De Brabander Research Articles

"Age-related changes in plasma biomarkers and their association with mortality in COVID-19." E.H.A. Michels, B. Appelman, J. de Brabander, et al. Eur Respir J 2023; 62: 2300011.

"Age-related changes in plasma biomarkers and their association with mortality in COVID-19." E.H.A. Michels, B. Appelman, J. de Brabander, et al. Eur Respir J 2023; 62: 2300011.

Valences and sense of personal autonomy with regard to professional development in Dutch primary teachers: Do decision contexts and age make a difference?

In this study on motivations concerning professional development (PD) we interviewed 95 primary school teachers in the Netherlands. We coded these data using the Unified Model of Task-specific Motivation (de Brabander & Martens, 2014) in different decision contexts concerning who decides about teacher participation in PD: school board, teacher teams, or individual teachers. We analysed the valences that teachers associated with PD activities, their experiences of autonomy, and whether and how these variables were affected by decision context and teacher age. Results show that decision contexts relate differently to valences and autonomy experiences. Positive autonomy and positive valences increased going from schoolboard to team to individual decision contexts. Whereas the literature on effective teacher PD stresses the importance of PD design features, our study is the first to empirically demonstrate the crucial influence of decision contexts. Among older teachers, teaching experience informed the selection of PD content to transfer to their classrooms. Younger teachers tended to first explore whether PD worked in their classrooms before deciding about adoption. Direct applicability emerged as a dominant criterion for evaluating PD. Decision context and autonomy regarding PD programmes play important roles in ensuring applicability. Our research revealed that the dominance of the direct applicability criterion was not motivated by student benefits alone. It was also based in an attitude of efficiency among primary teachers, reflecting growing work pressures and a general prioritisation of classroom teaching above all other tasks, including PD.

Castration and alternatives in pig: advantages and disadvantages

Castration and alternatives in pig: advantages and disadvantages

Total Synthesis and Structural Revision of Greensporone F and Dechlorogreensporone F.

The first asymmetric total syntheses of the real isolation product (2S,5R,8R)-greensporone F and (2S,5R,8R)-dechlorogreensporone F, 14-membered resorcylic acid lactones with a cis-2,5-disubstituted tetrahydrofuran ring system, was accomplished. The synthesis features a late-stage Lewis acid-catalyzed stereoselective intramolecular oxa-Michael reaction, E-selective ring-closing metathesis, De Brabander's esterification, and Jacobsen's hydrolytic kinetic resolution as the key steps. Synthesis of both real isolation and erroneously proposed structure necessitated the revision of the absolute configuration of greensporone F and dechlorogreensporone F. The erroneous representation of (2S,5S,8S)-configuration in greensporone F and dechlorogreensporone F was assigned to be (2S,5R,8R) by comparison with the NMR data and specific rotation of the synthetic compounds with that of the reported data.

Bioinspired First Stereoselective Total Synthesis of Spinosulfate B

AbstractAn efficient bioinspired stereoselective first total synthesis of spinosulfate B has been accomplished following Jacobsen's hydrolytic kinetic resolution, Stille coupling, olefin‐cross metathesis (OCM), Horner Wadsworth Emmons olefination, and De Brabander's esterification as key steps.

Total Synthesis and Structural Revision of Monocillin VII.

The first asymmetric total synthesis of macrolactone monocillin VII and its C-10' epimer was achieved starting from a known chiral pure epoxide in 16 longest linear sequences. The present synthesis highlights the macrolactone formation involving an alkyne-dicobalt carbonyl complex under De Brabander's conditions followed by an unexpected regioselective hydration. The asymmetric total synthesis resulted in the revision of the configuration at C10' and reassignment of the absolute configuration of the natural product.

Asymmetric total synthesis of filamentous fungi related resorcylic acid lactones 7-epi-zeaenol and zeaenol

AbstractAn efficient, short and, a convenient asymmetric total synthesis of filamentous fungi related resorcylic acid lactones 7-epi-zeaenol (2) and zeaenol (1) have been achieved in 7 and 9 linear steps with the high overall yield of 32% and 21% respectively, from the known intermediate 13. Mitsunobu inversion, De Brabander’s protocol for macrolactonisation, Heck cross-coupling, diastereoselective alkyne aldehyde coupling and Ohira–Bestmann alkynylation are the key reactions.

