The growing threat of intentional attacks on major petrochemical plants underscores the urgent need for robust security risk assessments (SRA). Such assessments are widely acknowledged as crucial for risk mitigation and are currently a focus of active research. This study introduces a methodology for assessing the attractiveness of the petrochemical sector to intentional attacks, considering chemical hazards, domino effects, and plant traits. Within this framework, we have identified 12 risk factors that capture the multifaceted nature of targeting incentives, relating to the enterprise, location, population, and other key features. We have developed a hybrid decision-making model that analyzes the interrelationships among these factors and determines their weights, integrating the Decision-Making Trial and Evaluation Laboratory (DEMATEL) and the Analytic Network Process (ANP). The applicability of this method is demonstrated through a detailed case study. The results indicate that our method can effectively rank the attractiveness of chemical plants within a specific region, serving as a preliminary screening phase in the SRA. The findings of the attractiveness assessment may assist in identifying potential targets among numerous existing plants and support the allocation of security resources and the formulation of defensive measures.