Decline In Organization Research Articles

Accelerated cognitive decline in adult survivors of pediatric central nervous system (CNS) tumors: A report from the Childhood Cancer Survivor Study (CCSS).

10049 Background: Survivors of pediatric CNS tumors may be at elevated risk for accelerated cognitive decline as they age through adulthood relative to the general population, which may be an early risk factor for dementia. Methods: Longitudinal analysis of 512 CNS tumor survivors (52.3% female, mean [SD] 30.6 [7.1] years at T1) and 232 siblings (57.8% female, mean [SD] 34.2 [8.4] years at T1) from the CCSS was conducted using the Neurocognitive Questionnaire (NCQ) to assess task efficiency, emotional regulation, organization and memory at two timepoints separated by a mean of 11.6 [0.7] years. Impairment in each NCQ domain was defined as a score ≥ 90th percentile of the CCSS sibling distribution at each survey, with decline defined as moving from unimpaired at T1 to impaired at T2. Treatment exposures were abstracted from medical records. Chronic health conditions were self-reported at T1 and graded according to CTCAE v4.3. Relative risk of decline for group, treatment and chronic condition predictors was estimated using generalized linear models with robust variance estimates. Mediation analysis examined direct effects of treatments and mediating effects of chronic conditions. All models were adjusted for age, sex, and race. Results: At T1, survivors demonstrated higher frequency of impaired memory (24.5% vs. 6.5%, p < 0.001), emotional regulation (14.3 % vs. 5.6%, p < 0.001), task efficiency (43.3% vs. 13.8%, p < 0.001) and organization (17.7% vs. 10.8%, p = 0.015) than siblings. Among those unimpaired at T1, more survivors vs. siblings declined in memory (34.7% vs. 7.8; RR 4.2, 95% CI 2.6-6.9), emotional regulation (15.5% vs. 5.0%; RR 2.8, 95% CI 1.5-5.3), task efficiency (22.7% vs. 7.0%; RR 2.9, 95% CI 1.7-5.2), and organization (14.5% vs. 2.9%; RR 4.9, 95% CI 2.1-11.0) by T2. Decline in survivor memory was associated with exposure to craniospinal irradiation (RR 1.9, 95% CI 1.3-2.8) and focal irradiation (RR 1.6, 95% CI 1.1-2.3) compared with no radiation, and exposure to Ara-C (RR 1.7, 95% CI 1.0-2.8) and cyclophosphamide (RR 1.7, 95% CI 1.01-2.8). Independent of therapy, serious/disabling or life-threatening cardiopulmonary conditions at T1 predicted future decline in memory (RR 1.5, 95% CI 1.02-2.2) and organization (RR 2.0, 95% CI 1.1-3.6), with the presence of 2 or more cardiopulmonary conditions associated with even higher risk (memory RR 2.6, 95% CI 2.0-3.1; organization RR 3.4, 95% CI 1.1-10.5). Chronic conditions did not mediate associations between treatment exposures and cognitive decline. Conclusions: CNS tumor survivors are at elevated risk for impairment and accelerated cognitive decline compared to siblings. Cranial radiation, Ara-C, cyclophosphamide, and cardiopulmonary morbidity are risk factors for decline. Survivors with these exposures/conditions may benefit from interventions to prevent additional future cognitive decline.

The reactivity of think-alouds in writing research: quantitative and qualitative evidence from writing in English as a foreign language

The reactivity of think-alouds (TAs) (i.e., their effects on thinking) has remained an inevitable concern whenever their use is considered or evaluated. This paper reports findings from a study that involved 85 Chinese sophomores, who, having received some instruction in diction, and then written a narrative in English as a baseline task, completed a similar main writing task, either silently or while thinking aloud. Between-groups differences were analysed in 20 measures of writing performance. TA was found to significantly impair only two measures, lexical diversity and nondysfluencies. TA may have constrained newly developed, still unstable thoughts that were perceived as peripheral, apart from its effects on fluency. Further analyses revealed differential effects. Those with high working memory capacity (WMC), especially high reading span, were most affected in lexical diversity, while those with low WMC experienced a significant decline in organization. The participants’ reflections in a follow-up questionnaire, analyzed inductively, show their diverse feelings about the effects of TA, its processing load emerging as the likely primary reactivity-causing factor. Results suggest that, although the reactivity of TAs is small, participants’ between- and within-individual differences should be duly attended to in conducting TAs in second language writing and writing research.

