DC Extract Research Articles

LC-HRMS Profiling of Phytochemicals with Assessment of Antioxidant, Anticholinesterase, and Antimicrobial Potentials of Astragalus brachystachys DC.

This study provides the first comprehensive report on the chemical constituents and biological activities of an important medicinal plant, Astragalus brachystachys DC. The aerial part samples were collected from Adana, Türkiye, and an ethanol extract was prepared with these parts. The secondary metabolites of the extract were determined by an LC-HRMS analysis. The LC-HRMS analysis showed the presence of 39 different constituents, hyperoside (303.419±10.50 μg/g extract), p-coumaric acid (256.975±8.51 μg/g extract), and rutin (72.684±2.23 μg/g extract) were determined as major compounds in the aerial parts ethanol extract. Attributed to its high total phenolic (58.53±1.30 μg PEs/mg extract) and total flavonoid content (29.98±0.83 μg QEs/mg extract), the extract demonstrated strong antioxidant activity according to three different assays namely DPPH free (IC50: 33.08±0.61 mg/mL), and ABTS cation radical scavenging (IC50: 15.39±0.72 mg/mL) and CUPRAC activity (A0.5: 36.25±0.28 mg/mL) methods. In vitro assays showed that cholinesterase inhibitory activity results were found to be exceptional with 85.95±0.52 % inhibition on acetylcholinesterase and 66.32±1.33 % inhibition on butyrylcholinesterase at 200 mg/mL. Regarding antimicrobial properties, Astragalus brachystachys DC extract was found to be effective against Enterococcus faecalis with a MIC value of 39.06 μg/mL.

Green synthesis of silver nanoparticles using Osbeckia leschenaultiana DC extract: Optimization of synthesis, biological activities, larvicidal activity and toxicity analysis

Presently the Osbeckia leschenaultiana DC leaf - extract was used to synthesis the silver nanoparticles and the green synthesized AgNPs were characterized by UV–vis spectrophotometer, FTIR, XRD, DLS, Zeta potential and SEM. Absorbance at 405 nm was obtained in UV–vis spectrophotometer and multiple peaks emerged in FTIR analyses that represent the presence of some interesting functional groups. XRD results proved that the synthesised AgNPs were face-centered cubic and crystalline in nature. SEM revealed the particles are Cuboid and irregular forms; the particle size ranged between 70 nm and 100 nm. And the antibacterial and antioxidant characterization of green synthesized silver nanoparticles Osbeckia leschenaultiana DC leaf − extract against. Methicillin-resistant Staphylococcus aureus, Vibrio cholerae, Bacillus subtilis and Escherichia coli, revealed the potential antibacterial efficiency against gram positive bacteria Methicillin-resistant Staphylococcus aureus (23.0 ± 1.0) and Bacillus subtilis (22.0 ± 1.0) and they showed 60–70 % high antioxidant activity compared to Osbeckia leaf extract. AgNPs showed the highest mortality against Aedes aegypti with LC50 value of 49.17 µg/mL, followed by the Osbeckia leaf extract have LC50 value of 85.95 µg/mL. The toxicity profile analyzed using non-target organism Artemia salina exhibited less toxicity. The results revealed that the Osbeckia leschenaultiana DC mediated AgNPs had multifaceted antibacterial, antioxidant and larvicidal potential.

Enhancing the antimicrobial activity of silver nanoparticles against pathogenic bacteria by using Pelargonium sidoides DC extract in microwave assisted green synthesis.

