Database Website Research Articles

Comprehensive analysis of cuproptosis-related genes in immune infiltration in ischemic stroke.

Immune infiltration plays an important role in the course of ischemic stroke (IS) progression. Cuproptosis is a newly discovered form of programmed cell death. To date, no studies on the mechanisms by which cuproptosis-related genes regulate immune infiltration in IS have been reported. IS-related microarray datasets were retrieved from the Gene Expression Omnibus (GEO) database and standardized. Immune infiltration was extracted and quantified based on the processed gene expression matrix. The differences between the IS group and the normal group as well as the correlation between the infiltrating immune cells and their functions were analyzed. The cuproptosis-related DEGs most related to immunity were screened out, and the risk model was constructed. Finally, Gene Ontology (GO) function, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses and drug target were performed using the Enrichr website database. miRNAs were predicted using FunRich software. Finally, cuproptosis-related differentially expressed genes (DEGs) in IS samples were typed, and Gene Set Variation Analysis (GSVA) was used to analyze the differences in biological functions among the different types. Seven Cuproptosis-related DEGs were obtained by merging the GSE16561 and GSE37587 datasets. Correlation analysis of the immune cells showed that NLRP3, NFE2L2, ATP7A, LIPT1, GLS, and MTF1 were significantly correlated with immune cells. Subsequently, these six genes were included in the risk study, and the risk prediction model was constructed to calculate the total score to analyze the risk probability of the IS group. KEGG analysis showed that the genes were mainly enriched in the following two pathways: D-glutamine and D-glutamate metabolism; and lipids and atherosclerosis. Drug target prediction found that DMBA CTD 00007046 and Lithocholate TTD 00009000 were predicted to have potential therapeutic effects of candidate molecules. GSVA showed that the TGF-β signaling pathway and autophagy regulation pathways were upregulated in the subgroup with high expression of cuproptosis-related DEGs. NLRP3, NFE2L2, ATP7A, LIPT1, GLS and MTF1 may serve as predictors of cuproptosis and play an important role in the pathogenesis of immune infiltration in IS.

CircRNA, a novel diagnostic biomarker for coronary heart disease.

This study aimed to identify the potential diagnostic biomarkers of coronary heart disease (CHD) from exosome-derived circRNA. The microarray data of circRNA derived from the exosomes of patients with CHD and mRNA in acute myocardial infarction was retrieved from exoRBase website and GEO database (GSE61144), respectively, to identify the differentially expressed genes (DEGs). Our findings detected the differentially expressed circRNAs and mRNAs and predicted their correlation with microRNAs using the microRNA target prediction website, thus ascertaining the corresponding circ-microRNA and micro-mRNAs. Then, we performed systematic Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on the differentially expressed mRNA. Protein-Protein Interactions (PPI) of these DEGs were examined using STRING. The receiver operator characteristic (ROC) curve was used to validate the diagnostic efficacy of circRNA in patients with CHD. Finally, the RNAs identified in this study were verified by quantitative real-time polymerase chain reaction (qRT-PCR). A total of 85 differentially expressed circRNAs (4 up-regulated and 81 down-regulated) were identified by screening the circRNAs in exosome of CHD patients. Based on the prediction data of circRNA, mRNA, and the corresponding microRNA, a ceRNA network was constructed, including 7 circRNA nodes, 5 microRNA nodes, and 2 mRNA nodes. Finally, validated by qRT-PCR testing, we found circRNA0001785, circRNA0000973, circRNA0001741, and circRNA0003922 to be the promising candidate for the effective prediction of CHD. These potential diagnostic markers can provide insight for further research on the occurrence of CHD or even acute coronary syndrome (ACS).

