Event Days Research Articles

Disruptions in global trade routes: market reactions to the US–Houthi conflict in the consumer cyclical sector

Purpose This study aims to investigate the market reaction in the cyclical consumer sector to the US–Houthi conflict. Furthermore, the authors explore the impact of this conflict on market reactions by market and region. Design/methodology/approach Using an event study methodology, this paper analyze a sample of 1,973 companies. This paper used multiple event windows, including a 15-day period before the invasion announcement as the preinvasion event and a 15-day period after the invasion announcement as the postinvasion event. Findings The authors find that pre the event of war, the market tended to show a positive reaction, but toward the event day until post event, the market in the consumer cyclical sector actually reacted significantly negatively to the conflict, especially in developed and developing markets. The Asia and Pacific market is the market that feels the most negative impact from the US–Houthi conflict compared to other markets. Furthermore, in terms of industry types in the consumer staples sector, Food and Tobacco and Personal and Household Products and Services felt the negative impact, although the majority of all industries reacted significantly negatively. Originality/value This study focuses on the US–Houthi conflict, an event that has not been extensively studied in the context of market reactions. Unlike previous research, this study specifically examines the impact of the conflict on the consumer cyclical sector, emphasizing the significance of trade route disruptions, particularly the Suez Canal, on global markets. By providing insights into how such geopolitical events affect different regions and industries, this study offers valuable guidance for policymakers and managers in mitigating the adverse effects of geopolitical risks on market stability.

Unveiling the safety profile of lecanemab: A comprehensive analysis of adverse events using FDA adverse event reporting system data.

Lecanemab, a novel monoclonal antibody targeting amyloid-β, has shown promise in treating Alzheimer's disease. Comprehensive post-marketing safety data analysis is crucial to understand its real-world risk profile. This study aimed to evaluate the safety profile of lecanemab using data from the FDA Adverse Event Reporting System (FAERS), with a focus on nervous system disorders and amyloid-related imaging abnormalities. We conducted a disproportionality analysis using the FAERS database to evaluate the safety signals associated with lecanemab. Reporting odds ratio (ROR), proportional reporting ratio, empirical Bayesian geometric mean, and information component were calculated at both system organ class (SOC) and preferred term (PT) levels. Additionally, we performed a time-to-onset analysis using Weibull shape parameter estimation. Analysis at the SOC level revealed significant signals for nervous system disorders (ROR: 7.32, 95% CI: 6.69-8.00). At the PT level, strong signals were observed for amyloid-related imaging abnormalities, particularly those associated with microhemorrhages and oedema (ROR: 4122.81 and 3922.78, respectively). Headache was the most frequently reported adverse event (200 cases), followed by chills (107 cases) and fatigue (97 cases). Time-to-onset analysis showed a median time of 33 days (range: 1-1283) for all adverse events, with neurological events occurring slightly later (median: 42 days, range: 1-1260). Our findings highlight a distinct safety profile for lecanemab, with a predominant impact on the nervous system and a notable association with imaging abnormalities. These results underscore the importance of vigilant monitoring and further research to optimize the risk-benefit profile of lecanemab in clinical practice.

An Event Study on Impact of Russia-Ukraine War on Indian Banking Sector Stock

Aim: To study the impact of the Russia-Ukraine event on the performance of banking sector stocks. Study Designs: The descriptive statistical analysis has been done for six selected banks and is based on the Russia-Ukraine war. Study employs event analysis method for analysis. Place and Duration of Study: The secondary data has been downloaded from the NSE site, and the study duration is pre- and post-90 days from the event day and 120 days for the event window and 210 days for the estimation window has been considered. Methodology: The event analysis method has been used in which a paired t-test has been employed. We have checked significant at a p-value of 0.10 (10% level). Significant at p-value of 0.05 (5% level) Significant at p-value of 0.01 (1% level). Results: By examining a wide range of degrees of relationship between the two variables, we have tried to analyze how financial markets respond to changes in the warlike situation and how conditions impact asset prices. The results show the impact of the event before and after the event date. This analysis fills the gap in understanding event-specific impacts on financial institutions. Conclusion: The study provides insights into whether market behavior remained stable (null hypothesis accepted) or displayed volatility (alternate hypothesis accepted) across 90 days for global crises like the Russia-Ukraine war. The findings of the research have implications for the banking sector of India, policymakers, investors, and researchers. The research provides numerical and non-numerical information that other researchers can employ for cross-study analysis or for verifying theories. Lingering questions from the investors, including those in search of portfolio diversification strategies and the right time to invest. The discovery empowers the firms to have better policies inside and better relations outside, with customers and other stakeholders, such as during the change in monetary policy or in external shocks.

