Sichuan-Tibet Railway is an important transportation system in China, which is of great significance to promote the communication between Tibet and the mainland. This paper takes the lin-chang section of the Sichuan-Tibet railway with a width of 2km on both sides as the research area. The occurrence of debris flow must have appropriate solid source, water source and topographic conditions. In this paper, ten disaster-causing factors are selected, including relief degree of land surface, profile curvature, silty soil, distance to the rive, distance to the fault, elevation, slope aspect, NDVI, average annual rainfall and land utilization rate. The information of disaster-causing factors was extracted from Arcgis and evaluated by the certainty factor model. The probability of debris flow in the study area was calculated by the coupling model of binary Logistic regression model combined with certainty factor model. ROC curve analysis of the CF-LR model shows that AUC is 0.89, indicating that the model has a good effect. The distribution map of debris flow susceptibility in the study area was obtained by using grid calculator in GIS. The results show that under the CF-LR model, extremely low, low, medium and high prone areas cover 2547km<sub>2</sub>, 235km<sub>2</sub>, 246km<sub>2</sub> and 1099km<sub>2</sub> respectively, accounting for 61.72%, 5.69%, 5.96% and 26.63% of the total area of the study area, respectively. The high risk areas are mainly in Milin, Nyingchi and Bomi counties. This study provides an important reference for assessing the risk of debris flow geological disaster on Sichuan-Tibet Railway.
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