Daytime Values Research Articles

Polygraphy of Sleep at Altitudes Between 5300 m and 7500 m During an Expedition to Mt. Everest (MedEx 2006)

Sleep at extreme altitudes is characterized by the repetitive occurrence of central apneas that in some cases may lead to a marked decrease in arterial oxygen saturation. During the Ludwig Maximilians University Expedition to Mt. Everest (MedEx 2006), nocturnal polygraphic recordings were made at different altitudes and included the first recordings ever made at 7500 m, which were completed on 8 separate occasions during the expedition. The study was performed on the author (K.M., 58 years, 181 cm, 75 kg), who is an experienced high-altitude mountaineer. The standard polygraphic parameters, such as nasal and oral airflow, thoracic and abdominal effort, oxygen saturation, heart rate, body position, movement, and snoring, were collected with a portable sleep recording device (AlphaScreen, SensorMedics, Germany, Hochberg) at different altitudes between 5300 m and 7500 m, and were compared with baseline assessments made in Munich, Germany (altitude 508 m). The daytime value of oxygen saturation at rest was measured at South Col (8000 m) and at the South Summit (8763 m) without breathing supplemental oxygen for at least 10 minutes. The number of apneas and hypopneas of central origin increased up to a maximum of 148/h with a minimal blood oxygen saturation of 48% at 7500 m, compared with <5/h at Munich. After 11 days of acclimatization, data recorded at 5300 m showed a marked reduction of disturbed sleep. The Apnea-Hypopnea-Index dropped from 138/h to 51/h, and the minimal blood oxygen saturation rose from 57% to 67%. At South Col (8000 m), the daytime value of oxygen saturation at rest ranged between 53% and 55%, and on South Summit (8673 m) without breathing supplemental oxygen for at least 10 minutes, it fluctuated around 50%. These data correlate well compared with those obtained in hypobaric chamber studies and show that regardless of physiologic adjustment to low oxygen conditions at Base Camp altitude, during the final summit attempt oxygen saturation drops further to 55% and even less. Thus recordings of nocturnal oxygen saturation at Camp 3 (7500 m) on Everest, where the night is spent before the summit attempt, may help to show the actual efficiency of hypoxic ventilatory response and to detect the individual hypoxic tolerance to altitudes above 8000 m.

Influence of Concurrent Obesity and Low Birth Weight on Blood Pressure Phenotype in Youth

The aim of this study was to assess the impact of obesity and low birth weight on both office and ambulatory blood pressure (BP) values, as well as on aortic-derived parameters in youths. A total of 422 white youths, from 10 to 18 years of age, were included. Subjects were divided into 4 groups according to the presence (234; 55%) or the absence (188; 45%) of obesity and according to low (114; 27%) or normal (308; 73%, birth weight. Spacelabs 90207 was used to measure ambulatory BP during a 24-hour period. SphygmoCor radial/aortic transform software was used to estimate aortic pressure waveform. Office, 24-hour, daytime, and nighttime systolic BP values were significantly higher in those subjects with low birth weight who became obese. The lowest BP values were present in nonobese subjects in the absence of low birth weight. In the middle, with similar BP values, were nonobese subjects with low birth weight and obese subjects in the absence of low birth weight. No interaction existed between obesity and low birth weight in the office (P=0.165) or ambulatory (P=0.603) systolic BP values. Augmentation index, an estimate of the pulse wave reflection, was significantly higher in the nonobese low birth weight group when compared with the other groups after controlling for height, heart rate, and diastolic BP. A significant interaction between low birth weight and obesity (P<0.005) existed. In conclusion, although the low birth weight children who become obese have the highest systolic BP values, the presence of obesity blunts the increment of the reflecting wave observed in low birth weight subjects.

A new mass conservation approach to the study of CO2 advection in an alpine forest

A new method is proposed for the computation of CO2 Net Ecosystem Exchange (NEE) and its components in a forest ecosystem. Advective flux is estimated by taking into account the air mass conservation principle. For this purpose, wind and dry air density values on the surface of the control volume are first corrected and then the advective flux is estimated on the surface of the control volume. Turbulent flux is also computed along the surface of the control volume while storage flux is computed inside the volume. Additional characteristics of this method are that incompressibility of the mean flow is not assumed a priori, and that vertical and horizontal advective fluxes are not treated separately, but their sum is estimated directly. The methodology is applied to experimental data collected with a three‐dimensional scheme at the alpine site of Renon during the Advex project (July 2005). The advection flux was found to be prevailing positive at night and negative during the day, as was found in previous studies on advection for the same site, but showed a lower scatter in half‐hour calculated values. We tested the effect of its summation on turbulent and storage fluxes to produce half‐hourly values of NEE. Nighttime NEE values were used in functional relations with soil temperature, daytime values with PPFD. The effect of addition of the advection component was an increase in the values of parameters indicating ecosystem respiration, quantum yield, and photosynthetic capacity. The coefficient of correlation between NEE and environmental drivers increased.

