David King Research Articles

Entrevista com David King Dunaway: o documentário radiofônico

Durante o mes de maio de 2016, o MidiaSon e a ECA-USP receberam David King Dunaway, documentarista, historiador, biografo e professor de Ingles e Literatura na Universidade do Novo Mexico, para um curso de curta-duracao sobre a producao do documentario radiofonico. Com a conclusao da serie de aulas, convidamos o professor para uma conversa sobre seu trabalho como investigador de historia oral e, principalmente, a importância do documentario radiofonico. A entrevista foi organizada em tres partes: a primeira foca a carreira e algumas das producoes mais relevantes do professor; a segunda aborda o documentario radiofonico em suas especificidades, e em relacao a outros formatos, como o feature e o jornalismo cotidiano; e a terceira parte concentra-se nos assuntos como comunidades, ativismo por meio do radio e os espacos disponiveis para a producao radiofonica documental.

Is there a Relationship between Spiritual Intelligence and Self- Efficacy of the Elderly?

With the growing number of elders, improving the quality of their life has been of great importance. One of the factors affecting the quality of life is self-efficacy. On the other hand, spiritual intelligence is one of the known aspects of intelligence that some studies have shown its relationship with self-efficacy, but it has not been investigated so far. Therefore, this study is aimed at investigating the relationship between spiritual intelligence and self-efficacy in the elderly. In this study, self-efficacy questionnaire Schwarz and David King Spiritual Intelligence Questionnaire was used in 2016 in Arak Metropolis. After collecting the data, the results were analyzed by software SPSS 16. Results showed that the average self-efficacy and Spiritual Intelligence of the elderly are 68/52% ± 7/27% and 78/38% ± 19/58%, respectively. ANOVA and T test results revealed that self-efficacy is associated with some demographic variables such as sex, marital status, education, lifestyle, occupation, education and going to the mosque.

Abstract LB-154: Generation of antagonistic anti-DDR1 monoclonal antibodies as a potential novel cancer therapeutic

Abstract Discoidin domain receptor 1 (DDR1) is a nonintegrin tyrosine kinase receptor for collagen implicated in diverse cellular roles, including cell adhesion, proliferation, and extracellular matrix remodeling. Multiple tumor types have been shown to overexpress DDR1, including lung, esophageal, breast, ovarian, and pediatric brain cancers, suggesting a potential role for DDR1 in tumor progression. Inhibition of DDR1 signaling may therefore represent a novel therapeutic approach for treating these cancers. Potential therapeutic molecules that modulate human DDR1 activity were identified by screening the AnaptysBio Evolvable Library (ABEL) of fully human germline antibodies. The initial ABEL screen used the soluble DDR-1 extra cellular domain, followed by secondary screening on cell-surface DDR-1. The resulting panel of human antibodies was affinity matured using SHM-XELTM which uses mammalian cell display of human IgG followed by in vitro somatic hypermutation (SHM) as described for a number of other antibodies (Bowers et al., 2014, Methods 65, 44-56). The matured antibodies bound specifically to DDR1 with high affinity (KD<1nM as measured by Biacore), and were able to functionally inhibit collagen triggered DDR1 signaling in multiple cell-based assays. The antibody panel shows selectivity for DDR1 over closely related molecules such as DDR2 and has other properties suitable for preclinical development, including cross-reactivity with the cynomolgus monkey DDR-1 ortholog and good biophysical properties. These antibodies are being further explored for their therapeutic efficacy in tumor types where DDR1 signaling plays a role in disease progression. Citation Format: H. Toni Jun, Brandon Hynes, John L. Macomber, Andrew Lassen, Larry Altobell, Josh MacLaren, David King, Robert A. Horlick. Generation of antagonistic anti-DDR1 monoclonal antibodies as a potential novel cancer therapeutic. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-154. doi:10.1158/1538-7445.AM2014-LB-154

Abstract LB-266: Generation of antagonistic anti-TIM-3 and anti-LAG-3 monoclonal antibodies for potential novel immunotherapy combinations

