This study aimed to determine the effect of financial ratios on stock returns of manufacture company listed in Indonesia Stock Exchange (IDX) during the period 2017-2021, either partially or simultaneously. Financial ratios studied were: current ratio (CR), debt to equity ratio (DER), return on asset (ROA), total assets turnover (TATO) and price to book value (PBV). The population in this study were manufacture companies listed in Indonesia Stock Exchange (IDX) during the period 2017-2021. Samples were 62 manufacture companies that obtained by using purposive sampling method. Data collection techniques used were documentation. Methods used for data analysis performed by multiple linear regression. These results indicate that the partial CR and TATO variable has positive effect and DER has negative effect on stock returns, while ROA and PBV has no effect. Simultaneously CR, DER, ROA, TATO, and PBV has effect on stock returns. The result of the coefficient of determination (Adjusted R2) obtained a value of 0,322, this indicates that the variable CR, DER, ROA, TATO, and PBV has effect on stock returns on manufacture company listed in Indonesia Stock Exchange (IDX) during the period 2012-2015 amounted 32,2%.