De La Hoz Research Articles

Abstract 3093: Combining lab automation with data analysis automation to enable high-throughput screening of patient-derived organoids

Abstract Although patient-derived tumor organoids (PDOs) better-represent patient tumors compared to traditional in vitro cell cultures, limitations of PDO analysis remain a major hurdle for high-throughput screening (HTS) applications. In particular, current PDO analysis fall short in at least 1 of 2 major criteria: 1) accurate recapitulation of patient tumor or 2) scalability. To address this, we have developed an automation-compatible protocol to satisfy these 2 major criteria to facilitate the adoption of PDOs for HTS applications1. Our novel protocol leverages live-cell imaging techniques to capture the dynamic interactions and intricate complexities of PDOs, which allowed for more precise and comprehensive analysis. To further enhance the accuracy and efficiency of our approach, we developed a fully automated image and data analysis pipeline (Orbits). Using label-free detection of organoids from brightfield images, Orbits integrates growth-rate-based drug response metrics with drug synergy metrics to significantly improve the identification of synergistic drug interactions. Here, present the results of our HTS protocol on 10 distinct drug combination strategies, specifically focusing on the repurposed drug candidate Auranofin, a Thioredoxin reductase inhibitor. We screened on 10 PDOs sourced from healthy lung, non-small cell lung cancer, and pancreatic ductal adenocarcinoma. Not only were we able to distinguishing cytostatic from cytotoxic drug responses at a single-organoid level, we identified drug candidates that can synergistically enhanced the efficacy of Auranofin in a tumor selective manner. Our study presents a major step forward in the field of PDO-based drug discovery, offering a robust protocol for HTS and automated data analysis. The implementation of our method will accelerate the discovery of effective therapeutic strategies, ultimately translating to improved patient outcomes. 1 Le Compte, M., et al JoVE 190 (2022) Citation Format: Abraham Lin, Maxim Le Compte, Tyler Gilcrest, Edgar Cardenas De La Hoz, Geert Roeyen, Jeroen Hendriks, Filip Lardon, Christophe Deben. Combining lab automation with data analysis automation to enable high-throughput screening of patient-derived organoids [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3093.

Geometrías en el arte: la divina proporción y la proporción cordobesa

Since Euclid, it has been contemplated that the average and extreme ratio, known as the golden ratio or divine proportion according to Luca Pacioli, is the ultimate canon of beauty. Numerous studies have been conducted in an attempt to support this thesis. However, in the latter half of the 20th century, a new study emerged to confirm that in the city of Córdoba, a previously unknown proportion dominated, which had not been studied in either art or architecture. Rafael de la Hoz, the architect responsible for this discovery, referred to it as the Cordovan proportion or Human Proportion. Once discovered, it became evident that it was not a peculiarity unique to this Andalusian city, but rather, a canon of beauty that has been used on numerous occasions, albeit not explicitly acknowledged as such.

Avant-garde humour as ideological supplement

In 1939, when the Spanish civil war had recently ended, avant-garde humorists Miguel Mihura and Tono published an absurdist propaganda ‘novel’, María de la Hoz [María of the Sickle], about the republican zone during the conflict. Unlike other Francoist propaganda pieces of the time, it did not focus on the violence or the alleged moral degeneracy of the ‘reds’ but rather on what its authors perceived as the absurdity of egalitarianism and the progressive ideals. The novel, while not contradicting the emerging official ideology, conspicuously overlooked some of its key tenets, particularly those related to nationalism, Catholicism and Franco’s leadership. This article contextualises María de la Hoz in the development process of Spanish avant-garde humour and in Francoist propaganda fiction during and immediately after the civil war in order to analyse the ideological stance it represented and, potentially, reinforced. As a political piece, the book seems to convey the position of an affluent middle class who did not enthusiastically believe in Francoism but preferred it to the republican alternative, caricatured as a communist regime by nationalist propaganda.