Sistematis Literatur Review (SLR) : Peningkatan Kapasitas dan Pengelola Sumber Daya dalam Usaha Mikro, Kecil dan Menengah pada Badan Usaha Milik Desa

The purpose of this study is to analyze capacity building and resource management in micro, small and medium enterprises, village-owned enterprises, namely in the field of human resource development and training in several villages by providing ongoing assistance and collaborating with various parties. The study used a systematic literature review approach through several stages, namely identifying research questions, establishing a data base for research results, selecting relevant research results and indexing data extraction, synthesizing results using narrative methods and presenting data. Methodology This research was conducted with a search engine (Google Chrome) using the address https://scholar.google.com/ chosen according to the address of the largest open database website that can be accessed by many parties who search with the search term "UMKM BUMDES. PDFs”. From the results of a literature review search found 31 articles with topics related to MSMEs using BUMDes then the results of the analysis show that creative industry synergy is needed, this synergy requires a support system, namely the state, universities, the media and the business world. state support is very important in this case then the university can help with concept development and further assistance the mass media is a means of publication and village products then the community can become successful and the company can become a productive partner in the village. Then it is then managed by several regions in Indonesia starting from planning to controlling BUMDes so that it continues to run well then it is regulated in regulations and based on the approved articles of association. As for how to start a business such as services and trade as well as BUMDes management can be done digitally so that management can function optimally.

Rural-Urban Differences in Physical Fitness and Overweight Prevalence of Children and Adolescents from Central South China.

This present study aims to determine the rural-urban differences in physical fitness and overweight prevalence among children and adolescents from Central South China. All the original parameters of physical fitness indicators for 216,718 participants aged from 7 to 15 years old were obtained from the website of the Chinese National Student Physical Fitness Database and were analyzed by SPSS. (1) Children and adolescents from rural areas were observed to have a more adverse physical fitness ratio, and the urban-rural differences were identified in each physical fitness indicator. (2) Rural areas had a higher overweight prevalence (p < 0.01). When compared to urban cities, overweight students from rural towns measured a significantly poorer cardiorespiratory and muscular fitness in primary school (p < 0.05), while the result in middle school was showed the opposite. (3) Rural-urban residence and sex were the moderately correlated factors for muscular fitness among overweight students. Urban children and adolescents in central south China had an overall healthier profile than their rural peers, particularly in overweight groups. The government and related functional departments should take the factors of rural-urban residence and sex of students into consideration when building a state strategy and interventions to promote physical activity and health.

What is the evidence that advertising policies could have an impact on gambling-related harms? A systematic umbrella review of the literature

ObjectiveTo summarise the evidence on the impacts of gambling-related advertising that could lead to gambling-related harm, including impacts on vulnerable individuals and inequalities in the distribution of harms. Study designAn umbrella review of studies investigating the impact of gambling advertising. MethodsA review was undertaken of systematic reviews of qualitative, quantitative and mixed method studies reporting outcomes associated with gambling advertising and marketing. The search strategy included database searches (Web of Science, PsycInfo) and website searches. The quality of the included reviews was determined using A MeaSurement Tool to Assess systematic Reviews 2. Results1024 papers were identified by database searches. Eight systematic reviews, including 74 unique studies, met inclusion criteria. Included studies, using quantitative and qualitative methods, consistently support the existence of a causal relationship between exposure to advertising of gambling products/brands and more positive attitudes to gambling, greater intentions to gamble and increased gambling activity at both individual and population level. There is evidence of a ‘dose–response’ effect; greater advertising exposure increases participation which leads to a greater risk of harm. There was more evidence for the impact on children and young people and for those already at risk from current gambling activity with those most vulnerable more likely to be influenced. ConclusionGambling advertising restrictions could reduce overall harm and mitigate the impact of advertising on gambling-related inequalities. Public health harm prevention strategies should include policies which limit exposure to advertising, particularly among children and vulnerable groups.

Crypto Price Prediction as an Investment Opportunity: An Empirical Study of Three Global Cryptocurrencies

