In this paper we present a DC-Bus control strategy elaborated to manage electrical power transfer for desalination system coupled to hybrid source (PV-Wind) via DC-Bus without using electrochemical storage. Reverse Osmosis (RO) technology is used to produce freshwater in this desalination system. The power control strategy elaborated called Power Field Oriented Control (PFOC) allows simultaneously the control of DC-Bus voltage and electrical power flow transfer from hybrid source to centrifugal motor-pump used for desalination. Experimental results issued from implementation of the proposed control are presented and compared to simulation results. A critical discussion is detailed to evaluate performance and effectiveness of the global system.