Abstract Among the most promising approaches in the treatment of cancer is the activation of antitumor immunity by blockade of immune checkpoints. These inhibitory immune checkpoints are crucial for maintaining self-tolerance in the normal immune system but can be co-opted in cancer to allow tumor escape from immune surveillance. Therapeutic validation has been provided using antibodies that inhibit the CTLA-4 and PD-1 signaling pathways, which have shown significant clinical activity. Interestingly, blockade of other T-cell inhibitory signaling molecules TIM-3 and LAG-3 has also been shown to be effective in mouse models of cancer. Potential therapeutic molecules that inhibit the negative signaling of TIM-3 or LAG-3 were identified by screening the AnaptysBio Evolvable Library (ABEL) of fully human germline antibodies. The initial ABEL screens used the soluble extra cellular domains (ECD) of either TIM-3 or LAG-3, followed by screening on cell-surface expressed antigens. The resulting panels of human antibodies were matured to high affinity and potency using SHM-XEL™ which uses mammalian cell display of human IgG followed by in vitro somatic hypermutation (SHM). We have explored the activity of these antibodies both as single agents as well as simultaneous blockade of multiple pathways in in vitro cell-based assays. Inhibition of each pathway in isolation demonstrated immune stimulatory activity as evidenced by increased secretion of IL-2 in a mixed lymphocyte reaction or an activated T-cell assay. Combination of an anti LAG-3 or an anti TIM-3 antibody with an anti-PD-1 inhibitory antibody could increase IL-2 secretion over that seen with blockade of a single checkpoint alone. The magnitude of this effect was donor cell dependent. These data are suggestive that combination immunotherapy towards these targets is worthy of clinical evaluation and may lead to increased efficacy. Citation Format: H. Toni Jun, Patricia A. McNeeley, Andrew Lassen, Brandon Hynes, Larry Altobell, Mark Chhoa, Jesus Olvera, Josh MacLaren, Minjee Do, Michael Brown, Jean da Silva Correia, David King. Generation of antagonistic anti-TIM-3 and anti-LAG-3 monoclonal antibodies for potential novel immunotherapy combinations. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-266. doi:10.1158/1538-7445.AM2014-LB-266

Editorial: steps towards global flood risk modelling

Editorial: steps towards global flood risk modelling

Book Review: Astronomy in Islam

ASTRONOMY IN ISLAM Islamic Astronomy and Geography. David A. King (Variorum Collected Studies Series, CS1009; AshgatePublishing, Franham, Surrey, 2012). Pp. xlii + 376. £90. ISBN 978-1-4094-4201-1.The papers reprinted in this welcome addition to the series of three previous collections of David King's papers further witness to the breadth and depth of his researches on medieval Islamic astronomy, as well as the extent to which that discipline was responsive to the concerns of Islamic religion and culture.King has divided the papers into five groups, the first of which (General) begins with a 1996 overview of problems and achievements in Islamic astronomy. The two following papers deal with Islamic astronomical instruments (2004) and illustrations in astronomical manuscripts (1995). In the former, inscriptions to context, King related a number of cases in which physical features (such as inscription) and (sometimes) separate treatises have given us information about the purpose of these instruments and the context in which they were produced. One such instrument is an astrolabe the design of whose rete and stars displayed thereon are identical with that of the sole surviving Byzantine astrolabe. It predates all known early Islamic astrolabes; the inscriptions tell us that the instrument was reworked (and slightly muddled) by an Ottoman craftsman almost a thousand years after it was made. In the past decades instruments and illustrations in scientific works have received careful scholarly attention and King has been a leading contributor to the study of both.The second section, Regional studies, treats astronomy in Fatimid and Mamluk Egypt, as well as astronomy in the medieval Maghrib. The treatment of astronomy in the medieval Maghrib has received much attention in past decades, as King points out, thanks to the efforts of the Barcelona school under the leadership of Julio Samso. However King has to be considered the principal authority on mathematics in Fatimid and Mamluk Egypt, and his paper, Aspects of Fatimid astronomy: From hard-core mathematical astronomy to architectural orientations in Cairo, connects, as do so many of his works, the exact sciences in Islam with the wider context of Islamic culture. In this case King shows how the effects of the work of the great Cairene astronomer, Ibn Yunus (d. 1009), and his successors were felt for centuries in such seemingly unlikely matters as the orientation of ventilators in Cairo.Much of King's work has been devoted to the study of astronomical tables, and the third section of this book, Mathematical astrology, contains one paper, tracing the Arabic tradition of two tables by the second-century Antiochian astronomer Vettius Valens. These tables ostensibly predicted a person's length of life based on the longitude of the ecliptic rising at the moment of birth, subject to the bound determined by half the maximum length of daylight at the place of birth. Although such use of exact science may seem nonsensical to a scientific 'modem' it seems appropriate to modify a remark that King makes in a later paper (VIII, p. …