LARGE-SCALE, MULTICENTER, RETROSPECTIVE STUDY ON NEPHROTOXICITY ASSOCIATED WITH EMPIRIC, BROAD-SPECTRUM ANTIBIOTICS IN CRITICALLY ILL PATIENTS

LARGE-SCALE, MULTICENTER, RETROSPECTIVE STUDY ON NEPHROTOXICITY ASSOCIATED WITH EMPIRIC, BROAD-SPECTRUM ANTIBIOTICS IN CRITICALLY ILL PATIENTS

Review: Cuzco: Incas, Spaniards, and the Making of a Colonial City

Review: <i>Cuzco: Incas, Spaniards, and the Making of a Colonial City</i>

ЛА МИЛАГРОСА: ВОТИВНЫЕ ПРАКТИКИ НА КЛАДБИЩЕ КОЛУМБА И В ВИРТУАЛЬНОМ ПРОСТРАНСТВЕ

The paper examines the legends and votive practices that exist around one of the graves at the Colon cemetery in Havana, the capital of the Republic of Cuba. Amelia Goyri de Adot (nee Amelia Goyri de la Hoz) was buried in this cemetery in 1901. In 1909 on her grave a tombstone was erected, which became an object of religious veneration for both Cubans and visitors from other countries. Pilgrims perform a certain ritual near the monument and leave votive tablets with gratitude to Amelia, worshiped as a saint with the name of La Milagrosa. Nowadays, the legend that has developed around this burial is actively circulating on the Internet, transforming and acquiring new details. Virtual practices of worship are also appearing, markedly different from those performed in the cemetery.

COVID-19 effects on my social and family life as student

&lt;p&gt;The COVID-19 pandemic we have undergone has hit us unexpectedly and has affected our lives one way or another, requiring us to readapt in order to coexist with this virus. My name is Gabriel de la Hoz Ruiz, and I recently completed my research work for my Master’s Degree with Dr. Manojkumar Arthikala in the unit ENES-UNAM under the joint degree program between Spain and Mexico. I am currently doing paperwork to defend my thesis. During the pandemic, the entire administrative process slowed down, although all academic activities are being held in their regular fashion, so there has been no need to put them off. Research has continued, always respecting safety guidelines, helping us acquire more and more knowledge on the agro-genomic area. At a personal level, my lifestyle has changed very much. Family time has been cut down as much as possible in order to avoid risks of infection and due to local mobility restrictions. My social life has also been affected, since there is a feeling of insecurity towards the health situation of others regarding COVID-19. This produces a sense of monotony in me since social interaction is so important to me. However, confinement has led to greater social connectivity and greater unity in the family via digital media, which have helped make up for social distance and the lack of our loved ones. Through these media, we have had the emotional support of our families when we need them the most. In conclusion, we are adapting in all spheres of life in the best way possible, proving that, as a society, we can continue having academic and work lives with the greatest normality possible to continue with our personal growth, but with the adequate protection and responsibility of looking after the health of those around us.&lt;/p&gt;

On the Schrödinger map for regular helical polygons in the hyperbolic space

The main purpose of this article is to understand the evolution of X t = X s ∧− X ss , with X(s, 0) a regular polygonal curve with a nonzero torsion in the three-dimensional Minkowski space. Unlike in the case of the Euclidean space, a nonzero torsion now implies two different helical curves. This generalizes recent works by the author with de la Hoz and Vega on helical polygons in the Euclidean space as well as planar polygons in the Minkowski space. Numerical experiments in this article show that the trajectory of the point X(0, t) exhibits new variants of Riemann’s non-differentiable function whose structure depends on the initial torsion in the problem. As a result, we observe that the smooth solutions (helices, straight line) in the Minkowski space show the same instability as displayed by their Euclidean counterparts and curves with zero-torsion. These numerical observations are in agreement with some recent theoretical results obtained by Banica and Vega.

Community-acquired pneumonia: is less more?

Community-acquired pneumonia is a topic of maximum interest because it remains a leading cause of morbidity and mortality due to an infection. 1 Metlay JP Waterer GW Long AC et al. Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med. 2019; 200: e45-e67 Crossref PubMed Scopus (870) Google Scholar At the same time, antimicrobial resistance and antimicrobial stewardship programmes are essential issues surrounding community-acquired pneumonia. 2 Viasus D Vecino-Moreno M De La Hoz JM Carratalà J Antibiotic stewardship in community-acquired pneumonia. Expert Rev Anti Infect Ther. 2017; 15: 351-359 Crossref PubMed Scopus (15) Google Scholar , 3 Barlam TF Cosgrove SE Abbo LM et al. Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016; 62: e51-e77 Crossref PubMed Scopus (1273) Google Scholar , 4 Postma DF van Werkhoven CH van Elden LJ et al. Antibiotic treatment strategies for community-acquired pneumonia in adults. N Engl J Med. 2015; 372: 1312-1323 Crossref PubMed Scopus (238) Google Scholar Narrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trialIn patients hospitalised with moderately severe community-acquired pneumonia, a multifaceted antibiotic stewardship intervention might safely reduce broad-spectrum antibiotic use. Full-Text PDF

