To promote a bioactive surface on cobalt base alloys a biomimetic method was used. The metallic substrates were alkali- and heat-treated. The treated substrates were immersed in simulated body fluid for 21 days in presence of wollastonite ceramics or bioactive glass. Two different simulated body fluids were used, one with an ion concentration close to human blood plasma (SBF) and other with a concentration of 1.5 times of that of the SBF (1.5SBF). Some tests were performed by soaking the samples for 7 days in SBF with bioactive material, followed by an immersion in 1.5SBF (re-immersion method). Tests with no bioactive material were also performed in all the cases. A bonelike apatite layer was formed on the substrates treated with wollastonite and bioactive glass. The morphology more similar to that of the existing bioactive systems was obtained by using the re-immersion method with wollastonite. No apatite layer was formed on the substrates treated with no bioactive material, apart from the cases when the re-immersion method was used.