Anomalous variations of &amp;lt;I&amp;gt;Nm&amp;lt;/I&amp;gt;F2 over the Argentine Islands: a statistical study

Abstract. We present a statistical study of variations in the F2-layer peak electron density, NmF2, and altitude, hmF2, over the Argentine Islands ionosonde. The critical frequencies, foF2, and, foE, of the F2 and E-layers, and the propagation factor, M(3000)F2, measured by the ionosonde during the 1957–1959 and 1962–1995 time periods were used in the statistical analysis to determine the values of NmF2 and hmF2. The probabilities to observe maximum and minimum values of NmF2 and hmF2 in a diurnal variation of the electron density are calculated. Our study shows that the main part of the maximum diurnal values of NmF2 is observed in a time sector close to midnight in November, December, January, and February exhibiting the anomalous diurnal variations of NmF2. Another anomalous feature of the diurnal variations of NmF2 exhibited during November, December, and January when the minimum diurnal value of NmF2 is mainly located close to the noon sector. These anomalous diurnal variations of NmF2 are found to be during both geomagnetically quiet and disturbed conditions. Anomalous features are not found in the diurnal variations of hmF2. The statistical study of the NmF2 winter anomaly phenomena over the Argentine Islands ionosonde was carried out. The variations in a maximum daytime value, R, of a ratio of a geomagnetically quiet daytime winter NmF2 to a geomagnetically quiet daytime summer NmF2 taken at a given UT and for approximately the same level of solar activity were studied. The conditional probability of the occurrence of R in an interval of R, the most frequent value of R, the mean expected value of R, and the conditional probability to observe the F2-region winter anomaly during a daytime period were calculated for low, moderate, and high solar activity. The calculations show that the mean expected value of R and the occurrence frequency of the F2-region winter anomaly increase with increasing solar activity.

Daytime levels of melatonin in patients with age‐related macular degeneration

Melatonin (N-acetyl-5-methoxytryptamine) (MT) is a hormone that acts as an antioxidant. It is produced by the pineal gland and within the retina; its release is blocked by light entering the eye. We examined whether MT daytime levels differ between pseudophakic patients with age-related macular degeneration (ARMD) and pseudophakic subjects without any ocular pathology of the same age. A prospective, cross-sectional, observational study was performed. Pseudophakic patients of the same age group were included. Patients underwent complete ophthalmic examinations and blood sampling between 08:00 and 10:00 hr. MT daytime value in the serum was the main outcome measure. Sixty-nine pseudophakic patients were included. Fifty patients with exudative and non-exudative ARMD were in the study group while 19 patients were controls. Patients with ARMD had significantly higher daytime levels of MT (P = 0.003). There were significant differences in MT daytime levels between the exudative and non-exudative forms (P = 0.009). MT values also correlated with the best-corrected visual acuity (r = -0.285, P = 0.019). These data indicate that pseudophakic patients with ARMD produce more MT during the day compared to pseudophakic subjects without ARMD. This may be caused by the reduced visual acuity in patients with ARMD, whereby less light reaches the photoreceptors, allowing MT secretion to continue during the day. Because MT also acts as an antioxidant and daytime levels are higher in patients with ARMD, these results might be interpreted as a rescue factor.

Spectral wave analysis at the mesopause from SCIAMACHY airglow data compared to SABER temperature spectra

Abstract. Space-time spectral analysis of satellite data is an important method to derive a synoptic picture of the atmosphere from measurements sampled asynoptically by satellite instruments. In addition, it serves as a powerful tool to identify and separate different wave modes in the atmospheric data. In our work we present space-time spectral analyses of chemical heating rates derived from Scanning Imaging Absorption SpectroMeter for Atmospheric CHartographY (SCIAMACHY) hydroxyl nightglow emission measurements onboard Envisat for the years 2002–2006 at mesopause heights. Since SCIAMACHY nightglow hydroxyl emission measurements are restricted to the ascending (nighttime) part of the satellite orbit, our analysis also includes temperature spectra derived from 15 μm CO2 emissions measured by the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument. SABER offers better temporal and spatial coverage (daytime and night-time values of temperature) and a more regular sampling grid. Therefore SABER spectra also contain information about higher frequency waves. Comparison of SCIAMACHY and SABER results shows that SCIAMACHY, in spite of its observational restrictions, provides valuable information on most of the wave modes present in the mesopause region. The main differences between wave spectra obtained from these sensors can be attributed to the differences in their sampling patterns.