Aims: To determine the investment feasibility of evaluating cryptocurrency opportunities as an investment product under the possibility of crypto price valuation selection. The study analyzes three indicators: asset price returns in unrelated time, selection of cryptocurrency investment price weights, and crypto price forward contract opportunities on ARCH-GARCH probability forecasts in the selection of price valuations by individual cryptocurrency prices.&#x0D; Study Design: Quantitative research.&#x0D; Place and Duration of Study: The period from 10 September 2021 to 4 September 2022 using sample data downloaded from the Yahoo Finance website database with metric data retrieval bound in amount, data quantity, or distance relative to writing opportunities to examine the distribution of the amount of research data.&#x0D; Methodology: This study employed Bitcoin (BTC), Ethereum (ETH), and Tether (USDT) cryptocurrencies as the research objects with used panel and multiple regression analysis methodologies and using forecasting the appropriate ARCH and GARCH methods&#x0D; Results: The results show that the prediction of future crypto price selection in BTC and ETH tokens has a probability of 78.6% and 59.6%, respectively. The study highlights the prediction of future BTC and ETH price selection with 79.21% and 78.64% forecast results as found in the ARCH-GARCH(1, 0, 1) technique. Meanwhile, USDT token has no possibility to be forecasted in the future, leaving a 7.3% possibility of crypto price selection under probability by investors in the form of high (or different) price fluctuation inequalities.&#x0D; Conclusion: Conclusions could state that the partial (combined) selection of crypto coin price assessments and individual crypto assets can reduce the expected return from the selection of the asset price so that this form of investment in crypto assets can reduce the level of observation of return on wealth from crypto assets for investors especially in expecting the chance on that investment.

Anatomical features of the malformation, methods and results of bladder exstrophy primary closure. Literature review

Background. Bladder exstrophy (ВE) is a complex combined malformation of the organs of the genitourinary system, the methods of treatment of which have not been fully developed. Materials and methods. When writing a literature review, materials devoted to the problem of BE published in the databases of PubMed, eLIBRARY (the scientific electronic library of Russia), Scopus, Medline, EMBASE, websites and journals of foreign and domestic professional associations were used. Results. Multiple anatomical features of the structure of organs and entire systems make BE one of the most difficult-to-correct congenital malformations in the field of pediatric urology, requiring a comprehensive, systematic approach to diagnosis and treatment. The paper reflects the key, in our opinion, positions of the author’s Kelly, Mainz operations, the approaches of Schrott–Erlangen, CPRE, MSRE, as well as the view of a number of authors on osteotomy. Conclusion. The abundance of primary closure techniques and the difference in views of numerous authors on the required amount ofsurgical intervention presented in thisliterature review are indisputable proof ofthe relevance ofthe problem.

A Raman spectral database of naturally aged plastics: A proof‐of‐concept study for waste plastic sorting

AbstractA Raman spectral database of naturally aged plastics for years is developed aiming to support efficient and proper plastic waste management based on Raman sorting technology. The database is designed as a website and contains the Raman spectral data for 146 plastic waste samples degraded for years in natural environmental conditions. Plastic samples aged for years in indoor conditions are also included along with a few undegraded, common plastics. The natural environmental degradation occurring for years of exposure to sun radiation, terrestrial and aquatic factors, or temperature variations is poorly understood in terms of spectral changes of representative plastics. The samples of choice are represented by the widespread types of plastics such as polyethylene terephthalate, high‐density polyethylene, low‐density polyethylene, polyvinyl chloride, polypropylene, and polystyrene. Each plastic sample is described individually on the database's website, and its Raman spectrum is available as a txt file for both educational and analytical purposes. Moreover, the database was validated by external validation of the machine‐learning classifiers: k‐nearest neighbor, support vector machine, logistic regression, random forest, and Naïve Bayes resulting in a classification accuracy between 0.902 and 0.973.

Gender disparity among ophthalmologists awarded Canadian institute of health research grants

ABSTRACT Despite efforts toward equity, diversity, and inclusion in academic ophthalmology faculties, gender disparity continues to exist. Current evidence indicates that female ophthalmologists consistently hold lower academic ranks and receive less funding from the National Institutes of Health compared to their male colleagues. The extent of this disparity is unknown in the Canadian context. We sought to characterize the gender gap in Canadian Institutes of Health Research funding among ophthalmologists. From inception, funding decision data were collected from the official Canadian Institutes of Health Research website database hosted by the Government of Canada. Measures including gender, number of grants held over the study period, number of simultaneous grants, and total funding were collected. Female ophthalmologists were consistently awarded fewer grants (21.43 percent) compared to male counterparts and were less likely to hold multiple grants since 2008. An over five-fold disparity was found in total funding for female compared to male ophthalmologists. As well, females were less likely than males to hold a grant in each particular year except in 2020. Female ophthalmologists continue to face barriers to attaining academic support from Canadian Institute of Health Research funds. Continued action to mitigate this gender gap may improve gender-based parity in federal research funding.