Symmetry in stationary and uniformly rotating solutions of active scalar equations

We study the radial symmetry properties of stationary and uniformly rotating solutions of the 2D Euler and gSQG equations, both in the smooth setting and the patch setting. For the 2D Euler equation, we show that any smooth stationary solution with compactly supported and nonnegative vorticity must be radial, without any assumptions on the connectedness of the support or the level sets. For the 2D Euler equation in the patch setting, we show that every uniformly rotating patch D with angular velocity Ω≤0 or Ω≥1 2 must be radial, where both bounds are sharp. For the gSQG equation, we obtain a similar symmetry result for Ω≤0 or Ω≥Ωα (with the bounds being sharp), under the additional assumption that the patch is simply connected. These results settle several open questions posed by Hmidi, de la Hoz, Hassainia, and Mateu on uniformly rotating patches. Along the way, we close a question by Choksi, Neumayer, and Topaloglu on overdetermined problems for the fractional Laplacian, which may be of independent interest. The main new ideas come from a calculus-of-variations point of view.

146-LB: Association of Serum 1,5-Anhydroglucitol with Severe COVID-19 in T2D patients

Background: Hyperglycemia worsens the prognosis and severity in Covid-19 patients. Objective: To assess the impact of glycemic control on COVID-19 severity. Methods and Findings: Data from 460 individuals collected in Spain between April and July 2020 was analyzed in a cross-sectional study: healthy, Sars-Cov-2 negative (group 0, N = 197), Sars-Cov-2 positive, with mild COVID-19 symptoms (group 1, N = 113), Sars-Cov-2 positive, with severe COVID-19 symptoms who required hospitalization (group 2, N = 150) at Hospital Universitario Cruces in Bilbao, Spain. Fasting blood glucose, HbA1c and serum 1,5-anhydroglucitol (1,5-AG, indicator of hyperglycemic excursions over the prior 1-2 weeks) were measured. Differences in 1,5-AG (normal range &amp;gt;10µg/mL) were observed between all three groups (mean 1,5-AG of 21.19, 18.99, 14.64 µg/mL, respectively) when compared by an unpaired t-test. 1,5-AG levels across groups decreased with increasing severity, with the hospitalized patients (group 2) showing the greatest difference when compared to healthy individuals, p value &amp;lt; 0.0001. Logistic regression analysis showed that 1,5-AG had a mild positive association with increased COVID-19 severity (group 0 vs. group 2: AUC = 0.69, p value &amp;lt; 0.0001). A previous T2D diagnosis did not show association with COVID-19 severity (group 0 vs. group 2: AUC = 0.58, p value &amp;lt; 0.0001). Analysis of patients with a previous diagnosis of T2D showed a robust positive association between 1,5-AG and COVID-19 (group 0 vs. group 2, AUC = 0.79, p value 0.008). There was no association between HbA1c or fasting glucose with severity. Combination of 1,5-AG and HbA1c was similar than 1,5-AG alone (AUC = 0.80, p value 0.028). Conclusions: Glycemic fluctuations in T2D patients may contribute to severe COVID-19. Measurement of serum 1,5-AG in T2D patients might help clinicians quickly identify diabetes patients at risk of severe COVID-19. These patients may benefit from more intensive management, treatment and vaccine prioritization. Disclosure G. Sonia: None. L. Castano: None. E. A. Button: Employee; Self; Precision Diabetes, Inc. M. Zulueta: Employee; Self; Patia Europe. E. Arana: None. A. B. De la hoz: None. L. Mendizabal: Employee; Self; PATIA. J. Del olmo: None. R. Muñoz: None. L. Simon: Board Member; Self; Oncomatryx Biopharma, S. L, Patia Biopharma, SA de CV, Patia Europe S. L., Permedika Entrepeneurs, S. L, SunRock, S. L, Employee; Self; Oncomatryx Biopharma, S. L, Patia Biopharma, SA de CV, Patia Europe S. L., PatiaCan, SA de CV, Permedika Entrepeneurs, S. L, Other Relationship; Self; Oncomatryx Biopharma, S. L, Patia Biopharma, SA de CV, Quimatryx, S. L, Stock/Shareholder; Self; Helenes Ventures, S. L, Nelum, Corp, Oncomatryx Biopharma, S. L, Patia Biopharma, SA de CV, Patia Europe S. L., PatiaCan, SA de CV, Permedika Entrepeneurs, S. L, Stemcell Therapeutics, S. L, SunRock, S. L.