King, David. Red Star Over Russia: A Visual History of the Soviet Union from 1917 to the Death of Stalin. Posters, Photographs and Graphics from the David King Collection (review)

King, David. Red Star Over Russia: A Visual History of the Soviet Union from 1917 to the Death of Stalin. Posters, Photographs and Graphics from the David King Collection (review)

Was Bathsheba the Original Bridget Jones? A New Look at Bathsheba on Screen and in Biblical Scholarship

This article addresses the reception in text and cinema of the story told of the biblical character Bathsheba in 2 Samuel 11; specifically, it addresses the scholarly interpretations of Bathsheba and the portrayals of her story in the films David and Bathsheba (1951) and King David (1985), and in the NBC mini-series Kings (2009). I shall examine the ways in which each medium fills the gaps left by 2 Samuel 11 and investigate how the rise of feminism and feminist biblical scholarship has changed the reception of Bathsheba’s story. Recognizing that people participate in a reading that speaks to them on a personal level, the article concludes with a post-feminist interpretation of 2 Samuel 11, one that represents Bathsheba as an “ancient” Bridget Jones. Such a reading is missing, as made clear by the review of scholarship and film. This new interpretation is important, because it has the potential to resonate with today’s generation of young women.

Die Erhebung Davids zum König nach der Darstellung der Chronik

The Chronicler’s account of David’s accession to the kingship is attached to his model (2 Sm 5.1-3), but goes much further : it is the entire army gathered at Hebron which makes David king, which recalls to some extent Macedonian military royalty. Whilst the coronation of David is not a genuinely religious act, it does offer a certain cultural colouring which arises particularly from the meals to which it is linked, these meals being constitutive of access to royal status. Concerning the menus of the meals which take place at Hebron, the Chronicler looks to the presents which Abigail brings to David to coax him (1 Sm 25.18). The Chronicler creates in David’s future wife a forerunner of the entire army : she proclaims the king before the army does, as is clear from a reading of 1 Chr 12.41.

The Earliest Astronomical Tables in French (c. 1271)

