The incidence of preterm birth (gestational age <37 weeks) worldwide was 15·2 million in 2019, occurring in 11% of livebirths. 1 Cao G Liu J Liu M Global, regional, and national incidence and mortality of neonatal preterm birth, 1990-2019. JAMA Pediatr. 2022; 176: 787-796 Crossref PubMed Scopus (6) Google Scholar , 2 Our World in DataNumber of births and deaths per year, world. https://ourworldindata.org/grapher/births-and-deaths-projected-to-2100Date: 2022 Date accessed: November 7, 2022 Google Scholar In 2015, an estimated 20·5 million livebirths globally were low birthweight (LBW; weight <2500g at birth). 3 Blencowe H Krasevec J de Onis M et al. National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis. Lancet Glob Health. 2019; 7: e849-e860 Summary Full Text Full Text PDF PubMed Scopus (322) Google Scholar The survival, health, growth, and neurodevelopment of preterm and LBW infants lags behind that of full-term infants and special care is needed for these vulnerable infants. 4 Escobar GJ McCormick MC Zupancic JA et al. Unstudied infants: outcomes of moderately premature infants in the neonatal intensive care unit. Arch Dis Child Fetal Neonatal Ed. 2006; 91: F238-F244 Crossref PubMed Scopus (119) Google Scholar , 5 Wang ML Dorer DJ Fleming MP Catlin EA Clinical outcomes of near-term infants. Pediatrics. 2004; 114: 372-376 Crossref PubMed Scopus (535) Google Scholar Preterm and LBW infants are susceptible to impaired respiration, difficulty feeding, growth failure, poor body temperature regulation, and infection. 4 Escobar GJ McCormick MC Zupancic JA et al. Unstudied infants: outcomes of moderately premature infants in the neonatal intensive care unit. Arch Dis Child Fetal Neonatal Ed. 2006; 91: F238-F244 Crossref PubMed Scopus (119) Google Scholar , 5 Wang ML Dorer DJ Fleming MP Catlin EA Clinical outcomes of near-term infants. Pediatrics. 2004; 114: 372-376 Crossref PubMed Scopus (535) Google Scholar Globally, preterm birth accounts for 36·1% of neonatal deaths and 17·7% of deaths among children younger than 5 years. 6 Perin J Mulick A Yeung D et al. Global, regional, and national causes of under-5 mortality in 2000-19: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet Child Adolesc Health. 2022; 6: 106-115 Summary Full Text Full Text PDF PubMed Scopus (52) Google Scholar Complications of preterm birth are the leading cause of death in children before their fifth birthday. An estimated 0·94 million deaths worldwide were due to preterm birth in 2019. 6 Perin J Mulick A Yeung D et al. Global, regional, and national causes of under-5 mortality in 2000-19: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet Child Adolesc Health. 2022; 6: 106-115 Summary Full Text Full Text PDF PubMed Scopus (52) Google Scholar
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