The World Meteorological Organization Aircraft Meteorological Data Relay (AMDAR) programme refers to meteorological data gathered by commercial aircraft and made available to weather services. It has become a major source of upper-air observations whose assimilation into global models has greatly improved their performance. Near busy airports, AMDAR data generate semi-continuous vertical profiles of temperature and winds, which have been utilized to produce climatologies of atmospheric-boundary-layer (ABL) heights and general characterizations of specific cases. We analyze 2017–2019 AMDAR data for Santiago airport, located in the centre of a 40times 100 km^2 subtropical semi-arid valley in central Chile, at the foothills of the Andes. Profiles derived from AMDAR data are characterized and validated against occasional radiosondes launched in the valley and compared with routine operational radiosondes and with reanalysis data. The cold-season climatology of AMDAR temperatures reveals a deep nocturnal inversion reaching up to 700 m above ground level (a.g.l.) and daytime warming extending up to 1000 m a.g.l. Convective-boundary-layer (CBL) heights are estimated based on AMDAR profiles and the daytime heat budget of the CBL is assessed. The CBL warming variability is well explained by the surface sensible heat flux estimated with sonic anemometer measurements at one site, provided advection of the cool coastal ABL existing to the west is included. However, the CBL warming accounts for just half of the mean daytime warming of the lower troposphere, suggesting that rather intense climatological diurnal subsidence affects the dynamics of the daytime valley ABL. Possible sources of this subsidence are discussed.