Modified method for qualitative thyroestatic substances determination in muscle tissue and urine of food producing animals and the application of Planar Thin Layer Chromatography 2D and 4x4D horizontal development.

Substances with thyreostatic action, also known as anti-hormones [AHs], are extracted by methanol in the presence of an internal standard. Percolation of the methanol extract through a mercurated adsorption mini-column allows a selective and reproducible extraction of the AHs by creating a specific complex with Hg ions. After elution of the Ahs with an acidic sodium chloride solution, the pH of the eluate is adjusted with buffer to 8,0 and allowed to react with NBDCl, a reagent which reacts only with thiols and amines. After reaction, the AH-NBD complexes formed are extracted in acid medium using TBME and after it has been dried down and reconstituted with TBME to the required volume, the ether fraction is spotted on to a HPTLC plate for horizontal development using sophisticated instrumentation. A cysteine water solution reacts with the AH-NBD complexes which are not fluorescent and they are converted into cystein-NBD complexes which are strongly fluorescent at 366 nm. This method, based on Verbeke R, de Brabander HF, 1984 method, has been modified in some steps concerning the mini-column preparation, the elution, the buffer replacement and chromatography step. The limit of detection no the plate, has been determined to be lower than lng by direct UV observation at 366nm, while the lower limit of detection achieved in the sample was 25 μg/kg.

Report for 2015 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products

EFSA Supporting PublicationsVolume 14, Issue 11 1150E Technical reportOpen Access Report for 2015 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products European Food Safety Authority, European Food Safety AuthoritySearch for more papers by this author European Food Safety Authority, European Food Safety AuthoritySearch for more papers by this author First published: 30 November 2017 https://doi.org/10.2903/sp.efsa.2017.EN-1150Citations: 5 Requestor: European Commission Question number: EFSA-Q-2016-00213 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References Clouet AS, Le Bizec B, Montrade MP, Monteau F and André F, 1997. Identification of endogenous 19-nortestosterone in pregnant ewes by Gas-Chromatography-Mass Spectrometry.Analyst, 122, 471– 474. EC (European Commission), 2007. European Commission Staff Working Document on the implementation of National Residue Monitoring Plans in the Member States in 2007. Available online: http://ec.europa.eu/food/food/chemicalsafety/residues/workdoc_2007_en.pdf EFSA (European Food Safety Authority), 2010. Report for 2008 on the results from the monitoring of veterinary medicinal product residues and other substances in food of animal origin in the Member States. EFSA Journal 2010; 8(4):1559, 55 pp. doi:10.2903/j.efsa.2010.1559 EFSA (European Food Safety Authority), 2011a. Evaluation of the data collection performed in the framework of Directive 96/23/EC. EFSA Supporting Publication 2011; 8(1):EN-103, 20 pp. doi:10.2903/sp.efsa.2011.EN-103 EFSA (European Food Safety Authority), 2011b. Report for 2009 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting Publication 2011; 8(5):158, 70 pp. doi:10.2903/sp.efsa.2011.EN-158 EFSA (European Food Safety Authority), 2012. Technical report of EFSA: Report for 2010 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting publication 2012; 9(3):212, 65 pp. doi:10.2903/sp.efsa.2012.EN-212 EFSA (European Food Safety Authority), 2013. Report for 2011 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting publication 2013; 10(4):EN-363, 65 pp. doi:10.2903/sp.efsa.2013.EN-363 EFSA (European Food Safety Authority), 2014. Report for 2012 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting publication 2014; 11(6):EN-540, 65 pp. doi:10.2903/sp.efsa.2014.EN-540 EFSA (European Food Safety Authority), 2015. Report for 2013 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting publication 2015; 12(11):EN-723, 69 pp. doi:10.2903/sp.efsa.2015.EN-723 EFSA (European Food Safety Authority), 2016. Report for 2014 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA Supporting publications 2016; 13(5):EN-923, 70 pp. doi:10.2903/sp.efsa.2016.EN-923 Fidani M, Pompa G, Mungiguerra F, Casati A, Fracchiolla ML and Arioli F, 2012. Investigation of the presence of endogenous prednisolone in equine urine by high-performance liquid chromatography mass spectrometry and high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry, 26, 879– 886. Pinel G, Mathieu S, Cesbron N, Maume D, De Brabander HF, André F and Le Bizec B, 2006. Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyrostats in meat production. Food Additives and Contaminants, 23, 974– 980. Pompa G, Arioli F, Casati A, Fidani M, Bertocchi L and Dusi G, 2011. Investigation of the origin of prednisolone in cow urine. Steroids, 76, 104– 110. Samuels TP, Nedderman A, Seymour MA and Houghton E, 1998. Study of the metabolism of testosterone, nandrolone and estradiol in cattle. Analyst, 123, 2401– 2404. Van der Fel-Klerx HJ, Liu C and Battilani P, 2016. Modelling climate changes impacts on mycotoxin contamination. World Mycotoxin Journal, 9, 717– 726. Citing Literature Volume14, Issue11November 20171150E ReferencesRelatedInformation