Marmora Bizantina: A digital corpus of marble finds from the southern Levant

Archaeological excavations in the Levant have provided a significant number of marble finds dated to the early Byzantine period (4th – mid-7th century CE). Information on these objects is, however, scattered over numerous publications, hindering synthetic studies of marble imports that reached this part of the Mediterranean world. A way to address this problem was to create a database facilitating access to the dataset of marble finds from the southern Levant. This paper presents the Marmora Bizantina database, describes its content and interface, and discusses the geographic and chronological scope of the dataset. Some uses of the database are discussed, remarking on the limitations that need to be taken into account. The paper also provides information on the analytical tools available on the database website.

PRIMARY TOTAL HIP ARTHROPLASTIES UNDER BRAZILIAN PUBLIC HEALTH SYSTEM (2012-2021).

To describe the regional distribution of hospital admission authorizations (HAA), hospitalization costs (HC), the average length of stay (LOS), and mortality rates (MR) related to primary total hip arthroplasties (THA) funded by the Brazilian Health Unic System (SUS) from 2012 to 2021. Descriptive cross-sectional study using secondary data of public domain obtained from the Department of Informatics of SUS (DATASUS) database website. A total of 125,463 HAA were released with HC of 552,218,181.04 BRL in the evaluated period. The average LOS was of 6.8 days. MR was 1.62%. The regional distribution of HAA was 65,756 (52%) in the Southeast; 33,837 (27%) in the South; 14,882 (12%) in the Northeast; 9,364 (8%) in Midwest; and 1,624 (1%) in North - in 2020 there was a sharp decrease of the released HAA, probably due to the COVID-19 pandemic. HC was 293,474,673.20 BRL in the Southeast; 144,794,843.11 BRL in the South; 61,751,644.36 BRL in the Northeast; 45,724,353.80 BRL in the Midwest; and 6,472,666.57 BRL in the North. The average LOS was 6.7 in the Southeast; 5.3 in the South; 9.2 in the Northeast; 7.6 in the Midwest; and, 13.6 in the North. MR was as follows: Southeast=1.88%; South=1.07%; Northeast=1.83%; Midwest=1.44%; and North=1.47%. Evidence Level III; Retrospective Comparative Study .

Эволюция студенческого инновационного предпринимательства в России

All over the world, students are regarded as the most creative and driving force of innovative entrepreneurship. Technological entrepreneurship is an essential tool for the transition to innovative economic development. It is especially in demand in modern conditions, when the most sensitive and strategically significant blow to Russia is inflicted precisely in the technological plane. The purpose of the article is to analyze the evolution of student entrepreneurship in Russia in order to generalize the accumulated experience, identify promising areas for further development of youth innovations. Based on a significant historiographical analysis, the study of the documentary database, statistical data and qualitative content analysis of the official websites of nine universities, three main stages in the development of youth innovative entrepreneurship in Russia have been identified. The first stage is associated with the creation of student business incubators for the development of small innovative enterprises, the second - with an increase in the involvement of business incubators in the educational process, when universities begin to practice the protection of final qualifying work as startups, the third – with the beginning of the formation of a unified startup ecosystem of student technological entrepreneurship in Russia. The first results of the implementation of the federal project "Platform of University Technological Entrepreneurship" are summarized, achievements and problems are shown. Conclusions are drawn about the weak coverage of non-technical universities by innovative entrepreneurship, special attention is paid to new financial instruments aimed at commercializing the results of intellectual activity created in educational institutions and supporting student startups at earlier stages of development.

Exploration and practice in the course of “Website Design and Production” form the ideological and political perspective

Website Design and Production is the core course of the curriculum system for e-commerce majors. It is an integrated course of theory and practice of systematic design and development of an e-commerce website by comprehensively using HTML5+CSS3 program design, website art foundation, database and other e-commerce professional knowledge and skills. Guided by the goal of curriculum moral education, stay The knowledge points of website design and production are imperceptibly integrated into the ideological and political elements of the curriculum, and moral education runs through the whole process of teaching. At the important knowledge points, students are guided to brainstorm, imagine application scenarios, and apply what they have learned. At the same time, they pay attention to the current affairs of the country, understand the historical development and future development trend of the subject, link the content of the course with the national development, design teaching cases, and carry out Guided by the values, we can achieve the goal of making virtue, cultivating people, moistening things silently.

