Abstract Background There are multiple decision nodes, during or after a subtotal colectomy for UC, regarding the management of the rectal stump. Intra-operatively, the retained stump may be closed intraperitoneally in the pelvis, secured at the subcutaneous tissue, or exteriorised as a mucous fistula. Post-operatively, microscopic evidence of proctitis is present in the majority of UC patients.Given the increased risk of cancer in UC, the presence of a retained rectal stump necessitates endoscopic surveillance. The aim of this scoping review was to summarise all available evidence on these 3 aspects of the management of the rectal stump in UC. Methods A scoping review of the literature was performed. Relevant studies were identified through a systematic search of Ovid Medline and Embase. Inclusion criteria were adult population and diagnosis of UC. Cohort studies, review articles and guidelines were eligible for inclusion. Articles were screened and reviewed by 2 independent reviewers and conflicts resolved by a 3rd reviewer. The references were grouped according to the subject of interest. Results Initial search returned 1267 studies, and after title and abstract screening and full-text screening, 93 studies were found eligible for inclusion in the review. Surgical management of the rectal stump at subtotal colectomy remains controversial. Intra-peritoneal closure has been shown to have higher pelvic sepsis rates, whereas subcutaneous placement results in higher rates of wound infections. A mucous fistula has been shown to have the lowest overall complication rate. Microscopic findings compatible with diversion proctitis develop in most patients, with incidence ranging from 71.4% to 100%. However, only a minority of these patients (30-40%) develop symptoms. Suggested treatments for diversion proctitis include topical mesalamine, corticosteroids or short-chain fatty acids. The overall risk of rectal stump neoplasia in patients with UC after subtotal colectomy is as low as 0.7% (2021 systematic review), with prior colorectal neoplasia being a major risk factor. No universal standardized guidance exists regarding endoscopic surveillance in this patient population. Conclusion This scoping review has appraised the latest evidence on 3 crucial stages of the management of the rectal stump in UC. There is still uncertainty about the optimal surgical management of the stump, with different complication profiles. Medical management of diversion proctitis remains a major unmet need, and there are no randomized trials addressing this issue. There are no universally accepted guidelines on endoscopic surveillance of the rectal stump.
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