In this work, we propose a passive radio frequency (RF) front-end tailored for wake-up receivers (WuRx) to be deployed in cellular IoT devices and wearables networks, featuring a low radiation resistance antenna and a high-Q matching network implemented with microacoustic resonators integrated to obtain a systematic higher node’s sensitivity at no cost in terms of power consumption. We show how these components can be co-designed to obtain high passive voltage gain, hardwarelevel blocker immunity, and increased resilience to integration parasitics, relaxing link budget for low-power IoT nodes. We report experimental validation of a PCB antenna with 2 dBi gain measured on an 11Ω input resistance at resonance, and an in-house fabricated Micro-Electro-Mechanical System (MEMS) thin-film aluminum nitride bulk acoustic resonator with a quality factor Q = 550 and a piezoelectric coupling coefficient k2 t =7%, hybridly integrated with a commercial off-the-shelf low-power WuRx circuit to benchmark the proposed RF front-end design at 850MHz. We demonstrate a passive voltage gain of 12 dB due to the MEMS resonator, and an additional 11 dB due to the proposed antenna design (for a total of an unprecedented 23 dB passive gain in this frequency range) leading to an over the air.61dBm minimum detectable input power and 23 dB blocker rejection.