Evaluating the Policy Implications of Renewable Portfolio Standards on Grid Reliability in the United States: An Instrumental Variable Quantile Analysis

This paper investigates the influence of Renewable Portfolio Standards (RPSs) on the reliability of grids while considering key indicators, including the System Average Interruption Duration Index (SAIDI), System Average Interruption Frequency Index (SAIFI), and Customer Average Interruption Duration Index (CAIDI), both without and with the inclusion of Major Event Days (MEDs). The study adopted the instrumental variable quantile regression (IVQR) method for estimation purposes. The first-stage 2SLS results confirm the robustness and validity of the instruments used, including the Democrats’ Participation Rate, Real Average Household Income, and Renewable Energy Capacity, which show strong relevance and satisfy the conditions of homogeneity. Our findings demonstrated that the adoption of RPS policies has significantly decreased the interruption of power in all of the considered quantiles. The impact is more potent in states facing more severe reliability challenges. The results proved the important role of the policies of RPSs in improving the stability of grids in the context of states having relatively poor reliability. In summary, the obtained findings demonstrate significant insights related to the policies of renewable energy in the resilience of infrastructure. Finally, the findings suggest that the government authorities should promote the RPS as a tool for enhancing the performance of grids in different states.

Mental health and sleep routines: Uttarkashi, India tunnel collapse workers' experience.

Among the mental health outcomes and disaster types (determined by damage to life, property, long-term consequences, displacement, and unpredictability), floods are associated with anxiety and sleep problems, mudslides with anxiety and mood disturbance, volcanic eruptions with acute stress reactions, and earthquakes with anxiety, depression, and physical complaints. Disasters such as tunnel collapse are unique as it involves the healthy, without loss of personal property or displacement; hence, they can have very different health-related outcomes. In this study, we explore mental health and sleep-related issues in workers rescued from an under-construction collapsed tunnel trapped for 17 days. After the initial triage and stabilization and a detailed evaluation of their physical and mental health status, the participants responded to self-administered scales for assessing anxiety [Generalized Anxiety Disorder-7], depression [Patient Health Questionnaire-9], and insomnia [Insomnia Severity Index] in the local language (Hindi). A separate research team conducted open-ended interviews to explore daily routines and concerns, circadian rhythm, orientation to time and day of tunnel collapse to day of rescue events, and sleep routine (and other nuances such as sleep quality and daytime napping) during the 17 days of entrapment. Thirty-three workers consented and hailed from the northern and eastern states of India. They report a mix of hope and worry in the initial days. On the assessment of anxiety, depression, and sleep, only 2-5 scored above the cut-off value, and scales correlated with each other, though clinically it had no bearing. One-third were disoriented to the passage of time, which was related to difficulty falling asleep and more napping. Daytime napping was associated with delayed waketime. Those depressed had more difficulty in the onset, maintinance, and termination of sleep, and reduced total sleep time. Victims of tunnel collapse experience a different set of mental health and sleep problems compared to those reported in other disasters. The findings can partly be attributed to the disruption of light-dark cycles. As only a fraction develops these problems, there is a need for triaging while providing mental health and sleep-related interventions in such circumstances. Lastly, there is a need to establish a light-dark cycle to prevent disorientation among victims.

What they did next: Using follow-up phone calls to investigate health care access patterns of patients who take their own leave.