This study presents an optimized microwave-assisted method for the green synthesis of silver nanoparticles (AgNPs) using a root extract obtained from Pelargonium sidoides DC. The influence of temperature, reagent concentration, and irradiation time was systematically investigated to enhance synthesis yield. Characterization techniques including XRD, UV-vis, FTIR, XPS, and zetametry were employed to confirm the successful formation of nanoparticles with a metallic silver core (∼17 nm) functionalized with organic molecules derived from the plant extract. The cytotoxicity of AgNPs was assessed using a cell viability assay, while the Minimum Inhibitory Concentration (MIC) of nanoformulation against pathogenic bacteria, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and the carbapenem-resistant Klebsiella pneumoniae (KPC), was determined using the Broth microdilution method. The nanoformulation synthesized with P. sidoides extract exhibited a dose-dependent response, demonstrating superior antimicrobial efficacy compared to the pure plant extract in most cases. The MIC values ranged from 0.85 to 17.1 μg mL-1, with particularly strong performance against the drug resistant KPC strain. The enhanced antimicrobial effect is attributed to the synergistic action of the metallic silver core and phytochemicals from P. sidoides on the surface of nanoparticles, which also contribute to notable colloidal stability of AgNPs at physiological pH levels.

Bioactivity Profiling of Daedaleopsis confragosa (Bolton) J. Schröt. 1888: Implications for Its Possible Application in Enhancing Women's Reproductive Health.

This study investigates the bioactivity profile of wood-rotting fungal species Daedaleopsis confragosa (Bolton) J. Schröt. 1888, focusing on its antioxidant, cytotoxic, and genotoxic activities and enzyme modulation properties with respect to its possible application in terms of enhancing women's reproductive health. Two types of extracts, including those based on EtOH extraction (DC) and hydrodistillation (DCHD), were investigated. The results indicate that the radical scavenging capacity against the DPPH radical and reduction potential were stronger in the DC extracts owing to the higher total phenolic content (TPC) and total flavonoid content (TFC) (25.30 ± 1.05 mg GAE/g d.w. and 2.84 ± 0.85 mg QE/g d.w., respectively). The same trend was observed in the protein phosphatase-1 (PP1) activity and in the genotoxic activity against the δ virus since only the DC extract exhibited DNA disintegration regarding a dilution of 1:100. Conversely, the DCHD extract exhibited increased hemolytic and cytotoxic effects (339.39% and IC50 = 27.76 ± 0.89 μg/mL-72 h incubation, respectively), along with greater inhibition of the AChE enzyme (IC50 = 3.11 ± 0.45 mg/mL) and hemolytic activity. These results suggest that terpenoids and steroids may be responsible for the observed activity in DCHD as these compounds could potentially be extracted following the HD procedure. This comprehensive bioactivity profiling offers valuable insights into the potential therapeutic applications of D. confragosa from Serbia and underscores the importance of further investigations for harnessing its pharmacological potential.

<i>In Vivo</i> Hepatoprotective Activity of Hydroalcohol Extract of <i>Gyrocarpus asiaticus</i> Willd and <i>Lactuca runcinata</i> DC

Objective: Investigation of hepatoprotective activity of Gyrocarpus asiaticus Willd (GA) and Lactuca runcinata DC (LR) prepared by hydroalcohol extraction. Methodology: Albino rats were used for the in vivo experiments for the determination of oral acute toxicity study. For these experiments, 6 groups were created of which 5 groups were for each plant extract and 1 group for control. A total of 11 groups were made for the toxicity study. Each group required 2 albino mice. Different doses of 0.025, 0.2, 0.5, 2, and 5 gm/kg body weight were administered orally for each plant extract. For the control group, these were administered with distilled water. For hepatoprotective activity, albino rats were randomly divided into 5 (control, toxic, standard, 2 samples) groups, and 4 animals were randomly divided into each group. For 2 plants, a total of 7 groups were made. 5% gum acacia was used as the vehicle. For induced hepatotoxicity CCl4 and as a standard drug silymarin was used. Result and Discussion: Plant extracts did not show any toxicity, and no histopathological changes were seen in the liver, kidney, or lungs due to toxicity. In the study of GA Willd and LR DC extract prepared by hydroalcohol solution, there was evidence of protection against CCl4-induced hepatotoxicity in the Histopathological study of the liver of albino rats. Conclusion: Hydroalcohol extract of LR DC and GA Willd shows no oral acute toxicity and LR DC shows no significant hepatoprotective activity but GA Willd shows significant hepatoprotective activity