Spatio-temporal Organization During Ventricular Fibrillation in the Human Heart

In this paper, we present a novel approach to quantify the spatio-temporal organization of electrical activation during human ventricular fibrillation (VF). We propose three different methods based on correlation analysis, graph theoretical measures and hierarchical clustering. Using the proposed approach, we quantified the level of spatio-temporal organization during three episodes of VF in ten patients, recorded using multi-electrode epicardial recordings with 30 s coronary perfusion, 150 s global myocardial ischaemia and 30 s reflow. Our findings show a steady decline in spatio-temporal organization from the onset of VF with coronary perfusion. We observed transient increases in spatio-temporal organization during global myocardial ischaemia. However, the decline in spatio-temporal organization continued during reflow. Our results were consistent across all patients, and were consistent with the numbers of phase singularities. Our findings show that the complex spatio-temporal patterns can be studied using complex network analysis.

A system to monitor statin-induced myopathy in individual engineered skeletal muscle myobundles.

Microphysiological tissue engineering models of human skeletal muscle (myobundles) provide a platform to investigate the mechanism of muscle diseases and to study the response to drugs and toxins in vitro. To examine the dynamic response to drugs, which often take several days to induce responses, we developed a system to monitor the contractile force of the same human skeletal muscle myobundles over time before and after treatment with drugs. Myobundles were formed in series with Ecoflex films (platinum-catalyzed silicones) with embedded microbeads. The displacement of the microbeads in Ecoflex exhibited a linear relation between muscle force production and Ecoflex film stretch. Forces measured with the microbeads embedded in Ecoflex agreed well with simultaneous measurements with a force transducer. Application of the Hill model for the myobundles showed that the Ecoflex affected the magnitude of the response, but not the kinetics. After continuous exposure to 100 nM cerivastatin, both active and passive forces were reduced relative to controls after 2-4 days. The decline in force was associated with a decline in the muscle myofiber organization. The inhibitory effect of cerivastatin was reduced when 0.1-1 mM mevalonate was added with cerivastatin. Although addition of co-enzyme Q10 with cerivastatin inhibited degradation of sarcomeric α-actinin (SAA) in myoblasts, the contractile force still declined, suggesting that statin-induced myopathy was related to mevalonate pathway but the addition of co-enzyme Q10 was insufficient to overcome the effect of statins on the mevalonate pathway. Thus, cerivastatin rapidly induces myopathy which can be reversds with mevalonate but not co-enzyme Q10.

Prevalence and Pharmacotherapy of Behavioral and Psychological Symptoms of Dementia in a Geriatric Psychiatry Unit: A Retrospective Analysis.

To observe (1) the proportion and nature of behavioral and psychological symptoms of dementia (BPSD) in patients treated at a geriatric psychiatry ward in Germany over a time span of 1 year and (2) the use and effect of various pharmacologic interventions in managing BPSD in a real-world scenario. This study was a naturalistic, retrospective analysis. Between May 2015 and May 2016, 437 patients aged 65 to 100 years with various psychiatric diseases (including dementia, schizophrenia, and depression) were admitted to a geriatric psychiatry unit in Germany. Their medical charts were reviewed to identify patients with dementia who presented with BPSD according to DSM-5 criteria. Since a decline in behavioral organization is a typical clinical manifestation of delirium, delirious patients with behavioral symptoms at admission were also included. Of 437 patients, 74 (16.9%) showed severe behavioral symptoms that were categorized into 6 groups: aggression, screaming, wandering, food refusal, self-harm, and a combination of both behavioral and psychological symptoms. Overall, 65 patients (87.5%) showed improvement in their behavior regardless of the pharmacotherapy they were receiving. BPSD is one of the main reasons for admission to a geriatric psychiatry unit. Most of the patients with BPSD showed an improvement of behavioral symptoms with pharmacotherapy. Nonetheless, a clear correlation between a specific pharmacologic agent and behavioral improvement could not be established. A multimodal concept that involves both pharmacologic and nonpharmacologic approaches in managing BPSD should be the focus of future research.