The purpose of the present study was to use telephone follow-up (TFU) to investigate the actions taken by patients after they took their own leave (TOL) from an ED, with a focus on priority groups who are at risk of experiencing health inequity. These included people experiencing homelessness (EH), people with a low socioeconomic status by index of relative socioeconomic disadvantage (IRSD) and First Nations people. The primary outcome was being seen by a general practitioner (GP) within 2 days of the TOL event. The utility of the TFU was also examined. This was an observational study of data collected during a quality improvement intervention at an inner-city, tertiary, teaching hospital in Melbourne from January to December 2022. Descriptive results were obtained from a TFU survey that was administered 24-48 h after the TOL event. During the study period, 4209 patients TOL from the ED. Eight hundred forty-one of these were contacted and consented to the TFU survey. 97.7% of patients expressed gratitude at being followed up. Patients EH, compared to patients not EH, were less likely to have seen their GP within 2 days of TOL event (0.295 [0.132-0.661], P < 0.001). Both First Nations patients and those from low IRSD areas were as likely to have seen their GP within 2 days as other groups. Patients EH were less likely to receive GP care within 2 days of TOL. Improving the access and acceptability of health care in these priority groups is important for achieving health equity.

Features of the situation of crimes against life and health committed by members of youth informal groups (associations)

The article emphasizes that the circumstances of crimes against life and health committed by members of youth informal groups (associations) are no less important elements of forensic characteristics than the trail picture and methods of their commission, because it allows obtaining objective forensically significant information , which contributes to more effective detection and investigation of criminal offenses. It is worth noting that the circumstances of committing the investigated crimes largely determine the overall mechanism of criminal activity of informal groups (associations) and are somewhat different from the circumstances of other types of crimes. the study of criminal proceedings (cases) made it possible to establish that crimes against life and health are committed by members of youth informal groups (associations), as a rule, in public places, in the time period from 18 to 24 hours. The date of the crime may be different and may be affected by the socio-psychological climate in the middle of the youth informal group (association), i.e. it may be in the evening from 18.00 to 24.00, or it may be at another time considering that sometimes such crimes occur spontaneously, are not planned in advance and can be committed under the influence of alcoholic beverages, psychotropic substances, narcotic drugs, etc. Also, delinquent behavior of representatives of informal groups can be provoked by spontaneous aggression towards representatives of other informal youth groups (associations). The commission of the researched type of crime can be associated with state, religious, cult holidays, dates of ceremonies and other important events for a certain informal youth group (association), as well as crimes can be committed on days of mass events, including sports events, rock concerts, festivals, etc. The practice of investigating crimes against a person’s life and health committed by members of youth informal groups (associations) shows that as tools and means in most cases criminals use metal sports equipment, rods, sticks, metal pipes, broken bottles, chains, military belt buckles, cold and firearms, etc. In addition, the places where informal youth commit crimes are mostly public places - roads and highways, underpasses, bus stops, premises of shops and entertainment establishments, residential areas located near houses, the same entertainment establishments and shops, recreation areas, including parks, parks, stadiums, concert halls, etc. Analysis of processed criminal proceedings indicates that crimes of the specified category are committed, as a rule, in conditions of obviousness (about 80%). The key factor for the specified category of crimes is that the situation of crimes against life and health committed by members of youth informal groups (associations) depends, first of all, on the type of youth informal group (bikers, skinheads, rockers, football fans, etc. .); secondly, from the degree of organization, hierarchy and structure of the group itself; thirdly, from other factors that immediately preceded the crime (drinking of alcoholic beverages, use of psychotropic or narcotic substances, etc.).

A Comparative Investigation of Different Ionospheric Models to Predict the MUF Parameter During Severe Geomagnetic Storm on 17th March 2015.

