The prevalence of diabetes mellitus, primarily type 2 diabetes mellitus, is increasing at epidemic rates in the United States and worldwide, driven largely by increasing rates of obesity and advancing age for populations living in westernized countries. Diabetes mellitus is associated with a 2- to 4-fold increase in the risk of coronary heart disease, and among people with diabetes, about two thirds of deaths are due to cardiovascular disease, including ischemic heart disease, congestive heart failure, and stroke.1 The increase in mortality for patients with diabetes mellitus after myocardial infarction is seen both acutely and in a sustained manner and holds true for both men and women. Indeed, many have suggested diabetes mellitus to be a coronary heart disease risk equivalent, because multiple studies have demonstrated that patients with diabetes but without prior cardiovascular disease have the same event rates as individuals without diabetes but with prior cardiovascular disease.2,3 However, this suggestion has remained somewhat controversial, especially for patients at younger ages.2,4,5 Article p 1945 Thus, to address whether diabetes mellitus accelerates the atherosclerotic process to such an extent that the presence of diabetes confers the same excess risk as that associated with prior myocardial infarction for the patient without diabetes, Schramm and colleagues,6 in the current issue of Circulation , report on the aggregate experience from the country of Denmark. All inhabitants of Denmark could be assessed with patient-level information through the Danish Civil Registration system, prescription drug use could be determined using The Danish Registry of Medicinal Product Statistics, and deaths could be identified via the Central Population Register. Integration of information from these administrative healthcare registries, together with uniform access of the population to health care, provides a definitive assessment of clinically significant risk. Furthermore, in a very large and complete population-based sample, …
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