Distribution Of Mortality Research Articles

Bridging research and dissemination in the CoViD-19 era: a WebGIS dashboard for the Autonomous Province of Trento (Italy)

Abstract. The paper presents an ongoing project devoted to the study, the analysis and the representation of epidemiological data related to CoViD-19 spread in the territory of the Province of Trento (Italy), both for scientific and communication purposes. In this broader context, the construction of a digital cartography tool as a WebGIS to allow local communities understanding of epidemiological spread is presented. Data have been supplied by the local Provincial Health Authority; statistic have been processed in order to develop municipality scale vector polygonal coropleth and point maps in order to show affected, health and death rate distribution. A timeline allows the representation of changes and dynamics from Spring 2020 to the current date. The database provides “on-the-fly” data to the production scripts of maps and time charts. These scripts querying the database produce a geographic file in the geojson standard interchange format. This file is read by the javascript scripts based on the leaflet libraries for the production of the final maps. In a similar process, scripts based on the chart.js library produce the graph of the data temporal variation, automatically reading dates and interval time of analysis. A custom procedure was developed to allow the periodic update of the dataset. New information is added to the database by uploading an external spreadsheet. The study presents the methodology to develop and assess the WebGIS for managing, visualize and analyse Coronavirus diffusion. Future implementation of the WebGIS will expand the used data and allow the comparison with social and environmental factors.

SARS – CoV-2: Reasons of epidemiology of severe ill disease cases and therapeutic approach using trivalent vaccine (tetanus, diphtheria and Bordetella pertussis)

The novel coronavirus Covid-19 follows transmission route and clinical presentation of all community-acquired coronaviruses. Instead, the rate of transmission is significative higher, with a faster spread of the virus responsible of the worldwide outbreak and a significative higher mortality rate due to the development of a severe lung injury. Most noteworthy is the distribution of death rate among age groups. Children and younger people are almost protected from severe clinical presentation.Possible explanation of this phenomenon could be the ability of past vaccinations (especially tetanic, diphtheria toxoids and inactivated bacteria as pertussis) to stimulate immune system and to generate a scattered immunity against non-self antigens in transit, as coronaviruses and other community-circulating viruses and make immune system readier to develop specific immunity against Covid-19.The first support to this hypothesis is the distribution of mortality rate during historical pandemics (“Spanish flu” 1918, “Asian flu” 1956 and “the Hong Kong flu” 1968) among age groups before and after the introduction of vaccines.The immunological support to the hypothesis derives from recent studies about immunotherapy for malignancies, which propose the use of oncolytic vaccines combined with toxoids in order to exploit CD4 + memory T cell recall in supporting the ongoing anti-tumour response.According to this hypothesis vaccine formulations (tetanus, diphtheria, Bordetella pertussis) could be re-administrate after the first contact with Covid-19, better before the development of respiratory severe illness and of course before full-blown ARDS (Acute Respiratory Distress Syndrome).The CD4 + memory exploiting could help immune system to recall immunity of already know antigens against coronaviruses, avoiding or limiting “lung crash” until virus specific immunity develops and making it faster and prolonged.Finally, this administration could be helpful not only in already infected patients, but also before infection. In fact, people could have an immune system more ready when the contact with the Covid-19 will occur.

Life Settlement Value Profiles across Different Death Rate Distributions

The life settlement asset class is a recognized part of the alternative investment market. Our article offers insight into the behavior of portfolios of life settlement contracts. We focus on the value profiles of pools of life settlement contracts in the value/cost of capital space. A pool of life settlement contracts has a death rate distribution that will determine the amount of premiums that must be paid each period and the amount of death benefits that will be collected each period. Because value is determined by the timing, magnitude, and certainty of the cash flows generated by an asset, it is inexorably linked to the timing of the life settlers’ deaths. We show that when certain conditions are met, pools with fundamentally different underlying mortality rates and risk profiles, but with the same cost of capital, can have the same value (pivot point in the value/cost of capital space). This pivot point can be useful for fund managers seeking to modify a portfolio of life settlements under a specific cost-of-capital constraint.

Maternal Age, Low Birth Weight and Early Neonatal Death in Tertiary Hospital in the Volta Region of Ghana

Objectives: Current study sought to determine an association between Low Birth Weight (LBW) and early neonatal mortality at a resource limited country’s referral hospital and to determine relationship between maternal age and birth outcomes. Method: A retrospective study analyzing data on births in the Volta Regional Hospital, Ghana from the period of November 2011 to June 2016. A total of 8279 births were analyzed. Results: Results suggest that teenage mothers (8.60%) are more likely to give birth to pre-term babies than the elderly (6.60%) and the adult mothers (4.61%). LBW is highest among the teenage mothers (12.69%) followed by the elderly mothers (7.87%) and then the least among the adult mothers (6.48%). Extremely Low Birth Weight (ELBW) and Macrosomia births were more observed among the elderly mothers (0.90%; 2.17%) than the teenage (0.28%; 0.14%) and adult mothers (0.34%; 1.61%) respectively. Data suggest that 100% of the ELBW were pre-term birth, 88.28% Very Low Birth Weight (VLBW), 34.56% LBW and only 1.06% of the pre-term birth were with Normal Birth Weight (NBW). Death rate ranges from 50% for ELBW, 33.59% for VLBW, 8.22% for LBW, 5.43% for Macrosomia and 1.5% for NBW. However, death rate distribution among the various age groups was statistically not significant (P 0.106). Conclusions: Our study suggests that early neonatal death, especially deaths among ELBW and VLBW is still high at the VRH of Ghana and therefore there is the need for further studies into interventions to reduce death among neonates born with VLBW and ELBW.