The present work aimed to make a comparative investigation between three different ionospheric models: IRI-2020, ASAPS and VOACAP. The purpose of the comparative study is to investigate the compatibility of predicting the Maximum Usable Frequency parameter (MUF) over mid-latitude region during the severe geomagnetic storm on 17 March 2015. Three stations distributed in the mid-latitudes were selected for study; these are (Athens (23.50o E, 38.00o N), Jeju (124.53o E, 33.6o N) and Pt. Arguello (239.50o W, 34.80o N). The daily MUF outcomes were calculated using the tested models for the three adopted sites, for a span of five-day (the day of the event and two days preceding and following the event day). The calculated datasets were compared for each location with the observed daily MUF values. In general, the findings show that the three investigated models gave good outcomes compared to the observed values for all selected stations. The comparative investigation results of the three tested models corresponding to the observed MUF values during the storm event revealed that the IRI -2020 Model indicate a clear impact of the geomagnetic storm on the predicted MUF values during the day of event. Similarly, for ASAPS Model, the storm's impact is clear on both the day of the event and the subsequent day, in contrast, the VOACAP model showed almost no impact of the geomagnetic storm on the observed MUF values throughout the entire study period for event 17 March 2015.

Anthropogenic Extremely Low Volatility Organics (ELVOCs) Govern the Growth of Molecular Clusters Over the Southern Great Plains During the Springtime

AbstractNew particle formation (NPF) often drives cloud condensation nuclei concentrations and the processes governing nucleation of molecular clusters vary substantially in different regions. The growth of these clusters from ∼2 to &gt;10 nm diameters is often driven by the availability of extremely low volatility organic vapors (ELVOCs). Although the pathways to ELVOC formation from the oxidation of biogenic terpenes are better understood, the mechanistic pathways for ELVOC formation from oxidation of anthropogenic organics are less well understood. We integrate measurements and detailed regional model simulations to understand the processes governing NPF and secondary organic aerosol formation at the Southern Great Plain (SGP) observatory in Oklahoma and compare these with a site within the Bankhead National Forest (BNF) in Alabama, southeast USA. During our two simulated NPF event days, nucleation rates are predicted to be at least an order of magnitude higher at SGP compared to BNF largely due to lower sulfuric acid (H2SO4) concentrations at BNF. Among the different nucleation mechanisms in WRF‐Chem, we find that the dimethylamine (DMA) + H2SO4 nucleation mechanism dominates at SGP. We find that anthropogenic ELVOCs are critical for explaining the growth of particles observed at SGP. Treating organic particles as semisolid, with strong diffusion limitations for organic vapor uptake in the particle phase, brings model predictions into closer agreement with observations. We also simulate two non‐NPF event days observed at the SGP site and show that low‐level clouds reduce photochemical activity with corresponding reductions in H2SO4 and anthropogenic ELVOC concentrations, thereby explaining the lack of NPF.

The Broad Impact of Contemporary Digital Marketing Strategies on Consumer Behavior

This research aims to explore the extensive impact of contemporary digital marketing strategies on consumer behavior. By analyzing the successful case of Alibaba’s Double Eleven event, it details how multi-channel reach, personalized marketing, and ad content influence consumer behavior. The case analysis reveals that Alibaba effectively increased consumer participation and purchase behavior during the promotional period and the event day through widespread media promotion, diverse interactive activities, and precise personalized recommendations using digital technology. The results demonstrate the significant impact of digital marketing strategies on consumer behavior. However, this research is limited by the recent data used, indicating certain constraints. Challenges such as privacy concerns and data security still need to be addressed. Future research should further explore the varying effects of digital marketing strategies across different cultural backgrounds and emerging technologies.