Home blood pressure telemonitoring improves hypertension control in general practice. The TeleBPCare study

Self blood pressure monitoring at home may improve blood pressure control and patients' compliance with treatment, but its implementation in daily practice faces difficulties. Teletransmission facilities may offer a more efficient approach to long-term home blood pressure monitoring. Twelve general practitioners screened 391 consecutive uncontrolled mild-moderate hypertensive patients (80% treated), 329 of whom (58 +/- 11 years, 54% men) were randomized to either usual care on the basis of office blood pressure (group A, n = 113) or to integrated care on the basis of teletransmitted home blood pressure (group B, n = 216). Twenty-four-hour ambulatory blood pressure monitoring was performed at baseline and after 6 months, during which treatment was optimized according to either office (group A) or home (group B) blood pressure values. We compared differences between groups in the rate of daytime ambulatory blood pressure normalization (<130/80 mmHg), need of treatment changes during follow-up, quality of life scores, and healthcare costs. Baseline office blood pressures were 149 +/- 12/89 +/- 9 and 148 +/- 13/89 +/- 7 mmHg in groups A (n = 111) and B (n = 187) respectively, the corresponding daytime values being 140 +/- 11/84 +/- 8 and 139 +/- 11/84 +/- 8 mmHg. The percentage of daytime blood pressure normalization was higher in group B (62%) than in group A (50%) (P < 0.05). There were less frequent treatment changes in group B than in group A (9 vs. 14%, P < 0.05). Quality of life tended to be higher and costs lower in group B. Patients' management based on home blood pressure teletransmission led to a better control of ambulatory blood pressure than with usual care, with a more regular treatment regimen.

Time and spatial variations of the foF2(night)/foF2(day) values

The ratio of daytime and nighttime values of the foF2 critical frequency is analyzed on the basis of the data of 35 ionospheric stations of the eastern hemisphere and 7 stations of the western hemisphere. The analysis confirms the results of Danilov [Danilov, A.D. Variations in the ratio of nighttime and daytime critical frequencies of the F2 layer. Geomagn. Aeronomy, 47 (6), 551–561 (in Russian) 2007; Danilov, A.D. Time and spatial variations in the ratio of nighttime and daytime critical frequencies of the F2 layer, J. Atmos. Sol-Terr. Phys. 70, 1201–1212, 2008.] that after about 1980, a systematic behavior of this ratio with time is observed: an increase with time (a positive trend) or a decrease with time (a negative trend). The sign of this trend is shown to be governed by the signs of the magnetic declination D and magnetic inclination I at the given ionospheric station. This fact makes it possible to assume that the above indicated trend is caused by long-term variations in the zonal component V ny of the horizontal wind in the thermosphere, the latter component contributing into the vertical drift velocity W.

Critical frequencies foF2 as an indicator of trends in thermospheric dynamics

The time variations in three parameters during the last decades are considered. R(foF2) is the correlation coefficient between the nighttime and daytime values of foF2 for the same day. Stable trends are found for the minimum (R(foF2)(max)) and maximum (R(foF2)(min)) values of R(foF2) during a year. The foF2(night)/foF2(day) ratio demonstrates both, negative and positive trends, and the trend sign depends on the inclination I and declination D of the magnetic field. The correlation coefficient r(h, fo) between foF2 and the 100 hP level in the stratosphere demonstrates a decrease (in the years of maximum and minimum solar activity) from the 1980s to the 1990s. The trends in all three groups of data are considered under the assumption of long-term changes in the circulation in the upper atmosphere.

