Apiculture has become a profitable profession due to the high economic importance of honey and various beehive products. Honeybees are tiny social insects that perform a crucial function in the agricultural field and are necessary for good yields. Honeybees are the biological indicators of environmental health. Unforeseen rapid decrease in honeybee numbers characterized by the departure of honeybees from the colonies and accompanied by the total absence of any dead bees in the hive surrounding and inside it suggests a condition called Colony Collapse Disorder (CCD). Pesticides, pathogens, and other ecological stresses such as nutritional deficiency may add to bee extinction or CCD. Besides this, the exposure to low-level radiofrequency and microwave radiations from mobile phones also have profound undesirable effects on honeybees. Research has shown changes in biology and behaviour which includes some undesirable changes in the biomolecules concentration in honeybees because of radiation exposure. Extremely low-frequency electromagnetic field (ELF- EMF ) also affects honeybee`s immune system and navigation activities. The radiation induces emotional disturbance and genetic disorders in brood which attributes to a decline in the breeding efficiency of bees. The present review is an attempt to compile the causes of CCD and discuss the management practices to be followed by the beekeepers to avoid the devastating loss to them and the planet Earth.