Predictors and outcomes of intracranial hemorrhage in 58,000 patients with atrial fibrillation on oral anticoagulation: insights from COMBINE-AF

Abstract Background Among anticoagulated patients with atrial fibrillation (AF), intracranial hemorrhage (ICH) is the leading cause of bleeding-related death and disability. The COMBINE-AF database has patient-level data from four major randomized-controlled trials [ROCKET-AF (rivaroxaban), RE-LY (dabigatran), ENGAGE-TIMI 48 (edoxaban), ARISTOTLE (apixaban)] of direct oral anticoagulants (DOACs) versus warfarin in patients with AF. Purpose/Methods We investigated the rates, predictors, and mortality of ICH in patients randomized to DOAC (rivaroxaban, dabigatran, edoxaban, apixaban) or warfarin. ICH was subclassified as subdural or non-subdural (intracerebral, intraventricular, subarachnoid, epidural). Multivariable Cox models were used to identify predictors of ICH. Frequencies and fatality rates of ICH were calculated and displayed as Kaplan-Meier curves. Results In COMBINE-AF, there were 58,634 patients randomized to either DOAC (n=29,362) or warfarin (n=29,272). The mean age was 70.5 years, 37% were female, and 81% were White. The mean CHA2DS2-VASc score was 2.6, 43% of patients had a history of smoking, 31% had diabetes, and 29% had prior stroke/TIA. After a mean of 32 months, ICH occurred in 593 patients (1.01%, 0.58 per 100-patient years, 95% CI [0.54, 0.63]). The most significant independent predictors of ICH in order of importance were: treatment with warfarin, older age, prior stroke/TIA, enrollment in Asia, antiplatelet use at randomization, and history/risk of falls (Figure 1). Mortality after ICH was 48.4% (287/593 participants), with a majority of deaths (82%) occurring within 30 days of ICH event. Non-subdural ICH was more common than subdural ICH (73% vs 25%) and had a higher risk of death (Figure 2). Participants randomized to DOAC had a lower risk of both subdural and non-subdural ICH than those treated with warfarin; however, mortality rates after ICH were similar regardless of anticoagulant type. Conclusion ICH is an uncommon but devastating complication of oral anticoagulation in patients with atrial fibrillation. The mortality rate following ICH is high, particularly following non-subdural ICH. To reduce the risk of ICH, clinicians should consider using DOACs over warfarin and carefully evaluate the need for antiplatelet therapy, particularly in patients with other significant predictors of ICH such as prior stroke, advanced age, residence in Asia, and history of falls.Predictors of Intracranial Hemorrhage90-Day Mortality after ICH

Estimated cost of VEGFR TKI associated adverse events in metastatic renal cell carcinoma patients

IntroductionThe majority of metastatic renal cell carcinoma (mRCC) patients receive one or more VEGFR TKI agents, alone or in combination with an immune-oncology (IO) agent or an mTOR inhibitor. To date, the cost of adverse events (AEs) common to VEGFR TKIs has not been quantified. This study estimated the potential impact of differences in VEGFR TKI AE profiles on treatment cost efficiency in the relapsed/refractory (R/R) setting.MethodsPatients with documented mRCC who were treated with VEGFR TKI therapies between Jan 2015 and Mar 2021 were identified using EMR. ICD-10 diagnosis codes were used to identify the first occurrence of each class effect AE. Patients were matched to 3rd party insurance claims, and costs associated to TKI AEs within 90 days of index event were captured. Average per patient AE cost data was calculated and applied to published incidence data to estimate regimen-specific AE total cost burden within a hypothetical commercial plan for mRCC patients undergoing treatment in the R/R setting.ResultsThe highest total cost for AE management was attributed to lenvatinib and everolimus use at $13,303, followed closely by sunitinib at $13,092. Tivozanib treatment was associated with the lowest total cost of AE management at $7,523, driven by the relatively lower incidence of certain high-cost AEs.ConclusionsThe estimated costs of managing VEGFR TKI class-effect AEs were lowest with tivozanib, and highest with lenvatinib and everolimus, indicating potentially differential healthcare resource burden by TKI regimen. The use of tivozanib in the 3 L + mRCC setting suggests potential costs offsets when compared to other TKI regimens.