Cognitive complaints in older adults at risk for Alzheimer's disease are associated with altered resting-state networks

IntroductionPathophysiological changes that accompany early clinical symptoms in prodromal Alzheimer's disease (AD) may have a disruptive influence on brain networks. We investigated resting-state functional magnetic resonance imaging (rsfMRI), combined with brain connectomics, to assess changes in whole-brain functional connectivity (FC) in relation to neurocognitive variables. MethodsParticipants included 58 older adults who underwent rsfMRI. Individual FC matrices were computed based on a 278-region parcellation. FastICA decomposition was performed on a matrix combining all subjects' FC. Each FC pattern was then used as a response in a multilinear regression model including neurocognitive variables associated with AD (cognitive complaint index [CCI] scores from self and informant, an episodic memory score, and an executive function score). ResultsThree connectivity independent component analysis (connICA) components (RSN, VIS, and FP-DMN FC patterns) associated with neurocognitive variables were identified based on prespecified criteria. RSN-pattern, characterized by increased FC within all resting-state networks, was negatively associated with self CCI. VIS-pattern, characterized by an increase in visual resting-state network, was negatively associated with CCI self or informant scores. FP-DMN-pattern, characterized by an increased interaction of frontoparietal and default mode networks (DMN), was positively associated with verbal episodic memory. DiscussionSpecific patterns of FC were differently associated with neurocognitive variables thought to change early in the course of AD. An integrative connectomics approach relating cognition to changes in FC may help identify preclinical and early prodromal stages of AD and help elucidate the complex relationship between subjective and objective indices of cognitive decline and differences in brain functional organization.

Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4.

We investigated whether midlife pulse pressure is associated with brain atrophy and cognitive decline, and whether the association was modified by apolipoprotein-E ε4 (APOE-ε4) and hypertension. Participants (549 stroke-free and dementia-free Framingham Offspring Cohort Study participants, age range=55.0 to 64.9 y) underwent baseline neuropsychological and magnetic resonance imaging (subset, n=454) evaluations with 5- to 7-year follow-up. Regression analyses investigated associations between baseline pulse pressure (systolic-diastolic pressure) and cognition, total cerebral volume and temporal horn ventricular volume (as an index of smaller hippocampal volume) at follow-up, and longitudinal change in these measures. Interactions with APOE-ε4 and hypertension were assessed. Covariates included age, sex, education, assessment interval, and interim stroke. In the total sample, baseline pulse pressure was associated with worse executive ability, lower total cerebral volume, and greater temporal horn ventricular volume 5 to 7 years later, and longitudinal decline in executive ability and increase in temporal horn ventricular volume. Among APOE-ε4 carriers only, baseline pulse pressure was associated with longitudinal decline in visuospatial organization. Findings indicate arterial stiffening, indexed by pulse pressure, may play a role in early cognitive decline and brain atrophy in mid to late life, particularly among APOE-ε4 carriers.

White Matter Microstructural Organization Is Higher with Age in Adult Superior Cerebellar Peduncles.

Using diffusion tensor imaging, we conducted an exploratory investigation of the relationship between white matter tract microstructure and age in 200 healthy adult subjects using tract-based spatial statistics (TBSS). Though most tracts showed the slight decline in microstructural organization with age widely noted, in both superior cerebellar peduncles (SCP) it correlated positively with age, a result not previously reported. We confirmed this by using an alternative method, and by repeating our TBSS analysis in an additional sample of 133 healthy adults. In exploring this surprising result we considered the possibility that this might arise from the continual cognitive and motor refinement that is enacted in the cerebellum: we found that tract microstructure in both SCPs was also strongly correlated with IQ, again in contrast with all other tracts, and its relationship with age mediated by IQ, as a training model would predict.

Eyes-closed task-free electroencephalography in clinical trials for Alzheimer's disease: an emerging method based upon brain dynamics.

Electroencephalography (EEG) is a longstanding technique to measure electrical brain activity and thereby an indirect measure of synaptic activity. Synaptic dysfunction accompanies Alzheimer’s disease (AD) and EEG can be regarded as a potentially useful biomarker in this disease. Lately, emerging analysis techniques of time series have become available for EEG, such as functional connectivity and network analysis, which have increased the possibilities for use in AD clinical trials. In this review, we report the EEG changes in the course of AD, including slowing of the EEG oscillations, decreased functional connectivity in the higher-frequency bands, and decline in optimal functional network organization. We discuss the use of EEG in clinical trials and provide directions for future research.

Class Formation and Class Identity: Birth, Death, and Possibilities for Renewal

AbstractWhile social class served as a powerful organizing identity for much of the 19th and 20th centuries, many doubt its contemporary relevance. This article examines the formation and development of theories of class identity over the past century. From a debate largely among Marxists in the early 20th century about the conditions under which the working class will mobilize to defend its interests – moving from a “class in itself” to a “class for itself” – the question of the relationship between individuals' class position, social interests, and political mobilization attracted greater attention among social scientists following World War II. However, postwar socioeconomic transformations led some to argue for the “death of class” as a central organizing principle for modern social and political life. While others countered that class identities remained relevant, the sharp decline in class‐based organization in the late 20th century led scholars to develop more nuanced understandings of the relationship between individuals' class position and collective identities. Although current scholarship shows that there is no natural translation of class identities into collective action, the reality of growing socioeconomic inequality, along with the resurgence of social and political mobilizations to contest that growth, suggests that class identities retain the capacity to unite.