Nonalcoholic fatty liver disease, adiponectin and insulin resistance in dipper and nondipper essential hypertensive patients

The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is multifactorial, and the presence of insulin resistance is recognized as the pathophysiological hallmark of this condition. Arterial hypertension is referred as an insulin-resistant state, and insulin resistance may substantially contribute to the cardiovascular risk in this disorder. We examined the inter-relationship between insulin sensitivity, adiponectin levels, and NAFLD in hypertensive patients with different circadian blood pressure profiles. Eighty never-treated patients with essential hypertension were selected for having a nocturnal decrement of blood pressure that was at least 10% (dippers, n=47) or less than 10% (nondippers, n=33) of daytime values. No patient had diabetes mellitus, obesity, hyperlipidemia, or other risk factors for hepatic disease. The two groups were similar as to sex, age, and BMI. Abdominal fat distribution and NAFLD were assessed by ultrasonography. Hepatic steatosis was detected in 57.5% of all patients. Nondippers showed a higher prevalence of NAFLD than dippers (81.8 vs. 40.4%, P<0.005). Insulin and the homeostasis model of assessment index were higher (P<0.001) and adiponectin was lower (P<0.001) in nondippers than in dippers, whereas no difference was found in regional fat, liver enzymes, and other metabolic parameters. At multivariate analysis, factors independently associated with nondipping were insulin (P<0.05) and adiponectin (P<0.01) with the homeostasis model of assessment index being of borderline significance. In the absence of major risk factors for the development of NAFLD, a high prevalence of liver steatosis was associated with insulin resistance and low adiponectin levels in essential hypertensive patients with a nondipping profile.

Hydroacoustic fish biomass assessment in man-made lakes in Tunisia: horizontal beaming importance and diel effect

We used a Simrad EK60 echosounder equipped with two split-beam transducers to develop a sampling strategy for assessing fish resources in Tunisian man-made lakes. Day and night surveys, using vertical and horizontal beaming, were carried out between December 2006 and February 2007, a period when fish catchability is high. Four reservoirs with differing surface areas and bathymetries were selected. Echogram analysis revealed that fish communities were mainly composed of individual targets. A few schools were detected near the surface during daylight, but these schools dispersed slightly at night. In these multispecies reservoirs, considerable day and night differences in density existed, but with no clear trend. Target strength (TS) distribution mode values detected at night were always lower or equal to daytime values. Biomass estimates were significantly higher during daytime in three reservoirs, corresponding with higher TS modal values. In the other reservoir, the biomass estimate was significantly higher during nighttime corresponding with higher mean density during this period. Using only a vertically aimed transducer in our study reservoirs would have led to an underestimate of density and biomass by 5–100% and 20–100%, respectively, depending on the man-made lake. We conclude that acoustic sampling in our reservoirs must be done during day and night and that both vertical and horizontal beaming must be used to obtain the best possible picture of the fish stocks.

Short-time variation of mercury speciation in the urban of Göteborg during GÖTE-2005

Mercury species samples for gaseous elemental mercury (GEM) with a temporal resolution of 5 min, 5 h and 20 min integrated measurements of reactive gaseous mercury (RGM), and 24-h sampling of particulate mercury (HgP) at urban Femman and total gaseous mercury (TGM) at rural Rörvik were conducted during the measurement campaign GÖTE-2005 in Göteborg, Sweden. Results showed that average concentrations for GEM, RGM, HgP and TGM were 1.96 ± 0.38 ng m −3, 2.53 ± 4.09 pg m −3, 12.50 ± 5.88 pg m −3 and 1.63 ± 0.19 ng m −3, respectively. A reverse diurnal distribution pattern between GEM and RGM was observed, and early morning GEM concentration was elevated compared to daytime values which was likely due to activation of fossil fuel combustion, electric utilities, etc., by the formation of a nighttime inversion layer, less activity of GEM and reduced mixing. The subsequent decline and afternoon minimum were likely related to increase vertical mixing, photochemical reaction, and coupling with the coal combustion. However, the photochemical conversion from GEM during daytime and nocturnal behavior of “sticky” gases under higher relative humidity may result in strong diurnal cycles for RGM. Sampling site was heavily affected by anthropogenic sources from two distinguished wind sectors. One was ESE-SSW sector which was likely impacted by long distance transport from south highly industrialized region; the other was likely tied with local sources from N–NE sector.