An International, Expert-Based Delphi Consensus Document on Controversial Issues about TransCarotid Artery Revascularization (TCAR)

ObjectiveTransCarotid Artery Revascularization (TCAR) has emerged as an alternative therapeutic modality to carotid endarterectomy (CEA) and transfemoral carotid artery stenting (TFCAS) for the management of patients with carotid artery stenosis. However, certain issues regarding the indications and contraindications of TCAR remain unanswered or unresolved. The aim of this international, expert-based Delphi Consensus document was to attempt to provide some guidance on these topics. MethodsA 3-Round Delphi Consensus process was performed including 29 experts. The aim of Round 1 was to investigate the differing views and opinions of the participants. Round 2 was carried out after the results from the literature on each topic were provided to the participants. During Round 3, the participants had the opportunity to finalize their vote. ResultsMost participants agreed that TCAR can/can probably/possibly be performed within 14 days of a cerebrovascular event, but it is best to avoid it in the first 48 hours. It was felt that TCAR cannot/should not replace TFCAS or CEA, as each procedure has specific indications and contraindications. Symptomatic patients >80 years should probably be treated with TCAR rather than with TFCAS. TCAR can/can probably be used for the treatment of restenosis following CEA/TFCAS. Finally, there is a need for a randomized controlled trial to provide better evidence for the unresolved issues. ConclusionsThis Delphi Consensus document attempted to assist the decision-making of physicians/interventionalists/vascular surgeons involved in the management of carotid stenosis patients. Furthermore, areas requiring additional research were identified. Future studies and randomized controlled trials should provide more evidence to address the unanswered questions regarding TCAR.

Numerical evaluation of the impact of sandbars on cross-shore sediment transport and shoreline evolution

Nearshore nourishments are a common intervention used to mitigate sediment deficits in coastal areas experiencing erosion problems. This coastal intervention involves placing nourished sediments in the submerged zone of the beach profile to form an artificial submerged sandbar which are then distributed by natural forces occurring in the coastal zone. Coastal processes that control the morphological evolution of coastal zones operate on several spatial and temporal scales (seconds to years) and can be divided into cross-shore and longshore components. Usually, the numerical models that simulate the evolution of cross-shore profiles due to sediment transport within the profiles, are related with short to medium-term events (days to months), and shoreline evolution models, that allow for long-term analysis (years to decades), are typically only considering longshore sediment transport. Describing all the processes in a single numerical model is complex and computationally demanding, and therefore, the numerical models are typically focused on specific processes, categorized by their temporal and spatial scales. This article presents a numerical study focused on medium to long-term numerical modelling of coastal zone evolution, examining the combined effects of cross-shore and longshore sediment transport processes of sediment transport. The model incorporates two simplified numerical models: LTC - Long Term Configuration, for shoreline evolution and CS-Model, for cross-shore sediment exchanges. Applied to nine different sandbar scenarios, model results revealed that disturbances in sandbar volume tend to return to equilibrium through cross-shore sediment transport processes. In situations that considered a constant sandbar volume alongshore, the longshore effects are null, because the volume entering in the coastal domain is equal to the volume leaving, and the sediment balance is only dependent of the cross-shore processes. Variable sandbar volume alongshore leads to impacts on shoreline position due to longshore sediment transport gradients generated by the sandbar disturbance. The results demonstrate the potential of the proposed combined model for medium to long-term projections, allowing for the interpretation of how physical aspects of nearshore nourishments evolve. These aspects include sandbar volume, shoreline position, berm width, and shoreline displacements induced by cross-shore and longshore sediment transport processes. These parameters aid in understanding sandbar-beach sediment dynamics, which is valuable for supporting coastal management, particularly in the development and design of shoreface sand nourishments, enabling the optimization of sand resources.

Overdose as a complex contagion: modelling the community spread of overdose events following law enforcement efforts to disrupt the drug market

BackgroundThe opioid overdose mortality crisis in the USA is an ongoing public health epidemic. Ongoing law enforcement strategies to disrupt local unregulated drug markets can have an iatrogenic effect of...