Age-related effects in the neocortical organization of chimpanzees: Gray and white matter volume, cortical thickness, and gyrification

Among primates, humans exhibit the most profound degree of age-related brain volumetric decline in particular regions, such as the hippocampus and the frontal lobe. Recent studies have shown that our closest living relatives, the chimpanzees, experience little to no volumetric decline in gray and white matter over the adult lifespan. However, these previous studies were limited with a small sample of chimpanzees of the most advanced ages. In the present study, we sought to further test for potential age-related decline in cortical organization in chimpanzees by expanding the sample size of aged chimpanzees. We used the BrainVisa software to measure total brain volume, gray and white matter volumes, gray matter thickness, and gyrification index in a cross-sectional sample of 219 captive chimpanzees (8–53years old), with 38 subjects being 40 or more years of age. Mean depth and cortical fold opening of 11 major sulci of the chimpanzee brains were also measured. We found that chimpanzees showed increased gyrification with age and a cubic relationship between age and white matter volume. For the association between age and sulcus depth and width, the results were mostly non-significant with the exception of one negative correlation between age and the fronto-orbital sulcus. In short, results showed that chimpanzees exhibit few age-related changes in global cortical organization, sulcus folding and sulcus width. These findings support previous studies and the theory that the age-related changes in the human brain is due to an extended lifespan.

The Views of Members towards Workplace Union Organization in Banking between 1999 and 2008

AbstractIn tracing the changing perceptions of members in banking of trade union workplace organization between 1999 and 2008, this article illustrates a pattern of decline in terms of the coverage and performance of workplace organization. Contrary to the claims made by proponents of partnership arrangements, merger involvement and organizing, these strategies were not sufficient to arrest the decline in workplace organization. In consequence, members remained reliant on trade union full‐time officers for support.

FROM WORK TO WELFARE

The rigidity of early class analysis and the recent demise of any type of class analytics have turned attention away from examining the growing population of informally employed workers as a class. By not examining informal workers as a class “in themselves,” we are losing insights into how they are translating their positions into a class “for themselves.” As a consequence, the recent literature on globalization and liberalization is increasingly concluding that the decreasing proportion of formally employed workers (and the subsequent rise in informal employment) the world over signifies a decline in all class-based organization. Such arguments have obscured our understanding of the current social dynamics of exploitation and resistance. In an attempt to begin filling this gap, this article recovers class as an important analytical tool with which to examine (1) the current relations of power between the state, employers, and the majority of India's workers, and (2) how the structures of production within which informal workers operate affect their collective action strategies. A reformulated labor movement model is offered to expose the underlying mechanisms through which informal workers translate their location in the class structure as a class “in itself” into a political group as a class “for itself.” Insights into how informal workers organize can have profound implications for our understanding of changing state-labor relations as national governments attempt to liberalize their economies and simultaneously rein in their welfare functions.

A 10-yr Study of Smokeless Tobacco Use in a Professional Baseball Organization

Professional baseball players frequently use smokeless tobacco and are at risk of oral leukoplakia. There are limited long-term data on current trends in tobacco use and resultant oral health in this high-risk group. The purpose of this study was to monitor the prevalence of smokeless tobacco use in a professional baseball organization over a 10-yr period, looking for changes in the patterns of use and resultant changes in the incidence of oral leukoplakia. During 10 successive spring training camps (1991-2000), players and management personnel were surveyed on their use of smokeless tobacco. A detailed mouth examination of each participant was performed by an examiner blinded to the questionnaire results. The main outcome measures were trends in self-reported tobacco use and the presence of oral leukoplakia on examination. We performed 2266 mouth examinations on participants with a completed questionnaire, with the yearly sample size ranging from 190 to 259. The prevalence of smokeless tobacco use declined, falling from 41.1% in year 1 to 25.6% in year 10 (P=0.029). Tobacco use was strongly associated with the prevalence of oral leukoplakia. As the overall prevalence of smokeless tobacco use fell, the prevalence of oral leukoplakia in the entire population declined; falling from 22.6% of all participants in year 1 to only 9.4% in year 10 (P<0.001). The prevalence of smokeless tobacco use showed a steady decline in this professional baseball organization over the 10 yr of the study, with a concomitant decline in the prevalence of oral leukoplakia in this population. We postulate that changes in league rules regarding tobacco use and regular education and support for tobacco cessation might explain the declining use.