Spatial and temporal distribution of gaseous elemental mercury in Chongqing, China

In order to investigate the spatial and temporal variability of atmospheric mercury (Hg) in Chongqing, China, gaseous elemental mercury (GEM) was measured from August 2006 to September 2007, using Lumex multifunctional mercury analyzer RA-915(+) (Lumex Ltd., Russia). The mean GEM concentration was 6.74 +/- 0.37 ng m(-3) in Chongqing, much higher than the accepted global background values (1.5-2 ng m(-3)). The GEM concentrations were different in different function areas. GEM in transport, industrial and commercial areas were 7.07 +/- 1.04, 7.05 +/- 0.96 and 6.71 +/- 1.10 ng m(-3), respectively, while GEM was 6.14 +/- 1.30 and 4.32 +/- 1.04 in the educational/recreational and nature conservation areas, suggesting that Hg emissions from mobile vehicles and industrial sources (specially coal combustion) were the most important contributors to atmospheric Hg in Chongqing. Mean Hg concentrations also had monthly variations with highest in November (8.24 +/- 0.50 ng m(-3)) and lowest values in August (5.36 +/- 0.70 ng m(-3)). Additionally, the diurnal variation of GEM concentrations was dependent on the local/regional atmospheric conditions. At Jinyun Mountain site (natural conservation area), hourly GEM concentrations had much higher values in daytime than at night. At Power Plant site, however, the hourly GEM concentrations were lower in daytime than at night. GEM concentrations in the air were correlated significantly with meteorological parameters except for barometric pressure.

Quarter‐wave modes of standing Alfvén waves detected by cross‐phase analysis

We have examined the diurnal variation of the local field line eigenfrequency at L ∼ 2.6 using cross‐phase analysis of Sub‐Auroral Magnetometer Network and Magnetometers Along the Eastern Atlantic Seaboard for Undergraduate Research and Education ground magnetometer array data. On several days the eigenfrequency was remarkably low near the dawn terminator, when one end of the field line was sunlit and the other end was in darkness. Later in the morning the eigenfrequency gradually increased to the normal daytime value. This type of diurnal eigenfrequency variation was found in both European and American meridians and in several seasons (March, June, and December). By modeling this situation we show that the extraordinarily low eigenfrequency events appeared when the ionospheric Pedersen conductance was strongly asymmetric between both ends of the field line, leading to the formation of quarter‐wavelength‐mode standing waves that revert to half‐wavelength modes as the dawn terminator passes both conjugate points. Ground‐based magnetometer measurements of local toroidal field line eigenfrequencies are often inverted to infer plasma mass density in the magnetosphere by assuming half‐wavelength‐mode standing field line oscillations. However, the mode structure and hence field line eigenfrequency also depend on the ionospheric conductance. In particular, we find that there is a threshold of interhemispheric conductance ratio for the quarter‐wavelength mode to be established. Our results therefore show that cross‐phase techniques can detect quarter‐wavelength‐mode waves, where the inferred mass density would be overestimated.

Long-term trends in the relation between daytime and nighttime values of &amp;lt;I&amp;gt;fo&amp;lt;/I&amp;gt;F2

Abstract. The data from the vertical ionospheric sounding for 12 stations over the world were analyzed to find the relation between the values of foF2 for 02:00 LT and 14:00 LT of the same day. It is found that, in general, there exists a negative correlation between foF2(02) and foF2(14). The value of the correlation coefficient R(foF2) can be in some cases high enough and reach minus 0.7–0.8. The value of R(foF2) demonstrates a well pronounced seasonal variations, the highest negative values being observed at the equinox periods of the year. It is also found that R(foF2) depends on geomagnetic activity: the magnitude of R(foF2) is the highest for the choice of only magnetically quiet days (Ap&lt;6), decreasing with the increase of the limiting value of Ap. For a fixed limitation on Ap, the value of R(foF2) depends also on solar activity. Apparently, the effects found are related to thermospheric winds. Analysis of long series of the vertical sounding data shows that there is a long-term trend in R(foF2) with a statistically significant increase in the R(foF2) magnitude after about 1980. Similar analysis is performed for the foF2(02)/foF2(14) ratio itself. The ratio also demonstrates a systematic trend after 1980. Both trends are interpreted in terms of long-term changes in thermospheric circulation.

Doppler lidar measurements of the great plains low-level jet: applications to wind energy

The southerly low-level jet (LLJ) of the Great Plains of the United States is a recurrent flow feature of the nighttime boundary layer of the region, which has been identified as a region of high potential for wind energy. The acceleration of the LLJ after sunset produces an enhancement of the wind speed over daytime values, and provides a dependable resource for wind energy. On the negative side, occasional bursts of strong turbulence may be generated that can be of just the right frequency to excite strong oscillatory response in the turbine rotors, thereby accelerating the fatigue of the rotor parts. High resolution Doppler lidar has been used in two studies of the LLJ over the U.S. Great Plains. In this paper we show the usefulness of this remote sensing tool in documenting the mean and turbulent vertical structure, and the evolution of these vertical structures through entire nights. This leads to implications about potential usefulness of Doppler lidar in monitoring mean winds and turbulence in real time to aid in turbine operations.