User experiences of older adults navigating an online database of community-based physical activity programs.

This study aimed to (1) explore older adult user experiences navigating an online health database of local physical activity programs; (2) compare navigational feedback with age-friendly website design guidelines; (3) assess online database completeness. Focus groups, including guided tasks and a semi-structured interview script, gathered navigational user experiences of fifteen older adults. A review of the literature sought age-friendly best practice website design guidelines and a website search for local physical activity programs was completed. The design of the online database website was challenging for older adult participants to navigate and was not 'intuitive'. Based on focus group feedback, there were multiple discrepancies between the evaluated online database and the established guidelines for designing age-friendly websites. A total of 187 physical activity programs were missing from the database. Findings provide novel insight into user experiences of older adults navigating online health and physical activity program sites. Redesigning the following age-friendly website recommendations would empower older adults in the use of online databases and promote awareness of local physical activity programs. Health care providers need reliable and age-friendly online resources to link their patients with local physical activity programs to promote healthy aging.

The Role of the Augmented Real-Time Feedback to Overcome the Imbalance of Cognitive, Psychomotor, and Social Interaction in Physical Education Class

The motor learning process requires the inter-coordination of the cognitive, emotional, and psychomotor stages. Diversity in students' cognitive abilities and emotions is a challenge in physical education. The issue has been stated that physical education is an area of less interest, thus resulting in lower student interaction with the social environment. Peer teaching is a method offered to combine the cognitive and emotional aspects of performing psychomotor tasks. This study investigates whether peer teaching can be used as a solution to the imbalance between psychomotor performance and social interaction in physical education. For 10 years, consecutive international papers published in the years 2012-2022 have been screened and reviewed from the ERIC database website according to PRISMA guidelines with specific keyword criteria. Finally, a total of 10 journals were taken as final summarized in the conclusion explaining the results of this study. Peer teaching has been cited as one of the learning models that can overcome the imbalance between psychomotor skills and social interaction. It has a better transfer of knowledge, skills, and social interactions in multicultural classes. Concerning physical education, peer teaching serves as an effective learning model for improving cognitive skills, motor skills, and social interaction at the same time. In addition to student diversity, this learning model can balance student abilities parallel. The concept of peer teaching with peer assistance makes a positive contribution to the practice of physical education. Students' psychomotor skills that are unevenly distributed are supported by their peers, and so their social interaction skills are. It can be concluded as a novelty that Peer teaching provides a positive contribution to a healthier social life, improved motor skills, and behavioral coordination through physical education interaction. Keywords: peer teaching, physical education, psychomotor, social interaction, school. https://doi.org/10.55463/issn.1674-2974.50.2.2

The effect of workload and burnout on auditor performance during the COVID-19 pandemic

The COVID-19 pandemic has put an auditor under pressure to help clients with financial reports. The objective of this research is to investigate the effect of workload and burnout on auditor performance during the COVID-19 pandemic of external auditors in Jakarta. This research employs a quantitative method with a convenience sampling approach. The sample of this study was 101 respondents from 34 public accounting firms in the Jakarta Capital Special Region that were active and registered on the website database of the Financial Services Authority (OJK). The results showed that workload had a positive effect on auditor performance while burnout has a negative effect on auditor performance. This shows that the high workload tends to affect the auditor’s motivation to improve the auditor’s performance and the high burnout tends to affect the auditor’s performance decline.

Web-Based Interactive Virtual Tour as an Information Media and Introduction to Post-Pandemic Lecture Buildings (Building B, Architecture, Faculty of Engineering, University of Lampung)

This study aims to determine the effectiveness of architectural communication methods using a link embedded in online media or social media. This research method is an interactive communication simulation in the form of a Virtual Tour using the 360o panoramic image method. A 360o panoramic image is multiple images combined to get a wider, more detailed image. Panorama images will be set using software and then uploaded to a website's database. The public, in this case more concerned with the academic community, can easily get information about the shape of buildings and spaces from various predetermined points, without installing certain 3D Architecture software. It is enough to use a computer or smartphone based on iOS or Android and without using object tracking or the like to activate communication, because it is web-based, it can be easily accessed anywhere and anytime as long as the user has the intended link. This is an alternative media in providing information about the object, which in this case is the Lecture Building to the public, especially students and parents during the post-pandemic period.