In memory of Emmanuel Poulie1. Introduction: Content and History of MS Bernkastel-Kues 215Among the astronomical codices that once belonged to the famous scholar Nicholas of Cues (1401-64), MS Bernkastel-Kues, Hospitalsbibliothek 215, has drawn little attention until now. The old catalogue published in 1905 by Jakob Marx, and Alois Krchnak's paper on Nicholas's astronomical manuscripts and instruments, are still useful but rather imprecise.' David King briefly described the last part of this codex in an appendix of his book The ciphers of the monks: MS Bernkastel-Kues CusanusStift 215,8 (ff. 103r-123v), he said, in a fourteenth century monastic hand, contains a set of solar, lunar and planetary tables and canons in the Picard or Walloon (?) dialect of medieval French, with Paris mentioned in some of the planetary tables (and a latitude of 48° used in the tables of oblique ascensions) and Ghent specifically mentioned in the canons (f. 128r).2 But no one seems to have previously noticed, in the second chapter of these French canons devoted to the calculation of the longitude of the Sun, the last sentence:Adone ares le vrai liu dou Soleil sans l'octave spere, ki est 9 degreis et 13 menus l'an del Incarnacion 1271, et cascun an monte le moitiet d'un menut?Therefore you'll get the true place of the Sun without the eighth sphere, which is 9 degrees and 1 3 minutes the year of Incarnation 1 27 1 , and each year it increases half a minute.The position of the eighth sphere is here mentioned in present indicative and is roughly coherent with the localization of this sphere at 9; 13,14,30,1° on 8 August 1271, i.e. the first day of a.h. 670, as Fritz S. Pedersen has deduced from a table of the motion of the eighth sphere for A.D. 1271-82 conserved in an Italian astronomical manuscript of the second half of the thirteenth century.4 The year 1271 could have been considered as a radix, but if these anonymous French canons and tables correspond to each other, we can reasonably infer that both were originally composed c. 1271.MS Bernkastel-Kues 215 is a codex of 132 folios, 252 ? 197 mm, in parchment. It was copied during the first half of the fourteenth century by one main hand, with some annotations of the fifteenth century (c. 1422-40) that may have done by Nicholas of Cues himself. The whole manuscript is thematically coherent since it contains seven Latin texts on optics and astronomy: John Peckham's Perspectiva (ff. lra-24ra); the Almanack planetarum of William of Saint-Cloud (ff. 24va-84v); the canons of Prophatius Judeus's Almanack perpetuimi and an extract of the tabular part of this perpetual almanac based on the radix of 1300 (ff. 85ra-94v); four treatises composed by or ascribed to Thebit (Thabit ibn Qurra), namely the De quantitatibus stellarum, De motu octave sphere, Uber de his que indigent expositione antequam legaturAlmagesti, and De imaginatione sphere (ff. 95ra-102vb). The French section is located at the end of manuscript: ff. 103r-127r for the tables and ff. 127va-132vb for the canons. Apart from Thebit's treatises, this codex contains scientific material put in circulation in the second half or at the very end of the thirteenth century, with an astronomical part still up-to-date before 1320 and the development of the Latin Alfonsine tables in Paris.The geographical discrepancy between the tables (adapted for Paris) and the canons (which mention only one place, Ghent) is of course a limit for their accuracy. But this discrepancy is partially offset by their linguistic consistency, with features more or less shared between Picard and Walloon, which is nicely consistent with the city of Ghent.5 This invites a mixed hypothesis on their possible origin: the adaptation of the tables to the meridian and latitude of Paris and the reference to Ghent in the canons direct us to the Picard Nation of the Faculty of Arts of the University of Paris, for we know that the students of Ghent belonged to this Nation. …

Oil's tipping point has passed

The economic pain of a flattening supply will trump the environment as a reason to curb the use of fossil fuels, say James Murray and David King.