Study on Broadband Dynamic Characteristics of Photovoltaic DC Arc

The low current and wideband characteristics of photovoltaic (PV) DC arc make it difficult for traditional protection devices to detect it effectively. Therefore, it is important to analyze the wide-band dynamic characteristics of PV DC arc and extract the fault features. In this paper, firstly, the fault simulation of the engineering PV DC arc with a compound arc model is performed in PSACD. Then the simulation of various interference conditions and the fault conditions are carried out. Taking the output current of the combiner box as the object, the randomness of the signal is described by the pulse factor, and the characteristics of arc fault are reflected from the time domain. Then the fault characteristic frequency band is obtained based on the band energy ratio and information entropy ratio and the characteristic of arc fault is reflected by the energy and information entropy. The results show that the proposed broadband dynamic characteristic analysis method can effectively reflect the DC arc fault.

Analysis of glucosinolates and their breakdown products from Mul-kimchis using UPLC-MS/MS

This study aimed to analyze glucosinolates and their breakdown products in three types of traditional cold vegetable soups kimchi known as Mul-kimchis (Dongchimi, DC; Yeolmu Mul-kimchi, YK; Nabak kimchi, NK) using UPLC-ESI-MS/MS. Glucosinolates and their breakdown products in the ethanolic extract from Mul-kimchis were analyzed via UPLC-ESI-MS/MS MRM mode, and the developed analysis method underwent validation for parameters including linearity, LOD, LOQ, accuracy, and precision. As a result, six glucosinolates (glucoraphanin, glucoraphenin, glucoerucin, glucoraphasatin, glucobrassicin, and 4-methoxyglucobrassicin; 4MGB) were detected in the DC extract. In contrast, the YK extract contained only two glucosinolates (glucoraphasatin and 4MGB), while the NK extract contained only one glucosinolate (4MGB). Among the glucosinolates, glucoraphasatin was the highest in the DC extract (21.1 ± 2.8 mg/100 g dry basis), while 4MGB dominated in Mul-kimchis overall, with the highest concentration found in DC (11.6 ± 2.1 mg/100 g). Regarding the breakdown products, indole-3-carboxaldehyde (I3CA), sulforaphane, and ascorbigen were detected in the extracts from both YK and NK. However, only I3CA and ascorbigen were detected in the extract from DC. Notably, ascorbigen exhibited significantly higher concentrations (p < 0.05) among the breakdown products in Mul-kimchis, with the highest levels observed in the YK extract (4.47 ± 0.26 mg/100 g).

Could Natural Products Help in the Control of Obesity? Current Insights and Future Perspectives.

Obesity is a global issue faced by many individuals worldwide. However, no drug has a pronounced effect with few side effects. Green tea, a well-known natural product, shows preventive effects against obesity by decreasing lipogenesis and increasing fat oxidation and antioxidant capacity. In contrast, other natural products are known to contribute to obesity. Relevant articles published on the therapeutic effect of natural products on obesity were retrieved from PubMed, Web of Science, and Scopus. The search was conducted by entering keywords such as "obesity", "natural product", and "clinical trial". The natural products were classified as single compounds, foods, teas, fruits, herbal medicines-single extract, herbal medicines-decoction, and herbal medicines-external preparation. Then, the mechanisms of these medicines were organized into lipid metabolism, anti-inflammation, antioxidation, appetite loss, and thermogenesis. This review aimed to assess the efficacy and mechanisms of effective natural products in managing obesity. Several clinical studies reported that natural products showed antiobesity effects, including Coffea arabica (coffee), Camellia sinensis (green tea), Caulerpa racemosa (green algae), Allium sativum (garlic), combined Ephedra intermedia Schrenk, Thea sinensis L., and Atractylodes lancea DC extract (known as Gambisan), Ephedra sinica Stapf, Angelica Gigantis Radix, Atractylodis Rhizoma Alba, Coicis semen, Cinnamomi cortex, Paeoniae radix alba, and Glycyrrhiza uralensis (known as Euiiyin-tang formula). Further studies are expected to refine the pharmacological effects of natural products for clinical use.

