, reduce the level of serum inflammatory cytokines, and improve the clinical efficacy. Key words: Lumbar sprain; Acute disease; Xue Fu Zhu Yu Tang; Interactive acupuncture

Effects of Da-Cheng-Qi decoction on enteroparalysis and serum inflammatory cytokines in patients with severe acute pancreatitis

Effects of Da-Cheng-Qi decoction on enteroparalysis and serum inflammatory cytokines in patients with severe acute pancreatitis

Effect of Shujin decoction fumigation and washing in the treatment of distal radius fractures in the elderly

Objective To observe the clinical effect of Shujin decoction combined with locking plate internal fixation in the treatment of senile distal radius fracture. Methods From January 2016 to January 2018, 90 patients with distal humeral fractures in Taizhou Hospital of Integrated Traditional Chinese and Western Medicine were selected and divided into two groups according to the random number table, with 45 patients in each group.The control group was treated with locking plate internal fixation alone.The observation group was given self-made Shujin decoction on the basis of the control group, and the patients were treated for 8 weeks.The swelling regression time, fracture healing time and hospitalization time were recorded.The pain score at 4 and 8 weeks after operation were calculated by the visual analog scale(VAS). The Gartland-Werley and McBride wrist joint function recovery was evaluated 6 months after operation.The occurrence of post-complication was recorded. Results The swelling subsidence, fracture healing and hospitalization time of the control group were (8.02±2.45)d, (42.50±4.20)d, (14.86±2.48)d, respectively, which were significantly longer than those of the observation group [(5.85±1.64)d, (34.30±5.60)d, (10.28±2.44)d]. The differences were statistically significant(t=5.036, 9.531, 4.372, all P<0.05). The VAS scores of the control group at 4 and 8 weeks after operation were (6.50±1.45)points, (4.55±1.74)points, respectively, which were significantly higher than those of the observation group[(5.26±1.16)points, (3.02±1.02)points], the differences were statistically significant(t=3.653, 3.436, all P<0.05). The excellent and good rate of Gartland-Werley wrist function recovery in the control group was 53%(24/45), which was significantly lower than that in the observation group [78%(35/45)], the difference was statistically significant(χ2=9.202, P<0.05). The excellent rate of McBride wrist joint function recovery in the control group was 51%(23/45), which was significantly lower than that in the observation group [76%(34/45)], the difference was statistically significant(χ2=8.011, P<0.05). The incidence rate of complications in the control group was 18%(8/45), which was significantly higher than that in the observation group [2%(1/45)], the difference was statistically significant(χ2=6.049, P<0.05). Conclusion Self-made Shujin decoction combined with locking plate internal fixation in the treatment of senile distal radius fractures is effective, which can promote postoperative swelling and fracture healing, improve wrist function, reduce the incidence of complications and improve clinical outcome. Key words: Radius fractures; Drugs, chinese herbal; Shujin Decoction; Fumigate-washing; Fracture fixation, internal; Wrist joint; Aged; Comparative study

Clinical study on Anzhong-Fuyuan decoction combined with western routine therapy for helicobacter pylori positive chronic atrophic gastritis