Review

Book Reviews 161 Frank E. Kuron. “Thus Fell Tecumseh”: The 1813 Struggle for the Northwest Territory, and the Mystery Surrounding Who Killed Tecumseh, Revealed through the Personal Accounts of the Participants. Toledo, Ohio: Kuron Publishing, 2011. Pp. 335. Illustrations. Index. Maps. Notes. Photographs. Paper, $21.95. In 1985 the English historian John Sugden published Tecumseh’s Last Stand. While emphasizing the British and Indian perspectives, Sugden’s well-researched and well-written examination of the 1813 battle of the Thames explored in detail the questions surrounding Tecumseh’s death. The focus of Frank Kuron’s book is found in its subtitle: “the mystery surrounding who killed Tecumseh, revealed through the personal accounts of the participants.” So before reading “Thus Fell Tecumseh,” one might legitimately ask if the subject has not already been fully examined. Kuron’s answer is found on the first page of his preface: he loves to study “the actual words of the person doing the telling” (p. ix). In order to provide a context for such contemporary accounts, the author devotes the first half of his book to the 1813 struggle for the Northwest Territory. Written in a conversational tone, this portion is the author’s weakest effort, in which he essentially engages in creating onedimensional heroes. Richard Johnson was a “restless and relentless patriot” (p. 48), William Henry Harrison “a savvy politician” (p. 48), William Whitley a Kentuckian of “proven patriotism and fighting skills” (p. 56), and Kentucky militiamen were willing to sacrifice for “their beliefs, their families, and their country” (p. 57). More valuable is the book’s second half, which is devoted to unedited versions of the “overwhelmingly contrary, ambiguous, selfserving , political and generally perplexing” testimonies related to the death of Tecumseh (p. 137). Kuron organizes his discussion and analysis into seven segments according to particular eyewitnesses—American, Indian, or British—and their position on the battlefield. In his summation, he recognizes that “the majority of testimonies point toward one of three men [having] done this deed”: Colonel Richard M. Johnson, William Whitley, or Private David King (p. 298). Kuron has also gone to great lengths to pursue antiquarian matters that are of debatable historical importance. For example, he devotes nearly three pages to a series of inquiries about Tecumseh’s death stemming from the contradictory nature of the assembled testimony. They range from questions about what armaments Tecumseh took into battle to whether he wore war paint and even to what color it might have been (pp. 141-44). The author acknowledges that there is a certain level of tedium involved in attempting to answer such queries. Kuron 162 The Michigan Historical Review offers full quotations and referenced primary sources not in the form of a traditional set of edited documents but within the context of his own folksy commentary. Notwithstanding this technique, I can envision the book being used as a text to explore conflicting historical sources and the process of arriving at a supportable conclusion. Near the end, “Thus Fell Tecumseh” introduces a fourth possibility for Tecumseh’s killer—David Thompson—who has a rather weak claim but allows Kuron to note that picking and choosing what is deemed pertinent is part of the scholarly process (p. 303). It is a good point for any researcher to absorb. David A. Simmons Editor, TIMELINE Ohio Historical Society Jonathon Riley. A Matter of Honour: The Life, Campaigns, and Generalship of Isaac Brock. Montréal: Robin Brass Studio, 2011. Pp. 336. Bibliography. Illustrations. Index. Maps. Notes. Paper, $27.95; and Wesley B. Turner. The Astonishing General: The Life and Legacy of Sir Isaac Brock. Toronto: Dundurn, 2011. Pp. 248. Appendices. Bibliography. Illustrations. Index. Maps. Notes. Cloth, $35.00. It is fitting that Maj. Gen. Sir Isaac Brock, KB (1769-1812) receives two biographies on the eve of the 200th anniversary of the War of 1812. Recently retired Professor Wesley Turner of Brock University continues his study of the era by expanding on his master’s thesis and his sketch of the “savior of Upper Canada” published in British Generals in the War of 1812: High Command in the Canadas (1999). And retired British Army Lt. Gen. Jonathon Riley, CB adds to his long list...

Essay Review: Piero's Flagellation of Christ Elucidated?

