Abstract The genesis potential index (GPI) has been used widely to estimate the influence of large-scale conditions on tropical cyclone (TC) genesis. Here we find that two GPIs, the Emanuel–Nolan GPI (ENGPI) and the dynamic GPI (DGPI), show opposite skills in quantifying decadal variability of TC genesis in the western North Pacific (WNP). During 1979–2020, ENGPI shows a reverse decadal variation to the WNP TC genesis with a significant negative correlation of −0.61, while DGPI can reasonably reproduce the decadal variation of the WNP TC genesis with a significant correlation of 0.66. The opposite skills of the two indices arise from the opposed effects of dynamic and thermodynamic parameters on TC genesis induced by a WNP anomalous cyclonic circulation that controls the decadal variation of TC genesis. On the one hand, the cyclonic circulation leads to favorable dynamical conditions including ascending motion, cyclonic vorticity, and weakened vertical shear, and thus tends to increase the DGPI. On the other hand, the cyclonic circulation leads to unfavorable thermodynamical conditions (decreased maximum potential intensity and midlevel humidity) that tends to decrease the ENGPI. As a result, the DGPI and ENGPI are reversely evolved and eventually lead to their opposite correlation between TC genesis. The significant positive correlation between DGPI and TC genesis suggests a critical role in the large-scale dynamical control of the decadal variability of the WNP TC genesis. Significance Statement Tropical cyclones (TCs) account for one-third of the deaths and economic losses from weather-, climate-, and water-related disasters. Understanding variations in TC activity from the perspective of large-scale conditions is of great importance to seasonal forecasting and disaster mitigation. Here we find that two genesis potential indexes (GPIs), the Emanuel–Nolan GPI (ENGPI) and dynamic GPI (DGPI), show opposite skill in quantifying decadal variability of TC genesis in the western North Pacific (WNP). The opposite skills of the two indices arise from the opposed effects of dynamic and thermodynamic parameters on TC genesis. The result suggests a critical role of large-scale dynamic control in the decadal variability of TC genesis in the WNP.