Analysing engineering students' information retrieval behaviour using online databases as information sources

Students at the tertiary education level need the information to complete their assignments at the university. Information retrieval behavior among university students is interesting to study because it shows the ability of search techniques and the diversity of information needed. The researcher has extensively researched information-seeking behavior at this level of education. However, more needs to be explicitly performed on the information retrieval process conducted by engineering students. The purpose of the present study was to reveal engineering students' information retrieval behavior process when using information sources from online database websites through analysis the types of online database websites the students used as primary information sources, why the students used these websites, and identified the challenges in information seeking using online database websites. For this study, data were collected using an internet-based questionnaire distributed among students at the Department of Urban and Regional Planning, ITS. The study results indicated that engineering students used search engines as the primary information source due to their richness and flexibility. In this case, we have found additional results regarding the patterns of presentation and the interactivity necessary to optimize the function of online database websites. Also, the study has found the challenges faced by students in retrieving information and how they overcome the situation by using different keywords.

A Comparison of Trend Models for Predicting Tea Production in Bangladesh

Background: Tea (Camellia sinensis) is a manufactured popular beverage that is mostly consumed around the globe including Bangladesh. Tea consumptions are increasing day by day due to its healthcare effects in the world as well as in Bangladesh. To meet the ever-growing population’s demand in Bangladesh, it is important to predict the production of tea.&#x0D; Objective: Although it is found in the literatures that studies have examined different trend models for tea and agricultural crops, no such study has been found to choose best trend model for predicting the production of tea in Bangladesh. Therefore, an attempt is made to identify the best trend model based on different model selection criterion for the prediction of tea production in Bangladesh.&#x0D; Materials and Methods: Six trend models namely linear, logarithmic, inverse, quadratic, cubic, and compound were applied on tea production dataset (1976 to 2020) collected from the Food and Agriculture Organization Corporate Statistical Database (FAOSTAT) website. For justification of the model, different model section criteria have been checked.&#x0D; Results: The results showed that the compound trend model is the most suitable among considered trend models for predicting the tea production in Bangladesh. Finally, the yearly growth rate of tea production for the period from1976 to 2020 found the compound growth rate of tea production in Bangladesh as 1.02 per year. It is important to note that for the next five years, forecasted increasing rate could be 4840.91 tonnes for the yearly tea production of Bangladesh. Furthermore, remarkable increased progresses of production have been noticed as 23585.7 and 21691.01 tonnes, respectively for the years 2019 and 2020 by the re-estimated model due to the proper nourishing and maintaining the input supply chain from government ends. &#x0D; Conclusion: In the respect of the growing demand, the best-fitted trend model applied herewith through outlier checking and related sophisticated justification tools on the tea production area could help to accumulate knowledge for the practitioner.

What percentage of patients switch from Invisalign to braces? A retrospective study evaluating the conversion rate, number of refinement scans, and length of treatment

This retrospective clinical study aimed to determine what percentage of patients switched from Invisalign to braces to finish treatment. We also examined the number of refinement scans per treatment and the estimated vs actual length of treatment. Records from 500 patients (average age 33.6 years) that started with Invisalign Full or Invisalign Teen were gathered from 2 orthodontic offices and evaluated. Data was collected from the doctors' consultation notes, treatment notes, and Invisalign Web site databases. There were 2 independent variables: gender (male and female) and age groups (aged<20 years, 20-30 years, and>30 years). One in every 6 patients (17.2%) switched from Invisalign to braces. Invisalign treatment required an average of 2.5 refinement scans, and only 6.0% of patients could complete their treatment without a single refinement scan. The average length of Invisalign treatment was 22.8 months, this was 5.1 months more than the estimated length. The average number of aligners was 64.1, but for the patients that switched to braces, the average number of aligners was 80.6 plus an additional 6.9 months of braces. There was no statistical difference between gender or age group and the conversion to braces. However, patients in the oldest age group had a significantly greater number of refinement scans. We are likely overestimating an office's efficiency using Invisalign. On average, an Invisalign patient will require approximately 2-3 refinement scans and 2 years of treatment, and there should be a reasonable expectation that braces may be needed.