PIERO'S FLAGELLATION OF CHRIST ELUCIDATED? Astrolabes and Angels, Epigrams and Enigmas: From Regiomontanus' Acrostic for Cardinal Bessarion to Piero della Francesca' s of Christ. David King (Boethius: Texte und Abhandlungen zur Geschichte der Mathematik und der Naturwissenschaften, Ivi; Franz Steiner Verlag, Stuttgart, 2007). Pp. xii + 348 + CD-ROM. euro78. ISBN 978-3-515-09061-2.Readers of this journal will recognize with respect name of David King, who has earned an international reputation in history of Islamic astronomy. King is arguably leading historian of astrolabe, for he probably has seen, catalogued, and studied more astrolabes than anyone else, and not only those of Islamic civilization. In main part of this book King returns to an instrument about which he and Gerard Turner published a fundamental article. It is famous astrolabe that Johannes Regiomontanus (1436-76) in 1462 gave to his patron, Greek emigre Cardinal Bessarion (1408-72), a leading intellectual and astronomical enthusiast.1 King's primary focus now is Regiomontanus's four-line dedication to Bessarion, which he believes to be an acrostic that not only identifies figures in of Christ by Piero della Francesca (d. 1492), but also explains structure of this famous, mysterious and controversial painting.King's title aptly warns us not to expect standard fare; indeed, book is unusual from beginning to end. Substituting for author's name on title page is phrase An essay by David A. King inspired by two remarkable discoveries by Berthold Holzschuh. Curious already. As a member of King's 2005 Frankfurt seminar, Holzschuh first proposed key ideas that King takes up. We soon learn that he disagrees with many of King's extensions of his own hypotheses in present book.2 In Notes to Reader, King acknowledges layout problems and missing footnotes that resulted from his rushing book into print. Next, he summarizes book, significance of which he links with extravagant claim (repeated) that his is the first hypothesis [about Piero 's Flagellation of Christ] to be based on a contemporaneous document (p. viii). By this, he means four-line dedication on Regiomontanus's astrolabe. The table of contents includes one prelude and one conclusion, two tributes to Holzschuh, and three interludes interspersed among four parts. Nine appendices (almost half book) discuss various aspects of history of astrolabe, including valuable - and controversial - material on sole surviving astrolabe with a Greek inscription (1062) and on several dozen fifteenthcentury astrolabes that King convincingly links to a Viennese workshop. After useful bibliographical and biographical material, King's acknowledgments broach candidly scepticism with which his critics, many of them sympathetic, from members of his 2005 seminar outward, have greeted his claims. Finally, after index, a CD-ROM inside back cover contains King's claims in form of a 238-slide show (the illustrations, both here and in book, are generally excellent).What is King arguing? This question is not always easy to answer. He took in such an impressive amount of history and art history in a short time that book is not fully digested. On expository grounds alone, it was published prematurely. Its pages offer a profusion of details and correlations - geometrical, numerical, alphabetical, symbolic, and biographical - that lead to sometimes competing claims. The reader is left to figure out when a specific point counts as a thesis, a suggestion, a probability, a coincidence, or a passing thought, and whether a new claim replaces, or should be added to, previous ones. Since King's Summary (pp. vii-viii) and Prelude (pp. 1-12) contain some concise declarative statements of core ideas, I will treat them as canonical, even though they are sometimes inconsistent with later ones:I maintain first that epigram on [1462] astrolabe provided ideas for composition and basic geometrical structure for painting, and second that each of eight images across painting represents at least two persons whose identities are deliberately partially concealed (p. …

Valuing Nature

Valuing Nature

The Spectator Debate

The Spectator Debate

A Bilingual Astrolabe from the Court of Jahāngīr

A Mughal astrolabe preserved in the Sampurnanand Sanskrit University at Varanasi is unique in many respects. While almost all the extant Indo-Persian astrolabes emanate from a single family of astrolabe makers of Lahore or are influenced by the products of this family, the present astrolabe differs from the characteristic style of the Lahore family and testifies to the presence of another style of astrolabe-making in the Indian subcontinent. Made by a Brahmin apprentice of a Muslim astrolabe maker at Jahāngīr’s court in Agra, this astrolabe carries legends in Arabic and Sanskrit so that it can be used by Muslim nuzūmis as well as by Hindu jyotiṣīs and is thus a ‘unique testimonial to an intercultural encounter’—to borrow David King’s phrase. This article offers a full technical description of this astrolabe and attempts to situate it in the history of production of Indo-Persian astrolabes on the one hand, and that of Sanskrit astrolabes on the other.

Latest News & Updates from the Personalized Medicine Coalition.