Latin American Transnational Children and Youth: Experiences of Nature and Place, Culture and Care across the Americas by Victoria Derr Yolanda Corona (review)

Book Review: Latin American Transnational Children and Youth: Experiences… 157 Latin American Transnational Children and Youth: Experiences of Nature and Place, Culture and Care across the Americas Victoria Derr and Yolanda Corona, editors (2021) Oxford and New York: Routledge, 262 pages $160.00 Hardback, $48.95 eBook; ISBN: 9780367463885 Latin American Transnational Children and Youth: Experiences of Nature and Place, Culture and Care across the Americas illustrates how children and youth perceive, learn about, and care for nature. With scholarship from Latin America and the United States in each section, the text offers stories from migrant and immigrant children and youth. Broadly, the book suggests experiences of childhood are changing over time along with the places with which children have contact. The chapters emphasize the role of family and community in creating a sense of place and identity. Part 1: Perspectives on Place illuminates how children and youth experience, recognize, and understand their experiences with nature. The concept of querencia, articulated by Derr in chapter one, provides a particularly powerful framing for this section as it calls attention to the ways children connect and disconnect from places through emotional attachments or lack thereof. This section gathers diverse cases including rural children in Tepoztlán, Mexico (by Corona, Perez, and Montoya, chapter 2), urban children in Mexico City (by Gulgonen, chapter 3), and Latinx immigrant children in Milwaukee, Wisconsin (by Cuevas, Fritzen-Pedicini, and Beyer, chapter 4). While Querencia is a strong theme throughout the book, it particularly resonates through chapter 4 on migrant children who use their sense of connection to land as a way to create a sense of belonging in new places. Part 2: Homeland, Belonging, and Transnational Identity shows how youths’ relationships to their homeland shapes their transnational identities. This section includes chapters on Amuzgo and Kuchumatán indigenous groups (by Trinidad and Otani, chapter 7), migrant youth who live in Insecure Infantile Migration (by Sánchez, chapter 8), and “1.5 generation” immigrants (by Domínguez, chapter 9). A notable theme in this section is that transnational identity is shaped by experiences with territory, land, and nature. The concept of “geographic habitus” presented by Schmalzbauer in chapter 6 is particularly powerful for understanding how place and environment can be part of transnational identity-making and sense of belonging. Chapter 10 by Derr et al. describes how Latina college students’ environmental identities are shaped by cultural ways of being and belonging in nature. Part 3: Learning and Expressing Care features work on emotional attachments and acts of care toward nature. A strong theme in this final section is decolonial and non-hierarchical forms of education and relationships. This section includes chapters with Zapatista children and intergenerational cultural education (by Montoya, chapter 12), the Chilean Mapuche community program “Listening to Elders” (by Ibarra et al., chapter 13), and early significant life experiences for Book Review: Latin American Transnational Children and Youth: Experiences… 158 environmental professionals (by de la Hoz, chapter 16). These works highlight the role of intergenerational relationships in teaching and learning care for nature. Another theme in this section is that youth participation can be unconventional and necessitates adults' commitment to supporting children's agency. The section includes chapters on science curricula that support indigenous and afro-descendent ways of knowing (by Herrera, chapter 14) and indigenous youth participation in climate justice and advocacy (by Corona and Alvarez, chapter 17). These three sections review different areas of children and youths’ experiences with their environments to advance research in a number of ways. Some of the most prominent areas are research on children and nature from a transnational perspective, the role of family and culture in environmental experiences, environmental and intergenerational education, and children and youths’ participation. These areas of research have impacts for policy on children’s rights, indigenous rights, and education. The book offers an overview of children’s participation, providing a transnational perspective and including several chapters with indigenous groups. Its greatest strength is its broad collection of work. Latin American Transnational Children and Youth includes an array of work from diverse disciplines including anthropology, urban planning, public health, and geography. The chapters include methodologies ranging from statistical analysis to drawings and community-engaged...

