In view of the current network information data security transmission method in the process of data transmission, the abnormal data detection performance is poor and the attack rate is high in the process of data transmission. This paper proposes a network information data security transmission method based on the DES algorithm. The 3DES algorithm is used to complete the data encryption process, and the RSA encryption algorithm is used to encrypt the key to get the final data transmission object. The network model is constructed. The LOF algorithm is used to eliminate the abnormal data nodes, and the reliable network nodes are used to complete the data transmission. The experimental results show that this method can effectively reduce the missing rate of abnormal data, further improve the data resistance to attack, and promote the development of network data transmission technology.