Initialization is essential for accurate seasonal-to-decadal (S2D) climate predictions. The initialization schemes used differ on the component initialized, the Data Assimilation method, or the technique. We compare five popular schemes within NorCPM following the same experimental protocol: reanalysis from 1980 to 2010 and seasonal and decadal predictions initialized from the reanalysis. We compare atmospheric initialization—Newtonian relaxation (nudging)—against ocean initialization—Ensemble Kalman Filter—(ODA). On the atmosphere, we explore the benefit of full-field (NudF-UVT) or anomaly (NudA-UVT) nudging of horizontal winds and temperature (U, V, and T) observations. The scheme NudA-UV nudges horizontal winds to disentangle the role of wind-driven variability. The ODA+NudA-UV scheme is a first attempt at joint initialization of ocean and atmospheric components in NorCPM. During the reanalysis, atmospheric nudging improves the synchronization of the atmosphere and land components with the observed data. Conversely, ODA is more effective at synchronizing the ocean component with observations. The atmospheric nudging schemes are better at reproducing specific events, such as the rapid North Atlantic subpolar gyre shift. An abrupt climatological change using the NudA-UV scheme demonstrates that energy conservation is crucial when only assimilating winds. ODA outperforms atmospheric-initialized versions for S2D global predictions, while atmospheric nudging is preferable for accurately initializing phenomena in specific regions, with the technique’s benefit depending on the prediction’s temporal scale. For instance, atmospheric full-field initialization benefits the tropical Atlantic Niño at 1-month lead time, and atmospheric anomaly initialization benefits longer lead times, reducing hindcast drift. Combining atmosphere and ocean initialization yields sub-optimal results, as sustaining the ensemble’s reliability—required for ODA’s performance—is challenging with atmospheric nudging.