A Ferrocement Patent for Emergency Housing: The Technological Hut

This article focuses on the comparison between the Spanish architects de La Hoz (Madrid, 1924) and José María García de Paredes (Seville, 1924) projects for ‘ultra-cheap’ housing in Cordoba, how it evolved from a British patent named Ctesiphon, and the study of some of existing buildings erected following this construction system. The aim of this article is to stablish the evolution of the system from the original patent into a new possibility for low-income social housing. This system was used to erect new developments in the 1950s that would relocate people living in huts during the dictatorship era in Spain, thus new “technological huts” were proposed and erected. The research process includes an analysis of the documents and literature available of the patent and the projects themselves, and in situ tests (infrared thermography and samples extraction) will allow to establish the relation between its original inventor, the dissemination of his works in publications from that era, and the Spanish company that subsequently, as a concession of the original patent, introduced that system in Spanish architecture. Analysis of the original patent document allows to study the primitive system as it was invented and for what uses it was conceived. Thus, such a methodology supports an establishment of the technical innovations achieved in order to adapt the system to the Andalusian environment at that time and its use for housing.

On the existence of stationary patches

In this paper, we show the existence of the first nontrivial family of analytic stationary patch solutions of the SQG and gSQG equations. This answers an open problem in F. de la Hoz et al. (2016) [13].

Elucidating Decomposition Mechanisms of Ethylene Carbonate on Layered Cathode Material Surfaces in Lithium Ion Batteries

During the charge/discharge cycling processes in lithium ion batteries (LIBs), degradation reactions of organic solvents would be inevitable at the electrode-electrolyte interface because of the instability of electrolyte components,1,2 leading to electrode degradation, capacity fade, poor cycling stability, and even safety issues. Since the reductive decomposition mechanisms of electrolytes at the anode-electrolyte interface have been extensively studied by theoretical simulations,3 it is critical to understand the interfacial reaction mechanisms at the cathode-electrolyte interface to provide more effective strategies to help design interfacial layer in LIBs, alleviating capacity fading and improving the cycle performance of batteries. First-principles calculations were conducted to study the oxidative decomposition reactions of ethylene carbonate (EC) on the (110) surface of LiNi1/3Co1/3Mn1/3O2 (NCM333). All the possible oxidative decomposition reaction steps of EC on cathode surfaces, including H-abstraction reaction and ring-opening reactions caused by Cc-Oe and/or Ce-Oe bond cleavage, were analyzed from both thermodynamic and kinetic aspects. We found that EC decompositions are initiated by the ring-opening reaction (Cc-Oe bond cleavage) as the first step with an activation barrier of 0.57 eV and reaction energy of -0.70 eV. Afterwards, the H-abstraction reaction is quite easily to occur with an activation energy of only 0.26 eV. Figure 1 shows the reaction energies (ΔE) and activation energies (Barriers) for four possible reaction pathways as the first decomposition step for EC on NCM333 (110) surfaces. Another layered cathode material LiCoO2 (LCO) was also considered, and the similar decomposition steps were found for EC decomposition on (110) surfaces. In a further study, lithium salt anions (PF6 -) and solvent molecules (EC) as well as Mn cations were introduced into the model. These molecules showed significant effects on the reaction pathways. References (1) Aurbach, D.; Gofer, Y.; Langzam, J. Journal of the Electrochemical Society 1989, 136, 3198. (2) Etacheri, V.; Marom, R.; Elazari, R.; Salitra, G.; Aurbach, D. Energy & Environmental Science 2011, 4, 3243. (3) Martinez de la Hoz, J. M.; Leung, K.; Balbuena, P. B. ACS Applied Materials & Interfaces 2013, 5, 13457. Figure 1. Reaction energies (ΔE) (black filled circles) and activation energies (Barriers) (red empty circles) for four possible reaction pathways as the first decomposition step for EC on NCM333 (110) surfaces. Color code: lithium, green; carbon, brown; oxygen, red; hydrogen, white; Co, dark blue; Ni, silver gray; Mn, purple. Figure 1

Existence of small loops in a bifurcation diagram near degenerate eigenvalues

In this paper, we study the global structure of a bifurcation diagram for rotating doubly connected patches near a degenerate case for incompressible Euler equations. We show that branches with the same symmetry merge, forming a small loop, provided that they are close enough. This gives an analytical proof for the numerical observations conducted in the recent work by de la Hoz et al (2016 SIAM J. Math. Anal. 48 1892–928).