Energy Management of Hybrid DC Microgrid with Different Levels of DC Bus Voltage for Various Load Types

This article suggests a hybrid DC microgrid (HDCMG) with different levels of DC bus voltages to use for various types of loads. The available sources in the HDCMG are wind generating systems (WGSs), photovoltaic (PV) systems, battery banks, and the AC grid for emergencies. The various levels of the DC bus voltages are 760 V, 380 V, and 48 V for different application uses such as electric vehicles and home applications. In addition, the controller plays an important role in the proposed system to achieve the desired DC bus voltage levels and extract the maximum power point (MPP) from the WGS and PV systems. In order to check the power continuity for the critical loads and improve the overall system performance, a suggested energy management strategy (SEMS) is developed. The SEMS is based on the optimum generated power and the state-of-charge (SOC) of the battery banks. Further, the SEMS is developed as a way to prevent battery storage from overcharging and deep discharging. The mathematical relations of the proposed HDCMG and MPP tracking are described. The bidirectional 3-Φ inverter connects the 760 V bus voltage to the AC grid for regulating this DC bus by absorbing the excess power or supplying the required power during the shortage in the generation and the low SOC of the battery storage. Buck converters with controlled duty cycles rather than constant duty cycles are used to obtain 380 V and 48 V from 760 V to achieve better dynamic responses. The overall HDCMG is evaluated using the MATLAB/Simulink package under different working cases to verify the capability of the control system and the PEMS. The obtained results are discussed and show the good performance and the capability of the overall system under the different scenarios, including (i) a comparison between variable duty and constant duty; (ii) high/low generated power and the SOC of the battery in the acceptable region; (iii) high/low generated power and the SOC of the battery in the critical region; and (iv) high/low generated power and the SOC of the battery in the overcharging region.

Antibacterial and Antioxidant Activities of Extracts from Selected Wild Plant Species Found in Jordan

In the past decade, there has been a growing global interest in the antibacterial and antioxidant properties of plants, which are considered safe for use. This study aimed to evaluate the ntibacterial and antioxidant activities, as well as the flavonoid and total henolic contents, of three wild plant species found in Jordan: Rubus canescens DC, Rumex vesicarus L, and Urtica pilulifera L. The 70% methanol extracts of these plants were tested for their antioxidant activity using various assays, such as total phenols, free radical scavenging, and reducing power. Results showed that Rubus canescens DC extract had a higher percentage of total phenols and free radical scavenging activity, while Rumex vesicarus L extract had a higher percentage of reducing power. The extracts' antimicrobial activity was evaluated using a two-fold dilution method, including Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) activity. The extract of Rubus canescens DC showed higher antibacterial activity against the tested microorganisms, as measured by inhibition zones in plate-diffusion assays. These findings suggest that Rubus canescens DC could be a potential source of natural antioxidants and warrant further investigation of its therapeutic properties.

Immuno histological evidence of ormocarpum sennoides dc extract in the expression of bax and bcl2 in wister rats with glucocorticoid induced osteoporosis

Immuno histological evidence of ormocarpum sennoides dc extract in the expression of bax and bcl2 in wister rats with glucocorticoid induced osteoporosis

Effect of Hydrogel Containing Achyrocline satureioides (Asteraceae) Extract–Loaded Nanoemulsions on Wound Healing Activity