A longitudinal study of Alzheimer's disease: rates of cognitive and functional decline.

To measure rates of decline in cognition and function in patients with Alzheimer's disease (AD) and to investigate their accelerating risk factors in Korea. This study presents longitudinal data on a community-based sample of 107 patients with AD, followed at 6 months and 12 months. The cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog), the Mini Mental State Examination (MMSE) and the Disability Assessment for Dementia Scale (DAD) were given. Mixed model analyses were conducted using the following independent variables: times of repeated assessment (0, 6 or 12 months), severity of dementia assessed by the Functional Assessment Staging (FAST) and individual indicators as covariates. Average annual rates of decline in the MMSE, the ADAS-cog and the DAD were 2.3, 11.4 and 15.1 points, respectively. Neither gender, duration of formal education, nor duration of AD since onset was significant predictors of cognitive and functional decline. Patterns of functional decline in total DAD, instrumental ADLs, planning and organization and performance subscale are linear as MMSE score declines, while those of the basic ADLs and the initiation are curvilinear. This naturalistic observational study measured rates of cognitive and functional decline in AD, and can provide reference data for further longitudinal studies or clinical trials. Further study will be necessary to determine whether linear or curvilinear pattern in functional decline is due to progression of AD itself or statistical artifact.

Organization by Person Category: Stability in the Face of Differences in Attentional Resources

Study 1 addressed the hypothesis that relative to younger adults, older adults exhibit reduced frequency for incidental recall of behavioral information concerning other people in an impression formation paradigm but do not exhibit any decline in person-based organization in their recall. Findings were as expected and the age difference in recall frequency was attributable to the reduced attentional resources of older participants. Study 2 was an experimental analogue of Study 1, in which younger adults completed the impression formation task either under concurrent load or under no load conditions. Load was shown to reduce recall frequency but not the level of person-based organization in incidental recall. Findings support the view that person-based organization is automatic in that it requires little, if any, attentional resources.

Learning to teach: Knowledge development in classroom management

How does knowledge acquisition contribute to the process of learning to teach? To answer this question, qualitative and quantitative data were collected to investigate the development of teacher candidate knowledge about classroom management within an elementary teacher education program. Specifically, concept maps and interviews revealed patterns of cognitive change over a two-quarter sequence of courses. Analysis of concept maps showed turbulent and idiosyncratic change influenced by program experiences, with an apparent decline in cognitive organization. In interviews candidates deemphasized program influences, focusing instead on clinical experiences as the impetus of cognitive change. These findings—the turbulent apparent decline in cognitive structure and the primacy of field experiences—are explained in terms of Anderson's ACT∗ learning theory. Implications for future research in teacher's conceptual development are discussed.

Rhetoric and law: An overview

Rhetoric and law had mutually beneficial influences on each other during the Graeco-Roman era..The relationship deteriorated during the middle ages because of a universal decline in learning, culture, and social organization; the hostility of the church toward rhetoric as a pagan concept; and the feudal structure in which there was no system of orderly government to prevail against individual domains. The disciplines of rhetoric and law were revived during the rebirth of learning and the development of the legal system in England, but in separate and different spheres. This segregation was a loss for both endeavors. The era since 1920, however, has witnessed the first signs of a trend toward the recognition of the role that rhetoric and law .can play in association with each other. Legal realists have broken the ground for a broader view of the factors that contribute to an understanding of the legal system, and lawyers and judges are becoming aware of their problems in communication and rhetoric. (Author/RN) U.S DEPARTMENT OF HEALTH. EDUCATION & WELFARE OFFICE OF EDUCATION THIS DOCUMENT HAS BEEN REPRO OUCEO EXACTLY AS RECEIVED FROM THE PERSON OR (IRGANIZATION ORtG INATING IT POINTS OF VIEW OR OPIN IONS STATED 00 NOT NECESSARILY REPRESENT OFFICIAL OFFICE OF E0u CATION POSITION OR POLICY RHETORIC AND LAW: AN OVERVIEW Malthon Anapol University of Delaware REPRINTED FROM adOtig gperfql eke 9OW1110e oi Ike Speech LA f:Snei a t inn of tile eastool States Fall, 1970, Volume 13, Number 4 PEHMISSION TO REPRODUCE THIS COPY RIGHTED MATERIAL HAS BEEN GRANTED 8Y Speech Association of the Eastern States TO ERIC AND EMGAMEATIONS OPERATING UNOER AGREEMENTS_ WITH THE US_OFFICE