Higher mortality in patients hospitalized for acute aortic rupture or dissection during weekends

The management of acute aortic aneurysm rupture or dissection (AARD) requires specific medical expertise, diagnostic techniques, and therapeutic options, not always available in all hospitals through the entire week. The aim of our study was to evaluate whether an association exists between weekday (WD) or weekend (WE) admission and mortality for patients with ARRD. Based on the database of routinely collected hospital admissions of the region of Emilia Romagna (RER) of Italy, we examined the discharge sheets of all patients with AARD (January 1999 to December 2009). The risk of in-hospital death was calculated for admissions on the WE compared with the admissions during a WD. The analysis considered 4559 events in 4461 patients. AARD admissions were most frequent on Monday (14.7%) and Friday (14.8%) and less frequent on Saturday (12.6%). The percentage of events admitted on Sunday/holiday was 15.0%, whereas the distribution of death rate with respect to day of admission was significantly different (χ(2) = 23.472; P < .001) with the highest frequency peak on Sunday/holiday (17.4%) and the lowest on Tuesday (12.9%). WE admissions were associated with significantly higher in-hospital mortality (43.4%) than WD admissions (36.9%, P < .001). Multivariate regression analysis showed that WE admission was an independent risk factor for increased in-hospital mortality odds ratio 1.318; 95% confidence interval, 1.144-1.517; P < .001). Our findings show that hospitalization for AARD on WE is associated with a significantly higher mortality rate than hospitalization on WD. Further studies are needed to investigate whether ensuring optimal diagnostic and therapeutic approaches during the entire week might improve the overall survival of patients with ARRD.

Geographic Patterns for Pleural Mesothelioma Deaths in the United States, 1968–81&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;

Deaths and death rates for mesothelioma of the pleura are presented by age, sex, and geographic area for the United States for the years 1968-81. Death rates increased with age and in every age group were roughly three times higher for males than for females. Over the period 1968-81, death rates increased for males aged 65 years or more, whereas death rates in other age-sex groupings remained fairly constant or declined slightly. It is known that asbestos is highly related to mesothelioma, and the increase in death rates among older males could be due to asbestos. Conversely, the fact that death rates in younger males and in females have not been increasing suggests some kind of background level not strongly related to the use of asbestos. When the geographic distribution of death rates was examined by state, there was considerable geographic variation with some clustering. High death rates for males appeared for the Northeastern States and along the Pacific Coast, and for Illinois, Florida, Wyoming, and Colorado. Females shared this geographic pattern to some extent. When death rates were examined by county, a relationship was seen between pleural mesothelioma deaths among males and the presence of asbestos products plants and shipbuilding facilities. Excessive death rates in some counties and states did not appear to be related to asbestos exposure. Although the similarity in geographic patterns of mortality for males and females suggests a common etiology, the trends in mortality suggest different etiologies. There may be important causes of pleural mesothelioma yet to be identified.

Measuring mortality trends and differentials.

Abstract The conventional approach to the measurement of mortality conceptualizes mortality as a function of the age distribution of deaths. Because at contemporary mortality levels the great bulk of deaths are concentrated at the high ages, measures based on deaths are insensitive to mortality changes over most of the life span. An alternative is to conceptualize mortality as a function of the age distribution of death rates. When this is done, large differentials in mortality by sex and by race emerge from the data, calling attention to serious social issues that have been masked by conventional mortality indicators.

Distribution of death rate in acute carbon monoxide intoxication in mice.

Toxicological study on carbon monoxide was carried out with special consideration to eliminate the effect of carbon dioxide expired by animals in the atmosphere. When 0.6% carbon monoxide in air was inhaled, mice did not manifest any toxic symptom. When 1.0% carbon monoxide-air mixture was inhaled, about 30% of mice died from respiratory failure following violent con-vulsion within a period of the first 30 minutes. Another 30% were alive at the end of 3 hours' observation, while the remainders died with almost even death rate in the course of the observation time. At a concentration of 1.5% carbon monoxide all the mice were killed within 30 minutes. Thus minimum lethal concentration was around 1.0%, but a normal distribution curve could not be obtained for the death rate of mice by the inhalation of this concentration of carbon monoxide. Effect of coenzyme Q7, premedication was studied in the expectation that it may protect mice from acute carbon monoxide poisoning, because it plays a role in biological electron carrier systems. In doses of 20 and 100mg/kg intraperito-neally, however, coenzyme Q7 could not influence the susceptibility of mice to carbon monoxide.