Endovascular intervention for carotid blowout syndrome and predictors of recurrence: A retrospective and multicenter cohort study

IntroductionCarotid blowout syndrome (CBS) is a potentially life-threatening complication of head and neck cancer and associated treatment. In this study, we assess the safety and efficacy of deconstructive and reconstructive procedures with a focus on CBS recurrence. MethodsWe conducted a multicenter retrospective analysis of a prospectively maintained database and identified 80 consecutive neurointerventions for CBS from 2016 to 2020. Patients were divided into 2 groups: deconstructive embolization (68 patients) and reconstructive stenting (12 patients). A comparative analysis was performed between the two groups. ResultsThe CBS recurrence rate was 23.8 % with 84.2 % of recurrences occurring within 90 days of the primary event. The median time to rebleeding was 8.0 days (IQR: 2.0 – 28.5) with a mortality rate of 26.3 %. There was no significant difference in rates of peri-operative ischemic stroke (1.5 % vs. 0 %, p=0.672) or peri-operative mortality (1.5 % vs. 0 %, p=0.670). CBS recurrence was significantly higher in the reconstructive group (58.3 % vs. 17.6 %, p=0.002). On multivariate analysis, reconstructive stenting independently predicted rebleeding (adjusted hazard ratio 8.31, 95 % CI: 2.34–29.59, p=0.001). There was no significant association between CBS recurrence and pre-operative (p=0.600) or post-operative (p=0.275) anticoagulant/antiplatelet use. ConclusionCBS remains a challenging and potentially catastrophic complication of head and neck cancers. Reconstructive procedures, including stenting, predicted CBS recurrence independent of bleeding site or tumor invasion. Postoperative surveillance based on time intervals to CBS recurrence and engineering advancements including improved vessel reconstruction devices have the potential to reduce rehemorrhage rates and improve patient outcomes. Further clinical investigations amongst larger cohorts are needed.

Results of a New Treatment Protocol for Sudden Sensorineural Hearing Loss Using Betamethasone for Intratympanic Therapy.

Introduction Sudden sensorineural hearing loss (SSNHL) is defined as a rapid sensation of hearing impairment in one or both ears. Based on its personal impact on patients, the present study advances the analysis of new treatments for the prompt recognition and management of SSNHL, with higher chances of improvements in terms of hearing recovery and quality of life of the patients. Objective To describe the intratympanic (IT) corticoid infiltration technique, to demonstrate the efficacy of betamethasone injection as a sequential treatment in patients whose initial systemic steroid treatment failed, as well as to compare its use in different treatment periods. Methods The present clinical trial was conducted with 37 patients referred to our office with the diagnosis of SSNHL, from September 2019 to May 2022, who provided informed consent to participate. Results Even dividing the analysis of increasing the pure tone average (PTA) or speech recognition threshold (SRT) between the difference into initiation of the salvage therapy in up to 15 days of the sudden deafness event, and between 15 days and 3 months of the event, we did not find any difference in hearing improvement. Conclusion Intratympanic corticosteroid therapy is prescribed when conventional therapy fails or when there is a limitation to the use of corticosteroids due to the presence of systemic disorders. As such, new drugs, such as bethametasone, are studied and show promising results.

Impact of the Israel–Hamas conflict on financial markets of MENA region – a study on investors’ reaction

PurposeThis study aims to examine market reactions to the Israel–Hamas conflict in neighboring countries, particularly focusing on the Middle East North Africa (MENA) region.Design/methodology/approachThe study adopts an event study methodology, employing average abnormal return (AAR) and cumulative abnormal return as measures to assess market reactions. The sample for this study comprises 1,314 companies, with October 9, 2023, identified as the event day for analysis.FindingsThe results of our study indicate that countries in close proximity to Israel and Palestine encountered detrimental effects on their capital markets, as evidenced by negative responses observed across various sectors. Our analysis also reveals that countries in the midst of conflict, particularly Israel, experienced a decrease in their stock markets across various sectors, with the exception of materials and real estate. In addition, our investigation reveals disparities in market responses according to different categories of company size.Originality/valueThis research is the first to study market reactions to Israel–Hamas in the MENA region at the company level.

