Currently, companies are called to meet variable market demand whilst having to comply with tighter delivery times, also due to the growing spread of e-commerce systems in the last decade. As never before, it is therefore mandatory to increase the efficiency within distribution centers to minimize operating costs and increase environmental and economical sustainability. The picking process is the most expensive task in a warehouse, both for the required resources and time for completing all the operations, which is typically carried out manually. Several policies can be identified, such as discrete or batch picking. Many studies tend to optimize both policies, treating them distinctly and integrating them with other factors including, for instance, the logic of product allocation. This article stands on a higher decision-making level: starting from a database obtained with a simulative approach that contains the average distances covered by pickers in different warehouse configurations, the aim is to provide an analysis of which factors have the greatest impact in preferring a discrete order picking policy over the batch one. The factors in question are shape factor, input–output point, routing and storage location assignment policies. Results can be useful for industrial practitioners in defining the most efficient managerial strategies.