Report for 2014 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products

EFSA Supporting PublicationsVolume 13, Issue 5 923E Technical reportOpen Access Report for 2014 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this author European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this author First published: 25 May 2016 https://doi.org/10.2903/sp.efsa.2016.EN-923Citations: 6 Published date: 25 May 2016 Question number: EFSA-Q-2015-00031 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References Clouet AS, Le Bizec B, Montrade MP, Monteau F and André F, 1997. Identification of endogenous 19-nortestosterone in pregnant ewes by Gas-Chromatography-Mass Spectrometry. Analyst, 122, 471474. EC (European Commission), 2007. European Commission Staff Working Document on the implementation of National Residue Monitoring Plans in the Member States in 2007. Available online: http://ec.europa.eu/food/food/chemicalsafety/residues/workdoc_2007_en.pdf EFSA (European Food Safety Authority), 2010a. Report for 2008 on the results from the monitoring of veterinary medicinal product residues and other substances in food of animal origin in the Member States. EFSA Journal 2010; 8(4):1559, 55 pp. doi:10.2903/j.efsa.2010.1559 EFSA (European Food Safety Authority), 2010b. Technical report of EFSA: Evaluation of the data collection performed in the framework of Directive 96/23/EC. 20 pp. Available online: http://www.efsa.europa.eu/en/supporting/doc/103e.pdf EFSA (European Food Safety Authority), 2011. Technical report of EFSA: Report for 2009 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. Supporting Publications 2011: 158, 70 pp. Available online: http://www.efsa.europa.eu/en/supporting/doc/158e.pdf EFSA (European Food Safety Authority), 2012. Technical report of EFSA: Report for 2010 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. Supporting Publications 2012: 212, 65 pp. Available online: http://www.efsa.europa.eu/en/search/doc/212e.pdf EFSA (European Food Safety Authority), 2013. Technical report of EFSA: Report for 2011 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA supporting publications 2013: EN-363, 65 pp. Available online: http://www.efsa.europa.eu/en/supporting/doc/363e.pdf EFSA (European Food Safety Authority), 2014. Technical report of EFSA: Report for 2012 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA supporting publications 2014: EN-540, 65 pp. Available online: http://www.efsa.europa.eu/en/supporting/pub/540e.htm EFSA (European Food Safety Authority), 2015. Technical report of EFSA: Report for 2013 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. EFSA supporting publications 2015: EN-723, 69 pp. Available online: http://www.efsa.europa.eu/en/supporting/pub/723e.htm Fidani M, Pompa G, Mungiguerra F, Casati A, Fracchiolla ML and Arioli F, 2012. Investigation of the presence of endogenous prednisolone in equine urine by high-performance liquid chromatography mass spectrometry and high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry, 26, 879– 886. Pinel G, Mathieu S, Cesbron N, Maume D, De Brabander HF, André F and Le Bizec B, 2006. Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyrostats in meat production. Food Additives and Contaminants, 23, 974– 980. Pompa G, Arioli F, Casati A, Fidani M, Bertocchi L and Dusi G, 2011. Investigation of the origin of prednisolone in cow urine. Steroids, 76, 104– 110. Samuels TP, Nedderman A, Seymour MA and Houghton E, 1998. Study of the metabolism of testosterone, nandrolone and estradiol in cattle. Analyst, 123, 2401– 2404. Citing Literature Volume13, Issue5May 2016923E This article also appears in:Chemical residues data ReferencesRelatedInformation

