The increasing penetration of renewable sources with power-electronic interfaces in power systems is raising technical problems and the overall efficiency of photovoltaic systems can decrease dramatically. In this context, the optimal layout for the photovoltaic system is required. The most adequate strategy to connect the renewable system to the electrical power grid or to supply the end users must be adopted. The present paper proposes a design layout of a PV plant using a DC bus system to improve the overall energy conversion efficiency. An analysis of steady-state system stability, voltage drop and DC cable conduction losses is conducted. The leakage currents to the ground are investigated through simulations. Experimental results are shown focused on the analysis of optimal layout of photovoltaic systems under particular operating conditions.