Objective To evaluate the efficacy of Anzhong-Fuyuan decoction combined with western routine therapy in the treatment of helicobacter pylori(H.pylori)-positive chronic atrophic gastritis (CAG). Methods A total of 110 H.pylori positive CAG patients who met the inclusion criteria were divided into two groups according to random number table method, 55 in each group. The control group was treated with quadruple therapy. On the basis of the control group, the study group was treated with Anzhong-Fuyuan decoction. Both groups were treated continuously for 40 days. The serum level of pepsinogen I (Pepsinogen Ⅰ, PG Ⅰ), pepsinogen Ⅱ (PG Ⅱ), gastrin (GAS), endothelin (ET), CRP, IL-6 and TNF-α were detected by ELISA. The eradication rate of H.pylori was measured by 14C urea breath test, and the clinical efficacy was evaluated. Results The total effective rate was 92.7% (51/55) in the study group and 78.2% (43/55) in the control group. There were significant differences between the two groups (χ2=4.681, P=0.031). The eradication rate of H.pylori was 89.1% (49/55) in the study group and 76.4% (42/55) in the control group. There was significant difference between the two groups (χ2=3.911, P=0.048). After treatment, the level of serum PGⅠ(84.87 ± 13.95 g/L vs. 78.05 ± 12.69 g/L, t=3.434) and PGⅠ/PGⅡ (6.71 ± 1.26 vs. 5.86 ± 1.13, t=2.861) in the study group was significantly higher than those in the control group (P<0.05), and PGⅡ (12.64 ± 1.94 g/L vs. 13.31 ± 2.10 g/L, t=3.725) was significantly lower than those in the control group (P<0.01). The serum level of gastrin (10.76 ± 3.06 mmol/L vs. 8.11 ± 2.84 mmol/L, t=4.707) was higher than that of control group (P<0.01), endothelin (56.64 ± 4.42 ng/L vs. 60.42 ± 5.13 ng/L, t=4.140) was significantly lower than that of control group (P<0.01). After treatment, the level of CRP, IL-6 and TNF-α in the study group was significantly lower than those in the control group (t=11.100, 9.571 and 8.687, respectively, all Ps< 0.001). Conclusions The Anzhong-Fuyuan decoction combined with routine therapy can significantly enhance the gastric mucosal secretion ability of H.pylori positive CAG patients, increase the ratio of PGⅠ/PGⅡ, promote the repair and regeneration of gastric mucosa, reduce the level of inflammatory cytokines. Key words: Helicobacter pylori; Gastritis, atrophic; Anzhong-Fuyuan decoction; Quadruple therapy; Clinical application

Modified Liumo decoction and polyethylene glycol 4000 powder in the treatment of functional constipation with Qi stagnation type

Objective To evaluate the efficacy of modified Liumo decoction combined with polyethylene glycol 4000 powder in the treatment of functional constipation (FC) with Qi stagnation type. Methods A total of 92 FC patients who met the inclusion criteria were divided into two groups by random number table method, 46 in each group. The control group was treated with polyethylene glycol 4000 powder orally on the basis of routine treatment. The treatment group was treated with modified Liumo decoction on the basis of the control group. Both groups were treated for 4 weeks and followed up for 6 months. TCM syndrome was scored before and after treatment. The Serum levels of NOS, NO, SOD, MDA and glutathione (GSH) were detected by ELISA. The adverse reaction during treatment was observed and the recurrence rate was calculated. Results After treatment, the score of defecation discomfort, abdominal distention, bowel ringing, sagittal frequency and chest and rib fullness in the treatment group was significantly lower than those in the control group (t=-4.749, -5.140, -5.835, -6.883, -6.919, all Ps<0.01). The level of serum NOS (26.95 ± 5.11 U/ml vs. 31.36 ± 7.61 U/ml, t=-3.263), NO (61.91 ± 12.62 U/ml vs. 72.35 ± 12.03 U/ml, t=-4.061) in the treatment group was significantly lower than those in the control group (P<0.01), the level of serum SOD (24.66 ± 3.82 U/ml vs. 21.39 ± 3.41 U/ml, t=4.331), GSH (12.15 ± 1.52 U/ml vs. 8.13 ± 1.42 U/ml, t=-13.278) in the treatment group was significantly higher than those of the control group (P<0.01), while the MAD level (2.73 ± 0.83 U/ml vs. 4.92 ± 0.75 U/ml, t=13.108) in the treatment group was significantly lower than that in the control group (P<0.01). After 6 months of follow-up, the recurrence rate of the control group was 27.3% (9/33), which was significantly higher than 4.8% (2/42) of the treatment group , and the difference was statistically significant (χ2=7.482, P=0.006). Conclusions The modified Liumo decoction combined with polyethylene glycol 4000 powder can improve the levels of intestinal neurotransmitters, SOD, MDA and GSH in patients with FC, alleviate the symptoms of traditional Chinese medicine and reduce the recurrence rate. Key words: Constipation; Functional; Qi stagnation syndrome; Neurotransmitter drugs (TCD); Modified Liumo decoction; Polyethylene glycol 4000 powder