Stereoselective synthesis of (3R,6S)-6-hydroxylasiodiplodin

The first stereoselective synthesis of polyketide natural product (3R,6S)-6-hydroxylasiodiplodin (1) has been described starting from commonly available starting materials d-mannitol and 2,4,6-trihydroxybenzoic acid. The key reactions involved are Keck asymmetric allylation, Stille coupling, De Brabander’s esterification, and ring-closing metathesis (RCM) reaction. The total synthesis was achieved in 19.3% overall yield making the route significant.

Abstract A63: Identification of small molecules for GBM study

Abstract Glioblastoma Multiforme (GBM) is the most frequent of malignant tumors of the brain. It is fatal usually within fifteen months after diagnosis. The Cancer Genome Atlas (TCGA) has surveyed the genomes of hundreds of human GBMs for presence of mutations in genes previously associated with cancer. Among those identified, three of the five most frequently mutated genes encode the well-known tumor suppressors: P53, NF1, and Pten (TCGA, 2008). We have generated genetic mouse models of GBM based on mutation in these same three tumor suppressors and they develop GBM with 100% incidence. These mouse GBMs resemble the human counterparts by all commonly used criteria for diagnosis. Extensive study of these mice and tumors has provided novel insights into the natural history of GBM development and moreover pointed at the adult neural stem cell/progenitor compartment as the most likely and frequent source of these tumors (Kwon CH, et al., 2008). We have thus isolated a cancer stem cell and demonstrated a hierarchical growth for these tumors in vivo. (Chen J, et al., 2012) In an effort to identify novel GBM specific molecular pathways that might serve as therapeutic targets, we undertook a 200,000 small compound high throughput screen using primary low passage GBM cells generated by pooling cells from multiple mouse tumors (Mut6 cells). A critical counter screen was designed to minimize compounds that targeted the cell division and DNA replication machinery of cells since many normal cells divide and this property is not unique to cancer cells. We therefore ruled out all compounds that displayed toxicity to primary mouse embryo fibroblasts (MEFs) or to primary astrocytes. At the end of the screen, we selected three lead compounds with amenable physical-chemical properties for further evaluation and development as research discovery reagents and possible translational tools for drug development. We verified the activity of one of these compounds, termed Compound X, on mouse and human GBM primary cells as well as on a subset of established cancer cell lines, but not on MEFs or primary astrocytes. We identified a rapid cellular stress response accompanied by the robust activation of a transcription factor and eventual apoptotic response that can be mimicked by glucose deprivation. Through intensive structure-activity relationship study, analogs were successfully developed for in vivo activity and also for biochemical pull-down assay. Another compound (Compound Y) also induced apoptosis, however displaying response through completely different pathway, which indicates our screen identified multiple vulnerabilities in GBM tumor cells. Citation Format: Sang Kyun Lim, Yufeng Shi, Qiren Liang, Inga Nazarenko, Shuguang Wei, Maya Palnitkar, Yanjiao Li, Woosung Cho, Noelle Williams, Bruce Posner, Jef De Brabander, Luis F. Parada. Identification of small molecules for GBM study. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr A63.

ChemInform Abstract: Stereoselective Total Syntheses of Paecilomycins E and F Through a Protecting Group Directed Diastereoselective Intermolecular Nozaki—Hiyama—Kishi (NHK) Reaction.

An efficient and concise approach to the total syntheses of paecilomycins E (1) and F (2) is described. A protecting group directed intermolecular diastereoselective Nozaki–Hiyama–Kishi (NHK) reaction, a Julia–Kocienski olefination, a Sharpless asymmetric dihydroxylation, and De Brabander's lactonization protocol are used as the key steps.

ChemInform Abstract: First Total Synthesis of Cryptosporiopsin A.