Abstract B040: Building a lung cancer awareness event

Abstract Introduction: Lung cancer is the top cancer killer in the United States. Lung cancer screening (LCS) can decrease mortality of lung cancer, but current uptake is low. Concentrated effort during lung cancer awareness month has potential to positively impact uptake. Patient engagement and education are meaningful ways for medical students to make an impact. Methodology: We created a lung cancer awareness event during November (Lung Cancer Awareness Month) that aims to educate and engage regarding lung cancer and LCS. Prior to event day: 1. We secured buy-in from LCS leadership at the hospital, nurse navigators of the LCS program, leaders of nonprofit organizations and lung cancer support group leadership. 2. We recruited medical students to assist with creating informational materials, promoting the event and staffing day-of. All students attended a 1-hour training session on priority messages regarding lung cancer and LCS, engaging people in surveys and connecting eligible patients with LCS. 3. Informational materials and promotional flyers were sent to the lung cancer screening leadership to ensure messaging was in-line with messaging by the hospital and nonprofit organizations. Day-of event prep: 4. Tables with lung cancer educational materials were placed at the hospital entrances where foot traffic was greatest and staffed by medical students, nurse navigators and representatives from the nonprofits and lung cancer support groups. Educational and engagement materials at the table included lung cancer informational pamphlets, smoking cessation pamphlets and surveys to determine LCS eligibility. 5. Each table had a lung cancer and LCS trivia wheel with small give away items to attract and engage people at the tables. Event: 6. Medical students greeted people who approached the table and explained the purpose of the event (e.g. increasing lung cancer and LCS awareness and education). High priority messages regarding lung cancer and LCS (e.g. lung cancer is the top cancer killer, LCS can lower risk of dying from lung cancer, many eligible patients may not be getting screened) was conveyed by the student to the participant. 7. Participants were invited to complete the survey to determine LCS eligibility. 8. Participants were invited to answer a trivia question to win a lung cancer awareness t-shirt prize. After event: 9. Eligible patients identified by event surveys were followed-up by the nurse navigators to connect to LCS. Results: This lung cancer awareness event was successful in engaging people with lung cancer and lung cancer screening education. 73 people were recorded to have stopped by the table; 58 completed the survey in full. This event is within the power of medical students to do and can be set up easily with buy-in from faculty, hospital staff and local nonprofits. Conclusion: A student-run lung cancer awareness event is a feasible and impactful method to quickly engage patients in lung cancer screening. This event model can be translatable to future years and potentially expanded to other institutions and centers. Citation Format: Michelle Gomez-Guevara, Kristine Chin, Anthony Smith Jr., Masashi Azuma, Grace X. Ma, Cherie P Erkmen. Building a lung cancer awareness event [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B040.

Exploring the influence of Silicon Valley Bank default and U.S. financial stress on sectoral interactions and effective hedging strategies

ABSTRACT The SVB implosion could trigger a domino effect, shaking confidence in U.S. banks. This research estimates the response of good and bad cumulative abnormal returns (G-CARs, B-CARs) on the event day, pre-event and post-event periods, using financial stress, oil, geopolitical and equity uncertainty as controls. We also examine the moderating impact of the SVB implosion and U.S. financial stress indices (US-FSI) on the good and bad dynamic conditional correlations between 132 U.S. sectoral pairings. Additionally, we assess the best portfolio distribution to determine if short positions in specific U.S. sectors offer better protection against SVB’s long-term volatility using the DCC-GARCH-t copulas. Overall findings suggest that B-CARs are more adversely affected than G-CARs. Therefore, investors need to consider bearish and bullish market conditions before devising hedging strategies. The Financials, Health Care, Industrial, Materials, Oil and Gas, Real Estate and Transportation sectors of U.S. experienced significant losses due to higher B-CARs around the SVB default event. Furthermore, the SVB default’s moderating impact on the U.S. sectoral stock returns is more pronounced during bearish market conditions compared to bullish ones following a Black Swan event. This suggests a differential moderating impact of SVB on good and bad conditional connectedness and a reduction in diversification benefits.