A clinical study on the effect of Tiaoli-Qixue decoction on bleeding and coagulation during perioperative period of total hip arthroplasty

Objective To explore the effect Tiaoli-Qixue decoction on bleeding and coagulation during perioperative period of total hip arthroplasty (THA). Methods A total of 180 THA patients who met the inclusion criteria were randomly divided into three groups with 60 cases in each group. All patients underwent routine anti-infection treatment after unilateral THA through lateral hip approach. The patients took the Tiaoli-Qixue decoction 3 days before THA in the treatment group. The patients in the Xuesaitong control group received intravenous Xuesaitong on the day of operation and rivaroxaban tablets were administered orally on the day of operation in the western medicine control group. The continuous medication was administered until 7 days after operation in three groups. The amount of hemorrhage and drainage after operation were recorded and the total amount of dominant hemorrhage was calculated. The Degao M4 semi-automatic hemagglutination instrument was used to detect plasma D-dimer level and observe thrombosis. Harris scale was used before and after operation to calculate the excellent and good rates of Harris score. Results The total amount of dominant hemorrhage (376.67 ± 61.44 ml vs. 400.08 ± 61.16 ml, 413.33 ± 53.76 ml, F=5.963), intraoperative hemorrhage (165.50 ± 15.67 ml vs. 174.75 ± 14.68 ml, 175.42 ± 11.13 ml, F=9.452) and postoperative drainage (211.17 ± 58.12 ml vs. 225.33 ± 56.93 ml, 237.92 ± 54.28 ml, F=3.370) in the treatment group of traditional Chinese medicine were significanlty less than those in the Xuesaitong control group and the Western medicine control group (P<0.01 or P<0.05). On the 7th day after operation, there were 6 cases of thrombosis in the treatment group of traditional Chinese medicine, 4 cases in the Xuesaitong control group and 4 cases in the Western medicine control group. There was no significant difference between the three groups (χ2=0.667, P=0.881). Six months after operation, the excellent and good rate of that the treatment group of traditional Chinese medicine was 45.0% (27/60), which of the the Xuesaitong control group was 11.7% (7/60), and which of the the Western medicine control group was 13.3% (8/60). There was significant difference among the three groups. Conclusions The Tiaoli-Qixue decoction bleeding and coagulation can reduce the amount of dominant bleeding during perioperative period in patients with THA, and effectively prevent and treat deep venous thrombosis of lower limbs after THA. Key words: Arthroplasty, replacement, hip; Perioperative period; Tiaoli-Qixue decoction; Hemorrhage; Bleeding time

Study on the content of aflatoxin B1 in 35 traditional Chinese medicine decoction pieces

Objective To investigate the contamination of aflatoxin B1 in traditional Chinese medicine decoction pieces.and to provide evidence for the development of sdandards and scientific management. Methods Immunoaffinity column and post-column photochemical derivatization were used to detect and quantify aflatoxin B1 in 35 traditional Chinese medicines. Results A total of 48.57%(17 out of 35 batches) traditional Chinese medicine were contained aflatoxin B1. The contents of aflatoxin B1 in all contaminated varieties were less than 1μg/kg, except for Sterculia lychnophorae Semen, Foeniculi Fructus, Corydalis Rhizoma, which exceeded the standard. Conclusions The tested traditional Chinese medicine are highly contaminated of aflatoxin, it is necessary to further study the increase of aflatoxin content under the examination of Chinese Pharmacopoeia Foeniculi Fructus and Corydalis Rhizoma to better control its quality. The degree of aflatoxin B1 pollution is reated to the site of drug use and the place of origin. Key words: Assay (TCD); Aflatoxin B1; Immunoaffinity column; Photochemical derivatization