Achyrocline satureioides (Lam.) DC extract-loaded nanoemulsions have demonstrated potential for wound healing, with promising effects on keratinocyte proliferation. We carried out the first in vivo investigation of the wound healing activity of a hydrogel containing A. satureioides extract-loaded nanoemulsions. We prepared hydrogels by adding the gelling agent (Carbopol® Ultrez) to extract-loaded nanoemulsions (~250 nm in diameter) obtained by spontaneous emulsification. The final flavonoid content in formulation was close to 1 mg/mL, as estimated by ultra-fast liquid chromatography. Permeation/retention studies using porcine ear skin showed that flavonoids reached deeper layers of pig ear skin when it was damaged (up to 3.2 µg/cm² in the dermis), but did not reach the Franz-type diffusion cell receptor fluid. For healing activity, we performed a dorsal wound model using Wistar rats, evaluating the lesion size, anti-inflammatory markers, oxidative damage, and histology. We found that extract-loaded formulations promoted wound healing by increasing angiogenesis by ~20%, reducing inflammation (tumor necrosis factor α) by ~35%, decreasing lipid damage, and improving the re-epithelialization process in lesions. In addition, there was an increase in the number of blood vessels and hair follicles for wounds treated with the formulation compared with the controls. Our findings indicate that the proposed formulation could be promising in the search for better quality healing and tissue reconstruction.

Berberis aristata DC Extract Counteracts the High Fat Diet-Induced Reproductive Toxicity in Female Wistar Rats via Modulating Oxidative Stress and Resistance to Leptin and Insulin.

The plant Berberis aristata is traditionally used and scientifically validated for treating obesity and hyperlipidemia. It is also traditionally used to treat gynecological abnormalities. Therefore, the present study was designed to evaluate the therapeutic potential of Berberis aristata for obesity-related reproductive changes and chemically characterize it. High-fat diet was given to 36 female rats for six weeks to induce obesity and infertility. These obese rats were treated with 10 mg/kg orlistat or the plant extract at 125-500 mg/kg for 45 days. The GC-MS analysis of the plant extract included fructose, thymic acid and other hydrocarbons. The plant extract revealed a remarkable free radical scavenging activity. The treated animals exhibited a decrease in total cholesterol and triglycerides (p<0.001), insulin and leptin levels (p<0.05), visceral fat, and body weight while increasing the estradiol level at 500 mg/kg dose of the plant extract as compared with untreated animals as demonstrated from the histology of the ovary. Oxidative stress biomarkers such as superoxide dismutase, nitric oxide, malondialdehyde and reduced glutathione were significantly (p<0.01-0.001) ameliorated in treated rats. B. aristata exhibited substantial potential against obesity-inducedreproductive damage in female rats by reducing oxidative stress and resistance to leptin and insulin.

Green Synthesis, in vitro Cytotoxicity, Antioxidant Activity and Interaction Studies of CuO Nanoparticles with DNA, Serum Albumin, Hemoglobin and Lysozyme

AbstractThe present study reports an environmentally safe synthesis of CuO NPs employing Echinophora platyloba DC extract. The production of CuO NPs was authenticated using various analytical characterization techniques such as FT‐IR, TEM, XRD, SEM‐EDX, DLS, zeta potential, and UV‐Vis. The DPPH assay was employed to assess the scavenging efficacy of synthesized CuO NPs. The results of the MTT assay exhibited that CuO NPs have efficient anticancer potential on two used cancer cell lines (MCF‐7 and Burkitt's lymphoma). Thus, it tempts us to study the synthesized CuO NPs biocompatible aspects by interactions with several biologically significant molecules. The present experimental evidence demonstrates the direct interaction of CuO NPs with DNA, which might be one of the credible highways elevating its anticancer potential. Moreover, we investigated the interaction of CuO NPs with the most important blood proteins (HSA, HHb, and Lys) in simulated physiological conditions using spectroscopic methods. The interaction findings suggest that the native conformation of the above proteins was preserved at the level of secondary structure in spite of complex formations with CuO NPs. The binding constant values revealed the greater binding affinity of CuO NPs with HSA, HHb, and Lys as compared to ct‐DNA; the binding affinity was found in the order HSA&gt;HHb&gt;Lys&gt;ct‐DNA.