The first total synthesis of polyketide natural product cryptosporiopsin A (1) was described. It has been accomplished in 12 longest linear steps with 15.4% overall yield starting from enantiomerically pure epoxide 12 prepared by hydrolytic kinetic resolution. Other key steps were Stille coupling, Grignard reaction, De Brabander's esterification and ring closing metathesis (RCM) reaction.

Stereoselective Total Syntheses of Paecilomycins E and F through a Protecting Group Directed Diastereoselective Intermolecular Nozaki–Hiyama–Kishi (NHK) Reaction

AbstractAn efficient and concise approach to the total syntheses of paecilomycins E (1) and F (2) is described. A protecting group directed intermolecular diastereoselective Nozaki–Hiyama–Kishi (NHK) reaction, a Julia–Kocienski olefination, a Sharpless asymmetric dihydroxylation, and De Brabander's lactonization protocol are used as the key steps.

Age-related changes of lateral ventricular width and periventricular white matter in the human brain: a diffusion tensor imaging study.

Aging is the accumulation of multidimensional deterioration of processing of biological, psychological, and social changes with expansion over time (Bowen and Atwood, 2004; Grady, 2012). Aging-related changes are typically accompanied by decline in cognitive function, urinary control, sensory-motor function, and gait ability (Bradley et al., 1991; Bowen and Atwood, 2004; Hedden and Gabrieli, 2004; Grady, 2012; Moran et al., 2012). In addition, a number of studies have suggested changes in brain structure with normal aging, such as decrease in cortical thickness or increase in ventricular width (Blatter et al., 1995; Tang et al., 1997; Uylings and de Brabander, 2002; Preul et al., 2006; Apostolova et al., 2012). In particular, ventricular enlargement has been suggested as a structural biomarker for normal aging and progression of some illnesses, such as Alzheimer's disease (Blatter et al., 1995; Tang et al., 1997; Uylings and de Brabander, 2002; Preul et al., 2006; Apostolova et al., 2012). However, the question of how this structural change in the brain in normal elderly affects change of white matters remains a topic of interest and concern. Diffusion tensor imaging allows for evaluation of white matter due to its ability to capture and quantify water diffusion characteristics (Mori et al., 1999; Assaf and Pasternak, 2008; Neil, 2008). In normal white matter, water molecules move relatively freely in a direction parallel to nerve fiber tracts, however, their movements are restricted across tracts, which cause diffusion anisotropy in white matter. This selective restriction of water molecule movement allows for exploration of physical changes in white matter caused by normal aging using diffusion anisotropy. Some studies using DTI have reported on changes in periventricular white matter in patients with stroke or other brain injuries (Yeo et al., 2011; Hattori et al., 2012; Jang et al., 2013). In the current study, using DTI, we investigated ventricular enlargement with normal aging, and its effect on periventricular white matter.

First total synthesis of cryptosporiopsin A

The first total synthesis of polyketide natural product cryptosporiopsin A (1) was described. It has been accomplished in 12 longest linear steps with 15.4% overall yield starting from enantiomerically pure epoxide 12 prepared by hydrolytic kinetic resolution. Other key steps were Stille coupling, Grignard reaction, De Brabander's esterification and ring closing metathesis (RCM) reaction.

ChemInform Abstract: A Room Temperature Copper Catalyzed N‐Selective Arylation of β‐Amino Alcohols with Iodoanilines and Aryl Iodides.

ChemInformVolume 45, Issue 2 Isocyclic Compounds ChemInform Abstract: A Room Temperature Copper Catalyzed N-Selective Arylation of β-Amino Alcohols with Iodoanilines and Aryl Iodides. Priyabrata Das, Priyabrata Das Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75390, USASearch for more papers by this authorJef K. De Brabander, Jef K. De Brabander Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75390, USASearch for more papers by this author Priyabrata Das, Priyabrata Das Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75390, USASearch for more papers by this authorJef K. De Brabander, Jef K. De Brabander Dep. Biochem., Univ. Tex. Southwest. Med. Cent., Dallas, TX 75390, USASearch for more papers by this author First published: 19 December 2013 https://doi.org/10.1002/chin.201402061Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume45, Issue2January 14, 2014 RelatedInformation