The Personalized Medicine Coalition (PMC) has proudly sponsored the Partners’ Healthcare Center for Personalized Genetic Medicine (Partners, MA, USA) annual conference on personalized medicine since 2005. This pre-eminent meeting on the subject also serves as the PMC’s annual conference, and brings together the leading figures in the field to explore opportunities, progress and challenges in science, business and policy. Scheduled this year for the 9–10 November in the Joseph B Martin Conference Center at Harvard Medical School in Boston (MA, USA), the conference promises to provide unique insights into personalized medicine in keeping with its venue and its partnership with the Harvard Business School. I caught up with Raju Kucherlapati (RK), PhD, Paul C Cabot, Professor of Genetics and Professor of Medicine at the Harvard Medical School, and the conference’s director, to ask him about plans for the seventh annual meeting. Edward Abrahams (EA): How would you say the field has evolved since 2005; the conference’s first year? RK: In 2005 many people were skeptical about personalized medicine. Some suggested that it would not have any significant impact on healthcare in less than 10–15 years. During the past 6 years; however, we have seen many examples of how personalized medicine products can improve medical care and reduce costs. As a result of these scientific and medical devel opments, an entire industry that serves patients has undergone a revolution. Nowhere is this more evident than in cancer care. The diagnosis, prognosis and care of many types of cancer depends on obtaining information about the genetics of the tumor. Several new drugs that use companion diagnostics have been approved, and others are awaiting approval from the US FDA. Many new business models that incorporate personalized medicine have emerged. There is a greater awareness and interest among policymakers of how personalized medicine can improve the quality of medical care at a reduced cost. All of these developments make me optimistic about the future, provided that we invest properly to make sure it happens. EA: What are the themes for this year’s conference? RK: This year we plan to take a close look at how the science underlying personalized medicine has the capacity to impact large populations, and have invited a number of distinguished speakers who can help us understand the power of the paradigm. They include Stephen Spielberg, MD PhD, the newly appointed Deputy Commissioner for medical products at FDA, and Fabien Calvo, MD PhD, Director General and Director of Research, French National Cancer Institute (Boulogne-Billancourt, France). We will also look at emerging business models for personalized medicine, hearing from David King, President and CEO, LabCorp (NC, USA), and Stephen Little, Vice President, Personalized Healthcare, QIAGEN (Hilden, Germany), among others. EA: Why is this conference different? RK: Because it is an international conference that focuses especially on the business of personalized medicine, the meeting attracts speakers and a diverse audience from around the world. Another unique component is the annual PMC Award for Leadership in Personalized Medicine, whose winner is invited to define his or her vision for the future of personalized medicine in remarks which are later published. A feature we began 2 years ago that has become very popular, the Harvard Business School Case Study on a topic of relevance to the field, adds a unique interactive component to the meeting. This year, with the rapidly declining cost of sequencing, it will focus on the development of these technologies and how they are likely to impact on medicine in the future.

Archaeological Sites Along King Creek in Western Nacogdoches County, in East Texas

The King Creek area of western Nacogdoches County in East Texas is known to be a locality where Historic Caddo sites (of the Allen phase, ca. A.D. 1650-1800) are abundant, or at least abundant relative to many other parts of East Texas. In addition to there being at least two branches of the late 17th-early 19th century El Camino Real de los Tejas that bisect the area on their way to crossings on the nearby Angelina River, three important Historic Caddo sites have been identified not far apart in the valley: J. T. King (41NAI5), David King (41NA32l), and Wes Wisener (41NA336); the David King and Wes Wisener sites lie a short distance south of the J. T. King site, on the west side of the King Creek valley. Tom Middlebrook suggests these sites, and other Historic Caddo sites yet to be identified in the valley, are part of an early 18th century Hainai Caddo village that had farmstead compounds dispersed across at least a 3-4 km stretch of the valley. In 2009, we had the opportunity to conduct archaeological survey investigations on private land on King Creek and one of its tributaries. The survey area is about l-1.5 km northeast of the J. T. King site. The principal focus of the survey work was to identify other Historic Caddo sites in the King Creek valley. Our interest in this property had first been piqued because the landowner had reported that a iron Spanish sword had been found on the property some years earlier; the landowner also mentioned that there were preserved segments of El Camino Real de los Tejas on the property. This article summarizes the findings from a first round of archaeological survey investigations

Singing out: an oral history of America's folk music revivals

Foreword by Pete Seeger Introduction by David King Dunaway 1. I Never Heard A Horse Sing It!: Defining Folk Music 2. Early Collectors 3. Music for the Masses 4. Greenwich Village: 1940s 5. Am I In America?: The Red Scare 6. Folk Boom 7. Movement Music: Civil Rights 8. Folk-Rock 9. Nu Folk 10. The Power of Music Biographies of Interviewees Notes on the Interviews Interview Index Discography Bibliography

Spending review leaves research in the lurch

A revised research spending plan won't meet the challenges Britain faces from its international competitors or from climate change, argues David King.