Approaches for CO2 Capture and Sequestration Inspired by Biological Systems

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 180718, “Approaches for CO2 Capture and Sequestration Inspired by Biological Systems,” by Z. Ouled Ameur and S. Gupta, Cenovus Energy, and Hector De La Hoz Siegler, University of Calgary, prepared for the 2016 Canada Heavy Oil Technical Conference, Calgary, 7–9 June. The paper has not been peer reviewed. In this study, several process alternatives for the permanent sequestration of carbon dioxide (CO2) as solid carbonates are evaluated. Although the formation of mineral carbonates is thermodynamically favorable, it does not occur significantly because of kinetic limitations and the formation of products that hinder the evolution of the process. In the complete paper, the authors propose biomimicking approaches to precipitate solid carbonates while limiting the amount of energy required or using the byproducts to generate valuable materials. Introduction Permanent sequestration of CO2 as solid carbonates is a feasible solution to the increased levels of CO2 in the atmosphere. Mineral carbonation—the process of capturing CO2 in the atmosphere in the form of solid carbonates through the reaction of CO2 with silicates—is a spontaneous, thermodynamically favorable process. Unfortunately, the kinetics of natural mineral carbonation is very slow and the process is only significant over geological time periods (millions of years). Accelerated formation of solid carbonates is, nonetheless, widely observed in biological systems, particularly in corals, bivalve molluscs, echinoderms, and foraminifera. These organisms have developed mechanisms to induce and accelerate the precipitation of carbonates, required for their skeletons, in natural saline waters. Biomimicking is the imitation of biological processes in other contexts for achieving a result not originally present in the mimicked biological systems. While corals need to precipitate carbonate to build their exoskeletons, they do not significantly modify the concentration of CO2 in the atmosphere. The authors propose use of the mechanisms for carbonate precipitation relied upon by corals and other organisms to develop a large-scale process for accelerating the sequestration of CO2 in the form of stable mineral rock. Process Alternatives The conversion of CO2 into a mineral form involves the transformation of gaseous CO2 into ionic form and the further reaction of the carbonate ions (CO32−) with divalent cations [e.g., calcium (Ca2+) and magnesium (Mg2+)] to form an insoluble precipitate (e.g., CaCO3). Because the reaction system must maintain electroneutrality, an exchange of ions is usually required. In the case of corals, the carbonate-precipitation reaction occurs in the presence of sea water, which naturally contains Ca2+ and chlorine (Cl−) ions. The Ca2+ ions react with CO32− ions, which are present because of the reaction of CO2 with water. The process results in the reduction of one mole of Ca2+ ions per mole of CO2 removed, and the production of 2 moles of hydrogen ions (H+), thus maintaining electroneutrality. To preserve a favorable pH, however, corals couple the production of H+ with photosynthesis, which provides a net sink of H+ ions.

Relative equilibria with holes for the surface quasi-geostrophic equations

We study the existence of doubly connected rotating patches for the inviscid surface quasi-geostrophic equation left open by de la Hoz, Hassainia and Hmidi in 2016 in [10]. By using the approach proposed in 2016 by Castro, Córdoba and Gomez-Serrano in [4] we also prove that close to the annulus the boundaries are actually analytic curves.

Rehabilitación integral de barriadas con dificultades sociales en Andalucía. La experiencia de San Martín de Porres en Córdoba

The recovery of the districts built during the second half of the twentieth century, especially those with greater social difficulties, constitutes a sustainable alternative to the failure of continuous urban growth. It is essential to promote integral actions in order to correct both deficiencies and deterioration in residential buildings, improve the relationship of these areas with their urban environments, provide them with facilities and high quality public spaces, as well as to encourage local civil community involvement. On the basis of the experiences and tools that have been developed over the past decade in Andalusia, this paper analyzes the integral renovation of the so called San Martin de Porres district. Here we study its urban and architectural development –standing out the work of the architect Rafael de La-Hoz– as well as the social transformations of its population. From the study of the design, management and execution of its renovation the most relevant aspects are deduced with the objective of facilitating their consideration in future renovation policies.

Extinction-time for stochastic population models

The analysis of interacting population models is the subject of much interest in mathematical ecology. Moreover, the persistence and extinction of these models is one of the most interesting and important topics, because it provides insight into their behavior. The mean extinction-time for stochastic population models considered in this paper depends on the initial population size and satisfies a stationary partial differential equation, related to the backward Kolmogorov differential equation, a linear second-order partial differential equation with variable coefficients. In this communication we review several papers where we have proposed some numerical techniques in order to estimate the mean extinction-time for stochastic population models. Besides, we will compare the theoretical predictions and numerical simulations for stochastic differential equations (SDEs). This work can be viewed as a unified review of the contributions de la Hoz and Vadillo (2012), de la Hoz et al. (2014) and Doubova and Vadillo (2014).