Polyphenols from Dichrostachys cinerea Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund's Adjuvant-Induced Arthritic Rat Model.

Dichrostachys cinerea (L.) Wigth & Arn. (DC) is widely used in traditional medicine against several inflammatory diseases, especially rheumatoid arthritis, because of its antioxidant and anti-inflammatory effects. This study aimed to characterize the polyphenol-rich DC fruit extracts and investigate the analgesic, anti-inflammatory, and antioxidant effects in a rat inflammation model induced by complete Freund’s adjuvant (CFA). Water and ethanolic extracts were characterized using liquid chromatography coupled with mass spectrometry (LC-MS), Fourier-transform infrared (FTIR) spectroscopy, and gas chromatography coupled with mass spectrometry (GC-MS). The polyphenol-rich extracts were administered in three different concentrations for 30 days. Pain threshold, thermal hyperalgesia, edema, and serum biomarkers specific to inflammatory processes or oxidative stress were evaluated. Both extracts were rich in polyphenolic compounds, mainly flavan-3-ols, proanthocyanidins, and flavone glycosides, which had important in vitro antioxidant capacity. DC fruit extracts administration had the maximum antinociceptive and anti-inflammatory effects after one day since the CFA injection and showed promising results for long-term use as well. The measurement of pro-inflammatory cytokines, cortisol, and oxidative stress parameters showed that DC extracts significantly reduced these parameters, being dose and extract-type dependent. These results showed potential anti-inflammatory, analgesic, and antioxidative properties and revealed the necessity of using a standardized polyphenolic DC extract to avoid result variability.

Modified symmetrical sinusoidal integrator and instantaneous reactive power theory-based control of shunt active filter

Instantaneous reactive power theory (IRPT) based control of shunt active filter (SAF) is designed to work with balanced load currents and balanced as well as undistorted supply voltages. This can be overcome by individually pre-processing the supply voltages and load currents through the modified symmetrical sinusoidal integrator (MSSI) for the extraction of the respective positive sequence fundamental components, which can be further processed by the IRPT for the reference current generation. MSSI can reject harmonics and dc offset and extract the fundamental component. For proper functioning of MSSI, it is important that the coefficients of its transfer function are properly selected. This paper presents IRPT based control of SAF with pre-processing of supply voltages and load currents by MSSI. In this work, the coefficients for the MSSI are determined by comparing its characteristic equation with that of the standard third order system. The coefficients are selected such that the real poles of MSSI are closer to imaginary axis as compared to the complex conjugate poles. This results in system operating as a first order system with reduced settling time and peak overshoot, which is evident from the steady state and dynamic performance of the MSSI with selected coefficients. SAF operation with this MSSI for pre-processing the input signals for the IRPT based control, results in improved dynamic and good steady state response of SAF even under non-ideal grid conditions.

Involvement of a neutrophil-mast cell axis in the effects of Piper malacophyllum (C. PESL) C. DC extract and its isolated compounds in a mouse model of dysmenorrhoea.

The effects of Piper malacophyllum (C. Pesl) C. DC extracts and its isolated compounds were analysed in a mouse model of primary dysmenorrhoea (PD). Female Swiss mice (6-8weeks old) on proestrus were intraperitoneally treated with estradiol benzoate for 3days, to induce PD. Twenty-four hours later, animals were treated 24h later with vehicle, plant extract, gibbilimbol B, 4,6-dimethoxy-5-E-phenylbutenolide, mixture of 4,6-dimethoxy-5-E-phenylbutenolide and 4,6-dimethoxy-5-Z-phenylbutenolide, or ibuprofen. One hour later, oxytocin was injected and the numbers of abdominal writhing were counted. Then, mice were euthanized and uteri were collected for morphometrical and histological analyses. The effects of P. malacophyllum in inflammation were investigated in mouse peritoneal neutrophils culture stimulated with LPS or fMLP (chemotaxis and mediator release). Finally, uterus contractile and relaxing responses were assessed. Similar to ibuprofen, P. malacophyllum extract and isolated compounds reduced abdominal writhing in mice with PD. Histology indicated a marked neutrophil and mast cell infiltrate in the uterus of PD animals which was attenuated by the extract. The compounds and the extract reduced neutrophil chemotaxis and inflammatory mediator release by these cells. Reduced TNF levels were also observed in uteri of PD mice treated with P. malacophyllum. The extract did not affect spontaneous uterine contractions nor those induced by carbachol or KCl. However, it caused relaxation of oxytocin-induced uterine contraction, an effect blunted by H1 receptor antagonist. Overall the results indicate that P. malacophyllum may represent interesting natural tools for reliving PD symptoms, reducing the triad of pain, inflammation and spasmodic uterus behaviour.