Critical frequency foF2 as an indicator of trends in thermospheric dynamics

Variations with time during recent decades of three parameters are considered. R(foF2) is the correlation coefficient between the nighttime and daytime values of foF2 within the same day. Stable trends are found for minimal ( R(foF2)(min)) and maximal ( R(foF2)(max)) values of R(foF2) over the year. The foF2(day)/foF2(night) ratio demonstrates both negative and positive trends; the sign of the trend being governed by the inclination I and declination D of the magnetic field. The correlation coefficient r( h,fo) between foF2 and the 100-hPa level in the stratosphere demonstrates a decrease (both, for the years of maximum and minimum solar activity) from the 1980s to the 1990s. The trends in all three groups of data are considered in the scope of an assumption that there is a long-term change in the circulation in the upper atmosphere. The data considered in the paper provide an indirect confirmation of the existence of this change and show the possibility that further studies of the thermospheric dynamics can be undertaken using ground-based ionospheric observations.

Ozone diurnal variations and mean profiles in the mesosphere, lower thermosphere, and stratosphere, based on measurements from SABER on TIMED

Ozone measurements from SABER on the TIMED satellite form a unique data set. They provide global information over the range of local solar times, from the lower stratosphere into the lower thermosphere, from the beginning of 2002, by one instrument. On the basis of zonal means of these data, we present new results from 20 to 100 km in altitude and from 48°S to 48°N in latitude, of ozone diurnal variations over 24 h in local solar time and over an annual cycle. While some of the results are new for the stratosphere, such comprehensive results for the mesosphere and lower thermosphere have not been available before. The diurnal variations generally become increasingly significant from the upper stratosphere into the lower thermosphere and provide information on the photochemistry of ozone and effects of transport over a diurnal cycle. Over most altitudes in the mesosphere and lower thermosphere (MLT), our estimates show the expected decrease in ozone after sunrise, with smaller variations during the day, and the increase near sunset. Outside of a small altitude near 80 km, the nighttime mixing ratios are generally larger than the daytime values. The diurnal variations themselves appear to exhibit variations over an annual cycle, including semiannual and annual variations. We compare the SABER results with data obtained about 10 years earlier by the MLS instrument on UARS, and with results by others based on data from HRDI on UARS, from the Solar Mesosphere Explorer (SME), from selected space shuttle experiments, and from ground‐based measurements. From the middle mesosphere to higher altitudes, departures from local thermodynamic equilibrium (non‐LTE) can be significant, and the uncertainties can be larger than those at lower altitudes.

Circadian rhythm in salivary melatonin in narcoleptic patients

Narcolepsy is characterized, beside other features, by excessive daytime sleepiness and disturbed sleep at night. The pineal hormone melatonin may affect the sleep characteristics. The aim of the study was to compare the circadian rhythm in salivary melatonin in narcoleptic patients with that in control healthy subjects; 18 patients and 21 age- and gender-matched controls were involved. Narcoleptic patients exhibited a nocturnal increase in salivary melatonin similar to the one in control subjects. The morning melatonin decline in the narcoleptic group, as opposed to the control group was, however, not significant, as 8 out of 18 patients exhibited elevated melatonin levels also during the day. In these patients, the mean daytime value of the multiple sleep latency test (MSLT) was decreased when compared with that in patients with undetectable daytime melatonin levels. The results suggest that in some narcoleptic patients the circadian rhythm might be disturbed.

Background ozone levels of air entering the west coast of the US and assessment of longer-term changes

An analysis of surface ozone measurements at a west coast site in northern California (Trinidad Head) demonstrates that this location is well situated to sample air entering the west coast of the US from the Pacific Ocean. During the seasonal maximum in the spring, this location regularly observes hourly average ozone mixing ratios ⩾50 ppbv in air that is uninfluenced by the North American continent. Mean daytime values in the spring exceed 40 ppbv. A location in southern California (Channel Islands National Park) demonstrates many of the characteristics during the spring as Trinidad Head in terms of air flow patterns and ozone amounts suggesting that background levels of ozone entering southern California from the Pacific Ocean are similar to those in northern California. Two inland locations (Yreka and Lassen Volcanic National Park) in northern California with surface ozone data records of 20 years or more are more difficult to interpret because of possible influences of local or regional changes. They show differing results for the long-term trend during the spring. The 10-year ozone vertical profile measurements obtained with weekly ozonesondes at Trinidad Head show no significant longer-term change in tropospheric ozone.