Abstract C16: Mapping synthetic vulnerabilities in non-small cell lung cancer

Abstract Diversity in the genetic lesions that drive cancer initiation and progression is extreme. This diversity exists not only among tumors from different patients, but also among cancer cells within the same patient. This nefarious complexity is, in large measure, responsible for the capacity of this disease to evade current best efforts for effective therapy. “Personalized medicine” has been proposed in response to this conundrum as a mechanism to tailor cancer treatment to a specific tumor's genetic and epigenetic characteristics. However, selection of appropriate treatment is dramatically limited by the paucity of appropriate drugs and by the difficulty of linking treatment options to the appropriate patients. The challenge is to identify authentic intervention targets for development of an appropriately diverse cohort of therapies to contend with disease heterogeneity. We are addressing this challenge by a focused investigation of common vulnerabilities that arise as a consequence of oncogene expression and tumor evolution. Here we will describe a cancer intervention discovery pipeline using parallel genetic and chemical perturbations within an extensive panel of cell lines representative of the molecular lesions detected in lung cancer by national and international cancer genome sequencing efforts. We have found that current first line targeted therapies are discoverable within this panel together with the enrollment biomarkers required to stratify patient treatment regimens. Further, we have found that new genetic and chemical vulnerabilities can be revealed that are linked to recurrent mutations in lung cancer patients that are not currently “actionable”. We are leveraging this approach to stratify lung cancer subtypes and elaborate intervention targets that are linked to those subtypes by robust molecular discriminators. Note: This abstract was not presented at the conference. Citation Format: Hyun Seok Kim, Saurabh Mendiratta, Jiyeon Kim, Chad Victor Pecot, Jill E. Larsen, Iryna Zubovych, Bo Yeun Seo, Jimi Kim, Banu Eskiocak, Hannah Chung, Elizabeth McMillan, Sherry Wu, Jef De Brabander, Kakajan Komurov, Bruce A. Posner, Rolf Brekken, Anil K. Sood, Ralph J. Deberardinis, Michael G. Roth, John D. Minna, Michael A. White. Mapping synthetic vulnerabilities in non-small cell lung cancer. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr C16.

Report for 2010 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products

EFSA Supporting PublicationsVolume 9, Issue 3 212E Technical reportOpen Access Report for 2010 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this author European Food Safety Authority (EFSA), European Food Safety Authority (EFSA)Search for more papers by this author First published: 20 March 2012 https://doi.org/10.2903/sp.efsa.2012.EN-212Citations: 3 Published date: 20 March 2012 Question number: EFSA-Q-2011-00228 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References Clouet AS, Le Bizec B, Montrade MP, Monteau F, Andre F, 1997. Identification of endogenous 19-nortestosterone in pregnant ewes by Gas-Chromatography-Mass Spectrometry. Analyst, 122, 471– 474. European Commission (EC), 2007. European Commission Staff Working Document on the implementation of National Residue Monitoring Plans in the Member States in 2007. Available at http://ec.europa.eu/food/food/chemicalsafety/residues/workdoc_2007_en.pdf European Food Safety Authority (EFSA), 2010a. Report for 2008 on the results from the monitoring of veterinary medicinal product residues and other substances in food of animal origin in the Member States. EFSA Journal 2010; 8(4):1559 [ 55 pp.]. doi:10.2903/j.efsa.2010.1559. Available online: www.efsa.europa.eu European Food Safety Authority (EFSA), 2010b. Technical report of EFSA: Evaluation of the data collection performed in the framework of Directive 96/23/EC. Available at http://www.efsa.europa.eu/en/supporting/doc/103e.pdf European Food Safety Authority (EFSA), 2011. Technical report of EFSA: Report for 2009 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products. Supporting Publications 2011:158. [ 70pp.]. Available online: www.efsa.europa.eu Pinel G, Mathieu S, Cesbron N, Maume D, De Brabander HF, Andre F, Le Bizec B, 2006. Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyrostats in meat production. Food Additives and Contaminants, 23, 974– 980. Samuels TP, Nedderman A, Seymour MA, Houghton E, 1998. Study of the metabolism of testosterone, nandrolone and estradiol in cattle. Analyst, 123, 2401– 2404. Citing Literature Volume9, Issue3March 2012212E This article also appears in:Chemical residues data ReferencesRelatedInformation