Isolation and identification of hair growth potential fraction from active plant extract of Blumea eriantha DC grown in Western Ghat of India: In silico study

BackgroundIn Aayurveda, Blumea eriantha DC has been used in the management of various diseases and is found to exhibit antioxidant and anti-hyperlipidemic, hypoglycemic, anti-diarrhoeal, larvicidal, antimicrobial properties. ObjectiveThe present study has focused on isolation of the active fraction from B. eriantha DC extract and to investigate its effect as a hair growth promoter along with identification of phytoconstituent(s) responsible for hair growth activity and its probable mechanism of action. Materials and methodsOur work introduces an effective isolation protocol for the active fraction from B. eriantha DC extract using chromatographic techniques. Fraction A was isolated by using mobile phase toluene:acetone (9:1). In-vitro and in-vivo methods were executed for the evaluation of hair growth activity. Moreover, the docked conformations of the isolated phytoconstituent Dimethyl sulfone was compared to Minoxidil for selected proteins namely 2FGF, 2PVC and 4U7P. The PDB identifications 2PVC (DNMT3L recognizes unmethylated histone H3 lysine 4), 4U7P (Crystal structure of DNMT3A-DNMT3L complex and 2FGF (Human Basic Fibroblast Growth Factor) were downloaded from Protein Data Bank. ResultsThe study data revealed that B. eriantha DC alcoholic extracts exhibited prominent hair growth activity and it was affirmed that Dimethyl sulfone a phyto-constituent isolated from B. eriantha DC alcoholic extract contributed for the same. ConclusionThe findings strongly suggest hair growth promotion potential of the extract of B. eriantha DC.

Effect of Treatment with Cleome Scaposa DC and Cleome Viscose L on Plasma Cholesterol and Atherogenic Index

This study aims to evaluate the effect of Cleome scaposa DC and Cleome viscose L on the lipid profile in Albino rabbits. The goal of the study was to discover newer ways to treat hyperlipidemia. Thirty albino rabbits were randomly divided into three groups (n = 10, per group). The daily oral dosing of ethanol extract of Cleome scaposa DC and ethanol extract of Cleome viscose L was administered respectively to groups1 and 2, while group 3 was considered the control group. Blood samples were taken at the end of the first, second, and fourth weeks. There was significant reduction in total cholesterol (F2, 4 = 10.85, P &lt; 0.05), triglyceride levels (F2, 4 = 1.686, P &lt; 0.05) and low-density lipoprotein (LDL) levels (F2, 4 = 1.97, P &lt; 0.045) in the treated groups of albino rabbits. A significant increase was seen in high-density lipoprotein (HDL) levels (F2, 4 = 29.095, P &lt; 0.05) in both groups treated. Cleome scaposa and Cleome viscose decreased total cholesterol. Both the herbs possess various constituents, which would be beneficial for treating different diseases. Studies regarding the phytochemistry of these herbs will be required before knowing the mechanism of action.

Effect of the dry Rhaponticum uniflorum (L.) DC extract on the state of the immune and antioxidant systems of the body in experimental immunodeficiency

Effect of the dry Rhaponticum uniflorum (L.) DC extract on the state of the immune and antioxidant systems of the body in experimental immunodeficiency